{"title":"以树突状细胞为目标的免疫检查点,用于基于抗体的癌症调控。","authors":"Xin Lei, Yizhi Wang, Chayenne Broens, Jannie Borst, Yanling Xiao","doi":"10.1016/bs.ircmb.2023.07.006","DOIUrl":null,"url":null,"abstract":"<p><p>Dendritic cells (DC) are professional antigen-presenting cells which link innate to adaptive immunity. DC play a central role in regulating antitumor T-cell responses in both tumor-draining lymph nodes (TDLN) and the tumor microenvironment (TME). They modulate effector T-cell responses via immune checkpoint proteins (ICPs) that can be either stimulatory or inhibitory. Functions of DC are often impaired by the suppressive TME leading to tumor immune escape. Therefore, better understanding of the mechanisms of action of ICPs expressed by (tumor-infiltrating) DC will lead to potential new treatment strategies. Genetic manipulation and high-dimensional analyses have provided insight in the interactions between DC and T-cells in TDLN and the TME upon ICP targeting. In this review, we discuss (tumor-infiltrating) DC lineage cells and tumor tissue specific \"mature\" DC states and their gene signatures in relation to anti-tumor immunity. We also review a number of ICPs expressed by DC regarding their functions in phagocytosis, DC activation, or inhibition and outline position in, or promise for clinical trials in cancer immunotherapy. Collectively, we highlight the critical role of DC and their exact status in the TME for the induction and propagation of T-cell immunity to cancer.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"382 ","pages":"145-179"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer.\",\"authors\":\"Xin Lei, Yizhi Wang, Chayenne Broens, Jannie Borst, Yanling Xiao\",\"doi\":\"10.1016/bs.ircmb.2023.07.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Dendritic cells (DC) are professional antigen-presenting cells which link innate to adaptive immunity. DC play a central role in regulating antitumor T-cell responses in both tumor-draining lymph nodes (TDLN) and the tumor microenvironment (TME). They modulate effector T-cell responses via immune checkpoint proteins (ICPs) that can be either stimulatory or inhibitory. Functions of DC are often impaired by the suppressive TME leading to tumor immune escape. Therefore, better understanding of the mechanisms of action of ICPs expressed by (tumor-infiltrating) DC will lead to potential new treatment strategies. Genetic manipulation and high-dimensional analyses have provided insight in the interactions between DC and T-cells in TDLN and the TME upon ICP targeting. In this review, we discuss (tumor-infiltrating) DC lineage cells and tumor tissue specific \\\"mature\\\" DC states and their gene signatures in relation to anti-tumor immunity. We also review a number of ICPs expressed by DC regarding their functions in phagocytosis, DC activation, or inhibition and outline position in, or promise for clinical trials in cancer immunotherapy. Collectively, we highlight the critical role of DC and their exact status in the TME for the induction and propagation of T-cell immunity to cancer.</p>\",\"PeriodicalId\":14422,\"journal\":{\"name\":\"International review of cell and molecular biology\",\"volume\":\"382 \",\"pages\":\"145-179\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International review of cell and molecular biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.ircmb.2023.07.006\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/8/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of cell and molecular biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.ircmb.2023.07.006","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
树突状细胞(DC)是连接先天性免疫和适应性免疫的专业抗原递呈细胞。树突状细胞在调节肿瘤引流淋巴结(TDLN)和肿瘤微环境(TME)中的抗肿瘤T细胞反应方面发挥着核心作用。它们通过免疫检查点蛋白(ICPs)调节效应 T 细胞反应,ICPs 既可以是刺激性的,也可以是抑制性的。DC的功能往往会因肿瘤微环境的抑制而受损,从而导致肿瘤免疫逃逸。因此,更好地了解(肿瘤浸润)DC 表达的 ICPs 的作用机制将带来潜在的新治疗策略。基因操作和高维分析深入揭示了 ICP 靶向后 TDLN 和 TME 中 DC 和 T 细胞之间的相互作用。在这篇综述中,我们将讨论(肿瘤浸润)DC 系细胞和肿瘤组织特异性 "成熟 "DC 状态及其与抗肿瘤免疫相关的基因特征。我们还回顾了一些由 DC 表达的 ICPs,它们在吞噬、DC 激活或抑制方面的功能,并概述了它们在癌症免疫疗法临床试验中的地位或前景。总之,我们强调了直流电的关键作用及其在TME中的确切地位,以诱导和传播针对癌症的T细胞免疫。
Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer.
Dendritic cells (DC) are professional antigen-presenting cells which link innate to adaptive immunity. DC play a central role in regulating antitumor T-cell responses in both tumor-draining lymph nodes (TDLN) and the tumor microenvironment (TME). They modulate effector T-cell responses via immune checkpoint proteins (ICPs) that can be either stimulatory or inhibitory. Functions of DC are often impaired by the suppressive TME leading to tumor immune escape. Therefore, better understanding of the mechanisms of action of ICPs expressed by (tumor-infiltrating) DC will lead to potential new treatment strategies. Genetic manipulation and high-dimensional analyses have provided insight in the interactions between DC and T-cells in TDLN and the TME upon ICP targeting. In this review, we discuss (tumor-infiltrating) DC lineage cells and tumor tissue specific "mature" DC states and their gene signatures in relation to anti-tumor immunity. We also review a number of ICPs expressed by DC regarding their functions in phagocytosis, DC activation, or inhibition and outline position in, or promise for clinical trials in cancer immunotherapy. Collectively, we highlight the critical role of DC and their exact status in the TME for the induction and propagation of T-cell immunity to cancer.
期刊介绍:
International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.