Future microbiology最新文献

Diagnosis and treatment of Helicobacter pylori infection: past, present, and future. 幽门螺杆菌感染的诊断和治疗：过去、现在和将来。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-10-05 DOI: 10.1080/17460913.2025.2568326

Jun-Hyung Cho, So-Young Jin

{"title":"Diagnosis and treatment of Helicobacter pylori infection: past, present, and future.","authors":"Jun-Hyung Cho, So-Young Jin","doi":"10.1080/17460913.2025.2568326","DOIUrl":"https://doi.org/10.1080/17460913.2025.2568326","url":null,"abstract":"Helicobacter pylori infects more than half of the world's population. Chronic H. pylori infection is associated with the development of precancerous gastric conditions, including chronic atrophic gastritis and intestinal metaplasia, which may progress to peptic ulcer disease and gastric cancer. In 2020, an estimated 1.09 million new cases of gastric cancer were reported worldwide. Gastric cancer continues to pose a significant health burden and is the fourth leading cause of cancer-related deaths globally, with an estimated 769,000 deaths occurring annually. To decrease gastric cancer-related deaths, international guidelines recommend H. pylori eradication in all infected individuals. Increasing antibiotic resistance of H. pylori has significantly compromised the effectiveness of standard eradication regimens, highlighting the urgent need for alternative and effective treatment strategies. Over the past decade, molecular technologies and genome sequencing have advanced H. pylori diagnosis and treatment. This comprehensive review discusses the latest evidence on H. pylori management to guide the development of effective testing and treatment strategies. It also offers updates for clinicians, including the optimized H. pylori diagnosis, the history of H. pylori treatment and guideline development, updated empirical H. pylori treatment regimens, molecular testing for tailored H. pylori eradication, and next-generation sequencing of the gastric microbiome.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-17"},"PeriodicalIF":2.4,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of wastewater-based and environmental surveillance for monitoring resistance to next-generation antibiotics. 废水监测和环境监测对监测下一代抗生素耐药性的重要性。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-10-03 DOI: 10.1080/17460913.2025.2567804

Rubens R Sousa-Carmo, Nilton Lincopan

引用次数: 0

A plain language summary of the LOCK IT-100 study of taurolidine/heparin catheter lock solution and catheter-related bloodstream infection in hemodialysis. LOCK IT-100研究对血液透析中牛罗列丁/肝素导管锁液和导管相关血流感染的研究进行简单的语言总结。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-09-02 DOI: 10.1080/17460913.2025.2547498

Anil K Agarwal, Jared Crandon, Elizabeth Hurlburt, Mary Michaud, Antony Pfaffle, Prabir Roy-Chaudhury, Celina Medina, Paul T Conway, Edward V Hickey

引用次数: 0

Clinical impact of fluconazole-resistant Candida parapsilosis: a narrative review. 氟康唑耐药假丝酵母旁裂症的临床影响：叙述性回顾。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-11 DOI: 10.1080/17460913.2025.2544443

Claudia Bartalucci, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti

{"title":"Clinical impact of fluconazole-resistant Candida parapsilosis: a narrative review.","authors":"Claudia Bartalucci, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti","doi":"10.1080/17460913.2025.2544443","DOIUrl":"https://doi.org/10.1080/17460913.2025.2544443","url":null,"abstract":"Fluconazole resistance in Candida parapsilosis is an increasing global concern, with resistance rates varying widely and reaching up to 80% in some regions. This trend has led to hospital outbreaks, primarily driven by mutations in the ERG11 gene, especially the Y132F substitution. The clinical relevance of fluconazole resistance remains controversial, as studies have yielded conflicting results regarding its impact on mortality. While some studies described an increased mortality associated with resistant strains, others reported no significant difference. Treatment options are limited: echinocandins and liposomal amphotericin B (L-AmB) are commonly used alternatives, but their use is challenged by intrinsic and emerging echinocandin resistance and L-AmB toxicity and cost. These limitations emphasize the need for robust antifungal stewardship and the development of new therapies. Novel agents such as rezafungin, fosmanogepix, and ibrexafungerp have shown promising activity against fluconazole-resistant C. parapsilosis, though further clinical studies are needed to confirm their efficacy. This narrative review aims to summarize current evidence on the epidemiology, clinical implications, and therapeutic approaches for fluconazole-resistant C. parapsilosis infections.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isavuconazole activity against Candida species from Brazil focusing on C. auris: MIC comparison between EUCAST and CLSI. Isavuconazole对巴西假丝酵母菌（C. auris）的活性：EUCAST与CLSI的MIC比较。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-08 DOI: 10.1080/17460913.2025.2544485

