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Future microbiology最新文献

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Mice fatal pneumonia model induced by less-virulent Streptococcus pneumoniae via intratracheal aerosolization. 通过气管内雾化吸入低毒性肺炎链球菌诱发小鼠致命肺炎模型。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2355738
Jiazhen Wang, Lingfei Hu, Zhijun Zhang, Chengyu Sui, Xiaoyu Zhu, Chengxi Wu, Lili Zhang, Meng Lv, Wenhui Yang, Dongsheng Zhou, Zhengling Shang
{"title":"Mice fatal pneumonia model induced by less-virulent <i>Streptococcus pneumoniae</i> via intratracheal aerosolization.","authors":"Jiazhen Wang, Lingfei Hu, Zhijun Zhang, Chengyu Sui, Xiaoyu Zhu, Chengxi Wu, Lili Zhang, Meng Lv, Wenhui Yang, Dongsheng Zhou, Zhengling Shang","doi":"10.1080/17460913.2024.2355738","DOIUrl":"10.1080/17460913.2024.2355738","url":null,"abstract":"<p><p><b>Aim:</b> Animal models of fatal pneumonia caused by <i>Streptococcus pneumoniae</i> (<i>Spn</i>) have not been reliably generated using many strains of less virulent serotypes.<b>Materials & methods:</b> Pulmonary infection of a less virulent <i>Spn</i> serotype1 strain in the immunocompetent mice was established via the intratracheal aerosolization (ITA) route. The survival, local and systemic bacterial spread, pathological changes and inflammatory responses of this model were compared with those of mice challenged via the intratracheal instillation, intranasal instillation and intraperitoneal injection routes.<b>Results:</b> ITA and intratracheal instillation both induced fatal pneumonia; however, ITA resulted in better lung bacterial deposition and distribution, pathological homogeneity and delivery efficiency.<b>Conclusion:</b> ITA is an optimal route for developing animal models of severe pulmonary infections.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
microRNAs: a new class of endogenous antimicrobials for the treatment of infections in cystic fibrosis and beyond. 微小核糖核酸：治疗囊性纤维化及其他感染的一类新的内源性抗菌素。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-08-06 DOI: 10.1080/17460913.2024.2357971
Yunfei Ye, Yin He Richard Sun, Fidelma Fitzpatrick, Catherine M Greene
{"title":"microRNAs: a new class of endogenous antimicrobials for the treatment of infections in cystic fibrosis and beyond.","authors":"Yunfei Ye, Yin He Richard Sun, Fidelma Fitzpatrick, Catherine M Greene","doi":"10.1080/17460913.2024.2357971","DOIUrl":"10.1080/17460913.2024.2357971","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and treatment of a patient with pulmonary infection caused by Emergomyces Orientalis: a case report. 东方酵母菌肺部感染患者的诊断和治疗：病例报告。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-29 DOI: 10.1080/17460913.2024.2366653
Yifang Jiang, Ruixin Tian, Chi Zhang, Lujie Zhang, Xiaoman Cui, Ping Wang
{"title":"Diagnosis and treatment of a patient with pulmonary infection caused by <i>Emergomyces Orientalis</i>: a case report.","authors":"Yifang Jiang, Ruixin Tian, Chi Zhang, Lujie Zhang, Xiaoman Cui, Ping Wang","doi":"10.1080/17460913.2024.2366653","DOIUrl":"https://doi.org/10.1080/17460913.2024.2366653","url":null,"abstract":"<p><p>Emergomycosis is a dimorphic fungal disease that is typically disseminated and fatal among immunocompromised individuals. In the case report, we presented a patient with intermittent fever, night sweats, coughing and phlegm. Chest computed tomography revealed multiple soft-tissue nodules in both lungs. Routine pathological and microbiological tests did not confirm the diagnosis. Therefore, we conducted pathogen detection using metagenomic next-generation sequencing in bronchoalveolar lavage fluid and identified the pulmonary infection caused by <i>Emergomyces orientalis</i> (<i>Es. orientalis</i>). During the antifungal treatment, the patient experienced renal function damage, and we have attempted various antifungal drugs for treatment. Finally, the patient's condition was brought under control. Therefore, the metagenomic next-generation sequencing pathogen detection was essential.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional lung parenchyma model for studies of Aspergillus fumigatus infection and antifungal treatment. 用于研究曲霉菌感染和抗真菌治疗的三维肺实质模型。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-16 DOI: 10.1080/17460913.2024.2371926
Bruna Nakanishi Fortes, Fernanda Wirth, Aline Martins Dos Santos, Marlus Chorilli, Vanessa Morais Freitas, Jennifer Farias, Felipe S Chambergo, Viviane Abreu Nunes C Dantas, Kelly Ishida
