Future microbiology最新文献_第5页

A plain language summary of the STRIVE and ReSTORE studies, which tested if rezafungin is effective and as safe as caspofungin at treating people with candidaemia and invasive candidiasis. 对STRIVE和ReSTORE研究的简单语言总结，该研究测试了rezafungin在治疗念珠菌血症和侵袭性念珠菌病方面是否与caspofungin一样有效和安全。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1080/17460913.2024.2426387

George R Thompson, Alex Soriano, Oliver A Cornely, Jalal A Aram, Peter G Pappas

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Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid. 精氨酸与氟化物和甘油磷酸钙的结合：浓度和对生物膜液体的影响。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI: 10.1080/17460913.2024.2411921

Marina Lins Miranda, Karina Borges Salomão, Alberto Carlos Botazzo Delbem, Marcelle Danelon, Elis Rodrigues Oliveira Barbosa, Caio Sampaio, Lucas Arrais Campos, Fernanda Lourenção Brighenti

{"title":"Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid.","authors":"Marina Lins Miranda, Karina Borges Salomão, Alberto Carlos Botazzo Delbem, Marcelle Danelon, Elis Rodrigues Oliveira Barbosa, Caio Sampaio, Lucas Arrais Campos, Fernanda Lourenção Brighenti","doi":"10.1080/17460913.2024.2411921","DOIUrl":"10.1080/17460913.2024.2411921","url":null,"abstract":"Aim: To study the influence of varying concentrations of arginine (Arg) combined with fluoride (F) and/or calcium glycerophosphate (CaGP) on biofilms.Materials & methods: Biofilms were analyzed for acidogenicity, microbial viability and Ca, F and inorganic phosphorus (P) concentrations.Results: For total bacteria, the lowest viability was found in F-containing groups, regardless of the arginine concentrations and presence of CaGP. For aciduric bacteria, no significant differences were found among arginine concentrations in the presence of F. For MS, arginine concentrations did not influence MS viability in the presence of fluoride and CaGP only decreased viability at 3.2% Arg concentration. The arginine-treated groups showed the lowest acidogenicity. For ion concentrations in biofilms, CaGP showed the highest values for P; Arg+F for F; and CaGP/Arg+CaGP for Ca.Conclusion: Different concentrations of arginine did not affect the microbial viability or acidogenicity of biofilms. Moreover, 0.8% Arg did not increase ion concentration in biofilm fluid.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"201-212"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of MPT-64 protein in pleural tuberculosis cases by magnetic bead-gold nanoparticle-PCR amplified immunoassay. 磁珠-金纳米颗粒- pcr扩增免疫分析法检测胸膜结核患者MPT-64蛋白。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI: 10.1080/17460913.2024.2432179

Aishwarya Soni, Kiran Nehra, Bhawna Dahiya, Anam Rais, Tulika Prasad, Anjum Gahlaut, Vikas Raj, Reetu Sheoran, Aparna Parmar, Promod K Mehta

{"title":"Detection of MPT-64 protein in pleural tuberculosis cases by magnetic bead-gold nanoparticle-PCR amplified immunoassay.","authors":"Aishwarya Soni, Kiran Nehra, Bhawna Dahiya, Anam Rais, Tulika Prasad, Anjum Gahlaut, Vikas Raj, Reetu Sheoran, Aparna Parmar, Promod K Mehta","doi":"10.1080/17460913.2024.2432179","DOIUrl":"10.1080/17460913.2024.2432179","url":null,"abstract":"Aim: Diagnosis of pleural tuberculosis (TB) is challenging; thus, an efficient method is urgently needed.Methods: We developed a magnetic-bead-gold nanoparticle-PCR amplified immunoassay (MB-AuNP-I-PCR, liquid system) to detect the Mycobacterium tuberculosis MPT-64 protein in pleural TB patients. AuNPs functionalized with detection antibodies/oligonucleotides were characterized by UV-vis spectroscopy, Transmission/Scanning electron microscopy, Fourier-transform infrared spectrometer, ELISA, and PCR, whereas MBs conjugated with detection antibodies were validated by magneto-ELISA/UV-vis spectroscopy.Results: We utilized the MB-AuNP-I-PCR for MPT-64 detection in 99 clinical specimens which displayed 85.2% sensitivity and 97.8% specificity to diagnose pleural TB cases. Markedly, the sensitivity achieved by MB-AuNP-I-PCR was noticeably higher (p < 0.01) than magneto-ELISA and GeneXpert.Conclusion: This is a preliminary report to diagnose pleural TB cases by MB-AuNP-I-PCR with promising results that require further corroboration in a higher number of specimens.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"107-115"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic evaluation of treating invasive aspergillosis with isavuconazole, posaconazole and voriconazole in China. 在中国使用异武康唑、泊沙康唑和伏立康唑治疗侵袭性曲霉菌病的经济评估。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2423530