Bruna Rodrigues de Sousa, Camylla Carvalho de Melo, Manoel Marques Evangelista Oliveira, Sylvia Maria de Lemos Hinrichsen, Rossana de Aguiar Cordeiro, Reginaldo Gonçalves de Lima-Neto

{"title":"Isavuconazole activity against Candida species from Brazil focusing on C. auris: MIC comparison between EUCAST and CLSI.","authors":"Bruna Rodrigues de Sousa, Camylla Carvalho de Melo, Manoel Marques Evangelista Oliveira, Sylvia Maria de Lemos Hinrichsen, Rossana de Aguiar Cordeiro, Reginaldo Gonçalves de Lima-Neto","doi":"10.1080/17460913.2025.2544485","DOIUrl":"https://doi.org/10.1080/17460913.2025.2544485","url":null,"abstract":"Aim: We evaluated the in vitro activity of isavuconazole against different Candida clinical species from Brazil, with an emphasis on C. auris, using CLSI and EUCAST, and compared the results to expand the literature on this new triazole.Methods: A total of 102 strains of Candida spp. were isolated from critically ill patients admitted to tertiary hospitals in Recife, Pernambuco, Brazil. All isolates were identified using MALDI-TOF MS and tested using broth microdilutions.Results: The species identified were C. auris (62), C. albicans (14), C. tropicalis (9), C. parapsilosis (5), C. glabrata (3), C. metapsilosis, C. orthopsilosis (2) each, C. duobushaemulonii, Meyerozyma guilliermondii, Clavispora lusitaniae, C. nivariensis, and Wickerhamomyces anomolus (1). A modal MIC90 of ≤0.008 µg/mL and a wild-type modal upper limit value of <0.03 µg/mL were found. Thus, 99.1% (CLSI) and 95.1% (EUCAST) of the strains were wild-type. The overall essential agreement rate between the methods was 95.1% (±2 log2 dilutions) and 89.2% (±1 log2 dilution).Conclusion: Both methodologies were useful for evaluating the antifungal potential of isavuconazole and highlighted the low MICs of this triazole against the Brazilian collection of Candida spp., especially the emerging yeast C. auris.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-7"},"PeriodicalIF":2.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a bivalent vaccine composed of iron scavenger receptors PMI1426 and PMI1945 against Proteus mirabilis. 铁清除受体PMI1426和PMI1945组成的抗奇异变形杆菌二价疫苗的评价。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1080/17460913.2025.2525711

Roghayeh Mohammadzadeh, Mehri Habibi, Mohammad Reza Asadi Karam

{"title":"Evaluation of a bivalent vaccine composed of iron scavenger receptors PMI1426 and PMI1945 against Proteus mirabilis.","authors":"Roghayeh Mohammadzadeh, Mehri Habibi, Mohammad Reza Asadi Karam","doi":"10.1080/17460913.2025.2525711","DOIUrl":"10.1080/17460913.2025.2525711","url":null,"abstract":"Aim: Urinary tract infections (UTIs) caused by Proteus mirabilis are common infectious diseases. Currently, no vaccine is available against UTIs, making the development of an effective vaccine a critical goal to reduce the prevalence and antibiotic resistance of UTIs. Hence, we have investigated the immunogenicity and protective potential of a bivalent vaccine candidate comprising the iron scavenger receptors PMI1426 and PMI1945 from P. mirabilis in mice.Methods: In this study, vaccine candidates composed of PMI1426 and PMI1945 from P. mirabilis were developed, and their immunogenicity, efficacy, and synergistic effects were evaluated in mice.Results: Serum levels of IgG, IgG isotypes, IgA, and urinary IgA, as well as cytokine levels including IFN-γ, IL-4, and IL-17 were significantly elevated following vaccination with PMI1426 and PMI1945 as compared to the controls. The addition of alum enhanced the immune responses in both single and combined vaccine formulations. Furthermore, bacterial colonization in the bladder of mice challenged with P. mirabilis was significantly reduced in mice received the proteins admixed with alum compared to control groups.Conclusion: Our results support the development of a promising vaccine candidate against P. mirabilis UTIs. Future human clinical trials are needed to validate the efficacy and safety of the vaccine candidates.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"723-733"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous leaf extract from Eugenia dysenterica exhibits antimicrobial and antibiofilm activity against Staphylococcus aureus. 赤霉素叶水提物对金黄色葡萄球菌具有抗菌和抗膜活性。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-01 Epub Date: 2025-07-24 DOI: 10.1080/17460913.2025.2528419