{"title":"Three-dimensional lung parenchyma model for studies of <i>Aspergillus fumigatus</i> infection and antifungal treatment.","authors":"Bruna Nakanishi Fortes, Fernanda Wirth, Aline Martins Dos Santos, Marlus Chorilli, Vanessa Morais Freitas, Jennifer Farias, Felipe S Chambergo, Viviane Abreu Nunes C Dantas, Kelly Ishida","doi":"10.1080/17460913.2024.2371926","DOIUrl":"https://doi.org/10.1080/17460913.2024.2371926","url":null,"abstract":"<p><p><b>Aim:</b> This work aims to standardize the three-dimensional hydroxyethyl-alginate-gelatin (HAG) scaffold as a model to evaluate <i>Aspergillus fumigatus</i> biofilm and antifungal treatments. <b>Methods:</b> The scaffold was characterized by physical, rheological and microscopic analyses; the antibiofilm action was evaluated by determination of cfu and metabolic activity. <b>Results:</b> The scaffold was non-toxic showing stability in aqueous media, swelling capacity, elasticity and had homogeneously distributed pores averaging 190 μm. The <i>A. fumigatus</i> biofilm established itself very well on the scaffold and treatment with amphotericin B and voriconazole reduced viable cells and metabolic activity. <b>Conclusion:</b> The HAG scaffold proved to be a model to mimic lung parenchyma, suitable for establishing a 3D biofilm culture of <i>A. fumigatus</i> and evaluating the efficacy of antifungals.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fecal microbiota live - jslm (Rebyota™/RBL) for management of recurrent Clostridioides difficile infection. 粪便微生物群活体--jslm（Rebyota™/RBL）用于治疗复发性艰难梭菌感染。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-11 DOI: 10.1080/17460913.2024.2364583
Bethany L Boyle, Sahil Khanna
{"title":"Fecal microbiota live - jslm (Rebyota™/RBL) for management of recurrent <i>Clostridioides difficile</i> infection.","authors":"Bethany L Boyle, Sahil Khanna","doi":"10.1080/17460913.2024.2364583","DOIUrl":"https://doi.org/10.1080/17460913.2024.2364583","url":null,"abstract":"<p><p>There is an unmet need for effective treatments of <i>Clostridioides difficile</i> infection, an emerging health crisis in the United States. The management of <i>C. difficile</i> infection should include treatment of active infection and a strategy to prevent recurrence. Current gold standard therapy includes oral antibiotics which predispose patients to gut dysbiosis and increase the risk of recurrent infection. Addressing dysbiosis via fecal microbiota transplantation is an active and promising area of research, but studies have lacked standardization which makes outcome and safety data difficult to interpret. Rebyota™, formerly known as RBX2660, is a live biotherapeutic product designed using a standardized protocol and manufacturing process that has been shown to be effective for preventing recurrent <i>C. difficile</i> infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation. 含有钒酸银和纳米银颗粒的抗菌凝胶：抗真菌和理化评价。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-09 DOI: 10.1080/17460913.2024.2366630
João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis
{"title":"Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation.","authors":"João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis","doi":"10.1080/17460913.2024.2366630","DOIUrl":"https://doi.org/10.1080/17460913.2024.2366630","url":null,"abstract":"<p><p><b>Aim:</b> To develop a β-AgVO<sub>3</sub> gel and evaluate its physicochemical stability and antifungal activity against <i>Candida albicans</i>. <b>Materials & methods:</b> The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO<sub>3</sub>. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion. <b>Results:</b> The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO<sub>3</sub> concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO<sub>3</sub> gel with 20xMIC. <b>Conclusion:</b> The β-AgVO<sub>3</sub> gel showed physicochemical stability and antifungal activity.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii. 当前针对鲍曼不动杆菌毒力因子和生物膜形成的治疗策略。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-04-29 DOI: 10.2217/fmb-2023-0263
Seetha Lakshmi Rajangam, Manoj Kumar Narasimhan
