Future microbiology最新文献_第4页

Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies. 肠道菌群在川崎病中的相互作用：肠道菌群的作用和潜在的治疗策略。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-03-01 Epub Date: 2025-02-27 DOI: 10.1080/17460913.2025.2469432

Qing Yang, Yaqing Kang, Wei Tang, Meng Li, Cuifen Zhao

{"title":"Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies.","authors":"Qing Yang, Yaqing Kang, Wei Tang, Meng Li, Cuifen Zhao","doi":"10.1080/17460913.2025.2469432","DOIUrl":"10.1080/17460913.2025.2469432","url":null,"abstract":"Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing the most common form of pediatric vasculitis in children less than 5 years old. Numerous diseases, especially those related to the immune system, have established links with the intestinal flora. Recent studies have investigated the intestinal flora changes throughout the management of KD. There was gut microbiota dysbiosis in pediatric KD at the acute phase, particularly the downregulation of short-chain fat acids-producing microbiota and the over-proliferation of opportunistic pathogens. The relationship between the response to therapies in individuals with KD and specific microbiota remains uncertain. Targeted microbial supplements and dietary regulation may serve as potential measures to alleviate KD complications and thus improve prognosis. This review provides an overview of the current understanding of the interplay of the gut microbiota and KD. Furthermore, it discusses the possibility of altering the gut microbiota to reinstate a healthy condition.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"357-369"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel inhibitory strategy of Leishmania major using Kluyveromyces lactis and Saccharomyces cerevisiae killer toxins. 利用乳酸克鲁维酵母菌和酿酒酵母杀手毒素抑制大利什曼病菌的新策略。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1080/17460913.2024.2443329

Azadeh Zolfaghari, Keivan Beheshti-Maal, Ali Mohammad Ahadi, Ramesh Monajemi

{"title":"A novel inhibitory strategy of Leishmania major using Kluyveromyces lactis and Saccharomyces cerevisiae killer toxins.","authors":"Azadeh Zolfaghari, Keivan Beheshti-Maal, Ali Mohammad Ahadi, Ramesh Monajemi","doi":"10.1080/17460913.2024.2443329","DOIUrl":"10.1080/17460913.2024.2443329","url":null,"abstract":"Aim: Leishmaniasis is a globally prevalent parasitic disease that has drawn significant attention. Killer yeasts offer a novel biological control method, presenting a potential alternative for treating leishmaniasis. This study evaluates the antileishmanial activity of Kluyveromyces lactis and Saccharomyces cerevisiae killer toxins against Leishmania major.Materials & methods: Killer yeasts were isolated using the Well method. The genes encoding K2 and K.L killer toxins were identified by PCR, and the toxins were purified via SDS-PAGE. Antileishmanial and cytotoxic effects on L. major promastigotes and amastigotes were evaluated using the MTT assay.Results: The first killer isolate was identified as Saccharomyces cerevisiae ZBAM (GenBank accession: OQ376749.1) and the second as Kluyveromyces lactis ZBAM (GenBank accession: OQ401036.1). IC50 values of K2 and K.L toxins against L. major promastigotes were significantly lower than Glucantime and Amphotericin B. The EC50 values at 24 hours for Glucantime, K2, and K.L were 11.83 ± 0.02 μg/ml, 2.35 ± 0.01 μg/ml, and 3.23 ± 0.03 μg/ml, respectively. The EC50 values for K2 and K.L against L. major amastigotes were also lower than Glucantime.Conclusion: This is the first report of the antileishmanial effects of K2 and K.L toxins against L. major, suggesting these yeasts as promising candidates for biological leishmaniasis treatment.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"189-199"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dual role of microbes in food safety and human health: from pathogens to probiotics. 微生物在食品安全和人类健康中的双重作用：从病原体到益生菌。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI: 10.1080/17460913.2024.2437273

Helen Onyeaka, Olumide Odeyemi

引用次数: 0

Sex and gender in rhinosinusitis: a review. 鼻鼻窦炎的性别和性别：综述。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-14 DOI: 10.1080/17460913.2024.2441010

