Future microbiology最新文献

Live biotherapeutics in the post-antibiotic era: exploring the potential of probiotics to counter multidrug resistance. 后抗生素时代的活体生物疗法：探索益生菌对抗多药耐药的潜力。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-20 DOI: 10.1080/17460913.2026.2749225

Supriya Shidhaye, Anis Chaudhary, Yogendra Gautam, Vishal Chafle, Harshad Patil, Milind Umekar, Hassan Ahmed Rudayni, Rashmi Trivedi

{"title":"Live biotherapeutics in the post-antibiotic era: exploring the potential of probiotics to counter multidrug resistance.","authors":"Supriya Shidhaye, Anis Chaudhary, Yogendra Gautam, Vishal Chafle, Harshad Patil, Milind Umekar, Hassan Ahmed Rudayni, Rashmi Trivedi","doi":"10.1080/17460913.2026.2749225","DOIUrl":"https://doi.org/10.1080/17460913.2026.2749225","url":null,"abstract":"Antimicrobial resistance (AMR) is a major global health threat that compromises the effectiveness of existing antibiotics and highlights the urgent need for alternative and adjunctive therapeutic strategies. Probiotics have emerged as potential adjunctive strategies because of their ability to modulate host-microbe interactions and influence microbial ecology without promoting resistance. This review examines the current evidence on the potential role of probiotics in combating multidrug-resistant organisms, based on findings from in vitro studies, animal models, and clinical investigations. The review is based on a narrative literature search of the PubMed database, covering studies published between 2020 and 2025, with earlier landmark studies. The mechanisms discussed include competitive exclusion of pathogens, the production of antimicrobial compounds, the enhancement of intestinal barrier function, and the modulation of host immune responses. In addition, probiotics are evaluated for their capacity to interfere with quorum sensing and inhibit biofilm formation, thereby reducing pathogen virulence and colonization. The review also addresses key limitations, including strain-specific variability, safety concerns in vulnerable populations, and the lack of standardized clinical protocols. Current evidence suggests that probiotics may represent a useful adjunct to existing AMR management strategies. However, their broader clinical application requires larger research to establish their efficacy and safety.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-14"},"PeriodicalIF":2.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eucalyptus camaldulensis essential oil inhibits biofilm formation and disrupts pre-formed biofilms in clinical isolates of Pseudomonas aeruginosa: an in vitro study. 桉树精油抑制生物膜的形成和破坏预先形成的生物膜在临床分离铜绿假单胞菌：一项体外研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-20 DOI: 10.1080/17460913.2026.2751608

Aalia Khanem, Farhan Younas, Ikram Ullah, Islam-Ud-Din

{"title":"Eucalyptus camaldulensis essential oil inhibits biofilm formation and disrupts pre-formed biofilms in clinical isolates of Pseudomonas aeruginosa: an in vitro study.","authors":"Aalia Khanem, Farhan Younas, Ikram Ullah, Islam-Ud-Din","doi":"10.1080/17460913.2026.2751608","DOIUrl":"https://doi.org/10.1080/17460913.2026.2751608","url":null,"abstract":"Aim: P. aeruginosa biofilms enable persistent colonization. This study evaluated Eucalyptus camaldulensis essential oil (EUEO) against twenty four clinical Pseudomonas aeruginosa isolates.Methodology: EUEO was obtained by hydro-distillation and characterized by FT-IR and GC-MS. Antibacterial activity was assessed by agar well diffusion, MIC and MBC. Biofilm inhibition (oil added at the start of incubation) and disruption (oil added to 18-h pre-formed biofilms) were quantified. Membrane damage was inferred from the leakage of cytoplasmic content after 4, 8, and 12 h of exposure at 1×MIC.Results: EUEO was rich in Eucalyptol, comprising 90%. 79.16% isolates formed strong biofilms with OD >0.240, 12.5% showed no biofilm formation (OD <0.120) and 8.3% had moderate biofilms (OD 0.120-0.240). MICs ranged from 3.125 to 25 µg/mL and MBCs from 25 to 50 µg/mL. At 1×MIC, EUEO reduced biofilm formation by 40-85.71% and reduced the biomass of pre-formed biofilms by 46-90%. Time-dependent increase in release of cytoplasmic content, post EUEO exposure was consistent with loss of membrane integrity.Conclusion: These in vitro findings suggest that EUEO may be a candidate natural agent against P. aeruginosa biofilms, although viability-based and in vivo studies are needed to confirm this.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting phenol-soluble modulins: eco-friendly theragnostic strategies against Staphylococcus aureus biofilms. 靶向酚溶性调节素：针对金黄色葡萄球菌生物膜的生态友好治疗策略。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-19 DOI: 10.1080/17460913.2026.2751166