Ivanilde Carmo Dos Santos, Flávio Santos Lopes, Paulo Henrique Gonçalves Dias Diniz, Cláudia Vieira Prudêncio

{"title":"Aqueous leaf extract from Eugenia dysenterica exhibits antimicrobial and antibiofilm activity against Staphylococcus aureus.","authors":"Ivanilde Carmo Dos Santos, Flávio Santos Lopes, Paulo Henrique Gonçalves Dias Diniz, Cláudia Vieira Prudêncio","doi":"10.1080/17460913.2025.2528419","DOIUrl":"10.1080/17460913.2025.2528419","url":null,"abstract":"Staphylococcus aureus is a pathogen associated with various diseases, exhibiting biofilm ability and antimicrobial resistance. The search for new antimicrobial agents, especially natural ones, is crucial. This study evaluated the antibacterial and antibiofilm activities of the aqueous leaf extract from Eugenia dysenterica against S. aureus. Healthy leaves were dried, powdered and infused in water to obtain the extract. Reference strains S. aureus ATCC 25,923 and ATCC 29,213 were employed as model organisms. The minimum inhibitory concentration (MIC) was assessed using the microdilution technique in 96-well polystyrene microplates. The minimum bactericidal concentration (MBC) was evaluated by plating on standard count agar. Test surface assays were performed with polystyrene coupons, where the count of viable sessile cells (CVSC) was determined after sonication and agitation. Biofilm resistance was assessed after exposure to a chlorinated compound. The extract showed antimicrobial activity, with MICs values of 156-313 μg/mL and MBC values of 625-1,250 μg/mL. Antibiofilm activity was observed at inhibitory and subinhibitory concentrations. Even when CVSC was similar, the extract increased biofilm sensitivity to chlorinated compounds. The antimicrobial and antibiofilm potential of the aqueous leaf extract of E. dysenterica could aid S. aureus control in various fields, including the food and medical industries.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"735-742"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of Candida albicans and Staphylococcus aureus dual species interkingdom biofilm development via SAP5 inhibition. 通过SAP5抑制白色念珠菌和金黄色葡萄球菌双种界间生物膜发育。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-01 Epub Date: 2025-08-03 DOI: 10.1080/17460913.2025.2539011

Anmol Kulshrestha, Pratima Gupta

{"title":"Control of Candida albicans and Staphylococcus aureus dual species interkingdom biofilm development via SAP5 inhibition.","authors":"Anmol Kulshrestha, Pratima Gupta","doi":"10.1080/17460913.2025.2539011","DOIUrl":"10.1080/17460913.2025.2539011","url":null,"abstract":"Aim: Microbial biofilms, particularly polymicrobial ones formed by Candida albicans and Staphylococcus aureus, exhibit increased resistance to conventional treatment. This study investigates the inhibitory effect of 4-hydroxyphenylacetic acid on Secreted Aspartyl Protease 5, a key virulence factor involved in hyphal development and biofilm formation in Candida albicans, to investigate its therapeutic potential in inhibiting polymicrobial biofilms developed with Staphylococcus aureus.Materials & methods: Biofilm formation was studied using a Biofilm Infection Simulator System and polymethylmethacrylate coupons. Biofilms were analyzed under untreated and 4-HPA-treated conditions. SAP5 proteinase activity on BSA was quantified in treated & un-treated cultures.Results: 4-HPA treatment significantly restricted C. albicans hyphal growth, reducing S. aureus attachment. The biofilm decreased by over 78% in mono-species and 81% in polymicrobial cultures. The inhibition of SAP5 protease activity was 79% in mono-species and 65% in mixed cultures.Conclusions: 4-HPA effectively reduces biofilm formation and SAP5 activity, highlighting its potential as a biofilm-specific therapeutic for polymicrobial infections.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"779-791"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts. 唑类药物对不同模型的斑马鱼免疫抑制有不同的效果。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-01 Epub Date: 2025-08-03 DOI: 10.1080/17460913.2025.2539639

