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Future microbiology最新文献

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microRNAs: a new class of endogenous antimicrobials for the treatment of infections in cystic fibrosis and beyond. 微小核糖核酸：治疗囊性纤维化及其他感染的一类新的内源性抗菌素。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-08-06 DOI: 10.1080/17460913.2024.2357971
Yunfei Ye, Yin He Richard Sun, Fidelma Fitzpatrick, Catherine M Greene
{"title":"microRNAs: a new class of endogenous antimicrobials for the treatment of infections in cystic fibrosis and beyond.","authors":"Yunfei Ye, Yin He Richard Sun, Fidelma Fitzpatrick, Catherine M Greene","doi":"10.1080/17460913.2024.2357971","DOIUrl":"10.1080/17460913.2024.2357971","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1041-1043"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii. 当前针对鲍曼不动杆菌毒力因子和生物膜形成的治疗策略。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-04-29 DOI: 10.2217/fmb-2023-0263
Seetha Lakshmi Rajangam, Manoj Kumar Narasimhan
{"title":"Current treatment strategies for targeting virulence factors and biofilm formation in <i>Acinetobacter baumannii</i>.","authors":"Seetha Lakshmi Rajangam, Manoj Kumar Narasimhan","doi":"10.2217/fmb-2023-0263","DOIUrl":"10.2217/fmb-2023-0263","url":null,"abstract":"<p><p>A higher prevalence of <i>Acinetobacter baumannii</i> infections and mortality rate has been reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of <i>A. baumannii</i> makes it an extremely dangerous pathogen, especially in device-associated hospital-acquired infections (DA-HAI), thereby it resists the penetration of antibiotics. Further, the transmission of the SARS-CoV-2 virus was exacerbated in DA-HAI during the epidemic. This review specifically examines the complex interconnections between several components and genes that play a role in the biofilm formation and the development of infections. The current review provides insights into innovative treatments and therapeutic approaches to combat <i>A. baumannii</i> biofilm-related infections, thereby ultimately improving patient outcomes and reducing the burden of HAI.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"941-961"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric analysis and evaluation of publications on non-Helicobacter pylori helicobacters from 1993 to 2023. 对 1993 年至 2023 年期间有关非幽门螺旋杆菌螺旋体的出版物进行文献计量分析和评估。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-05-03 DOI: 10.2217/fmb-2024-0034
Menghui Wang, Hui Fang, Chulin Zhou, Yaobin Ouyang, Chenfeng Yu, Yang Zhang, Xiaoyi Zhu, Chuan Xie, Qiliang Deng
{"title":"Bibliometric analysis and evaluation of publications on non-<i>Helicobacter pylori helicobacters</i> from 1993 to 2023.","authors":"Menghui Wang, Hui Fang, Chulin Zhou, Yaobin Ouyang, Chenfeng Yu, Yang Zhang, Xiaoyi Zhu, Chuan Xie, Qiliang Deng","doi":"10.2217/fmb-2024-0034","DOIUrl":"10.2217/fmb-2024-0034","url":null,"abstract":"<p><p><b>Aim:</b> A bibliometric analysis and evaluation of research on non-<i>Helicobacter pylori Helicobacter</i> species (NHPHs) is essential to determining future research directions. <b>Materials & methods:</b> A comprehensive search was carried out using predetermined search terms within the Web of Science Core Collection (WoSCC) to gather publications spanning from 1993 to 2023. VOSviewer and Citespace were employed for data analysis and visualization. <b>Results:</b> 308 publications on NHPHs were included. Among these, gastric NHPHs received more publications and attention compared with enterohepatic NHPHs. Key findings included the identification of most productive countries, institutions, journals, authors, keywords, research trends and notable perspectives in the field. <b>Conclusion:</b> The article guides further research and clinical applications on NHPHs.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"889-901"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis. 乳铁蛋白及其衍生功能片段的协同作用是防治粘液瘤病的一种有前途的治疗剂。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-06-21 DOI: 10.1080/17460913.2024.2352263
Surabhi Pandit, Anamika Singh, Jiya Singh, Immaculata Xess, Tej P Singh, Gagandeep Singh, Pradeep Sharma, Sujata Sharma
