Future microbiology最新文献_第2页

Systematic review of silver and vanadium-based antibiofilm agents: mechanisms and efficacy in oral biofilms. 银基和钒基抗生物膜药物的系统综述：口服生物膜的机制和疗效。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-01 Epub Date: 2025-06-22 DOI: 10.1080/17460913.2025.2520080

João Marcos Carvalho-Silva, Andréa Cândido Dos Reis

{"title":"Systematic review of silver and vanadium-based antibiofilm agents: mechanisms and efficacy in oral biofilms.","authors":"João Marcos Carvalho-Silva, Andréa Cândido Dos Reis","doi":"10.1080/17460913.2025.2520080","DOIUrl":"10.1080/17460913.2025.2520080","url":null,"abstract":"Aim: To review the literature on the efficacy of silver (Ag) and vanadium (V) in disorganizing and eradicating oral biofilms (OB).Materials & methods: A systematic review was conducted following PRISMA guidelines, with searches performed in PubMed, Lilacs, ScienceDirect, Scopus, Google Scholar, and ProQuest databases.Results: Ag nanoparticles (AgNPs) showed efficacy in disorganizing and eradicating OB of Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Streptococcus mutans, Pseudomonas aeruginosa, and Candida glabrata, but were less effective against Candida albicans. Vanadium chloroperoxidase (VCPO) disorganized OB of S. mutans and eradicated E. faecalis. The association of Ag and V in the compound β-AgVO3 showed high biofilm eradicating effect.Conclusion: Ag exhibits significant antibiofilm effect against Gram-positive and Gram-negative oral bacteria, with limited activity against C. albicans. The antibiofilm activity of V compounds requires further validation. The association of Ag and V presented efficacy in eradicating OB. These findings highlight the potential for integrating Ag and V compounds into dental materials to enhance oral health. Despite methodological heterogeneity and limitations in evaluating unispecies biofilms under in vitro conditions, future research should standardize methodologies and validate these effects in vivo to assess their clinical potential.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"639-655"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis. 病毒性被忽视热带病的研究趋势和热点：文献计量学分析。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-01 Epub Date: 2025-06-20 DOI: 10.1080/17460913.2025.2520694

Yuni Wang, Mengqi Zhang, Mingyu Li, Yajun Lu

{"title":"Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis.","authors":"Yuni Wang, Mengqi Zhang, Mingyu Li, Yajun Lu","doi":"10.1080/17460913.2025.2520694","DOIUrl":"10.1080/17460913.2025.2520694","url":null,"abstract":"Background: The World Health Organization's \"2021-2030 Strategic Plan for Neglected Tropical Diseases (NTDs)\" spotlights 21 NTDs, including three viral pathogens: Dengue, Rabies, and Chikungunya. These diseases, prevalent in tropical and subtropical areas, pose a global health threat driven by globalization. Comprehending their research trends and hotspots is vital. Hence, this bibliometric analysis aims to reveal the global research landscape and guide future strategies of viral NTDs.Methods: Data from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) was analyzed for the period 2014-2023, focusing on publications related to Dengue, Rabies, and Chikungunya. Bibliometric analysis and visualization were carried out using VOSviewer, Bibliometrix in RStudio, and CiteSpace to generate descriptive statistics and identify latent thematic structures.Results: The analysis covered 13,472 publications from 184 countries/regions, involving 12,219 institutions/organizations, published across 1,673 journals by 56,733 researchers. An upward trend in annual publication output was seen from 2014 to 2021, peaking at 1,534 articles in 2021, followed by a significant drop. Bibliometric indicators were used to identify core journals, prolific authors, leading institutions, dominant countries, and emerging research themes.Conclusion: The study offers valuable insights and practical guidance for researchers in the domain of viral NTDs.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"657-668"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus. 普拉西粪杆菌在妊娠期糖尿病中的优势。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-01 Epub Date: 2025-06-27 DOI: 10.1080/17460913.2025.2520699

Hanieh Safarzadeh, Amir Aliramezani, Arian Rahimi, Bahareh Yousefi, Siamak Heidarzadeh

{"title":"The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus.","authors":"Hanieh Safarzadeh, Amir Aliramezani, Arian Rahimi, Bahareh Yousefi, Siamak Heidarzadeh","doi":"10.1080/17460913.2025.2520699","DOIUrl":"10.1080/17460913.2025.2520699","url":null,"abstract":"In recent years, the incidence of metabolic disorders has exponentially increased worldwide mainly due to the misfunctioning of chemical reactions. Gestational diabetes mellitus (GDM) occurred during pregnancy when placenta prevent absorption of sufficient insulin in mother's body. Although this disorder usually disappears after delivery, it could raise the probability of developing complications in the future. GDM is associated with adverse effects on women and their children, such as obesity, cardiovascular disease, and type 2 diabetes. On the other hand, administration of probiotics as a live microorganism with the wide array of health values could contribute to restore and stabilize gut microbiota and subsequently regulate essential internal functions such as development of immunity. In this review, we focus primarily on some causes and effects of GDM in pregnant women and then Faecalibacterium prasnitzii, the most abundant butyrate-producing bacterium in gut, which have been using as a prominent biomarker in health and disease and also potential anti-inflammatory treatment owing to the production of active molecules.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"695-706"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commercial utilization of bacteriocins: tackling challenges and exploring their potential as alternatives to antibiotics. 细菌素的商业利用：应对挑战并探索其作为抗生素替代品的潜力。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-01 Epub Date: 2025-06-19 DOI: 10.1080/17460913.2025.2520693

