Future microbiology最新文献_第2页

Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis. 寄生虫与微生物群的相互作用：创新性干预恰加斯病、利什曼病和蛔虫病的途径。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-22 DOI: 10.1080/17460913.2024.2431417

Juan David Ramírez, Sergio Castañeda, Jill Weatherhead, Cristina Poveda

{"title":"Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis.","authors":"Juan David Ramírez, Sergio Castañeda, Jill Weatherhead, Cristina Poveda","doi":"10.1080/17460913.2024.2431417","DOIUrl":"https://doi.org/10.1080/17460913.2024.2431417","url":null,"abstract":"Parasitic infections are a major global health challenge, driven in part by complex interactions between parasites, host microbiota, and immune responses. Recent advances in microbiome research highlight the critical role of microbiota in influencing disease outcomes and treatment effectiveness. This review examines how changes in the microbiota impact parasite transmission, disease progression, and responses to treatment, focusing on key parasitic diseases such as Chagas disease, leishmaniasis, and ascariasis. The microbiota can either exacerbate or mitigate disease severity, depending on its composition, providing critical insights for novel therapeutic strategies. Emerging approaches discussed include the use of targeted probiotics, prebiotics, and microbiota-modulating drugs to influence parasite dynamics and enhance conventional therapies. The review also explores the potential of integrating microbiota knowledge into vaccine design and immunotherapy, aiming to develop vaccines that elicit stronger immune responses and identify new therapeutic targets. A multidisciplinary approach is essential for translating these findings into effective clinical solutions, with future research focusing on validating microbiota-based interventions in clinical settings. In conclusion, the interaction between microbiota and parasitic infections presents a promising avenue for innovative therapies, with the potential to significantly improve global health outcomes.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streptococcus intermedius: an underestimated pathogen in brain infection? 中间链球菌：脑部感染中被低估的病原体？

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-18 DOI: 10.1080/17460913.2024.2423524

Eliza Gil, James Hatcher, Sophia de Saram, Rebecca L Guy, Theresa Lamagni, Jeremy S Brown

{"title":"Streptococcus intermedius: an underestimated pathogen in brain infection?","authors":"Eliza Gil, James Hatcher, Sophia de Saram, Rebecca L Guy, Theresa Lamagni, Jeremy S Brown","doi":"10.1080/17460913.2024.2423524","DOIUrl":"https://doi.org/10.1080/17460913.2024.2423524","url":null,"abstract":"Streptococcus intermedius is an oral commensal organism belonging to the Streptococcus anginosus group (SAG). S. intermedius causes periodontitis as well as invasive, pyogenic infection of the central nervous system, pleural space or liver. Compared with other SAG organisms, S. intermedius has a higher mortality as well as a predilection for intracranial infection, suggesting it is likely to possess virulence factors that mediate specific interactions with the host resulting in bacteria reaching the brain. The mechanisms involved are not well described. Intracranial suppuration (ICS) due to S. intermedius infection can manifest as an abscess within the brain parenchyma, or a collection of pus (empyema) in the sub- or extra-dural space. These infections necessitate neurosurgery and prolonged antibiotic treatment and are associated with a considerable burden of morbidity and mortality. The incidence of ICS is increasing in several settings, with SAG species accounting for an increasing proportion of cases. There is a paucity of published literature regarding S. intermedius pathogenesis as well as few published genomes, hampering molecular epidemiological research. This perspective evaluates what is known about the clinical features and pathogenesis of ICS due to S. intermedius and explores hypothetical explanations why the incidence of these infections may be increasing.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic evaluation of treating invasive aspergillosis with isavuconazole, posaconazole and voriconazole in China. 在中国使用异武康唑、泊沙康唑和伏立康唑治疗侵袭性曲霉菌病的经济评估。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-18 DOI: 10.1080/17460913.2024.2423530

Qiang Liu, Pingyu Chen, Dunming Xiao, Jingxuan Wei, Yintao Lin, Tiantian Tao, Xin Li

引用次数: 0

Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella. 来自灰飞虱的抗隐球菌多肽：在三维细胞培养物和灰飞虱中的毒性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-18 DOI: 10.1080/17460913.2024.2421632

Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida

{"title":"Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella.","authors":"Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida","doi":"10.1080/17460913.2024.2421632","DOIUrl":"https://doi.org/10.1080/17460913.2024.2421632","url":null,"abstract":"Aim: This work aimed to test peptides against the planktonic and biofilm form of Cryptococcus spp. and in vitro toxicity using three-dimensional (3D) cells characterized and evaluate in vivo toxicity in Galleria mellonella.Materials & methods: Susceptibility tests were conducted on the planktonic form and biofilm formation. The toxicity of the peptides was evaluated in lung and brain cells in monolayer (2D) and 3D mono- and co-culture, in addition to in vivo analysis with G. mellonella.Results: Susceptibility values ranged from 31.25 to over 250 µg/ml with a fungicidal profile. Regarding toxicity, the PepM2 peptide was not toxic in 3D culture (500 µg/ml). G. mellonella, showed a survival rate of more than 85% In assays with brain and lung cell lines, concentrations ranged from 4 × 104 to 4 × 103 cells/well for brain cells and 1 × 103 cells/well for lung cells. Cocultures used 1 × 105 brain and 1 × 103 lung cells.Conclusion: This study shows that the peptides have great potential against cryptococcosis, and all spheroids were characterized as having a spheroidal and compact structure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study. 肠道双歧杆菌与移植失败之间的因果关系：孟德尔随机研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-18 DOI: 10.1080/17460913.2024.2417608

Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li

{"title":"Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study.","authors":"Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li","doi":"10.1080/17460913.2024.2417608","DOIUrl":"https://doi.org/10.1080/17460913.2024.2417608","url":null,"abstract":"Aim: Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure.Materials & methods: A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.Results: The abundance of Bifidobacteriaceae demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] p = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW p > 0.200). Notably, a higher intestinal abundance of Bifidobacteriaceae corresponded to a decreased risk of transplant failure. Bifidobacteriaceae instrumental variables were enriched in pathways related to synapses and membranes.Conclusion: The Bifidobacteriaceae may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of granulomatous mastitis by Brucella species. 一例罕见的布鲁氏菌引起的肉芽肿性乳腺炎。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-16 DOI: 10.1080/17460913.2024.2429263

Necati Mumcu, Yusuf Emre Ozdemir

引用次数: 0

Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series. 脊髓神经囊虫病患者的治疗效果：已发表病例和系列病例的系统回顾。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-15 DOI: 10.1080/17460913.2024.2428526

Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal

{"title":"Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series.","authors":"Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal","doi":"10.1080/17460913.2024.2428526","DOIUrl":"https://doi.org/10.1080/17460913.2024.2428526","url":null,"abstract":"Aims: Spinal neurocysticercosis is a rare central nervous system infection caused by the larval form of the Taenia solium. Due to its rarity, most knowledge is derived from isolated case reports. This review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease's clinical presentation and treatment outcomes.Methods: Following PRISMA guidelines, a comprehensive search was performed across various databases. The review included case reports, case series, and observational studies, and it is registered with PROSPERO (CRD42024496957).Results: This review analyzed 206 spinal neurocysticercosis cases (from 171 published reports). Symptoms persisted for one week to six months in 49% of cases, and common presentations included paraparesis/quadriparesis (61.7%) and neck/limb/back pain (40.8%). CSF abnormalities were observed in 23.8%. Thoracic involvement was most frequent (39.3%), followed by cervical (27.2%). Neurocysticercosis lesions in other regions, primarily the brain, were found in 18.9%. Differential diagnoses included spinal cord tumors (13.1%). Treatment often involved surgery alone (32%) or with cysticidal drugs (45.6%), with a 91.3% improvement rate, indicating favorable outcomes.Conclusions: Spinal neurocysticercosis primarily affects the thoracic and cervical regions. Most patients respond well to medical therapy; surgery is mainly for progressive neurological deficits.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biliary tract infections caused by Enterococcus gallinarum and Escherichia coli: a rare case report. 由胆囊肠球菌和大肠埃希菌引起的胆道感染：罕见病例报告。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-12 DOI: 10.1080/17460913.2024.2417597

