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Future microbiology最新文献

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Nanomedicine for the eradication of Helicobacter pylori: recent advances, challenges and future perspective. 根除幽门螺旋杆菌的纳米药物：最新进展、挑战和未来展望。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI: 10.2217/fmb-2023-0189
Aakriti Garg, Sonali Karhana, Mohd A Khan
{"title":"Nanomedicine for the eradication of <i>Helicobacter pylori</i>: recent advances, challenges and future perspective.","authors":"Aakriti Garg, Sonali Karhana, Mohd A Khan","doi":"10.2217/fmb-2023-0189","DOIUrl":"10.2217/fmb-2023-0189","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics. Challenges include biocompatibility, stability, scalability and personalized therapies. Despite obstacles, nanomedicine's potential for reshaping <i>H. pylori</i> eradication is significant and showcased in this review focusing on benefits, limitations and future prospects of nanomedicine-based strategies.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"431-447"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a machine learning model to predict risk of development of COVID-19-associated mucormycosis. 开发机器学习模型，预测 COVID-19 相关粘孢子虫病的发病风险。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.2217/fmb-2023-0190
Rajashri Patil, Sahjid Mukhida, Jyoti Ajagunde, Uzair Khan, Sameena Khan, Nageswari Gandham, Chanda Vyawhare, Nikunja K Das, Shahzad Mirza
{"title":"Development of a machine learning model to predict risk of development of COVID-19-associated mucormycosis.","authors":"Rajashri Patil, Sahjid Mukhida, Jyoti Ajagunde, Uzair Khan, Sameena Khan, Nageswari Gandham, Chanda Vyawhare, Nikunja K Das, Shahzad Mirza","doi":"10.2217/fmb-2023-0190","DOIUrl":"10.2217/fmb-2023-0190","url":null,"abstract":"<p><p><b>Aim:</b> The study aimed to identify quantitative parameters that increase the risk of rhino-orbito-cerebral mucormycosis, and subsequently developed a machine learning model that can anticipate susceptibility to developing this condition. <b>Methods:</b> Clinicopathological data from 124 patients were used to quantify their association with COVID-19-associated mucormycosis (CAM) and subsequently develop a machine learning model to predict its likelihood. <b>Results:</b> Diabetes mellitus, noninvasive ventilation and hypertension were found to have statistically significant associations with radiologically confirmed CAM cases. <b>Conclusion:</b> Machine learning models can be used to accurately predict the likelihood of development of CAM, and this methodology can be used in creating prediction algorithms of a wide variety of infections and complications.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"297-305"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats. 铁前列素-1能改善脂肪肝肝移植大鼠的预后并调节其肠道微生物群。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0133
Mengshu Yuan, Yuxin Wang, Xiaorong Tian, Weiping Zheng, Huaiwen Zuo, Xinru Zhang, Hongli Song
{"title":"Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats.","authors":"Mengshu Yuan, Yuxin Wang, Xiaorong Tian, Weiping Zheng, Huaiwen Zuo, Xinru Zhang, Hongli Song","doi":"10.2217/fmb-2023-0133","DOIUrl":"10.2217/fmb-2023-0133","url":null,"abstract":"<p><p><b>Aims:</b> To investigate the effects of Ferrostatin-1 (Fer-1) on improving the prognosis of liver transplant recipients with steatotic liver grafts and regulating gut microbiota in rats. <b>Methods:</b> We obtained steatotic liver grafts and established a liver transplantation model. Recipients were divided into sham, liver transplantation and Fer-1 treatment groups, which were assessed 1 and 7 days after surgery (n = 6). <b>Results & conclusion:</b> Fer-1 promotes recovery of the histological structure and function of steatotic liver grafts and the intestinal tract, and improves inflammatory responses of recipients following liver transplantation. Fer-1 reduces gut microbiota pathogenicity, and lowers iron absorption and improves fat metabolism of recipients, thereby protecting steatotic liver grafts.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"413-429"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trichosporon spp.: what's new? Trichosporon spp.：有什么新发现？
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-18 DOI: 10.2217/fmb-2023-0281
Yasmim Passos Lima, Vanessa Cordeiro Dias
{"title":"<i>Trichosporon</i> spp.: what's new?","authors":"Yasmim Passos Lima, Vanessa Cordeiro Dias","doi":"10.2217/fmb-2023-0281","DOIUrl":"10.2217/fmb-2023-0281","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"373-375"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of linezolid resistance in Streptococcus pneumoniae isolates: a systematic review and meta-analysis. 肺炎链球菌分离株中利奈唑胺耐药性的流行情况：系统综述和荟萃分析。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-18 DOI: 10.2217/fmb-2023-0170