Susai Arul Selvan, Vihang Vivek Ghalsasi, Anwesha Bandyopadhyay, Tarun Pal

{"title":"Commercial utilization of bacteriocins: tackling challenges and exploring their potential as alternatives to antibiotics.","authors":"Susai Arul Selvan, Vihang Vivek Ghalsasi, Anwesha Bandyopadhyay, Tarun Pal","doi":"10.1080/17460913.2025.2520693","DOIUrl":"10.1080/17460913.2025.2520693","url":null,"abstract":"The global surge in antibiotic resistance has accelerated the search for alternative antimicrobial strategies, with bacteriocins emerging as promising candidates. These ribosomally synthesized peptides exhibit potent, targeted antimicrobial activity against multidrug-resistant (MDR) pathogens and have shown efficacy in food preservation, pharmaceuticals, and clinical applications. Their specificity and rapid bactericidal action offer distinct advantages over conventional antibiotics, including a potentially lower risk of resistance development. Nonetheless, recent studies report resistance mechanisms such as membrane modifications, efflux pumps, and enzymatic degradation. Despite their potential, only a limited number of bacteriocins have been commercialized primarily for food applications with none yet approved for therapeutic use. Major barriers include low production yields, poor stability, and stringent regulatory challenges. This review presents a comprehensive overview of bacteriocins, including their classification, mechanisms of action, and commercial landscape. It further highlights current innovations aimed at overcoming translational bottlenecks, such as genetic engineering, nanotechnology-based delivery, and fermentation optimization. Ultimately, the review underscores the need for interdisciplinary research and harmonized regulatory frameworks to fully realize bacteriocins' potential in addressing the global antibiotic resistance crisis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"681-693"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world study of Ceftazidime-Avibactam for the treatment of disease caused by bacteria: a plain language summary. 头孢他啶-阿维巴坦治疗细菌引起的疾病的实际研究：简单的语言总结。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-07-01 Epub Date: 2025-06-20 DOI: 10.1080/17460913.2025.2515005

Alex Soriano, Philippe Montravers, Matteo Bassetti, Galina Klyasova, George Daikos, Paurus Irani, Gregory Stone, Pascale Peeters, Mitesh Shah, Claire Hulin, Benjamin Gaborit, Irene Kourbeti, Francesco Menichetti, Maria Teresa Perez-Rodriguez, Mathias W Pletz, Marisa Sanchez, Ivan Trompa, Anita Verma, Maria Lavinea N de Figueiredo, Claudie Charbonneau

引用次数: 0

Reassessing the promise of NGS in sepsis diagnosis: overcoming scalability barriers. 重新评估NGS在败血症诊断中的前景：克服可扩展性障碍。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-06-26 DOI: 10.1080/17460913.2025.2525714

Aycan Gundogdu

引用次数: 0

Vitamin C improves gut Bifidobacteria in humans. 维生素 C 能改善人类肠道双歧杆菌的状况。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-05-01 Epub Date: 2022-12-08 DOI: 10.2217/fmb-2022-0209

Sabine Hazan, Sonya Dave, Andreas J Papoutsis, Nirupama Deshpande, Mark C Howell, Leisha Ma Martin

引用次数: 0

Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities. 高危人群结核性脑膜炎的系统回顾：死亡率和诊断差异。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-05-01 Epub Date: 2024-10-03 DOI: 10.1080/17460913.2024.2366604

Andressa Lorena Ieque, Carolina Trevisolli Palomo, Deborah de Castro Moreira, Jean Eduardo Meneguello, Letícia Sayuri Murase, Lincoln Luís Silva, Vanessa Pietrowski Baldin, Katiany Rizzieri Caleffi-Ferracioli, Vera Lucia Dias Siqueira, Rosilene Fressatti Cardoso, Jorge Juarez Vieira Teixeira, Regiane Bertin De Lima Scodro

