发布求助
文献互助 智能选刊 最新文献

Future microbiology最新文献

筛选
英文 中文
Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis. 囊性纤维化患者感染非结核分枝杆菌的分子机制分析。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-05-03 DOI: 10.2217/fmb-2023-0237
Qihuang Chen, Jin Li
{"title":"Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis.","authors":"Qihuang Chen, Jin Li","doi":"10.2217/fmb-2023-0237","DOIUrl":"10.2217/fmb-2023-0237","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. <b>Materials & methods:</b> Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. <b>Results:</b> Five hub genes (<i>PIK3R1</i>, <i>IL1A</i>, <i>CXCR4</i>, <i>ACTN1</i>, <i>PFN1</i>) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors <i>RELA</i>, <i>JUN</i>, <i>NFKB1</i> and <i>FOS</i> that regulated hub genes modulated <i>IL1A</i> expression, while 21 other transcription factors regulated <i>CXCR4</i> expression. <b>Conclusion:</b> In summary, this study may provide new insights into the mechanisms of CF with NTM infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"877-888"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online dashboards for SARS-CoV-2 wastewater-based epidemiology. 基于废水的 SARS-CoV-2 流行病学在线仪表板。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-05-23 DOI: 10.2217/fmb-2024-0033
Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi
{"title":"Online dashboards for SARS-CoV-2 wastewater-based epidemiology.","authors":"Daniele Focosi, Pietro Giorgio Spezia, Fabrizio Maggi","doi":"10.2217/fmb-2024-0033","DOIUrl":"10.2217/fmb-2024-0033","url":null,"abstract":"<p><p><b>Aim:</b> Wastewater-based epidemiology (WBE) is increasingly used to monitor pandemics. In this manuscript, we review methods and limitations of WBE, as well as their online dashboards. <b>Materials & methods:</b> Online dashboards were retrieved using PubMed and search engines, and annotated for timeliness, availability of English version, details on SARS-CoV-2 sublineages, normalization by population and PPMoV load, availability of case/hospitalization count charts and of raw data for export. <b>Results:</b> We retrieved 51 web portals, half of them from Europe. Africa is represented from South Africa only, and only seven portals are available from Asia. <b>Conclusion:</b> WBS provides near-real-time cost-effective monitoring of analytes across space and time in populations. However, tremendous heterogeneity still persists in the SARS-CoV-2 WBE literature.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"761-769"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe mold fungal infections in critically ill patients with COVID-19. 用 COVID-19 治疗重症患者的严重霉菌感染。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-05-31 DOI: 10.2217/fmb-2023-0261
Despoina Koulenti, Elisabeth Paramythiotou, Maria Panagiota Almyroudi, Marios Karvouniaris, Nikolaos Markou, Paschalis Paranos, Christina Routsi, Joseph Meletiadis, Stijn Blot
{"title":"Severe mold fungal infections in critically ill patients with COVID-19.","authors":"Despoina Koulenti, Elisabeth Paramythiotou, Maria Panagiota Almyroudi, Marios Karvouniaris, Nikolaos Markou, Paschalis Paranos, Christina Routsi, Joseph Meletiadis, Stijn Blot","doi":"10.2217/fmb-2023-0261","DOIUrl":"10.2217/fmb-2023-0261","url":null,"abstract":"<p><p>The SARS-CoV-2 pandemic put an unprecedented strain on modern societies and healthcare systems. A significantly higher incidence of invasive fungal co-infections was noted compared with the pre-COVID-19 era, adding new diagnostic and therapeutic challenges in the critical care setting. In the current narrative review, we focus on invasive mold infections caused by <i>Aspergillus</i> and <i>Mucor</i> species in critically ill COVID-19 patients. We discuss up-to-date information on the incidence, pathogenesis, diagnosis and treatment of these mold-COVID-19 co-infections, as well as recommendations on preventive and prophylactic interventions. Traditional risk factors were often not recognized in COVID-19-associated aspergillosis and mucormycosis, highlighting the role of other determinant risk factors. The associated patient outcomes were worse compared with COVID-19 patients without mold co-infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"825-840"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of Escherichia coli to antimicrobial peptide Brevinin-2CE. 外排泵抑制剂氯丙嗪能有效提高大肠杆菌对抗菌肽 Brevinin-2CE 的敏感性。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-04-29 DOI: 10.2217/fmb-2023-0272
Cao Bing, An Mengjuan, Ma Xinyu, Zhu Chixin, Tan Xinyao, Sun Yan, Li Zhi
