Future microbiology最新文献_第10页

Interaction with lipopolysaccharide is key to efficacy of tryptophan- and arginine-rich α-melanocyte-stimulating hormone analogs against Gram-negative bacteria. 与脂多糖的相互作用是富含色氨酸和精氨酸的α-黑色素细胞刺激素类似物对革兰氏阴性菌有效的关键。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2023-12-21 DOI: 10.2217/fmb-2023-0080

Kanchan Tiwari, Priya Patel, Aftab H Mondal, Kasturi Mukhopadhyay

{"title":"Interaction with lipopolysaccharide is key to efficacy of tryptophan- and arginine-rich α-melanocyte-stimulating hormone analogs against Gram-negative bacteria.","authors":"Kanchan Tiwari, Priya Patel, Aftab H Mondal, Kasturi Mukhopadhyay","doi":"10.2217/fmb-2023-0080","DOIUrl":"10.2217/fmb-2023-0080","url":null,"abstract":"Aim: In order to search for novel antibacterial therapeutics against Gram-negative bacteria, the antibacterial efficacies and mechanism of action of tryptophan- and arginine-rich α-melanocyte-stimulating hormone analogs were investigated. Materials & methods: We performed a killing assay to determine their efficacy; fluorescence, microscopic studies were used to understand their mechanism and peptide-lipopolysaccharide interaction. A checkerboard assay was used to find the effective combination of peptide and antibiotics. Results: Ana-peptides displayed good killing activity against Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Their strong interaction with lipopolysaccharide damaged the bacterial membranes and led to their subsequent death. Ana-5, the highest cationic and hydrophobic analog, emerged as the most potent peptide, showing synergistic action with rifampicin and erythromycin. Conclusion: Ana-5 can be presented as an important therapeutic candidate against bacterial infections.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"195-211"},"PeriodicalIF":3.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of isavuconazole antifungal medicine to treat mold infections in Asia and the Western Pacific region: a plain language summary. 使用异戊康唑抗真菌药物治疗亚洲和西太平洋地区霉菌感染:简单的语言总结。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.2217/fmb-2023-0191

Michael A Pfaller, Cecilia G Carvalhaes, Paul R Rhomberg, Mariana Castanheira

{"title":"Use of isavuconazole antifungal medicine to treat mold infections in Asia and the Western Pacific region: a plain language summary.","authors":"Michael A Pfaller, Cecilia G Carvalhaes, Paul R Rhomberg, Mariana Castanheira","doi":"10.2217/fmb-2023-0191","DOIUrl":"10.2217/fmb-2023-0191","url":null,"abstract":"What is this summary about?: Molds are types of fungus that can invade humans. It can cause a disease called invasive mold infection (IMI) and make people sick or cause death. This is a summary of a study that looked at mold samples collected from people in Asia and the Western Pacific region to check if an antifungal medicine called isavuconazole (ISC) can stop the growth of or kill these molds.What were the results?: One type of mold known as Aspergillus or type 1 molds, was more common than other molds. Antifungal medicines including ISC, posaconazole, voriconazole, and itraconazole slowed or stopped the growth of the type 1 molds. ISC was very active in slowing or stopping the growth of this mold. Other molds, known as non-Aspergillus or type 2 mold, were less common. The antifungals medicines mentioned above were able to slow or stop the growth of some but not all of the type 2 molds.What do the results of the study mean?: ISC stopped the growth of most type 1 molds and was as good as the other antifungal medicines against type 2 molds.What is the purpose of this plain language summary?: The purpose of this plain language summary is to help you to understand the findings from recent research. The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence not on the results of a single study.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"173-180"},"PeriodicalIF":2.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenols and their nanoformulations as potential antibiofilm agents against multidrug-resistant pathogens. 多酚类化合物及其纳米制剂作为潜在的抗生物膜剂，可对抗耐多药病原体。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0175

Modawy Em Elkhalifa, Muhammad Ashraf, Alshebli Ahmed, Assad Usman, Alashary Ae Hamdoon, Mohammed A Elawad, Meshari G Almalki, Osama F Mosa, Laziz N Niyazov, Muhammad Ayaz