{"title":"Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.","authors":"Andressa Lorena Ieque, Carolina Trevisolli Palomo, Deborah de Castro Moreira, Jean Eduardo Meneguello, Letícia Sayuri Murase, Lincoln Luís Silva, Vanessa Pietrowski Baldin, Katiany Rizzieri Caleffi-Ferracioli, Vera Lucia Dias Siqueira, Rosilene Fressatti Cardoso, Jorge Juarez Vieira Teixeira, Regiane Bertin De Lima Scodro","doi":"10.1080/17460913.2024.2366604","DOIUrl":"10.1080/17460913.2024.2366604","url":null,"abstract":"Aim: Tuberculous meningitis (TBM) is one of the most severe clinical forms of tuberculosis (TB). Since epidemiological studies can contribute to TB control, we conducted a review and meta-analysis of epidemiological publications of adults TBM cases in countries with high incidence of TB.Materials & methods: The search resulted in 11,855 articles, in which 21 ultimately were included in our review and 15 in our meta-analysis.Results: TBM mortality was 25% with death rates of 70% in Africa. The review showed different and non-concordant diagnostic techniques and treatment schemes.Conclusion: Adults living in the African region are at high risk of death from TBM, highlighting an urgent need of guidelines to support diagnosis and treatment, and ultimately, to reduce mortality.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"559-571"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiviral defense against filovirus infections: targets and evasion mechanisms. 丝状病毒感染的抗病毒防御：靶点和逃避机制。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1080/17460913.2025.2501924

Bianca S Bodmer, Lisa Wendt, Juliette Dupré, Allison Groseth, Thomas Hoenen

{"title":"Antiviral defense against filovirus infections: targets and evasion mechanisms.","authors":"Bianca S Bodmer, Lisa Wendt, Juliette Dupré, Allison Groseth, Thomas Hoenen","doi":"10.1080/17460913.2025.2501924","DOIUrl":"10.1080/17460913.2025.2501924","url":null,"abstract":"Filoviruses include a number of serious human pathogens, infections with which result in the development of hemorrhagic fevers with high case fatality rates. As for other RNA viruses, viral replication generates both protein and RNA species that can serve as danger signals, leading to the activation of antiviral defense pathways. However, in order to be able to efficiently infect humans these viruses have developed mechanisms that allow them to evade diverse host antiviral defense mechanisms. Consequently, in addition to their functions within the viral lifecycle many filovirus proteins have been shown to have accessory functions involved in the regulation of diverse host pathways. These include those of the type-I interferon response, other pathways involved in dsRNA-sensing, as well as the selective inhibition of interferon stimulated gene activities. Further, filoviruses have developed mechanisms to subvert recognition of infected cells and the generation of neutralizing antibodies. This review focuses on bringing together the evidence to date supporting the existence of diverse mechanisms aimed at regulating these pathways as well as providing details of the mechanisms involved.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"573-587"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing colistin efficacy with combination therapies for multidrug-resistant P. aeruginosa and A. baumannii isolates. 联合治疗多药耐药铜绿假单胞菌和鲍曼假单胞菌提高粘菌素疗效。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1080/17460913.2025.2490377

Elif Karaaslan, Ozlem Oyardi, Sibel Dosler

{"title":"Enhancing colistin efficacy with combination therapies for multidrug-resistant P. aeruginosa and A. baumannii isolates.","authors":"Elif Karaaslan, Ozlem Oyardi, Sibel Dosler","doi":"10.1080/17460913.2025.2490377","DOIUrl":"10.1080/17460913.2025.2490377","url":null,"abstract":"Aim: Increasing resistance among ESKAPEEc pathogens, particularly Acinetobacter baumannii and Pseudomonas aeruginosa, has necessitated the use of last-resort antibiotics such as colistin. This study aimed to evaluate the effectiveness and reveal a dynamic picture of colistin-based combination therapies.Materials & methods: This study evaluated the in vitro efficacy of colistin in combination with doxycycline, doripenem, and rifampicin against multidrug-resistant clinical isolates of P. aeruginosa (n = 23) and A. baumannii (n = 26). Susceptibility testing performed by microbroth dilution method, and synergistic interactions were assessed via checkerboard and time-kill curve (TKC) assays.Results: All isolates were resistant to colistin, according to their MICs. In checkerboard assays, according to synergism rates, colistin-doripenem and colistin-doxycycline combinations were particularly effective. The degrees of synergy for doripenem, doxycycline, and rifampicin were 30%, 90%, and 20%, respectively, against P. aeruginosa, and 30%, 60%, and 30%, respectively, against A. baumannii. In TKC analysis, synergistic interactions are generally observed with colistin at 1/4×MIC or 1×MIC, and indifference effects at 4×MIC, similar to colistin monotherapy. TKCs also confirmed the bactericidal activities of combinations that achieved ≥3-log10 reductions in initial bacterial counts.Conclusions: Colistin-based combination therapies, especially colistin-doripenem, may be promising approaches for combating multidrug-resistant pathogens while potentially reducing nephrotoxicity risk.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"523-531"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0