{"title":"Clinical characteristics of children with disseminated <i>Staphylococcus aureus</i> infection involving bone and joint.","authors":"Yingtie Cui, Yunzhen Zhang, Shiguang Feng, Zhen Mao, Pengyuan Luo, Xiaokang Zhou","doi":"10.1080/17460913.2025.2525709","DOIUrl":null,"url":null,"abstract":"<p><p>This retrospective study investigated the clinical characteristics and prognosis in 24 children (average age 5.6 ± 4.9 years) with disseminated <i>Staphylococcus aureus</i> bone and joint infections (May 2011-November 2022). Most infections (91.67%) were found to be associated with respiratory system infections. The femur (16 cases) was the most common bone; hip (6 cases) and knee (5 cases) were the most common joints. Notably, 14 cases (58.33%) had infections at > 3 osteoarticular sites, and 6 cases (25.00%) at > 4 sites (maximum 7). Cultures revealed 58.33% methicillin-resistant <i>S. aureus</i> ;(MRSA) and 41.67% methicillin-sensitive <i>S. aureus</i> ;(MSSA). All patients underwent surgery; 6 required secondary procedures. Patients were divided into sequelae (<i>n</i> = 10) and non-sequelae (<i>n</i> = 14) groups. The sequelae group had significantly longer time to surgery (11.20 ± 8.46 vs. 3.50 ± 2.53 days, <i>p</i> = 0.019), higher procalcitonin (27.28 ± 23.98 ng/ml vs. 9.02 ± 9.00 ng/ml, <i>p</i> = 0.043), and greater bacterial load (2760.86 ± 1592.02 vs. 155.25 ± 65.57, <i>p</i> = 0.005). Disseminated <i>S. aureus</i> bone and joint infections in children commonly affect the femur, hip, and knee. Delayed surgery and higher PCT levels are associated with sequelae.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"715-722"},"PeriodicalIF":2.4000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2025.2525709","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This retrospective study investigated the clinical characteristics and prognosis in 24 children (average age 5.6 ± 4.9 years) with disseminated Staphylococcus aureus bone and joint infections (May 2011-November 2022). Most infections (91.67%) were found to be associated with respiratory system infections. The femur (16 cases) was the most common bone; hip (6 cases) and knee (5 cases) were the most common joints. Notably, 14 cases (58.33%) had infections at > 3 osteoarticular sites, and 6 cases (25.00%) at > 4 sites (maximum 7). Cultures revealed 58.33% methicillin-resistant S. aureus ;(MRSA) and 41.67% methicillin-sensitive S. aureus ;(MSSA). All patients underwent surgery; 6 required secondary procedures. Patients were divided into sequelae (n = 10) and non-sequelae (n = 14) groups. The sequelae group had significantly longer time to surgery (11.20 ± 8.46 vs. 3.50 ± 2.53 days, p = 0.019), higher procalcitonin (27.28 ± 23.98 ng/ml vs. 9.02 ± 9.00 ng/ml, p = 0.043), and greater bacterial load (2760.86 ± 1592.02 vs. 155.25 ± 65.57, p = 0.005). Disseminated S. aureus bone and joint infections in children commonly affect the femur, hip, and knee. Delayed surgery and higher PCT levels are associated with sequelae.
期刊介绍:
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.