非编码rna在皮肤t细胞淋巴瘤的表观遗传景观。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Monaza Adeeb, Lubna Therachiyil, Safwan Moton, Joerg Buddenkotte, Majid Ali Alam, Shahab Uddin, Martin Steinhoff, Aamir Ahmad
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引用次数: 0

摘要

皮肤t细胞淋巴瘤(CTCL)是一种影响皮肤的癌症,其特征是皮肤中的t细胞异常。表观遗传变化在CTCL的发生和发展中起着重要作用。近年来,非编码rna (ncRNAs),如microRNAs和长链非编码rna,已被确定为CTCL中基因表达调控的关键角色。这些ncrna可以改变参与细胞生长、分化和凋亡的基因的表达,从而导致CTCL的发生和进展。在这篇综述中,我们总结了目前对ncrna在CTCL中的作用的理解,包括它们参与DNA甲基化和其他生物学过程。我们还讨论了ncrna的类型,它们作为致癌或肿瘤抑制的作用,以及它们作为诊断和预后生物标志物的假定用途,基于实验室和患者研究的新证据。此外,我们还介绍了受ncrna影响的潜在靶点和途径。更好地了解CTCL复杂的表观遗传格局,包括ncrna的作用,有可能导致针对该疾病的新型靶向治疗的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma.

Cutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. Epigenetic changes have been found to play a significant role in the development and progression of CTCL. Recently, non-coding RNAs (ncRNAs), such as microRNAs and long non-coding RNAs, have been identified as key players in the regulation of gene expression in CTCL. These ncRNAs can alter the expression of genes involved in cell growth, differentiation, and apoptosis, leading to the development and progression of CTCL. In this review, we summarize the current understanding of the role of ncRNAs in CTCL, including their involvement in DNA methylation, and other biological processes. We also discuss the types of ncRNAs, their role as oncogenic or tumor suppressive, and their putative use as diagnostic and prognostic biomarkers, based on the emerging evidence from laboratory-based as well as patients-based studies. Moreover, we also present the potential targets and pathways affected by ncRNAs. A better understanding of the complex epigenetic landscape of CTCL, including the role of ncRNAs, has the potential to lead to the development of novel targeted therapies for this disease.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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