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Capabilities of GPT-4o and Gemini 1.5 Pro in Gram stain and bacterial shape identification. GPT-4o 和 Gemini 1.5 Pro 在革兰氏染色和细菌形状鉴定方面的能力。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/17460913.2024.2381967
Joya-Rita Hindy, Tarek Souaid, Christopher S Kovacs
{"title":"Capabilities of GPT-4o and Gemini 1.5 Pro in Gram stain and bacterial shape identification.","authors":"Joya-Rita Hindy, Tarek Souaid, Christopher S Kovacs","doi":"10.1080/17460913.2024.2381967","DOIUrl":"10.1080/17460913.2024.2381967","url":null,"abstract":"<p><p><b>Aim:</b> Assessing the visual accuracy of two large language models (LLMs) in microbial classification.<b>Materials & methods:</b> GPT-4o and Gemini 1.5 Pro were evaluated in distinguishing Gram-positive from Gram-negative bacteria and classifying them as cocci or bacilli using 80 Gram stain images from a labeled database.<b>Results:</b> GPT-4o achieved 100% accuracy in identifying simultaneously Gram stain and shape for <i>Clostridium perfringens</i>, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>. Gemini 1.5 Pro showed more variability for similar bacteria (45, 100 and 95%, respectively). Both LLMs failed to identify both Gram stain and bacterial shape for <i>Neisseria gonorrhoeae</i>. Cumulative accuracy plots indicated that GPT-4o consistently performed equally or better in every identification, except for <i>Neisseria gonorrhoeae's</i> shape.<b>Conclusion:</b> These results suggest that these LLMs in their unprimed state are not ready to be implemented in clinical practice and highlight the need for more research with larger datasets to improve LLMs' effectiveness in clinical microbiology.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1283-1292"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The first case of urosepsis caused by Corynebacterium aurimucosum in an immunocompetent patient. 首例免疫功能正常的患者因金黄色棒状杆菌引起的尿毒症。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1080/17460913.2024.2344953
Lucia Corich, Carmen Losasso, Alessia Meneghel, Francesca Irene Blarasin, Giancarlo Basaglia, Maria Ada Corich
{"title":"The first case of urosepsis caused by <i>Corynebacterium aurimucosum</i> in an immunocompetent patient.","authors":"Lucia Corich, Carmen Losasso, Alessia Meneghel, Francesca Irene Blarasin, Giancarlo Basaglia, Maria Ada Corich","doi":"10.1080/17460913.2024.2344953","DOIUrl":"10.1080/17460913.2024.2344953","url":null,"abstract":"<p><p>Non-diphtheroid <i>Corynebacterium</i> sepsis is rare and has affected only immunocompromised or particularly predisposed patients so far. We present the first case of urosepsis caused by <i>Corynebacterium aurimucosum</i> in a 67-year-old woman, without any known immunodeficiencies and in absence of any immunosuppressive therapy, admitted to the hospital for fever and acute dyspnea. This work suggests a new approach in evaluating the isolation of <i>Corynebacteria</i>, especially if isolated from blood. In particular, it highlights the potential infectious role of <i>C. aurimucosum</i> (often considered a contaminant and only rarely identified as an etiological agent of infections) and its clinical consequences, detailing also interesting aspects about its microbiological diagnosis and relative therapy and clarifying contrasting data of literature.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":"19 11","pages":"963-970"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of lung and fungus ball lesions associated with Cladosporium Subcinereum A48 in a diabetic patient. 一例糖尿病患者的肺部和真菌球病变与亚金孢子菌 A48 有关。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-09-11 DOI: 10.1080/17460913.2024.2392454
Abozar Nasiri-Jahrodi, Mehdi Barati, Fatemeh-Maryam Sheikholeslami, Mona Fani, Azin Nikoozadeh