Cuilin He, Long Chen, Liangsong Zhao, Haixia Lin, Maozhu Liu, Enqiang Chen

引用次数: 0

Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid. 精氨酸与氟化物和甘油磷酸钙的结合：浓度和对生物膜液体的影响。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-07 DOI: 10.1080/17460913.2024.2411921

Marina Lins Miranda, Karina Borges Salomão, Alberto Carlos Botazzo Delbem, Marcelle Danelon, Elis Rodrigues Oliveira Barbosa, Caio Sampaio, Lucas Arrais Campos, Fernanda Lourenção Brighenti

{"title":"Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid.","authors":"Marina Lins Miranda, Karina Borges Salomão, Alberto Carlos Botazzo Delbem, Marcelle Danelon, Elis Rodrigues Oliveira Barbosa, Caio Sampaio, Lucas Arrais Campos, Fernanda Lourenção Brighenti","doi":"10.1080/17460913.2024.2411921","DOIUrl":"https://doi.org/10.1080/17460913.2024.2411921","url":null,"abstract":"Aim: To study the influence of varying concentrations of arginine (Arg) combined with fluoride (F) and/or calcium glycerophosphate (CaGP) on biofilms.Materials & methods: Biofilms were analyzed for acidogenicity, microbial viability and Ca, F and inorganic phosphorus (P) concentrations.Results: For total bacteria, the lowest viability was found in F-containing groups, regardless of the arginine concentrations and presence of CaGP. For aciduric bacteria, no significant differences were found among arginine concentrations in the presence of F. For MS, arginine concentrations did not influence MS viability in the presence of fluoride and CaGP only decreased viability at 3.2% Arg concentration. The arginine-treated groups showed the lowest acidogenicity. For ion concentrations in biofilms, CaGP showed the highest values for P; Arg+F for F; and CaGP/Arg+CaGP for Ca.Conclusion: Different concentrations of arginine did not affect the microbial viability or acidogenicity of biofilms. Moreover, 0.8% Arg did not increase ion concentration in biofilm fluid.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural polymicrobial Staphylococcus aureus-Pseudomonas aeruginosa interactions and antimicrobial resistance in ex vivo cornea model. 体外角膜模型中金葡萄球菌-铜绿假单胞菌相互作用的超微结构和抗菌药耐药性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-11-06 DOI: 10.1080/17460913.2024.2417617

Sanchita Mitra, Nagapriya Banka, Soumyava Basu, Tirupathi Rao

{"title":"Ultrastructural polymicrobial Staphylococcus aureus-Pseudomonas aeruginosa interactions and antimicrobial resistance in ex vivo cornea model.","authors":"Sanchita Mitra, Nagapriya Banka, Soumyava Basu, Tirupathi Rao","doi":"10.1080/17460913.2024.2417617","DOIUrl":"https://doi.org/10.1080/17460913.2024.2417617","url":null,"abstract":"Aim: To investigate antagonistic interactions among pathogens, in ex vivo donor corneas infected with monomicrobial or polymicrobial combinations of antibiotic susceptible and resistant clinical isolates of Staphylococcus aureus (MSSA, MRSA) and Pseudomonas aeruginosa (S-PA, MDR-PA).Materials & methods: Scanning electron microscopy and antimicrobial susceptibility testing (AST, broth microdilution for minimum inhibitory and bactericidal concentrations [MIC/MBC]) pre-and post-polymicrobial interactions, in infected donor corneas.Results: MSSA lost viability with S-PA/MDR-PA, while MRSA formed larger cells, biofilm and lower MIC (teicoplanin) with S-PA, but lost viability with MDR-PA. S-PA had lower MIC (ceftazidime, meropenem, chloramphenicol) with MSSA, and lower MBC (cefoperazone, ciprofloxacin) and fewer cells with MRSA. MDR-PA had abundant cells and no change in AST with MSSA or MRSA.Conclusion: Significant antagonistic interactions occur in ocular polymicrobial infections, affecting antibiotic susceptible isolates more than resistant ones.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1-19"},"PeriodicalIF":2.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0