Avijit Chakraborty, Anuvab De, Shubham Sharma, Shashi Prakash Dwivedi, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Harjot Singh Gill, Soumya Pandit

{"title":"Targeting phenol-soluble modulins: eco-friendly theragnostic strategies against Staphylococcus aureus biofilms.","authors":"Avijit Chakraborty, Anuvab De, Shubham Sharma, Shashi Prakash Dwivedi, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Harjot Singh Gill, Soumya Pandit","doi":"10.1080/17460913.2026.2751166","DOIUrl":"https://doi.org/10.1080/17460913.2026.2751166","url":null,"abstract":"The growing resistance to antibiotics by Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) is a global health threat. Traditional antibiotics act on the viability of bacteria, whereas new ones are now increasingly targeting virulence factors. Phenol-soluble modulins (PSMs) are essential virulence factors that play important roles in inflammation, neutrophil lysis, cytotoxicity and biofilm formation. PubMed, Scopus, Web of Science and Google Scholar were used for literature search of articles published between 2010 and 2026. Green-synthesized metal nanoparticles (NPs) have been found to be capable of altering these mechanisms by inducing reactive oxygen species (ROS) production, membrane damage, and by interfering with the quorum-sensing mechanism of the bacteria, along with inhibiting the Agr system. Optimization of NP-based interventions can be supported by multi-omics approaches such as genomics, transcriptomics, proteomics and metabolomics. Other potential methods of targeted PSM pathway and Agr pathway suppression are also available, such as CRISPR-Cas9 and dCas9, but there are delivery difficulties. The potential use of combining nanotechnology, gene editing, multi-omics, artificial intelligence, and synthetic biology could allow for development of more advanced anti-virulence strategies against S. aureus infections targeted at PSM.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-22"},"PeriodicalIF":2.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The growing zoonotic threat of Babesia and Theileria: the urgent case for piroplasm-specific drug pipelines. 巴贝斯虫和伊氏杆菌日益增长的人畜共患威胁：针对螺浆体的药物管道的紧急案例。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-19 DOI: 10.1080/17460913.2026.2751610

Mohamed Abdo Rizk

引用次数: 0

Beyond the colony: can MALDI-TOF identify non-cultivable bacteria and fungi? 菌落之外：MALDI-TOF能识别不可培养的细菌和真菌吗？

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-18 DOI: 10.1080/17460913.2026.2749315

Sahjid Mukhida, Nikunja Kumar Das, Sriram Kannuri, Tejashree Nare

引用次数: 0

Robust marine bacterium-mediated synthesis of Cu-ZnO nanocomposites: a novel antibiofilm and antivirulent strategy to combat carbapenem-resistant Acinetobacter baumannii. 海洋细菌介导的Cu-ZnO纳米复合材料的合成：对抗耐碳青霉烯不动杆菌的新型抗生素膜和抗病毒策略。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-17 DOI: 10.1080/17460913.2026.2749316

