Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-10-03 DOI:10.1080/17460913.2024.2366604

Andressa Lorena Ieque, Carolina Trevisolli Palomo, Deborah de Castro Moreira, Jean Eduardo Meneguello, Letícia Sayuri Murase, Lincoln Luís Silva, Vanessa Pietrowski Baldin, Katiany Rizzieri Caleffi-Ferracioli, Vera Lucia Dias Siqueira, Rosilene Fressatti Cardoso, Jorge Juarez Vieira Teixeira, Regiane Bertin De Lima Scodro

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引用次数: 0

Abstract

Aim: Tuberculous meningitis (TBM) is one of the most severe clinical forms of tuberculosis (TB). Since epidemiological studies can contribute to TB control, we conducted a review and meta-analysis of epidemiological publications of adults TBM cases in countries with high incidence of TB.Materials & methods: The search resulted in 11,855 articles, in which 21 ultimately were included in our review and 15 in our meta-analysis.Results: TBM mortality was 25% with death rates of 70% in Africa. The review showed different and non-concordant diagnostic techniques and treatment schemes.Conclusion: Adults living in the African region are at high risk of death from TBM, highlighting an urgent need of guidelines to support diagnosis and treatment, and ultimately, to reduce mortality.

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高危人群结核性脑膜炎的系统回顾：死亡率和诊断差异。

目的：结核性脑膜炎（TBM）是结核病（TB）最严重的临床形式之一。由于流行病学研究有助于结核病的控制，我们对结核病高发国家成人结核性脑膜炎病例的流行病学出版物进行了综述和荟萃分析：搜索结果为 11,855 篇文章，其中 21 篇最终被纳入我们的综述，15 篇被纳入我们的荟萃分析：结果：肺结核死亡率为 25%，非洲的死亡率为 70%。综述显示，诊断技术和治疗方案各不相同且不一致：结论：生活在非洲地区的成年人死于 TBM 的风险很高，迫切需要制定相关指南来支持诊断和治疗，最终降低死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.