C S Thornton, L Radu, N Boechler, J Clark, R Somayaji

引用次数: 0

Evaluation of the antibacterial properties of four bioactive biomaterials for chronic wound management. 四种生物活性材料在慢性伤口治疗中的抗菌性能评价。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2025-01-15 DOI: 10.1080/17460913.2025.2453334

Sarah Fakher, David Westenberg

{"title":"Evaluation of the antibacterial properties of four bioactive biomaterials for chronic wound management.","authors":"Sarah Fakher, David Westenberg","doi":"10.1080/17460913.2025.2453334","DOIUrl":"10.1080/17460913.2025.2453334","url":null,"abstract":"Aim: Chronic wound infections present a prevalent medical issue and a multifaceted problem that significantly impacts healthcare systems worldwide. Biofilms formed by pathogenic bacteria are fundamental virulence factors implicated in the complexity and persistence of bacterial-associated wound infections, leading to prolonged recovery times and increased risk of infection. This study aims to investigate the antibacterial effectiveness of commonly employed bioactive wound healing compositions with a particular emphasis on their effectiveness against common bacterial pathogens encountered in chronic wounds - Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa to identify optimal wound product composition for managing chronic wound infections.Methods: This study tested the antibacterial and antibiofilm effectiveness of four bioactive wound healing materials by performing in vitro antibacterial assays and measuring ion release profiles.Results: The anti-biofilm effectiveness differed extensively among the biomaterials tested and slightly among the bacterial species. Particularly, copper and zinc-doped borate bioactive glass wound healing compositions inhibited the three clinically relevant bacteria in both planktonic and biofilm forms, which were found to be ascribed to the copper and zinc gradual release.Conclusion: The findings suggest that copper and zinc-doped bioactive glasses hold great promise for improving chronic wound management by providing strong antibacterial action and promoting faster healing.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"247-258"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking natural product discovery to unblock the antibiotic pipeline. 重新思考天然产物发现，疏通抗生素管道。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2025-01-16 DOI: 10.1080/17460913.2025.2449779

Sarah M Barry

引用次数: 0

A rare case of granulomatous mastitis by Brucella species. 一例罕见的布鲁氏菌引起的肉芽肿性乳腺炎。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-16 DOI: 10.1080/17460913.2024.2429263

Necati Mumcu, Yusuf Emre Ozdemir

引用次数: 0

Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis. 寄生虫与微生物群的相互作用：创新性干预恰加斯病、利什曼病和蛔虫病的途径。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1080/17460913.2024.2431417

Juan David Ramírez, Sergio Castañeda, Jill Weatherhead, Cristina Poveda

{"title":"Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis.","authors":"Juan David Ramírez, Sergio Castañeda, Jill Weatherhead, Cristina Poveda","doi":"10.1080/17460913.2024.2431417","DOIUrl":"10.1080/17460913.2024.2431417","url":null,"abstract":"Parasitic infections are a major global health challenge, driven in part by complex interactions between parasites, host microbiota, and immune responses. Recent advances in microbiome research highlight the critical role of microbiota in influencing disease outcomes and treatment effectiveness. This review examines how changes in the microbiota impact parasite transmission, disease progression, and responses to treatment, focusing on key parasitic diseases such as Chagas disease, leishmaniasis, and ascariasis. The microbiota can either exacerbate or mitigate disease severity, depending on its composition, providing critical insights for novel therapeutic strategies. Emerging approaches discussed include the use of targeted probiotics, prebiotics, and microbiota-modulating drugs to influence parasite dynamics and enhance conventional therapies. The review also explores the potential of integrating microbiota knowledge into vaccine design and immunotherapy, aiming to develop vaccines that elicit stronger immune responses and identify new therapeutic targets. A multidisciplinary approach is essential for translating these findings into effective clinical solutions, with future research focusing on validating microbiota-based interventions in clinical settings. In conclusion, the interaction between microbiota and parasitic infections presents a promising avenue for innovative therapies, with the potential to significantly improve global health outcomes.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"149-161"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of extracts and isolated compounds Trichilia catigua against clinically relevant candida species. 毛毛菌提取物及分离化合物对临床相关念珠菌的活性研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-22 DOI: 10.1080/17460913.2024.2444163