{"title":"A case of lung and fungus ball lesions associated with <i>Cladosporium Subcinereum A48</i> in a diabetic patient.","authors":"Abozar Nasiri-Jahrodi, Mehdi Barati, Fatemeh-Maryam Sheikholeslami, Mona Fani, Azin Nikoozadeh","doi":"10.1080/17460913.2024.2392454","DOIUrl":"10.1080/17460913.2024.2392454","url":null,"abstract":"<p><p>This study reports the first case of lung and fungus ball lesions caused by <i>Cladosporium subcinereum A48</i>. A rural diabetic woman infected by <i>C. subcinereum A48</i>, presented with fever and hemoptysis. CT scans, bronchoalveolar lavage, culture and molecular methods were used to evaluate and confirm the disease. Our patient had not taken insulin during the last few months of her life which probably caused acidosis and a decrease in the patient's immunity level, resulting in penetration and formation of a fungal in the lung.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1359-1363"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nitric oxide-releasing self-healing hydrogel for antibacterial and antibiofilm efficacy against polymicrobial infection. 释放一氧化氮的自愈合水凝胶对多微生物感染具有抗菌和抗生物膜功效。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-11-13 DOI: 10.1080/17460913.2024.2411817
Nurhasni Hasan, Widya Luthfiyah, Juliana Palungan, Muneeb Ullah, Apon Zaenal Mustopa, Maritsa Nurfatwa, Herman Irawan, Usmar Usmar, Aliyah Putranto, Jin-Wook Yoo
{"title":"Nitric oxide-releasing self-healing hydrogel for antibacterial and antibiofilm efficacy against polymicrobial infection.","authors":"Nurhasni Hasan, Widya Luthfiyah, Juliana Palungan, Muneeb Ullah, Apon Zaenal Mustopa, Maritsa Nurfatwa, Herman Irawan, Usmar Usmar, Aliyah Putranto, Jin-Wook Yoo","doi":"10.1080/17460913.2024.2411817","DOIUrl":"10.1080/17460913.2024.2411817","url":null,"abstract":"<p><p><b>Aim:</b> Bacterial infections and the formation of biofilms are currently key factors in the delay of wound healing. S-Nitroso glutathione (GSNO) is recognized as a nitric oxide (NO) donor that exhibits potent antibacterial and antibiofilm activities. However, some of the stability limitations of NO require it to be prepared pharmaceutically.<b>Materials & methods:</b> Here, we developed a self-healing hydrogel dressing consisting of GSNO, polyvinyl alcohol/borax (PVA/B) and carboxymethyl chitosan (cmCHI). This research aimed to determine the antibacterial and antibiofilm activities of a self-healing hydrogel (PVA-B-cmCHI/GSNO) against multiple bacteria and polymicrobial biofilms.<b>Results:</b> Forty mg/ml PVA-B-cmCHI/GSNO significantly increased the antibacterial activity against <i>Pseudomonas aeruginosa</i>, <i>S. aureus</i>, Methicillin resistant <i>Staphylococcus aureus</i> (MRSA), as indicated by a >5 log reduction in bacterial viability (∼99.999% killing). PVA-B-cmCHI/GSNO showed antibiofilm activity three-times greater than that of the blank self-healing hydrogel (PVA-B-cmCHI) by inhibiting 80% of the biofilm formation.<b>Conclusion:</b> The results suggest that the NO-releasing self-healing hydrogels exhibit notable antibacterial and antibiofilm properties and thus could be a promising approach for the treatment of bacterial or biofilm-infected wounds.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1559-1571"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoinactivation mechanism of hypericin nanoencapsulated in P123 against Microsporum canis. 金丝桃素纳米封装在 P123 中对犬小孢子菌的光激活机制。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2412481
Camila Barros Galinari, Eduardo Victor Bergmann, Luis Carlos Malacarne, Ana Carolina Oliveira, Wilker Caetano, Erika Seki Kioshima Cotica, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça
{"title":"Photoinactivation mechanism of hypericin nanoencapsulated in P123 against <i>Microsporum canis</i>.","authors":"Camila Barros Galinari, Eduardo Victor Bergmann, Luis Carlos Malacarne, Ana Carolina Oliveira, Wilker Caetano, Erika Seki Kioshima Cotica, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça","doi":"10.1080/17460913.2024.2412481","DOIUrl":"10.1080/17460913.2024.2412481","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the photodynamic mechanism of hypericin nanoencapsulated in P123 copolymer micelles against <i>Microsporum canis in vitro</i>.<b>Material & methods:</b> Antifungal susceptibility tests were performed, including the determination of the minimum fungicidal concentration and time-kill curve. Flow cytometry was used to evaluate the internalization of P123-Hyp in conidia and the activation of PDT type I and II mechanisms via the detection of reactive oxygen species (ROS), as well as to assess changes in the cell membrane using propidium iodide (PI) and cell morphology.