Qiang Liu, Pingyu Chen, Dunming Xiao, Jingxuan Wei, Yintao Lin, Tiantian Tao, Xin Li

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Streptococcus intermedius: an underestimated pathogen in brain infection? 中间链球菌：脑部感染中被低估的病原体？

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2423524

Eliza Gil, James Hatcher, Sophia de Saram, Rebecca L Guy, Theresa Lamagni, Jeremy S Brown

{"title":"Streptococcus intermedius: an underestimated pathogen in brain infection?","authors":"Eliza Gil, James Hatcher, Sophia de Saram, Rebecca L Guy, Theresa Lamagni, Jeremy S Brown","doi":"10.1080/17460913.2024.2423524","DOIUrl":"10.1080/17460913.2024.2423524","url":null,"abstract":"Streptococcus intermedius is an oral commensal organism belonging to the Streptococcus anginosus group (SAG). S. intermedius causes periodontitis as well as invasive, pyogenic infection of the central nervous system, pleural space or liver. Compared with other SAG organisms, S. intermedius has a higher mortality as well as a predilection for intracranial infection, suggesting it is likely to possess virulence factors that mediate specific interactions with the host resulting in bacteria reaching the brain. The mechanisms involved are not well described. Intracranial suppuration (ICS) due to S. intermedius infection can manifest as an abscess within the brain parenchyma, or a collection of pus (empyema) in the sub- or extra-dural space. These infections necessitate neurosurgery and prolonged antibiotic treatment and are associated with a considerable burden of morbidity and mortality. The incidence of ICS is increasing in several settings, with SAG species accounting for an increasing proportion of cases. There is a paucity of published literature regarding S. intermedius pathogenesis as well as few published genomes, hampering molecular epidemiological research. This perspective evaluates what is known about the clinical features and pathogenesis of ICS due to S. intermedius and explores hypothetical explanations why the incidence of these infections may be increasing.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"163-177"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients. 门诊病人中引起甲癣的耐多药角化溶解性皮癣菌和非皮癣菌。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-26 DOI: 10.1080/17460913.2024.2428140

Sajeda Akter, Parveen Afroz Chowdhury, Marufatuzzahan, Al Hakim, Mehejabin Nurunnahar, Md Asraful Jahan, Md Siraj Uddin, Abul Kalam Azad

{"title":"Multidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients.","authors":"Sajeda Akter, Parveen Afroz Chowdhury, Marufatuzzahan, Al Hakim, Mehejabin Nurunnahar, Md Asraful Jahan, Md Siraj Uddin, Abul Kalam Azad","doi":"10.1080/17460913.2024.2428140","DOIUrl":"10.1080/17460913.2024.2428140","url":null,"abstract":"Aims: This study identified and determined antibiograms of keratinolytic dermatophytes (DM), non-dermatophytic molds (NDM), and yeasts causing onychomycosis.Methods: Morphological, cultural, and biochemical characteristics were used to identify DM and NDM. The keratinolytic activity (KA) and antibiograms were conducted with keratin azure and the agar diffusion method, respectively. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined using the microdilution method.Results: Onychomycosis was more prevalent in males (53%) than females, toenails (57%) than fingernails, and commercial employees (40%) than other employees or unemployed. Fungal growth was observed in 92.5% nail samples. DM, NDM, and yeasts caused 46%, 35%, and 19% onychomycosis, respectively. Trichophyton rubrum and Trichophyton mentagrophytes were the common DM. Five different genus of NDM and three different yeasts were isolated. The KA of DM was 30-45% higher than that of NDM and yeasts. All fungal isolates (FI) were resistant to griseofulvin and fluconazole. However, 71%, 64%, and 36% of FI were sensitive to terbinafine hydrochloride, nystatin, and ketoconazole, respectively, while 84% of DM and 46% of NDM were multidrug-resistant. The MIC and MFC of these antifungals against FI ranged from micrograms to milligrams.Conclusion: Multidrug resistance is growing in keratinolytic DM and NDM.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"137-147"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice. 肠道菌群和衍生的粪便代谢物的变化可能在他克莫司诱导的小鼠糖尿病中发挥作用。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-22 DOI: 10.1080/17460913.2024.2444761

