Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Pierre Van Mol, Elena Donders, Diether Lambrechts, Els Wauters
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引用次数: 0

Abstract

Immune checkpoints (ICs) play a central role in maintaining immune homoeostasis. The discovery that tumours use this physiological mechanism to avoid elimination by the immune system, opened up avenues for therapeutic targeting of ICs as a novel way of treating cancer. However, this therapy a new array of autoimmune side effects, termed immune-related adverse events (irAEs). In this narrative review, we first recapitulate the physiological function of ICs that are approved targets for cancer immunotherapy (CTLA-4, PD-(L)1 and LAG-3), as the groundwork to critically discuss current knowledge on irAEs. Specifically, we summarize clinical aspects and examine a molecular classification and predisposing factors of irAEs. Finally, we discuss irAE treatment, particularly emphasizing how molecular knowledge is changing the current treatment paradigm.

健康与疾病中的免疫检查点生物学:免疫检查点生物学与癌症患者的自身免疫。
免疫检查点(IC)在维持免疫平衡方面发挥着核心作用。肿瘤利用这种生理机制来避免被免疫系统消灭,这一发现开辟了以 ICs 为治疗靶点的途径,成为治疗癌症的一种新方法。然而,这种疗法也带来了一系列新的自身免疫副作用,即免疫相关不良事件(irAEs)。在这篇叙述性综述中,我们首先回顾了已被批准作为癌症免疫疗法靶点的 ICs(CTLA-4、PD-(L)1 和 LAG-3)的生理功能,并以此为基础批判性地讨论了当前有关 irAEs 的知识。具体而言,我们总结了临床方面的问题,并研究了虹膜急性睫状体反应的分子分类和易感因素。最后,我们讨论了虹膜睫状体激动的治疗,特别强调了分子知识如何改变当前的治疗模式。
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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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