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SUBA-itraconazole in the treatment of systemic fungal infections. 治疗全身性真菌感染的 SUBA-伊曲康唑。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2362128
Jennifer Liu, Kees A Vanderwyk, Monica A Donnelley, George R Thompson Iii
{"title":"SUBA-itraconazole in the treatment of systemic fungal infections.","authors":"Jennifer Liu, Kees A Vanderwyk, Monica A Donnelley, George R Thompson Iii","doi":"10.1080/17460913.2024.2362128","DOIUrl":"10.1080/17460913.2024.2362128","url":null,"abstract":"<p><p>Conventional itraconazole (c-ITZ) can be used for a variety of fungal infections although variable absorption has been a significant limitation. Super-bioavailable itraconazole (SUBA-ITZ) is a novel formulation that overcomes absorption concerns by utilizing a polymer-matrix to disperse active drug and facilitate dissolution. The pH-driven matrix allows concurrent proton pump inhibitor administration without significant effects on drug concentrations. The enhanced bioavailability of SUBA-ITZ allows for lower dosing, while achieving similar serum concentrations as c-ITZ and SUBA-ITZ is now US FDA approved in the treatment of blastomycosis, histoplasmosis and aspergillosis. Common side effects of SUBA-ITZ include gastrointestinal disorders, peripheral edema and drug-induced hypertension. Given the significant differences in pharmacokinetics between the formulations, c-ITZ and SUBA-ITZ capsules are not considered interchangeable. It is important to note that drug errors may occur when transitioning a patient from one formulation to another.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1171-1175"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clostridioides difficile infection epidemiology during the COVID-19 pandemic in Greece. 希腊 COVID-19 大流行期间的艰难梭菌感染流行病学。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2358653
Theodoros Karampatakis, Eleni Kandilioti, Helen Katsifa, Anna Nikopoulou, Celine Harmanus, Katerina Tsergouli, Ed Kuijper, Melina Kachrimanidou
{"title":"<i>Clostridioides difficile</i> infection epidemiology during the COVID-19 pandemic in Greece.","authors":"Theodoros Karampatakis, Eleni Kandilioti, Helen Katsifa, Anna Nikopoulou, Celine Harmanus, Katerina Tsergouli, Ed Kuijper, Melina Kachrimanidou","doi":"10.1080/17460913.2024.2358653","DOIUrl":"10.1080/17460913.2024.2358653","url":null,"abstract":"<p><p><b>Aim:</b> The aim was to highlight the incidence and epidemiology of <i>C. difficile</i> infections (CDI) in a tertiary Greek hospital during the COVID-19 pandemic.<b>Methods:</b> A single-center prospective observational cohort study was conducted (October 2021 until April 2022). 125 <i>C. difficile</i> isolates were cultured from hospitalized patients stool samples and screened by PCR for toxin A (<i>tcdA</i>), toxin B (<i>tcdB</i>), binary toxin (<i>cdtA</i> and <i>cdtB</i>) genes and the regulating gene of <i>tcdC</i>.<b>Results:</b> The incidence of CDI increased to 13.1 infections per 10,000 bed days. The most common PCR ribotypes identified included hypervirulent RT027-related RT181 (73.6%), presumably hypervirulent RT126 (8.0%) and toxin A negative RT017 (7.2%).<b>Conclusion:</b> Although the incidence of CDI increased significantly, the CDI epidemiology remained stable.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1119-1127"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori infection delays neutrophil apoptosis and exacerbates inflammatory response. 幽门螺杆菌感染会延缓中性粒细胞凋亡并加剧炎症反应。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1080/17460913.2024.2360798
Yu Song, Peng Liu, Xi Qi, Xiao-Lin Shi, Yu-Shan Wang, Dong Guo, Hong Luo, Zong-Jun Du, Ming-Yi Wang
{"title":"<i>Helicobacter pylori</i> infection delays neutrophil apoptosis and exacerbates inflammatory response.","authors":"Yu Song, Peng Liu, Xi Qi, Xiao-Lin Shi, Yu-Shan Wang, Dong Guo, Hong Luo, Zong-Jun Du, Ming-Yi Wang","doi":"10.1080/17460913.2024.2360798","DOIUrl":"10.1080/17460913.2024.2360798","url":null,"abstract":"<p><p><b>Aim:</b> Understanding molecular mechanisms of <i>Helicobacter pylori</i> (<i>H. pylori</i>)-induced inflammation is important for developing new therapeutic strategies for gastrointestinal diseases.<b>Materials & methods:</b> We designed an <i>H. pylori</i>-neutrophil infection model and explored the effects of <i>H. pylori</i> infection on neutrophils.<b>Results:</b> <i>H. pylori</i> infected neutrophils showed a low level of apoptosis. <i>H. pylori</i> stimulation activated the NACHT/LRR/PYD domain-containing protein 3 (NLRP3)-gasdermin-D (GSDMD) pathway for interleukin (IL)-1β secretion. However, IL-1β secretion was not completely dependent on GSDMD, as inhibition of autophagy significantly reduced IL-1β release, and autophagy-related molecules were significantly upregulated in <i>H. pylori</i>-infected neutrophils.<b>Conclusion:</b> Therefore, <i>H. pylori</i> infection inhibits neutrophils apoptosis and induces IL-1β secretion through autophagy. These findings may be utilized to formulate therapeutic strategies against <i>H. pylori</i> mediated chronic gastritis.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1145-1156"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential role of Akkermansia muciniphila in liver health. Akkermansia muciniphila 对肝脏健康的潜在作用。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-08-07 DOI: 10.2217/fmb-2023-0220