{"title":"Current treatment strategies for targeting virulence factors and biofilm formation in <i>Acinetobacter baumannii</i>.","authors":"Seetha Lakshmi Rajangam, Manoj Kumar Narasimhan","doi":"10.2217/fmb-2023-0263","DOIUrl":"10.2217/fmb-2023-0263","url":null,"abstract":"<p><p>A higher prevalence of <i>Acinetobacter baumannii</i> infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of <i>A. baumannii</i> makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat <i>A. baumannii</i> biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis. 乳铁蛋白及其衍生功能片段的协同作用是防治粘液瘤病的一种有前途的治疗剂。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-06-21 DOI: 10.1080/17460913.2024.2352263
Surabhi Pandit, Anamika Singh, Jiya Singh, Immaculata Xess, Tej P Singh, Gagandeep Singh, Pradeep Sharma, Sujata Sharma
{"title":"Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis.","authors":"Surabhi Pandit, Anamika Singh, Jiya Singh, Immaculata Xess, Tej P Singh, Gagandeep Singh, Pradeep Sharma, Sujata Sharma","doi":"10.1080/17460913.2024.2352263","DOIUrl":"10.1080/17460913.2024.2352263","url":null,"abstract":"<p><p><b>Aim:</b> Currently, we have limited armamentarium of antifungal agents against Mucorales. There is an urgent need to discover novel antifungal agents that are effective, safe and affordable. <b>Materials & methods:</b> In this study, the anti-Mucorale action of native lactoferrin (LF) and its functional fragments CLF, RR6 and LFcin against three common Mucorale species are reported. The synergistic action of LF with antifungal agents like amphotericin B, isavuconazole and posaconazole was analyzed using checkerboard technique. <b>Results:</b> All the three mucor species showed inhibition when treated with fragments. The checkerboard assay confirmed that native LF showed the best synergistic action against Mucorales in combination with Amphotericin B. <b>Conclusion:</b> These results highlight the potential therapeutic value of native LF against Mucorales.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric analysis and evaluation of publications on non-Helicobacter pylori helicobacters from 1993 to 2023. 对 1993 年至 2023 年期间有关非幽门螺旋杆菌螺旋体的出版物进行文献计量分析和评估。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-05-03 DOI: 10.2217/fmb-2024-0034
Menghui Wang, Hui Fang, Chulin Zhou, Yaobin Ouyang, Chenfeng Yu, Yang Zhang, Xiaoyi Zhu, Chuan Xie, Qiliang Deng
{"title":"Bibliometric analysis and evaluation of publications on non-<i>Helicobacter pylori helicobacters</i> from 1993 to 2023.","authors":"Menghui Wang, Hui Fang, Chulin Zhou, Yaobin Ouyang, Chenfeng Yu, Yang Zhang, Xiaoyi Zhu, Chuan Xie, Qiliang Deng","doi":"10.2217/fmb-2024-0034","DOIUrl":"10.2217/fmb-2024-0034","url":null,"abstract":"<p><p><b>Aim:</b> A bibliometric analysis and evaluation of research on non-<i>Helicobacter pylori Helicobacter</i> species (NHPHs) is essential to determining future research directions. <b>Materials & methods:</b> A comprehensive search was carried out using predetermined search terms within the Web of Science Core Collection (WoSCC) to gather publications spanning from 1993 to 2023. VOSviewer and Citespace were employed for data analysis and visualization. <b>Results:</b> 308 publications on NHPHs were included. Among these, gastric NHPHs received more publications and attention compared with enterohepatic NHPHs. Key findings included the identification of most productive countries, institutions, journals, authors, keywords, research trends and notable perspectives in the field. <b>Conclusion:</b> The article guides further research and clinical applications on NHPHs.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis. 囊性纤维化患者感染非结核分枝杆菌的分子机制分析。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-05-03 DOI: 10.2217/fmb-2023-0237
Qihuang Chen, Jin Li
{"title":"Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis.","authors":"Qihuang Chen, Jin Li","doi":"10.2217/fmb-2023-0237","DOIUrl":"10.2217/fmb-2023-0237","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. <b>Materials & methods:</b> Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. <b>Results:</b> Five hub genes (<i>PIK3R1</i>, <i>IL1A</i>, <i>CXCR4</i>, <i>ACTN1</i>, <i>PFN1</i>) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors <i>RELA</i>, <i>JUN</i>, <i>NFKB1</i> and <i>FOS</i> that regulated hub genes modulated <i>IL1A</i> expression, while 21 other transcription factors regulated <i>CXCR4</i> expression. <b>Conclusion:</b> In summary, this study may provide new insights into the mechanisms of CF with NTM infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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