Kevin E Ayala, Sarah Baum, Savini U Thrikawala, M Lynette Goins, Molly Anderson, Collin Davis, Hannah Pollock, Emily E Rosowski

{"title":"Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts.","authors":"Kevin E Ayala, Sarah Baum, Savini U Thrikawala, M Lynette Goins, Molly Anderson, Collin Davis, Hannah Pollock, Emily E Rosowski","doi":"10.1080/17460913.2025.2539639","DOIUrl":"10.1080/17460913.2025.2539639","url":null,"abstract":"Aims: Fungal infections are an increasing cause of mortality in immunosuppressed human patients, and antifungal drug treatments are still ineffective in a significant percentage of cases. A gap in our understanding of antifungal drug treatment is whether different drugs have differential efficacy in hosts that are experiencing different forms of immunosuppression.Materials & methods: Here, we used a larval zebrafish vertebrate host model of Aspergillus fumigatus infection to compare the efficacy of four different triazole drugs in five different immunosuppressed or immunodeficient conditions, including larvae treated with immunosuppressive drugs and genetically phagocyte-deficient larvae.Results: We report that voriconazole and posaconazole are highly effective in all host backgrounds tested, while isavuconazole and itraconazole exhibit host-specific efficacy and toxicity. Repeated daily imaging of whole live larvae treated with posaconazole demonstrates that posaconazole treatment can prevent germination of A. fumigatus spores inside infected hosts but that this drug does not significantly combat fungal hyphal growth post-germination.Conclusions: This study demonstrates the utility of the larval zebrafish host model for testing the efficacy of antifungal drugs in varied host backgrounds and determining the effects of these drugs on fungi living and growing inside infected hosts.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"793-806"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of children with disseminated Staphylococcus aureus infection involving bone and joint. 儿童弥散性金黄色葡萄球菌感染累及骨和关节的临床特点。

IF 2.4 4区生物学

Future microbiology Pub Date : 2025-08-01 Epub Date: 2025-07-09 DOI: 10.1080/17460913.2025.2525709

Yingtie Cui, Yunzhen Zhang, Shiguang Feng, Zhen Mao, Pengyuan Luo, Xiaokang Zhou

{"title":"Clinical characteristics of children with disseminated Staphylococcus aureus infection involving bone and joint.","authors":"Yingtie Cui, Yunzhen Zhang, Shiguang Feng, Zhen Mao, Pengyuan Luo, Xiaokang Zhou","doi":"10.1080/17460913.2025.2525709","DOIUrl":"10.1080/17460913.2025.2525709","url":null,"abstract":"This retrospective study investigated the clinical characteristics and prognosis in 24 children (average age 5.6 ± 4.9 years) with disseminated Staphylococcus aureus bone and joint infections (May 2011-November 2022). Most infections (91.67%) were found to be associated with respiratory system infections. The femur (16 cases) was the most common bone; hip (6 cases) and knee (5 cases) were the most common joints. Notably, 14 cases (58.33%) had infections at > 3 osteoarticular sites, and 6 cases (25.00%) at > 4 sites (maximum 7). Cultures revealed 58.33% methicillin-resistant S. aureus ;(MRSA) and 41.67% methicillin-sensitive S. aureus ;(MSSA). All patients underwent surgery; 6 required secondary procedures. Patients were divided into sequelae (n = 10) and non-sequelae (n = 14) groups. The sequelae group had significantly longer time to surgery (11.20 ± 8.46 vs. 3.50 ± 2.53 days, p = 0.019), higher procalcitonin (27.28 ± 23.98 ng/ml vs. 9.02 ± 9.00 ng/ml, p = 0.043), and greater bacterial load (2760.86 ± 1592.02 vs. 155.25 ± 65.57, p = 0.005). Disseminated S. aureus bone and joint infections in children commonly affect the femur, hip, and knee. Delayed surgery and higher PCT levels are associated with sequelae.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"715-722"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0