{"title":"Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis.","authors":"Surabhi Pandit, Anamika Singh, Jiya Singh, Immaculata Xess, Tej P Singh, Gagandeep Singh, Pradeep Sharma, Sujata Sharma","doi":"10.1080/17460913.2024.2352263","DOIUrl":"10.1080/17460913.2024.2352263","url":null,"abstract":"<p><p><b>Aim:</b> Currently, we have limited armamentarium of antifungal agents against Mucorales. There is an urgent need to discover novel antifungal agents that are effective, safe and affordable. <b>Materials & methods:</b> In this study, the anti-Mucorale action of native lactoferrin (LF) and its functional fragments CLF, RR6 and LFcin against three common Mucorale species are reported. The synergistic action of LF with antifungal agents like amphotericin B, isavuconazole and posaconazole was analyzed using checkerboard technique. <b>Results:</b> All the three mucor species showed inhibition when treated with fragments. The checkerboard assay confirmed that native LF showed the best synergistic action against Mucorales in combination with Amphotericin B. <b>Conclusion:</b> These results highlight the potential therapeutic value of native LF against Mucorales.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"857-866"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis. 囊性纤维化患者感染非结核分枝杆菌的分子机制分析。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-05-03 DOI: 10.2217/fmb-2023-0237
Qihuang Chen, Jin Li
{"title":"Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis.","authors":"Qihuang Chen, Jin Li","doi":"10.2217/fmb-2023-0237","DOIUrl":"10.2217/fmb-2023-0237","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. <b>Materials & methods:</b> Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. <b>Results:</b> Five hub genes (<i>PIK3R1</i>, <i>IL1A</i>, <i>CXCR4</i>, <i>ACTN1</i>, <i>PFN1</i>) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors <i>RELA</i>, <i>JUN</i>, <i>NFKB1</i> and <i>FOS</i> that regulated hub genes modulated <i>IL1A</i> expression, while 21 other transcription factors regulated <i>CXCR4</i> expression. <b>Conclusion:</b> In summary, this study may provide new insights into the mechanisms of CF with NTM infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"877-888"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online dashboards for SARS-CoV-2 wastewater-based epidemiology. 基于废水的 SARS-CoV-2 流行病学在线仪表板。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-05-23 DOI: 10.2217/fmb-2024-0033
Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi
{"title":"Online dashboards for SARS-CoV-2 wastewater-based epidemiology.","authors":"Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi","doi":"10.2217/fmb-2024-0033","DOIUrl":"10.2217/fmb-2024-0033","url":null,"abstract":"<p><p><b>Aim:</b> Wastewater-based epidemiology (WBE) is increasingly used to monitor pandemics. In this manuscript, we review methods and limitations of WBE, as well as their online dashboards. <b>Materials & methods:</b> Online dashboards were retrieved using PubMed and search engines, and annotated for timeliness, availability of English version, details on SARS-CoV-2 sublineages, normalization by population and PPMoV load, availability of case/hospitalization count charts and of raw data for export. <b>Results:</b> We retrieved 51 web portals, half of them from Europe. Africa is represented from South Africa only, and only seven portals are available from Asia. <b>Conclusion:</b> WBS provides near-real-time cost-effective monitoring of analytes across space and time in populations. However, tremendous heterogeneity still persists in the SARS-CoV-2 WBE literature.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"761-769"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe mold fungal infections in critically ill patients with COVID-19. 用 COVID-19 治疗重症患者的严重霉菌感染。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-05-31 DOI: 10.2217/fmb-2023-0261
Despoina Koulenti, Elisabeth Paramythiotou, Maria Panagiota Almyroudi, Marios Karvouniaris, Nikolaos Markou, Paschalis Paranos, Christina Routsi, Joseph Meletiadis, Stijn Blot
{"title":"Severe mold fungal infections in critically ill patients with COVID-19.","authors":"Despoina Koulenti, Elisabeth Paramythiotou, Maria Panagiota Almyroudi, Marios Karvouniaris, Nikolaos Markou, Paschalis Paranos, Christina Routsi, Joseph Meletiadis, Stijn Blot","doi":"10.2217/fmb-2023-0261","DOIUrl":"10.2217/fmb-2023-0261","url":null,"abstract":"<p><p>The SARS-CoV-2 pandemic put an unprecedented strain on modern societies and healthcare systems. A significantly higher incidence of invasive fungal co-infections was noted compared with the pre-COVID-19 era, adding new diagnostic and therapeutic challenges in the critical care setting. In the current narrative review, we focus on invasive mold infections caused by <i>Aspergillus</i> and <i>Mucor</i> species in critically ill COVID-19 patients. We discuss up-to-date information on the incidence, pathogenesis, diagnosis and treatment of these mold-COVID-19 co-infections, as well as recommendations on preventive and prophylactic interventions. Traditional risk factors were often not recognized in COVID-19-associated aspergillosis and mucormycosis, highlighting the role of other determinant risk factors. The associated patient outcomes were worse compared with COVID-19 patients without mold co-infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"825-840"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of Escherichia coli to antimicrobial peptide Brevinin-2CE. 外排泵抑制剂氯丙嗪能有效提高大肠杆菌对抗菌肽 Brevinin-2CE 的敏感性。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-04-29 DOI: 10.2217/fmb-2023-0272