Min Zhang, Yang Wang, Yong Gan
{"title":"The potential role of <i>Akkermansia muciniphila</i> in liver health.","authors":"Min Zhang, Yang Wang, Yong Gan","doi":"10.2217/fmb-2023-0220","DOIUrl":"10.2217/fmb-2023-0220","url":null,"abstract":"<p><p><i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) is a 'star strain' that has attracted much attention in recent years. <i>A. muciniphila</i> can effectively regulate host metabolism, significantly affect host immune function, and play an important role in balancing host health and disease. As one of the organs most closely related to the gut (the two can communicate through the hepatic portal vein and bile duct system), liver is widely affected by intestinal microorganisms. A growing body of evidence suggests that <i>A. muciniphila</i> may alleviate liver-related diseases by improving the intestinal barrier, energy metabolism and regulating inflammation through its protein components and metabolites. This paper systematically reviews the key roles of <i>A. muciniphila</i> and its derivatives in maintaining liver health and improving liver disease.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1081-1096"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recovery of Vandammella animalimorsus from an immunocompetent female patient following cat bite to the lower leg. 小腿被猫咬伤后，从一名免疫功能正常的女性患者身上发现了动物疫霉菌。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-07-17 DOI: 10.1080/17460913.2024.2357966
Joseph M Blondeau, Keith MacKenzie, Ryan McDonald
{"title":"Recovery of <i>Vandammella animalimorsus</i> from an immunocompetent female patient following cat bite to the lower leg.","authors":"Joseph M Blondeau, Keith MacKenzie, Ryan McDonald","doi":"10.1080/17460913.2024.2357966","DOIUrl":"10.1080/17460913.2024.2357966","url":null,"abstract":"<p><p>We report a case of <i>Vandammella animalimorsus</i> in an adult female patient following a cat scratch/bite. Animal bite/scratches may lead to zoonotic transmission of bacteria that subsequently lead to infection. Wound management and antimicrobial therapy is often necessary. The organism was initially misidentified as <i>Neisseria animaloris/zoodegmatis</i> and highlights the difficulty of correctly identifying some bacteria in clinical microbiology laboratories.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1049-1054"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter in reply: before biomolecules are claimed as biomarkers of COVID-19, their criteria must be met. 回信：在宣称生物分子为 COVID-19 的生物标志物之前，必须满足其标准。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2353486
Murat Karamese
{"title":"Letter in reply: before biomolecules are claimed as biomarkers of COVID-19, their criteria must be met.","authors":"Murat Karamese","doi":"10.1080/17460913.2024.2353486","DOIUrl":"10.1080/17460913.2024.2353486","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1047-1048"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: before molecules are claimed as biomarkers of COVID-19, their criteria must be met. 致编辑的信：在将分子宣称为 COVID-19 的生物标志物之前，必须满足其标准。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-07-04 DOI: 10.1080/17460913.2024.2353481
Josef Finsterer
{"title":"Letter to the editor: before molecules are claimed as biomarkers of COVID-19, their criteria must be met.","authors":"Josef Finsterer","doi":"10.1080/17460913.2024.2353481","DOIUrl":"10.1080/17460913.2024.2353481","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1045-1046"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current situation of sporotrichosis in China. 中国孢子丝虫病的现状。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-07-26 DOI: 10.1080/17460913.2024.2352283
Shuqiong Cheng, Siqi Zheng, Meizhen Zhong, Keshav Raj Gyawali, Wen Pan, Meinian Xu, Huaiqiu Huang, Xiaowen Huang
