Future microbiology最新文献

Beyond the blame game: fostering consumer engagement in addressing antimicrobial resistance. 超越指责游戏：促进消费者参与解决抗菌素耐药性问题。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-03 DOI: 10.1080/17460913.2025.2528405

Anna-Carin Nordvall, Elin Nilsson, Emma Oljans, Mirko Ancillotti

引用次数: 0

Next stop, precision: targeted therapies for Staphylococcus aureus infections. 下一站，精准：金黄色葡萄球菌感染的靶向治疗。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-03 DOI: 10.1080/17460913.2025.2528416

Frank J Hernandez

引用次数: 0

Evaluation of a bivalent vaccine composed of iron scavenger receptors PMI1426 and PMI1945 against Proteus mirabilis. 铁清除受体PMI1426和PMI1945组成的抗奇异变形杆菌二价疫苗的评价。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-02 DOI: 10.1080/17460913.2025.2525711

Roghayeh Mohammadzadeh, Mehri Habibi, Mohammad Reza Asadi Karam

{"title":"Evaluation of a bivalent vaccine composed of iron scavenger receptors PMI1426 and PMI1945 against Proteus mirabilis.","authors":"Roghayeh Mohammadzadeh, Mehri Habibi, Mohammad Reza Asadi Karam","doi":"10.1080/17460913.2025.2525711","DOIUrl":"https://doi.org/10.1080/17460913.2025.2525711","url":null,"abstract":"Aim: Urinary tract infections (UTIs) caused by Proteus mirabilis are common infectious diseases. Currently, no vaccine is available against UTIs, making the development of an effective vaccine a critical goal to reduce the prevalence and antibiotic resistance of UTIs. Hence, we have investigated the immunogenicity and protective potential of a bivalent vaccine candidate comprising the iron scavenger receptors PMI1426 and PMI1945 from P. mirabilis in mice.Methods: In this study, vaccine candidates composed of PMI1426 and PMI1945 from P. mirabilis were developed, and their immunogenicity, efficacy, and synergistic effects were evaluated in mice.Results: Serum levels of IgG, IgG isotypes, IgA, and urinary IgA, as well as cytokine levels including IFN-γ, IL-4, and IL-17 were significantly elevated following vaccination with PMI1426 and PMI1945 as compared to the controls. The addition of alum enhanced the immune responses in both single and combined vaccine formulations. Furthermore, bacterial colonization in the bladder of mice challenged with P. mirabilis was significantly reduced in mice received the proteins admixed with alum compared to control groups.Conclusion: Our results support the development of a promising vaccine candidate against P. mirabilis UTIs. Future human clinical trials are needed to validate the efficacy and safety of the vaccine candidates.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Employing machine learning for identifying antifungal compounds against Candida albicans. 利用机器学习鉴定抗白色念珠菌的抗真菌化合物。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-02 DOI: 10.1080/17460913.2025.2525717

Dienny Rodrigues de Souza, Lívia Do Carmo Silva, Kleber Santiago Freitas E Silva, Fabricio Silva de Jesus, Amanda Alves de Oliveira, Bruno Junior Neves, Maristela Pereira

引用次数: 0

The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus. 普拉西粪杆菌在妊娠期糖尿病中的优势。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-27 DOI: 10.1080/17460913.2025.2520699

Hanieh Safarzadeh, Amir Aliramezani, Arian Rahimi, Bahareh Yousefi, Siamak Heidarzadeh

{"title":"The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus.","authors":"Hanieh Safarzadeh, Amir Aliramezani, Arian Rahimi, Bahareh Yousefi, Siamak Heidarzadeh","doi":"10.1080/17460913.2025.2520699","DOIUrl":"https://doi.org/10.1080/17460913.2025.2520699","url":null,"abstract":"In recent years, the incidence of metabolic disorders has exponentially increased worldwide mainly due to the misfunctioning of chemical reactions. Gestational diabetes mellitus (GDM) occurred during pregnancy when placenta prevent absorption of sufficient insulin in mother's body. Although this disorder usually disappears after delivery, it could raise the probability of developing complications in the future. GDM is associated with adverse effects on women and their children, such as obesity, cardiovascular disease, and type 2 diabetes. On the other hand, administration of probiotics as a live microorganism with the wide array of health values could contribute to restore and stabilize gut microbiota and subsequently regulate essential internal functions such as development of immunity. In this review, we focus primarily on some causes and effects of GDM in pregnant women and then Faecalibacterium prasnitzii, the most abundant butyrate-producing bacterium in gut, which have been using as a prominent biomarker in health and disease and also potential anti-inflammatory treatment owing to the production of active molecules.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing the promise of NGS in sepsis diagnosis: overcoming scalability barriers. 重新评估NGS在败血症诊断中的前景：克服可扩展性障碍。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-26 DOI: 10.1080/17460913.2025.2525714

Aycan Gundogdu

引用次数: 0

Systematic review of silver and vanadium-based antibiofilm agents: mechanisms and efficacy in oral biofilms. 银基和钒基抗生物膜药物的系统综述：口服生物膜的机制和疗效。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-22 DOI: 10.1080/17460913.2025.2520080