Minyan Qian, Zhenwei Jiang, Caomei Xu, Liying Wang, Nan Hu

{"title":"Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice.","authors":"Minyan Qian, Zhenwei Jiang, Caomei Xu, Liying Wang, Nan Hu","doi":"10.1080/17460913.2024.2444761","DOIUrl":"10.1080/17460913.2024.2444761","url":null,"abstract":"Aims: A notable scarcity of research has focused on examining alterations in gut microbiota and its metabolites within tacrolimus (TAC)-induced diabetes models.Methods: Tacrolimus-induced changes in glucose and lipid metabolism indices were analyzed through different routes of administration. The potential role of gut microbiota and its metabolites in TAC-induced diabetes was investigated using 16S rRNA sequencing and non-targeted metabolomics.Results: After intraperitoneal(ip) and oral(po) administration of TAC, the α-diversity index of gut microbiota was significantly increased. The gut microbiota of the three groups of mice was significantly separated, and there were significant changes in composition and functional genes. Fecal metabolites changed significantly after TAC administration by different routes, and 53 metabolites (38 down-regulated and 15 up-regulated) were identified (CON vs. TACip). Similarly, 29 metabolites (8 down-regulated and 21 up-regulated) were identified (CON vs. TACpo). KEGG pathway analysis identified 4 and 13 significantly altered metabolic pathways, respectively. Correlation analysis suggested that microbiota and metabolites were involved in the pathogenesis of TAC-induced diabetes.Conclusion: This study investigated the alterations in gut microbiota and fecal metabolites in TAC-induced diabetic mice and evaluated the correlation between these changes. These findings provide valuable insights into potential biomarkers in the development of TAC-induced diabetes.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"237-246"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First case report of Corynebacterium minutissimum septic arthritis associated with an indwelling device. 微型棒状杆菌脓毒性关节炎与留置器相关的第一例报告。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1080/17460913.2024.2444160

Samiha Akkaya, Yusuf Emre Ozdemir, Esra Ensaroglu, Ergun Cetin, Hayat Kumbasar Karaosmanoglu

{"title":"First case report of Corynebacterium minutissimum septic arthritis associated with an indwelling device.","authors":"Samiha Akkaya, Yusuf Emre Ozdemir, Esra Ensaroglu, Ergun Cetin, Hayat Kumbasar Karaosmanoglu","doi":"10.1080/17460913.2024.2444160","DOIUrl":"10.1080/17460913.2024.2444160","url":null,"abstract":"Corynebacterium minutissimum usually presents with erythrasma, a macular rash, but rarely it can cause extracutaneous infections such as endocarditis, peritonitis, pyelonephritis, and catheter-related bloodstream infections. Here, we present the first case of septic arthritis caused by C. minutissimum and a literature review of invasive C. minutissimum infections. The diagnosis was confirmed by the patient's clinical findings and microbiological examination of the joint fluid. Considering the patients hemodialysis catheter and the pathogenic nature of the C. minutissimum, we strongly suspected a catheter-related infection. Clinical and laboratory follow-ups showed consistent improvement with treatment, characterized by reduced pain, swelling, and localized warmth in the left knee, along with a significant decline in acute-phase reactants. The patient achieved full recovery following a four-week course of antibiotics and catheter removal. Our report emphasizes the importance of not disregarding the isolation of non-diphtheria Corynebacterium from appropriately collected sterile samples in symptomatic patients, particularly those with indwelling devices. Based on this case report, clinicians should consider the rare possibility of this microorganism being the cause of septic arthritis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"183-188"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Effectiveness of Ivermectin-Based Multidrug Therapy in Severely Hypoxic, Ambulatory COVID-19 Patients. 撤回声明：以伊维菌素为基础的多种药物治疗重症缺氧门诊COVID-19患者的有效性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-09 DOI: 10.1080/17460913.2025.2451540

引用次数: 0

Biosensing technology for detection and assessment of pathogenic microorganisms. 用于检测和评估病原微生物的生物传感技术。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1080/17460913.2024.2417621

Sakshi Sinha, Lata Sheo Bachan Upadhyay

{"title":"Biosensing technology for detection and assessment of pathogenic microorganisms.","authors":"Sakshi Sinha, Lata Sheo Bachan Upadhyay","doi":"10.1080/17460913.2024.2417621","DOIUrl":"10.1080/17460913.2024.2417621","url":null,"abstract":"At present, the prevalence of infectious diseases is rising annually, making it an important risk factor for human health that should not be neglected. Consequently, infection control and prevention have become even more important. The key to determining and designing the most effective anti-infectious medication depends upon the immediate and accurate identification of the causative agent. The standard techniques used for routine infection screening and surveillance tests are shifting toward biosensors. Furthermore, biosensors are projected to be employed for microbiological detection to satisfy the higher accuracy required for clinical diagnosis. This is because of their compact size, real-time monitoring and ability to analyze large sample numbers with less sophistication and manpower requirement, which have allowed them to develop quickly with extensive uses. Biosensors have multiple applications in food safety, environmental surveillance, drug sensing and national security because they offer several advantages such as quick response, outstanding sensitivity, remarkable selectivity, high degree of accuracy and precision, ease of use and affordable price. This review highlights the performance aspects of recently developed biosensors for the detection of infectious bacteria and viruses in biological and environmental samples and emphasizes the significance of nanotechnology in signal amplification for enhanced biosensor performance and dependability.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"57-72"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0