化疗以增强辐射诱导的免疫反应。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Benoît Lecoester, Mylène Wespiser, Amélie Marguier, Céline Mirjolet, Jihane Boustani, Olivier Adotévi
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引用次数: 0

摘要

放化疗(CRT)是一种用于局部癌症的常规治疗方法,特别是当它们局部进展时。研究表明,CRT在临床前模型和人体中诱导了强烈的抗肿瘤反应,涉及多种免疫效应。在这篇综述中,我们描述了与CRT疗效有关的各种免疫效应。事实上,诸如免疫细胞死亡、抗原呈递细胞的激活和成熟以及适应性抗肿瘤免疫反应的激活等效应都归因于CRT。正如在其他疗法中经常描述的那样,各种免疫抑制机制,特别是由Treg和髓细胞群体介导的免疫抑制机制可能会降低CRT的疗效。因此,我们讨论了将CRT与其他治疗相结合以增强CRT诱导的抗肿瘤作用的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemotherapy to potentiate the radiation-induced immune response.

Chemoradiation (CRT) is a conventional therapy used in local cancers, especially when they are locally advanced. Studies have shown that CRT induces strong anti-tumor responses involving several immune effects in pre-clinical models and humans. In this review, we have described the various immune effects involved in CRT efficacy. Indeed, effects such as immunological cell death, activation and maturation of antigen-presenting cells, and activation of an adaptive anti-tumor immune response are attributed to CRT. As often described in other therapies, various immunosuppressive mechanisms mediated, in particular, by Treg and myeloid populations may reduce the CRT efficacy. We have therefore discussed the relevance of combining CRT with other therapies to potentiate the CRT-induced anti-tumor effects.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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