Cao Bing, An Mengjuan, Ma Xinyu, Zhu Chixin, Tan Xinyao, Sun Yan, Li Zhi
{"title":"Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of <i>Escherichia coli</i> to antimicrobial peptide Brevinin-2CE.","authors":"Cao Bing, An Mengjuan, Ma Xinyu, Zhu Chixin, Tan Xinyao, Sun Yan, Li Zhi","doi":"10.2217/fmb-2023-0272","DOIUrl":"10.2217/fmb-2023-0272","url":null,"abstract":"<p><p><b>Aim:</b> The response of <i>E. coli</i> ATCC8739 to Brevinin-2CE (B2CE) was evaluated as a strategy to prevent the development of antimicrobial peptide (AMP)-resistant bacteria. <b>Methods:</b> Gene expression levels were detected by transcriptome sequencing and RT-PCR. Target genes were knocked out using CRISPR-Cas9. MIC was measured to evaluate strain resistance. <b>Results:</b> Expression of <i>acrZ</i> and <i>sugE</i> were increased with B2CE stimulation. ATCC8739Δ<i>acrZ</i> and ATCC8739Δ<i>sugE</i> showed twofold and fourfold increased sensitivity, respectively. The survival rate of ATCC8739 was reduced in the presence of B2CE/chlorpromazine (CPZ). Combinations of other AMPs with CPZ also showed antibacterial effects. <b>Conclusion:</b> The results indicate that combinations of AMPs/efflux pump inhibitors (EPIs) may be a potential approach to combat resistant bacteria.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"771-782"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics. 基于噬菌体的生物测定：微生物诊断的预期范式转变。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-06-20 DOI: 10.2217/fmb-2023-0246
Braira Wahid, Muhammad Salman Tiwana
{"title":"Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics.","authors":"Braira Wahid, Muhammad Salman Tiwana","doi":"10.2217/fmb-2023-0246","DOIUrl":"10.2217/fmb-2023-0246","url":null,"abstract":"<p><p>Bacteriophages, as abundant and specific agents, hold significant promise as a solution to combat the growing threat of antimicrobial resistance. Their unique ability to selectively lyse bacterial cells without harming humans makes them a compelling alternative to traditional antibiotics and point-of-care diagnostics. The article reviews the current landscape of diagnostic technologies, identify gaps and highlight emerging possibilities demonstrates a comprehensive approach to advancing clinical diagnosis of microbial pathogens and covers an overview of existing phage-based bioassays. Overall, the provided data in this review effectively communicates the potential of bacteriophages in transforming therapeutic and diagnostic paradigms, offering a holistic perspective on the benefits and opportunities they present in combating microbial infections and enhancing public health.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"811-824"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria. 含有头孢他啶和妥布霉素的 Zein 纳米粒子：对革兰氏阴性菌的抗菌活性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/fmb-2023-0147
Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães
{"title":"Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria.","authors":"Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães","doi":"10.2217/fmb-2023-0147","DOIUrl":"10.2217/fmb-2023-0147","url":null,"abstract":"<p><p><b>Aims:</b> This work describes the encapsulation of ceftazidime and tobramycin in zein nanoparticles (ZNPs) and the characterization of their antibacterial and antibiofilm activities against Gram-negative bacteria. <b>Materials & methods:</b> ZNPs were synthesized by nanoprecipitation. Cytotoxicity was assessed by MTT assay and antibacterial and antibiofilm assays were performed by broth microdilution and violet crystal techniques. <b>Results:</b> ZNPs containing ceftazidime (CAZ-ZNPs) and tobramycin (TOB-ZNPs) showed drug encapsulation and thermal stability. Encapsulation of the drugs reduced their cytotoxicity 9-25-fold. Antibacterial activity, inhibition and eradication of biofilm by CAZ-ZNPs and TOB-ZNPs were observed. There was potentiation when CAZ-ZNPs and TOB-ZNPs were combined. <b>Conclusion:</b> CAZ-ZNPs and TOB-ZNPs present ideal physical characteristics for <i>in vivo</i> studies of antibacterial and antibiofilm activities.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"317-334"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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