癌症中的表观基因组编辑：潜在治疗方案的进展与挑战。

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI:10.1016/bs.ircmb.2023.10.001

Seung-Won Lee, Connor Mitchell Frankston, Jungsun Kim

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引用次数: 0

摘要

癌症是由遗传和非遗传环境因素引起的疾病。表观遗传学改变（有些是非遗传因素造成的）可导致癌症的发生。表观遗传学改变可能发生在肿瘤抑制因子或致癌基因中，也可能导致整体细胞状态改变，使细胞异常。基因编辑技术的最新进展显示了治疗癌症的潜力。在此，我们将讨论我们目前对癌症中发生的表观遗传学改变的了解，以及可用于开发治疗方案的表观遗传学编辑技术。

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Epigenome editing in cancer: Advances and challenges for potential therapeutic options.

Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic alterations, some attributed to non-genetic factors, can lead to cancer development. Epigenetic changes can occur in tumor suppressors or oncogenes, or they may contribute to global cell state changes, making cells abnormal. Recent advances in gene editing technology show potential for cancer treatment. Herein, we will discuss our current knowledge of epigenetic alterations occurring in cancer and epigenetic editing technologies that can be applied to developing therapeutic options.

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来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.