<b>Results:</b> P123-Hyp-PDT exerted a fungistatic action on fungus, maintaining this action up to 24 h after exposure, corroborating the PS internalization results, which showed satisfactory uptake of P123-Hyp from a concentration of 3.125 μmol/l. Among the ROS studied, singlet oxygen was detected. Furthermore, the increased fluorescence intensity of PI in treated cells indicated necrotic cell death, while the size and granularity of the cells were also altered.<b>Conclusion:</b> Our results show, for the first time, a proposal for the mechanism of action of P123-Hyp-mediated PDT against <i>M. canis</i>, proving that it has a prolonged action on the fungus through activation of the type II photodynamic pathway, which resulted in disruption of the plasma membrane and cellular alterations.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1535-1544"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and treatment of a patient with pulmonary infection caused by Emergomyces Orientalis: a case report. 东方酵母菌肺部感染患者的诊断和治疗：病例报告。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/17460913.2024.2366653
Yifang Jiang, Ruixin Tian, Chi Zhang, Lujie Zhang, Xiaoman Cui, Ping Wang
{"title":"Diagnosis and treatment of a patient with pulmonary infection caused by <i>Emergomyces Orientalis</i>: a case report.","authors":"Yifang Jiang, Ruixin Tian, Chi Zhang, Lujie Zhang, Xiaoman Cui, Ping Wang","doi":"10.1080/17460913.2024.2366653","DOIUrl":"10.1080/17460913.2024.2366653","url":null,"abstract":"<p><p>Emergomycosis is a dimorphic fungal disease that is typically disseminated and fatal among immunocompromised individuals. In the case report, we presented a patient with intermittent fever, night sweats, coughing and phlegm. Chest computed tomography revealed multiple soft-tissue nodules in both lungs. Routine pathological and microbiological tests did not confirm the diagnosis. Therefore, we conducted pathogen detection using metagenomic next-generation sequencing in bronchoalveolar lavage fluid and identified the pulmonary infection caused by <i>Emergomyces orientalis</i> (<i>Es. orientalis</i>). During the antifungal treatment, the patient experienced renal function damage, and we have attempted various antifungal drugs for treatment. Finally, the patient's condition was brought under control. Therefore, the metagenomic next-generation sequencing pathogen detection was essential.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1195-1202"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional lung parenchyma model for studies of Aspergillus fumigatus infection and antifungal treatment. 用于研究曲霉菌感染和抗真菌治疗的三维肺实质模型。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2371926
Bruna Nakanishi Fortes, Fernanda Wirth, Aline Martins Dos Santos, Marlus Chorilli, Vanessa Morais Freitas, Jennifer Farias, Felipe S Chambergo, Viviane Abreu Nunes C Dantas, Kelly Ishida
{"title":"Three-dimensional lung parenchyma model for studies of <i>Aspergillus fumigatus</i> infection and antifungal treatment.","authors":"Bruna Nakanishi Fortes, Fernanda Wirth, Aline Martins Dos Santos, Marlus Chorilli, Vanessa Morais Freitas, Jennifer Farias, Felipe S Chambergo, Viviane Abreu Nunes C Dantas, Kelly Ishida","doi":"10.1080/17460913.2024.2371926","DOIUrl":"10.1080/17460913.2024.2371926","url":null,"abstract":"<p><p><b>Aim:</b> This work aims to standardize the three-dimensional hydroxyethyl-alginate-gelatin (HAG) scaffold as a model to evaluate <i>Aspergillus fumigatus</i> biofilm and antifungal treatments.<b>Methods:</b> The scaffold was characterized by physical, rheological and microscopic analyses; the antibiofilm action was evaluated by determination of cfu and metabolic activity.<b>Results:</b> The scaffold was non-toxic showing stability in aqueous media, swelling capacity, elasticity and had homogeneously distributed pores averaging 190 μm. The <i>A. fumigatus</i> biofilm established itself very well on the scaffold and treatment with amphotericin B and voriconazole reduced viable cells and metabolic activity.<b>Conclusion:</b> The HAG scaffold proved to be a model to mimic lung parenchyma, suitable for establishing a 3D biofilm culture of <i>A. fumigatus</i> and evaluating the efficacy of antifungals.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1203-1216"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterologous expression of fungal L-asparaginase: a systematic review. 真菌L-天冬酰胺酶的异源表达：系统综述。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2023-10-26 DOI: 10.2217/fmb-2023-0131