Mohsen Heidary, Shirin Dashtbin, Arezoo Asadi, Parisa Asadollahi, Ali Khatib, Mohammad Amin Ebrahimi, Zahra Ghanbari, Atieh Darbandi, Roya Ghanavati, Reza Pakzad
{"title":"Prevalence of linezolid resistance in <i>Streptococcus pneumoniae</i> isolates: a systematic review and meta-analysis.","authors":"Mohsen Heidary, Shirin Dashtbin, Arezoo Asadi, Parisa Asadollahi, Ali Khatib, Mohammad Amin Ebrahimi, Zahra Ghanbari, Atieh Darbandi, Roya Ghanavati, Reza Pakzad","doi":"10.2217/fmb-2023-0170","DOIUrl":"10.2217/fmb-2023-0170","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to understand the current level of linezolid (LNZ) resistance in <i>Streptococcus pneumoniae</i> isolates reported over the past 10 years. <b>Material & methods:</b> An electronic search was conducted for the following keywords: ((<i>Streptococcus pneumoniae</i> [title/abstract]) OR (<i>Pneumococcus</i> [title/abstract]) OR (Pneumococci [title/abstract]) AND (linezolid [title/abstract]) OR (Zyvox [title/abstract])) OR (Zyvoxid [title/abstract])). <b>Result:</b> Out of all the studies, 80 had a cross-sectional design, while 11 followed a cohort approach. The prevalence of LNZ resistance among <i>S. pneumoniae</i> isolates ranged from 0% to 4.86%. <b>Discussion:</b> Urgent, high-powered, randomized, controlled trials with participants from endemic regions are needed to gain a comprehensive understanding of the impact on and significance of LNZ treatment to patients.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"449-459"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro mucin degradation and paracellular permeability by fecal water from Crohn's disease patients. 克罗恩病患者粪水的体外粘蛋白降解和细胞旁通透性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-12 DOI: 10.2217/fmb-2022-0265
Heike Ef Becker, Nader Kameli, Alice Rustichelli, Britt Am Heijnens, Frank Rm Stassen, John Penders, Daisy Mae Jonkers
{"title":"<i>In vitro</i> mucin degradation and paracellular permeability by fecal water from Crohn's disease patients.","authors":"Heike Ef Becker, Nader Kameli, Alice Rustichelli, Britt Am Heijnens, Frank Rm Stassen, John Penders, Daisy Mae Jonkers","doi":"10.2217/fmb-2022-0265","DOIUrl":"10.2217/fmb-2022-0265","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to examine the impact of fecal water (FW) of active and remissive Crohn's disease (CD) patients on mucin degradation and epithelial barrier function. <b>Methods:</b> FW and bacterial membrane vesicles (MVs) were isolated from fresh fecal samples of six healthy controls (HCs) and 12 CD patients. Bacterial composition was determined by 16S rRNA gene amplicon sequencing. <b>Results:</b> <i>In vitro</i> FW-induced mucin degradation was higher in CD samples versus HC (p < 0.01), but not associated with specific bacterial genera. FW of three remissive samples decreased transepithelial electrical resistance in Caco-2 cells by 78-87% (p < 0.001). MVs did not induce barrier alterations. <b>Conclusion:</b> The higher mucin-degradation capacity of CD-derived FW might suggest contributions of microbial products to CD pathophysiology.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"335-347"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic alterations associated with the formation of monocyte extracellular trap induced by Candida albicans hyphae. 与白色念珠菌菌丝诱导的单核细胞胞外陷阱的形成有关的蛋白质组变化。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.2217/fmb-2023-0029
Xian Wu, Liying Sun, Lei Huang, Chenwei Huang, Kuixia Sun, Haixia Li
{"title":"Proteomic alterations associated with the formation of monocyte extracellular trap induced by <i>Candida albicans</i> hyphae.","authors":"Xian Wu, Liying Sun, Lei Huang, Chenwei Huang, Kuixia Sun, Haixia Li","doi":"10.2217/fmb-2023-0029","DOIUrl":"10.2217/fmb-2023-0029","url":null,"abstract":"<p><p><b>Background:</b> The interaction between the host and <i>Candida albicans</i> is dynamic and intricate. We performed proteomic analysis to explore monocyte<i>-C. albicans</i> hyphae interaction. <b>Materials & methods:</b> Primary human monocytes were stimulated by heat-killed <i>C. albicans</i> hyphae and their proteins were profiled by tandem liquid chromatography with mass spectrometry (LC-MS/MS). <b>Results:</b> Based on the protein database of different species for analysis, we found that stimulation of monocytes by hyphae was accompanied by upregulation of histones and activation of extracellular traps (ETs) formation pathway. Meanwhile, monocyte ETs (MoETs) were evoked by synthesis or alteration of <i>C. albicans</i> cell wall proteins expression during the morphological switch to hyphal. <b>Conclusion:</b> MoETs formation is linked to cell wall proteins of <i>C. albicans</i> hyphae.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"307-316"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Yersinia enterocolitica, Shigella spp. and Salmonella spp. in Rattus norvegicus captured from Tehran, Iran. 在伊朗德黑兰捕获的鼠中检测到小肠结肠耶尔森菌、志贺氏菌属和沙门氏菌属。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0138