João Marcos Carvalho-Silva, Andréa Cândido Dos Reis

{"title":"Systematic review of silver and vanadium-based antibiofilm agents: mechanisms and efficacy in oral biofilms.","authors":"João Marcos Carvalho-Silva, Andréa Cândido Dos Reis","doi":"10.1080/17460913.2025.2520080","DOIUrl":"10.1080/17460913.2025.2520080","url":null,"abstract":"Aim: To review the literature on the efficacy of silver (Ag) and vanadium (V) in disorganizing and eradicating oral biofilms (OB).Materials & methods: A systematic review was conducted following PRISMA guidelines, with searches performed in PubMed, Lilacs, ScienceDirect, Scopus, Google Scholar, and ProQuest databases.Results: Ag nanoparticles (AgNPs) showed efficacy in disorganizing and eradicating OB of Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Streptococcus mutans, Pseudomonas aeruginosa, and Candida glabrata, but were less effective against Candida albicans. Vanadium chloroperoxidase (VCPO) disorganized OB of S. mutans and eradicated E. faecalis. The association of Ag and V in the compound β-AgVO3 showed high biofilm eradicating effect.Conclusion: Ag exhibits significant antibiofilm effect against Gram-positive and Gram-negative oral bacteria, with limited activity against C. albicans. The antibiofilm activity of V compounds requires further validation. The association of Ag and V presented efficacy in eradicating OB. These findings highlight the potential for integrating Ag and V compounds into dental materials to enhance oral health. Despite methodological heterogeneity and limitations in evaluating unispecies biofilms under in vitro conditions, future research should standardize methodologies and validate these effects in vivo to assess their clinical potential.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-17"},"PeriodicalIF":2.5,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis. 病毒性被忽视热带病的研究趋势和热点：文献计量学分析。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-20 DOI: 10.1080/17460913.2025.2520694

Yuni Wang, Mengqi Zhang, Mingyu Li, Yajun Lu

{"title":"Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis.","authors":"Yuni Wang, Mengqi Zhang, Mingyu Li, Yajun Lu","doi":"10.1080/17460913.2025.2520694","DOIUrl":"10.1080/17460913.2025.2520694","url":null,"abstract":"Background: The World Health Organization's \"2021-2030 Strategic Plan for Neglected Tropical Diseases (NTDs)\" spotlights 21 NTDs, including three viral pathogens: Dengue, Rabies, and Chikungunya. These diseases, prevalent in tropical and subtropical areas, pose a global health threat driven by globalization. Comprehending their research trends and hotspots is vital. Hence, this bibliometric analysis aims to reveal the global research landscape and guide future strategies of viral NTDs.Methods: Data from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) was analyzed for the period 2014-2023, focusing on publications related to Dengue, Rabies, and Chikungunya. Bibliometric analysis and visualization were carried out using VOSviewer, Bibliometrix in RStudio, and CiteSpace to generate descriptive statistics and identify latent thematic structures.Results: The analysis covered 13,472 publications from 184 countries/regions, involving 12,219 institutions/organizations, published across 1,673 journals by 56,733 researchers. An upward trend in annual publication output was seen from 2014 to 2021, peaking at 1,534 articles in 2021, followed by a significant drop. Bibliometric indicators were used to identify core journals, prolific authors, leading institutions, dominant countries, and emerging research themes.Conclusion: The study offers valuable insights and practical guidance for researchers in the domain of viral NTDs.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world study of Ceftazidime-Avibactam for the treatment of disease caused by bacteria: a plain language summary. 头孢他啶-阿维巴坦治疗细菌引起的疾病的实际研究：简单的语言总结。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-20 DOI: 10.1080/17460913.2025.2515005

Alex Soriano, Philippe Montravers, Matteo Bassetti, Galina Klyasova, George Daikos, Paurus Irani, Gregory Stone, Pascale Peeters, Mitesh Shah, Claire Hulin, Benjamin Gaborit, Irene Kourbeti, Francesco Menichetti, Maria Teresa Perez-Rodriguez, Mathias W Pletz, Marisa Sanchez, Ivan Trompa, Anita Verma, Maria Lavinea N de Figueiredo, Claudie Charbonneau

引用次数: 0

Commercial utilization of bacteriocins: tackling challenges and exploring their potential as alternatives to antibiotics. 细菌素的商业利用：应对挑战并探索其作为抗生素替代品的潜力。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-19 DOI: 10.1080/17460913.2025.2520693

Susai Arul Selvan, Vihang Vivek Ghalsasi, Anwesha Bandyopadhyay, Tarun Pal

{"title":"Commercial utilization of bacteriocins: tackling challenges and exploring their potential as alternatives to antibiotics.","authors":"Susai Arul Selvan, Vihang Vivek Ghalsasi, Anwesha Bandyopadhyay, Tarun Pal","doi":"10.1080/17460913.2025.2520693","DOIUrl":"https://doi.org/10.1080/17460913.2025.2520693","url":null,"abstract":"The global surge in antibiotic resistance has accelerated the search for alternative antimicrobial strategies, with bacteriocins emerging as promising candidates. These ribosomally synthesized peptides exhibit potent, targeted antimicrobial activity against multidrug-resistant (MDR) pathogens and have shown efficacy in food preservation, pharmaceuticals, and clinical applications. Their specificity and rapid bactericidal action offer distinct advantages over conventional antibiotics, including a potentially lower risk of resistance development. Nonetheless, recent studies report resistance mechanisms such as membrane modifications, efflux pumps, and enzymatic degradation. Despite their potential, only a limited number of bacteriocins have been commercialized primarily for food applications with none yet approved for therapeutic use. Major barriers include low production yields, poor stability, and stringent regulatory challenges. This review presents a comprehensive overview of bacteriocins, including their classification, mechanisms of action, and commercial landscape. It further highlights current innovations aimed at overcoming translational bottlenecks, such as genetic engineering, nanotechnology-based delivery, and fermentation optimization. Ultimately, the review underscores the need for interdisciplinary research and harmonized regulatory frameworks to fully realize bacteriocins' potential in addressing the global antibiotic resistance crisis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0