{"title":"Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of <i>Escherichia coli</i> to antimicrobial peptide Brevinin-2CE.","authors":"Cao Bing, An Mengjuan, Ma Xinyu, Zhu Chixin, Tan Xinyao, Sun Yan, Li Zhi","doi":"10.2217/fmb-2023-0272","DOIUrl":"10.2217/fmb-2023-0272","url":null,"abstract":"<p><p><b>Aim:</b> The response of <i>E. coli</i> ATCC8739 to Brevinin-2CE (B2CE) was evaluated as a strategy to prevent the development of antimicrobial peptide (AMP)-resistant bacteria. <b>Methods:</b> Gene expression levels were detected by transcriptome sequencing and RT-PCR. Target genes were knocked out using CRISPR-Cas9. MIC was measured to evaluate strain resistance. <b>Results:</b> Expression of <i>acrZ</i> and <i>sugE</i> were increased with B2CE stimulation. ATCC8739Δ<i>acrZ</i> and ATCC8739Δ<i>sugE</i> showed twofold and fourfold increased sensitivity, respectively. The survival rate of ATCC8739 was reduced in the presence of B2CE/chlorpromazine (CPZ). Combinations of other AMPs with CPZ also showed antibacterial effects. <b>Conclusion:</b> The results indicate that combinations of AMPs/efflux pump inhibitors (EPIs) may be a potential approach to combat resistant bacteria.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"771-782"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics. 基于噬菌体的生物测定：微生物诊断的预期范式转变。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-06-20 DOI: 10.2217/fmb-2023-0246
Braira Wahid, Muhammad Salman Tiwana
{"title":"Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics.","authors":"Braira Wahid, Muhammad Salman Tiwana","doi":"10.2217/fmb-2023-0246","DOIUrl":"10.2217/fmb-2023-0246","url":null,"abstract":"<p><p>Bacteriophages, as abundant and specific agents, hold significant promise as a solution to combat the growing threat of antimicrobial resistance. Their unique ability to selectively lyse bacterial cells without harming humans makes them a compelling alternative to traditional antibiotics and point-of-care diagnostics. The article reviews the current landscape of diagnostic technologies, identify gaps and highlight emerging possibilities demonstrates a comprehensive approach to advancing clinical diagnosis of microbial pathogens and covers an overview of existing phage-based bioassays. Overall, the provided data in this review effectively communicates the potential of bacteriophages in transforming therapeutic and diagnostic paradigms, offering a holistic perspective on the benefits and opportunities they present in combating microbial infections and enhancing public health.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"811-824"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria. 含有头孢他啶和妥布霉素的 Zein 纳米粒子：对革兰氏阴性菌的抗菌活性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/fmb-2023-0147
Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães
{"title":"Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria.","authors":"Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães","doi":"10.2217/fmb-2023-0147","DOIUrl":"10.2217/fmb-2023-0147","url":null,"abstract":"<p><p><b>Aims:</b> This work describes the encapsulation of ceftazidime and tobramycin in zein nanoparticles (ZNPs) and the characterization of their antibacterial and antibiofilm activities against Gram-negative bacteria. <b>Materials & methods:</b> ZNPs were synthesized by nanoprecipitation. Cytotoxicity was assessed by MTT assay and antibacterial and antibiofilm assays were performed by broth microdilution and violet crystal techniques. <b>Results:</b> ZNPs containing ceftazidime (CAZ-ZNPs) and tobramycin (TOB-ZNPs) showed drug encapsulation and thermal stability. Encapsulation of the drugs reduced their cytotoxicity 9-25-fold. Antibacterial activity, inhibition and eradication of biofilm by CAZ-ZNPs and TOB-ZNPs were observed. There was potentiation when CAZ-ZNPs and TOB-ZNPs were combined. <b>Conclusion:</b> CAZ-ZNPs and TOB-ZNPs present ideal physical characteristics for <i>in vivo</i> studies of antibacterial and antibiofilm activities.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"317-334"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of subgingival bacterial and fungal diversity in patients with peri-implantitis based on 16sRNA and internal transcribed spacer sequencing. 基于16sRNA和内部转录间隔序列分析种植体周围炎患者龈下细菌和真菌多样性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2023-12-04 DOI: 10.2217/fmb-2023-0228
Song Chen, Fuming He, Xi Cheng
