胶质母细胞瘤的细胞信号传导:分子和临床视角。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Debarati Ghosh, Brett Pryor, Nancy Jiang
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引用次数: 0

摘要

多形性胶质母细胞瘤(GBM)是侵袭性最强的脑肿瘤,平均预期寿命不到 15 个月。多形性胶质母细胞瘤患者死亡率如此之高,与各种基因和表观遗传学改变导致的临床和分子异质性有关。这种极其重要的信号通路的改变可归因于异常的基因信号转导。不同亚类的 GBM 主要表现出不同的基因改变,因此,了解不同亚类 GBM 中复杂的信号通路及其关键分子成分对于临床治疗极为重要。在本书的这一章中,我们总结了在不同亚类中发挥重要作用的常见和重要信号通路,并从临床前研究和临床试验的角度讨论了针对这些通路的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular signaling in glioblastoma: A molecular and clinical perspective.

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with an average life expectancy of less than 15 months. Such high patient mortality in GBM is pertaining to the presence of clinical and molecular heterogeneity attributed to various genetic and epigenetic alterations. Such alterations in critically important signaling pathways are attributed to aberrant gene signaling. Different subclasses of GBM show predominance of different genetic alterations and therefore, understanding the complex signaling pathways and their key molecular components in different subclasses of GBM is extremely important with respect to clinical management. In this book chapter, we summarize the common and important signaling pathways that play a significant role in different subclasses and discuss their therapeutic targeting approaches in terms of preclinical studies and clinical trials.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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