Anjana V Anand, Suvetha Selvam, Arun Kumar Mani

{"title":"Robust marine bacterium-mediated synthesis of Cu-ZnO nanocomposites: a novel antibiofilm and antivirulent strategy to combat carbapenem-resistant Acinetobacter baumannii.","authors":"Anjana V Anand, Suvetha Selvam, Arun Kumar Mani","doi":"10.1080/17460913.2026.2749316","DOIUrl":"https://doi.org/10.1080/17460913.2026.2749316","url":null,"abstract":"Aims: The rapid emergence of carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat to global health security, with high mortality rates. This study aims to develop biofabricated copper-doped zinc oxide nanocomposites (Cu-ZnO NCs) using cell-free extracts from the marine-derived Stenotrophomonas maltophilia and to evaluate their antibacterial, antibiofilm, and anti-efflux efficacy against CRAB.Materials and methods: The biofabricated NCs were synthesized at three different concentrations (0.5, 1, and 3%) and characterized using several techniques to determine their physicochemical and morphological properties. Biological assays, including antibacterial, antibiofilm, and anti-efflux assessments, were investigated using in vitro methods.Results: The biofabricated 1% Cu-ZnO NCs (80 μg/mL) effectively reduced the virulence phenotypes in CRAB, including biofilm formation, slime, and EPS-associated carbohydrate production in a concentration-dependent manner. Microscopic analysis revealed the disruption of biofilm architecture. In addition, NCs attenuated the CRAB virulence factors by reducing phospholipase production and efflux pump function.Conclusion: These findings highlight the importance of biofabricated Cu-ZnO NCs as a promising antivirulent approach for combating carbapenem-resistant Acinetobacter baumannii.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal neurocysticercosis: synthesizing evidence on clinical presentations, anatomical patterns, diagnostic approaches, and therapeutic strategies. 脊神经囊虫病：临床表现、解剖模式、诊断方法和治疗策略的综合证据。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-15 DOI: 10.1080/17460913.2026.2747566

Ravindra Kumar Garg

{"title":"Spinal neurocysticercosis: synthesizing evidence on clinical presentations, anatomical patterns, diagnostic approaches, and therapeutic strategies.","authors":"Ravindra Kumar Garg","doi":"10.1080/17460913.2026.2747566","DOIUrl":"https://doi.org/10.1080/17460913.2026.2747566","url":null,"abstract":"Spinal neurocysticercosis (NCC) is an uncommon manifestation of NCC involving the spinal cord, meninges, nerve roots, and subarachnoid spaces. Although less common than intracranial disease, spinal involvement can cause substantial neurological morbidity because even small lesions within the confined spinal canal may produce progressive myelopathy. Disease may result from hematogenous dissemination or cerebrospinal fluid (CSF) spread of Taenia solium larvae and may present as intramedullary, intradural extramedullary, subarachnoid, or, rarely, extradural lesions. Clinical manifestations are diverse and include paraparesis, quadriparesis, cauda equina syndrome, and chronic meningitis. Magnetic resonance imaging is the diagnostic modality of choice, providing detailed assessment of lesion location, evolutionary stage, inflammatory activity, and associated complications. CSF analysis and immunological or molecular tests provide supportive evidence, while histopathological examination confirms the diagnosis when tissue is available. Treatment is individualized and may include antiparasitic agents, corticosteroids, and surgery when indicated. Although outcomes are generally favorable with early diagnosis and appropriate treatment, delayed treatment, extensive arachnoiditis, diffuse leptomeningeal disease, and established spinal cord damage may result in permanent neurological deficits. Further prospective studies are needed to refine diagnostic strategies and optimize management. PubMed database was searched from inception to 13 July 2026, for spinal neurocysticercosis and spinal cysticercosis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical management and multimodal imaging features of brucellar mastitis mimicking metastatic breast carcinoma: a rare case report and literature review. 模拟转移性乳腺癌的布鲁氏杆菌性乳腺炎的临床处理及多模态影像特征：一例罕见病例报告及文献复习。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-13 DOI: 10.1080/17460913.2026.2747571

Bixue Deng, Xin Wen

引用次数: 0

Statement of Retraction: In Vivo Efficacy of Pyochelin-Mediated Delivery of Zingerone in Pseudomonas Aeruginosa-Induced Peritonitis. 撤回声明：绿脓杆菌介导的黄酮在铜绿假单胞菌诱导的腹膜炎中的体内疗效。

IF 2.5 4区生物学

Future microbiology Pub Date : 2026-10-08 DOI: 10.1080/17460913.2026.2745310

引用次数: 0

Statement of Retraction: Natural Bioactives Versus Synthetic Antibiotics for the Attenuation of Quorum Sensing-Regulated Virulence Factors of Pseudomonas Aeruginosa. 撤回声明：天然生物活性与合成抗生素对铜绿假单胞菌群体感应调节毒力因子的衰减。

IF 2.5 4区生物学