{"title":"Analysis of subgingival bacterial and fungal diversity in patients with peri-implantitis based on 16sRNA and internal transcribed spacer sequencing.","authors":"Song Chen, Fuming He, Xi Cheng","doi":"10.2217/fmb-2023-0228","DOIUrl":"10.2217/fmb-2023-0228","url":null,"abstract":"<p><p><b>Aim:</b> To analyze subgingival fungal diversity in peri-implant inflammation patients and their relationship with bacteria. <b>Methods:</b> We collected saliva samples from four groups. 16sRNA and internal transcribed spacer sequencing was performed preceded by quantitative PCR and enzyme-linked immunosorbent assay tests. Analyses were done using R and Cytoscape software. <b>Results:</b> Significant differences were observed in the Abundance-based Coverage Estimator (ACE) index between control and peri-implantitis samples. Basidiomycota was the dominant fungal species, while Firmicutes dominated the bacteria. The most abundant fungal and bacterial species were 's_unclassified g <i>Apiotrichum</i>' and 's_unclassified g <i>Streptococcus</i>', respectively. <i>Dothiorella</i> was strongly associated with immunoglobulin G levels, with positive correlations between specific microorganisms and peri-implantitis in Q-PCR. <b>Conclusion:</b> Our findings have significant clinical implications, suggesting specific fungal and bacterial taxa roles in peri-implant inflammation.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"397-411"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disinformation and trust in vaccines in the era of artificial intelligence: the necessity of implementing statistical recommendations. 人工智能时代的虚假信息与疫苗信任：实施统计建议的必要性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.2217/fmb-2024-0004
Michal Ordak
{"title":"Disinformation and trust in vaccines in the era of artificial intelligence: the necessity of implementing statistical recommendations.","authors":"Michal Ordak","doi":"10.2217/fmb-2024-0004","DOIUrl":"10.2217/fmb-2024-0004","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"293-295"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Staphylococcus aureus effects of natural antimicrobial peptides and the underlying mechanisms. 天然抗菌肽的抗金黄色葡萄球菌作用及其内在机制。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/fmb-2023-0168
Xueqi Chen, Jiuli Yang, Chang Qu, Qian Zhang, Shujuan Sun, Lihong Liu
{"title":"Anti-<i>Staphylococcus aureus</i> effects of natural antimicrobial peptides and the underlying mechanisms.","authors":"Xueqi Chen, Jiuli Yang, Chang Qu, Qian Zhang, Shujuan Sun, Lihong Liu","doi":"10.2217/fmb-2023-0168","DOIUrl":"10.2217/fmb-2023-0168","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> can cause localized infections such as abscesses and pneumonia, as well as systemic infections such as bacteremia and sepsis. Especially, methicillin-resistant <i>S. aureus</i> often presents multidrug resistance, which becomes a major clinical challenge. One of the most common reasons for methicillin-resistant <i>S. aureus</i> antibiotic resistance is the presence of biofilms. Natural antimicrobial peptides derived from different species have shown effectiveness in combating <i>S. aureus</i> biofilms. In this review, we summarize the inhibitory activity of antimicrobial peptides against <i>S. aureus</i> planktonic cells and biofilms. We also summarize the possible inhibitory mechanisms, involving cell adhesion inhibition, membrane fracture, biofilm disruption and DNA disruption. We believe this can provide the basis for further research against <i>S. aureus</i> biofilm-associated infections.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"355-372"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine for the eradication of Helicobacter pylori: recent advances, challenges and future perspective. 根除幽门螺旋杆菌的纳米药物：最新进展、挑战和未来展望。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI: 10.2217/fmb-2023-0189
Aakriti Garg, Sonali Karhana, Mohd A Khan
{"title":"Nanomedicine for the eradication of <i>Helicobacter pylori</i>: recent advances, challenges and future perspective.","authors":"Aakriti Garg, Sonali Karhana, Mohd A Khan","doi":"10.2217/fmb-2023-0189","DOIUrl":"10.2217/fmb-2023-0189","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics. Challenges include biocompatibility, stability, scalability and personalized therapies. Despite obstacles, nanomedicine's potential for reshaping <i>H. pylori</i> eradication is significant and showcased in this review focusing on benefits, limitations and future prospects of nanomedicine-based strategies.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"431-447"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信