引用次数: 0

Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 inhibit HIF-1α-mediated glycolysis of colon cancer. 副酸乳杆菌 PC-H1 的细胞外囊泡抑制 HIF-1α 介导的结肠癌糖酵解。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI: 10.2217/fmb-2023-0144

Yangqian Shi, Chunliang Zhang, Wanyu Cao, Luyi Li, Kaili Liu, Hanyue Zhu, Fikadu Balcha, Yong Fang

{"title":"Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 inhibit HIF-1α-mediated glycolysis of colon cancer.","authors":"Yangqian Shi, Chunliang Zhang, Wanyu Cao, Luyi Li, Kaili Liu, Hanyue Zhu, Fikadu Balcha, Yong Fang","doi":"10.2217/fmb-2023-0144","DOIUrl":"10.2217/fmb-2023-0144","url":null,"abstract":"Aims: Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 have antiproliferative activity of colon cells, but the effect on glycolytic metabolism of cancer cell remains enigmatic. The authors investigated how Lacticaseibacillus paracasei extracellular vesicles (LpEVs) inhibit the growth of colon cancer cells by affecting tumor metabolism. Materials & methods: HCT116 cells were treated with LpEVs and then differentially expressed genes were analyzed by transcriptome sequencing, the sequencing results were confirmed in vivo and in vitro. Results: LpEVs entered colon cancer cells and inhibited their growth. Transcriptome sequencing revealed differentially expressed genes were related to glycolysis. Lactate production, glucose uptake and lactate dehydrogenase activity were significantly reduced after treatment. LpEVs also reduced HIF-1α, GLUT1 and LDHA expression. Conclusion: LpEVs exert their antiproliferative activity of colon cancer cells by decreasing HIF-1α-mediated glycolysis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"227-239"},"PeriodicalIF":3.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial therapy using VIS plus water-filtered infrared-A as an alternative method to treat oral diseases. 使用 VIS 加水过滤红外线-A 作为治疗口腔疾病的替代方法进行抗菌治疗。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.2217/fmb-2023-0127

Sara Bernardi, Davide Gerardi, Sibylle Bartsch, Guido Macchiarelli, Elmar Hellwig, Ali Al-Ahmad

引用次数: 0

Effects of whey protein supplementation on gut microbiota of Wistar rats with valproic acid-induced autism symptoms. 补充乳清蛋白对具有丙戊酸诱导的自闭症症状的Wistar大鼠肠道微生物群的影响。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2023-11-07 DOI: 10.2217/fmb-2023-0051

Quezia Damaris Jones Severino Vasconcelos, Marisa Jadna Silva Frederico, Renata de Sousa Alves, Tereza de Jesus Pinheiro Gomes Bandeira, Maria Elisabete Amaral de Moraes, Gislei Frota Aragão

引用次数: 0

Synergistic interaction of polymyxin B with carvacrol: antimicrobial strategy against polymyxin-resistant Klebsiella pneumoniae. 多粘菌素 B 与香芹酚的协同作用：针对耐多粘菌素肺炎克雷伯菌的抗菌策略。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.2217/fmb-2023-0070

Gleyce Ha de Souza, Marcia Sm Vaz, Joyce A Dos Santos Radai, Thiago L Fraga, Luana Rossato, Simone Simionatto

引用次数: 0

Sulbactam-durlobactam: a β-lactam/β-lactamase inhibitor combination targeting Acinetobacter baumannii. 舒巴坦-杜鲁巴坦：针对鲍曼不动杆菌的β-内酰胺/β-内酰胺酶抑制剂组合。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-03-01 DOI: 10.2217/fmb-2023-0248

Sarah M McLeod, John P O'Donnell, Navaneeth Narayanan, John P Mills, Keith S Kaye

引用次数: 0

Establishment and evaluation of MIRA-qPCR assay for the rapid and sensitively detection of Mycoplasma pneumoniae. 建立并评估用于快速灵敏检测肺炎支原体的 MIRA-qPCR 检测方法。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-09-11 DOI: 10.1080/17460913.2024.2398886