Kellen Cruvinel Rodrigues Andrade, Joel Antonio Cordeiro de Abreu, Marina Borges Guimarães, Letícia Santos Abrunhosa, Ana Luisa Leôncio Rodrigues, Yris Maria Fonseca-Bazzo, Damaris Silveira, Paula Monteiro Souza, Pérola Oliveira Magalhães
{"title":"Heterologous expression of fungal L-asparaginase: a systematic review.","authors":"Kellen Cruvinel Rodrigues Andrade, Joel Antonio Cordeiro de Abreu, Marina Borges Guimarães, Letícia Santos Abrunhosa, Ana Luisa Leôncio Rodrigues, Yris Maria Fonseca-Bazzo, Damaris Silveira, Paula Monteiro Souza, Pérola Oliveira Magalhães","doi":"10.2217/fmb-2023-0131","DOIUrl":"10.2217/fmb-2023-0131","url":null,"abstract":"<p><p><b>Aim:</b> To review the available literature about heterologous expression of fungal L-asparaginase (L-ASNase). <b>Materials & methods:</b> A search was conducted across PubMed, Science Direct, Scopus and Web of Science databases; 4172 citations were identified and seven articles were selected. <b>Results:</b> The results showed that heterologous expression of fungal L-ASNase was performed mostly in bacterial expression systems, except for a study that expressed L-ASNase in a yeast system. Only three publications reported the purification and characterization of the enzyme. <b>Conclusion:</b> The information reported in this systematic review can contribute significantly to the recognition of the importance of biotechnological techniques for L-ASNase production.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"157-171"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinated surveillance of foodborne pathogens and antimicrobial resistance: insights from the PATH-SAFE pilot. 食源性病原体和抗菌药耐药性的协调监测：PATH-SAFE 试点项目的启示。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-10-09 DOI: 10.1080/17460913.2024.2398340
Edward Haynes, Rachel Baird, Laura Gent, Elaine Kinsella, Shona O'Rourke, Robin May, Rick Mumford
{"title":"Coordinated surveillance of foodborne pathogens and antimicrobial resistance: insights from the PATH-SAFE pilot.","authors":"Edward Haynes, Rachel Baird, Laura Gent, Elaine Kinsella, Shona O'Rourke, Robin May, Rick Mumford","doi":"10.1080/17460913.2024.2398340","DOIUrl":"10.1080/17460913.2024.2398340","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1355-1358"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Delhi metallo-β-lactamases among extensively drug-resistant clinical isolates from Lahore, Pakistan. 巴基斯坦拉合尔广泛耐药临床分离株中的新德里金属-β-内酰胺酶。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-06-17 DOI: 10.1080/17460913.2024.2343600
Noor Ul Ain, Abdul Hannan, Namrah Imran, Asad Ali, Farhan Rasheed, Sikander Sultan, Timothy D McHugh, Saba Riaz
{"title":"New Delhi metallo-β-lactamases among extensively drug-resistant clinical isolates from Lahore, Pakistan.","authors":"Noor Ul Ain, Abdul Hannan, Namrah Imran, Asad Ali, Farhan Rasheed, Sikander Sultan, Timothy D McHugh, Saba Riaz","doi":"10.1080/17460913.2024.2343600","DOIUrl":"10.1080/17460913.2024.2343600","url":null,"abstract":"<p><p><b>Aim:</b> The study determines rates of carbapenem resistance (CR) and frequency of <i>bla</i><sub>NDM</sub> in multidrug-resistance (MDR) or extensive drug resistance (XDR), and evaluates the potential of phenotypic tests for detecting NDM production. <b>Materials & methods:</b> Singleplex PCR was used to detect <i>bla</i><sub>NDM</sub>. Phenotypic tests, including combination disc test (CDST) and modified Hodge test (MHT), were evaluated for NDM production. <b>Results:</b> Among 338 CR isolates, 47.63% were MDR, whereas 52.36% were XDR with 53.25% carrying <i>bla</i><sub>NDM</sub>. MHT was found to be discriminative for detecting NDM production, whereas no significant association was observed for CDST. <b>Conclusion:</b> The high incidence of CR and MDR and XDR isolates possessing <i>bla</i><sub>NDM</sub> presents an impending threat in therapeutics. Limitations of phenotypic tests suggest better testing, including molecular detection of the enzyme.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"971-981"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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