Mariane Roberta Ritter, Daniella Renata Faria, Franciele Abigail Vilugron Rodrigues, Danielle Lazarin-Bidóia, Daniela Cristina de Medeiros Araújo, Flavio Augusto Vicente Seixas, Érika Seki Kioshima, João Carlos Palazzo de Mello

{"title":"Activity of extracts and isolated compounds Trichilia catigua against clinically relevant candida species.","authors":"Mariane Roberta Ritter, Daniella Renata Faria, Franciele Abigail Vilugron Rodrigues, Danielle Lazarin-Bidóia, Daniela Cristina de Medeiros Araújo, Flavio Augusto Vicente Seixas, Érika Seki Kioshima, João Carlos Palazzo de Mello","doi":"10.1080/17460913.2024.2444163","DOIUrl":"10.1080/17460913.2024.2444163","url":null,"abstract":"Objectives: To evaluate the in vitro antifungal activity of extracts and compounds from Trichilia catigua against clinically relevant Candida species, notably Candida glabrata, and investigate possible mechanisms of action using electron microscopy and in silico techniques.Methods: Extracts and fractions of T. catigua were obtained through turboextraction and partitioning, while the isolated compounds were previously purified. The ethyl acetate fraction (EAF) was characterized by HPLC. Antifungal activity against C. glabrata was evaluated through MIC tests, synergism was assessed via checkerboard assays, and structural changes were analyzed via electron microscopy. Molecular docking was performed to identify potential targets of action.Results: The EAF and isolated compounds (cinchonains and procyanidin B2) exhibited significant activity against C. glabrata, with MICs of 9.76 µg/mL (EAF) and 3.9 µg/mL (cinchonains Ia and Ib). Cinchonain Ib combined with epicatechin or procyanidin B2 displayed synergistic effects, particularly with amphotericin B. Microscopy analysis revealed cell membrane damage, and reverse docking analysis suggested that the compounds may target an enzyme essential to the metabolic processes of C. glabrata.Conclusions: The findings suggest that compounds isolated from T. catigua hold considerable potential for developing new antifungal agents against Candida species, particularly C. glabrata, with promising safety and synergistic profiles.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"227-235"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural polymicrobial Staphylococcus aureus-Pseudomonas aeruginosa interactions and antimicrobial resistance in ex vivo cornea model. 体外角膜模型中金葡萄球菌-铜绿假单胞菌相互作用的超微结构和抗菌药耐药性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1080/17460913.2024.2417617

Sanchita Mitra, Nagapriya Banka, Soumyava Basu, Tirupathi Rao

{"title":"Ultrastructural polymicrobial Staphylococcus aureus-Pseudomonas aeruginosa interactions and antimicrobial resistance in ex vivo cornea model.","authors":"Sanchita Mitra, Nagapriya Banka, Soumyava Basu, Tirupathi Rao","doi":"10.1080/17460913.2024.2417617","DOIUrl":"10.1080/17460913.2024.2417617","url":null,"abstract":"Aim: To investigate antagonistic interactions among pathogens, in ex vivo donor corneas infected with monomicrobial or polymicrobial combinations of antibiotic susceptible and resistant clinical isolates of Staphylococcus aureus (MSSA, MRSA) and Pseudomonas aeruginosa (S-PA, MDR-PA).Materials & methods: Scanning electron microscopy and antimicrobial susceptibility testing (AST, broth microdilution for minimum inhibitory and bactericidal concentrations [MIC/MBC]) pre-and post-polymicrobial interactions, in infected donor corneas.Results: MSSA lost viability with S-PA/MDR-PA, while MRSA formed larger cells, biofilm and lower MIC (teicoplanin) with S-PA, but lost viability with MDR-PA. S-PA had lower MIC (ceftazidime, meropenem, chloramphenicol) with MSSA, and lower MBC (cefoperazone, ciprofloxacin) and fewer cells with MRSA. MDR-PA had abundant cells and no change in AST with MSSA or MRSA.Conclusion: Significant antagonistic interactions occur in ocular polymicrobial infections, affecting antibiotic susceptible isolates more than resistant ones.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"117-135"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0