Taher Azimi, Sina Nasrollahian, Sahar Sabour, Nahal Hadi, Leila Azimi, Fatemeh Fallah, Mohammed Reza Pourmand
{"title":"Detection of <i>Yersinia enterocolitica</i>, <i>Shigella</i> spp. and <i>Salmonella</i> spp. in <i>Rattus norvegicus</i> captured from Tehran, Iran.","authors":"Taher Azimi, Sina Nasrollahian, Sahar Sabour, Nahal Hadi, Leila Azimi, Fatemeh Fallah, Mohammed Reza Pourmand","doi":"10.2217/fmb-2023-0138","DOIUrl":"10.2217/fmb-2023-0138","url":null,"abstract":"<p><p><b>Background:</b> The present study aims to determine the presence of <i>Yersinia</i> spp., <i>Yersinia pestis</i>, <i>Yersinia enterocolitica</i> pathogen, <i>Listeria monocytogenes</i>, <i>Salmonella</i> spp., <i>Shigella</i> spp., <i>Francisella tularensis</i> and <i>Borrelia</i> spp. in brown rats of Tehran, Iran. <b>Methods:</b> PCR was used to detect various bacteria in 100 brown rats, Also, ELISA was used to detect antibodies against the <i>F. tularensis</i> and <i>Borrelia</i> spp. <b>Results:</b> A total of 16% and 13% of fecal samples were positive for <i>Yersinia</i> spp. and <i>Y. enterocolitica</i> pathogen. ELISA results were negative for <i>F. tularensis</i> and <i>Borrelia</i>. No specific antibodies (IgG) were against these bacteria. <b>Conclusion:</b> According to the results of our analysis, rats are significant transmitters and carriers of a variety of illnesses that can spread to both people and other animals.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"377-384"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Manganese(II), copper(II) and silver(I) complexes containing 1,10-phenanthroline/1,10-phenanthroline-5,6-dione against Candida species. 含 1,10-菲罗啉/1,10-菲罗啉-5,6-二酮的锰(II)、铜(II)和银(I)配合物对念珠菌的作用。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI: 10.2217/fmb-2023-0212
Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos
{"title":"Manganese(II), copper(II) and silver(I) complexes containing 1,10-phenanthroline/1,10-phenanthroline-5,6-dione against <i>Candida</i> species.","authors":"Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos","doi":"10.2217/fmb-2023-0212","DOIUrl":"10.2217/fmb-2023-0212","url":null,"abstract":"<p><p><b>Background:</b> New chemotherapeutics are urgently required to treat <i>Candida</i> infections caused by drug-resistant strains. <b>Methods:</b> The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate complexed with Mn(II), Cu(II) and Ag(I) were evaluated against ten different <i>Candida</i> species. <b>Results:</b> Proliferation of <i>Candida albicans</i>, <i>Candida dubliniensis</i>, <i>Candida famata</i>, <i>Candida glabrata</i>, <i>Candida guilliermondii</i>, <i>Candida kefyr</i>, <i>Candida krusei</i>, <i>Candida lusitaniae</i>, <i>Candida parapsilosis</i> and <i>Candida tropicalis</i> was inhibited by three of six Cu(II) (MICs 1.52-21.55 μM), three of three Ag(I) (MICs 0.11-12.74 μM) and seven of seven Mn(II) (MICs 0.40-38.06 μM) complexes. Among these [Mn<sub>2</sub>(oda)(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>][Mn<sub>2</sub>(oda)(phen)<sub>4</sub>(oda)<sub>2</sub>].4H<sub>2</sub>O, where oda = octanedioic acid, exhibited effective growth inhibition (MICs 0.4-3.25 μM), favorable activity indexes, low toxicity against Vero cells and good/excellent selectivity indexes (46.88-375). <b>Conclusion:</b> [Mn<sub>2</sub>(oda)(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>][Mn<sub>2</sub>(oda)(phen)<sub>4</sub>(oda)<sub>2</sub>].4H<sub>2</sub>O represents a promising chemotherapeutic option for emerging, medically relevant and drug-resistant <i>Candida</i> species.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"385-395"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of PD-1 and immune cells in HSV infection and latency. PD-1 和免疫细胞在 HSV 感染和潜伏期中的作用。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.2217/fmb-2023-0151
Liqiong Ding
{"title":"Role of PD-1 and immune cells in HSV infection and latency.","authors":"Liqiong Ding","doi":"10.2217/fmb-2023-0151","DOIUrl":"10.2217/fmb-2023-0151","url":null,"abstract":"<p><p>A large proportion of the world's population is infected with HSV-1. Antiviral CD8<sup>+</sup> T cells and CD8α<sup>+</sup> dendritic cells are closely related to HSV-1 infection and latency. Latency-associated transcript of HSV-1 and PD-1 are involved in the regulation of latency and reactivation of HSV-1. Here, the role of latency-associated transcript, PD-1, CD8<sup>+</sup> T cells and CD8α<sup>+</sup> dendritic cells in HSV-1 infection, the inter-relationships between them and how these interactions lead to latency are discussed, possibly providing new ideas for the treatment of HSV-1 infection.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"349-354"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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