Qiao Qiao, Yi-Yue Ge, Xiao-Juan Zhu, Kang-Chen Zhao, Yin Chen, Lun-Biao Cui, Tao Wu

{"title":"Establishment and evaluation of MIRA-qPCR assay for the rapid and sensitively detection of Mycoplasma pneumoniae.","authors":"Qiao Qiao, Yi-Yue Ge, Xiao-Juan Zhu, Kang-Chen Zhao, Yin Chen, Lun-Biao Cui, Tao Wu","doi":"10.1080/17460913.2024.2398886","DOIUrl":"10.1080/17460913.2024.2398886","url":null,"abstract":"Aim: Mycoplasma pneumoniae (MP) is a common cause of respiratory infections, and its incidence has increased post-COVID-19 due to \"immune debt.\" Real-time quantitative polymerase chain reaction (qPCR) is the standard for detecting MP, but it has a lengthy detection time. This study aimed to establish a highly sensitive rapid detection method for MP.Materials & methods: We developed an integrated assay combining multienzyme isothermal rapid amplification (MIRA) with qPCR, referred to as MIRA-qPCR, for the rapid detection of MP, delivering results within approximately 40 min.Results: The analytic sensitivity of the MIRA-qPCR assay was 10 copies per reaction, and it exhibited no cross-reactivity with other respiratory pathogens, ensuring high specificity. Clinical sample analysis demonstrated higher sensitivity for MIRA-qPCR compared to qPCR reported in the literature, and 100% concordance with commercial qPCR kit.Conclusion: The MIRA-qPCR method established in this study is a promising tool for the clinical detection of MP, offering significant advantages for the rapid diagnosis of MP infections.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1455-1461"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial activity of hydralazine against methicillin-resistant and methicillin-susceptible Staphylococcus aureus. 肼屈嗪对耐甲氧西林和甲氧西林敏感金黄色葡萄球菌的抗菌活性。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI: 10.2217/fmb-2023-0160

Francisca B Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, João B de Andrade Neto, Lisandra Juvêncio da Silva, Daniel Sampaio Rodrigues, Vitória P de Farias Cabral, Amanda Dias Barbosa, Lara E Almeida Moreira, Camille R Braga Vasconcelos, Bruno Coêlho Cavalcanti, Maria E França Rios, Jacilene Silva, Emmanuel Silva Marinho, Helcio Silva Dos Santos, Jacó Rl de Mesquita, Marina Duarte Pinto Lobo, Manoel Odorico de Moraes, Hélio V Nobre Júnior, Cecília Rocha da Silva

{"title":"Antimicrobial activity of hydralazine against methicillin-resistant and methicillin-susceptible Staphylococcus aureus.","authors":"Francisca B Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, João B de Andrade Neto, Lisandra Juvêncio da Silva, Daniel Sampaio Rodrigues, Vitória P de Farias Cabral, Amanda Dias Barbosa, Lara E Almeida Moreira, Camille R Braga Vasconcelos, Bruno Coêlho Cavalcanti, Maria E França Rios, Jacilene Silva, Emmanuel Silva Marinho, Helcio Silva Dos Santos, Jacó Rl de Mesquita, Marina Duarte Pinto Lobo, Manoel Odorico de Moraes, Hélio V Nobre Júnior, Cecília Rocha da Silva","doi":"10.2217/fmb-2023-0160","DOIUrl":"10.2217/fmb-2023-0160","url":null,"abstract":"Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. Materials & methods: The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. Results: MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin (50%) and vancomycin (25%). Hydralazine reduced the viability of biofilms by 50%. After exposure to hydralazine 2× MIC, 58.78% of the cells were unviable, 62.07% were TUNEL positive and 27.03% presented damage in the comet assay (p < 0.05). Hydralazine showed affinity for DNA gyrase and TyrRS. Conclusion: Hydralazine is a potential antibacterial.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"91-106"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0