Clinical characteristics of children with disseminated Staphylococcus aureus infection involving bone and joint.

IF 2.4 4区 生物学 Q3 MICROBIOLOGY
Future microbiology Pub Date : 2025-08-01 Epub Date: 2025-07-09 DOI:10.1080/17460913.2025.2525709
Yingtie Cui, Yunzhen Zhang, Shiguang Feng, Zhen Mao, Pengyuan Luo, Xiaokang Zhou
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Abstract

This retrospective study investigated the clinical characteristics and prognosis in 24 children (average age 5.6 ± 4.9 years) with disseminated Staphylococcus aureus bone and joint infections (May 2011-November 2022). Most infections (91.67%) were found to be associated with respiratory system infections. The femur (16 cases) was the most common bone; hip (6 cases) and knee (5 cases) were the most common joints. Notably, 14 cases (58.33%) had infections at > 3 osteoarticular sites, and 6 cases (25.00%) at > 4 sites (maximum 7). Cultures revealed 58.33% methicillin-resistant S. aureus ;(MRSA) and 41.67% methicillin-sensitive S. aureus ;(MSSA). All patients underwent surgery; 6 required secondary procedures. Patients were divided into sequelae (n = 10) and non-sequelae (n = 14) groups. The sequelae group had significantly longer time to surgery (11.20 ± 8.46 vs. 3.50 ± 2.53 days, p = 0.019), higher procalcitonin (27.28 ± 23.98 ng/ml vs. 9.02 ± 9.00 ng/ml, p = 0.043), and greater bacterial load (2760.86 ± 1592.02 vs. 155.25 ± 65.57, p = 0.005). Disseminated S. aureus bone and joint infections in children commonly affect the femur, hip, and knee. Delayed surgery and higher PCT levels are associated with sequelae.

儿童弥散性金黄色葡萄球菌感染累及骨和关节的临床特点。
回顾性研究2011年5月- 2022年11月24例弥散性金黄色葡萄球菌骨关节感染患儿(平均年龄5.6±4.9岁)的临床特点及预后。感染以呼吸系统感染为主(91.67%)。股骨(16例)是最常见的骨;髋关节(6例)和膝关节(5例)是最常见的关节。值得注意的是,14例(58.33%)骨关节部位感染bbb3, 6例(25.00%)骨关节部位感染> 4(最多7例)。培养结果显示耐甲氧西林金黄色葡萄球菌(MRSA)为58.33%,耐甲氧西林金黄色葡萄球菌(MSSA)为41.67%。所有患者均接受手术治疗;6 .需二次手术。将患者分为后遗症组(n = 10)和非后遗症组(n = 14)。后遗症组手术时间明显延长(11.20±8.46天vs. 3.50±2.53天,p = 0.019),降钙素原较高(27.28±23.98 ng/ml vs. 9.02±9.00 ng/ml, p = 0.043),细菌负荷较高(2760.86±1592.02 vs. 155.25±65.57,p = 0.005)。儿童弥散性金黄色葡萄球菌骨关节感染通常累及股骨、髋关节和膝关节。延迟手术和较高的PCT水平与后遗症有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Future microbiology
Future microbiology 生物-微生物学
CiteScore
4.90
自引率
3.20%
发文量
134
审稿时长
6-12 weeks
期刊介绍: Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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