{"title":"Current situation of sporotrichosis in China.","authors":"Shuqiong Cheng, Siqi Zheng, Meizhen Zhong, Keshav Raj Gyawali, Wen Pan, Meinian Xu, Huaiqiu Huang, Xiaowen Huang","doi":"10.1080/17460913.2024.2352283","DOIUrl":"10.1080/17460913.2024.2352283","url":null,"abstract":"<p><p>Sporotrichosis, a mycosis resulting from cutaneous or subcutaneous infection with the dimorphic fungus <i>Sporothrix</i>, has been reported in China, particularly in the northeast region. In this review, we conducted a thorough examination of the recent advancements in sporotrichosis in China, encompassing aspects such as etiology, epidemiology, pathogenesis, clinical manifestations, diagnosis and treatment strategies. Within the Chinese context, fixed cutaneous sporotrichosis represents the prevailing clinical manifestation. Fungal culture stands as the gold standard for diagnosing sporotrichosis, while polymerase chain reaction techniques can enhance both the specificity and sensitivity of diagnosis. Besides conventional systemic antifungal agents, alternative modalities such as Chinese herbal medicines, photodynamic therapy and laser therapy show potential efficacy against sporotrichosis.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1097-1106"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of pulmonary microecology and clinical characteristics of patients carrying human herpesvirus. 分析携带人类疱疹病毒患者的肺部微生态学和临床特征。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-06-20 DOI: 10.1080/17460913.2024.2357994
Jing Luo, Rui Xie, Chongxi Bao, Jinyan Lin, Yang Xu, Xuexin Yan, Zhen Yang, Li Feng, Jianing Wu, Dan Chen, Zaiqing He, Jinliang Kong
{"title":"Analysis of pulmonary microecology and clinical characteristics of patients carrying human herpesvirus.","authors":"Jing Luo, Rui Xie, Chongxi Bao, Jinyan Lin, Yang Xu, Xuexin Yan, Zhen Yang, Li Feng, Jianing Wu, Dan Chen, Zaiqing He, Jinliang Kong","doi":"10.1080/17460913.2024.2357994","DOIUrl":"10.1080/17460913.2024.2357994","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the impact of human herpes virus (<i>HHV</i>) carriage on lung microbiota, and its correlation with clinical features and laboratory indicators in patients.<b>Methods:</b> Retrospective analysis was conducted on 30 outpatient lung infection cases, which were divided into <i>HHV</i> (n = 15) and non-<i>HHV</i> (n = 15) groups. mNGS detected microbial composition. Microbial diversity and abundance were tested using Shannon and Chao1 indices. Their relationship with laboratory indicators were explored.<b>Results:</b> Significant differences in microbial abundance and distribution were found between two groups (p < 0.05). Moreover, HHV group showed negative correlations (p < 0.05) between <i>Prevotella</i>, <i>Porphyromonas</i>, <i>Streptococcus</i> and basophil/eosinophil percentages.<b>Conclusion:</b> <i>HHV</i> carriage impacts lung microbiota, emphasizing the need for clinicians to pay attention to <i>HHV</i> reactivation in outpatient lung infection patients.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1071-1080"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mice fatal pneumonia model induced by less-virulent Streptococcus pneumoniae via intratracheal aerosolization. 通过气管内雾化吸入低毒性肺炎链球菌诱发小鼠致命肺炎模型。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2355738
Jiazhen Wang, Lingfei Hu, Zhijun Zhang, Chengyu Sui, Xiaoyu Zhu, Chengxi Wu, Lili Zhang, Meng Lv, Wenhui Yang, Dongsheng Zhou, Zhengling Shang
{"title":"Mice fatal pneumonia model induced by less-virulent <i>Streptococcus pneumoniae</i> via intratracheal aerosolization.","authors":"Jiazhen Wang, Lingfei Hu, Zhijun Zhang, Chengyu Sui, Xiaoyu Zhu, Chengxi Wu, Lili Zhang, Meng Lv, Wenhui Yang, Dongsheng Zhou, Zhengling Shang","doi":"10.1080/17460913.2024.2355738","DOIUrl":"10.1080/17460913.2024.2355738","url":null,"abstract":"<p><p><b>Aim:</b> Animal models of fatal pneumonia caused by <i>Streptococcus pneumoniae</i> (<i>Spn</i>) have not been reliably generated using many strains of less virulent serotypes.<b>Materials & methods:</b> Pulmonary infection of a less virulent <i>Spn</i> serotype1 strain in the immunocompetent mice was established via the intratracheal aerosolization (ITA) route. The survival, local and systemic bacterial spread, pathological changes and inflammatory responses of this model were compared with those of mice challenged via the intratracheal instillation, intranasal instillation and intraperitoneal injection routes.<b>Results:</b> ITA and intratracheal instillation both induced fatal pneumonia; however, ITA resulted in better lung bacterial deposition and distribution, pathological homogeneity and delivery efficiency.<b>Conclusion:</b> ITA is an optimal route for developing animal models of severe pulmonary infections.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1055-1070"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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