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Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of Escherichia coli to antimicrobial peptide Brevinin-2CE. 外排泵抑制剂氯丙嗪能有效提高大肠杆菌对抗菌肽 Brevinin-2CE 的敏感性。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-04-29 DOI: 10.2217/fmb-2023-0272
Cao Bing, An Mengjuan, Ma Xinyu, Zhu Chixin, Tan Xinyao, Sun Yan, Li Zhi
{"title":"Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of <i>Escherichia coli</i> to antimicrobial peptide Brevinin-2CE.","authors":"Cao Bing, An Mengjuan, Ma Xinyu, Zhu Chixin, Tan Xinyao, Sun Yan, Li Zhi","doi":"10.2217/fmb-2023-0272","DOIUrl":"10.2217/fmb-2023-0272","url":null,"abstract":"<p><p><b>Aim:</b> The response of <i>E. coli</i> ATCC8739 to Brevinin-2CE (B2CE) was evaluated as a strategy to prevent the development of antimicrobial peptide (AMP)-resistant bacteria. <b>Methods:</b> Gene expression levels were detected by transcriptome sequencing and RT-PCR. Target genes were knocked out using CRISPR-Cas9. MIC was measured to evaluate strain resistance. <b>Results:</b> Expression of <i>acrZ</i> and <i>sugE</i> were increased with B2CE stimulation. ATCC8739Δ<i>acrZ</i> and ATCC8739Δ<i>sugE</i> showed twofold and fourfold increased sensitivity, respectively. The survival rate of ATCC8739 was reduced in the presence of B2CE/chlorpromazine (CPZ). Combinations of other AMPs with CPZ also showed antibacterial effects. <b>Conclusion:</b> The results indicate that combinations of AMPs/efflux pump inhibitors (EPIs) may be a potential approach to combat resistant bacteria.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"771-782"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics. 基于噬菌体的生物测定：微生物诊断的预期范式转变。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-06-12 Epub Date: 2024-06-20 DOI: 10.2217/fmb-2023-0246
Braira Wahid, Muhammad Salman Tiwana
{"title":"Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics.","authors":"Braira Wahid, Muhammad Salman Tiwana","doi":"10.2217/fmb-2023-0246","DOIUrl":"10.2217/fmb-2023-0246","url":null,"abstract":"<p><p>Bacteriophages, as abundant and specific agents, hold significant promise as a solution to combat the growing threat of antimicrobial resistance. Their unique ability to selectively lyse bacterial cells without harming humans makes them a compelling alternative to traditional antibiotics and point-of-care diagnostics. The article reviews the current landscape of diagnostic technologies, identify gaps and highlight emerging possibilities demonstrates a comprehensive approach to advancing clinical diagnosis of microbial pathogens and covers an overview of existing phage-based bioassays. Overall, the provided data in this review effectively communicates the potential of bacteriophages in transforming therapeutic and diagnostic paradigms, offering a holistic perspective on the benefits and opportunities they present in combating microbial infections and enhancing public health.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"811-824"},"PeriodicalIF":2.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria. 含有头孢他啶和妥布霉素的 Zein 纳米粒子：对革兰氏阴性菌的抗菌活性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/fmb-2023-0147
Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães
{"title":"Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria.","authors":"Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães","doi":"10.2217/fmb-2023-0147","DOIUrl":"10.2217/fmb-2023-0147","url":null,"abstract":"<p><p><b>Aims:</b> This work describes the encapsulation of ceftazidime and tobramycin in zein nanoparticles (ZNPs) and the characterization of their antibacterial and antibiofilm activities against Gram-negative bacteria. <b>Materials & methods:</b> ZNPs were synthesized by nanoprecipitation. Cytotoxicity was assessed by MTT assay and antibacterial and antibiofilm assays were performed by broth microdilution and violet crystal techniques. <b>Results:</b> ZNPs containing ceftazidime (CAZ-ZNPs) and tobramycin (TOB-ZNPs) showed drug encapsulation and thermal stability. Encapsulation of the drugs reduced their cytotoxicity 9-25-fold. Antibacterial activity, inhibition and eradication of biofilm by CAZ-ZNPs and TOB-ZNPs were observed. There was potentiation when CAZ-ZNPs and TOB-ZNPs were combined. <b>Conclusion:</b> CAZ-ZNPs and TOB-ZNPs present ideal physical characteristics for <i>in vivo</i> studies of antibacterial and antibiofilm activities.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"317-334"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of subgingival bacterial and fungal diversity in patients with peri-implantitis based on 16sRNA and internal transcribed spacer sequencing. 基于16sRNA和内部转录间隔序列分析种植体周围炎患者龈下细菌和真菌多样性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2023-12-04 DOI: 10.2217/fmb-2023-0228
Song Chen, Fuming He, Xi Cheng
{"title":"Analysis of subgingival bacterial and fungal diversity in patients with peri-implantitis based on 16sRNA and internal transcribed spacer sequencing.","authors":"Song Chen, Fuming He, Xi Cheng","doi":"10.2217/fmb-2023-0228","DOIUrl":"10.2217/fmb-2023-0228","url":null,"abstract":"<p><p><b>Aim:</b> To analyze subgingival fungal diversity in peri-implant inflammation patients and their relationship with bacteria. <b>Methods:</b> We collected saliva samples from four groups. 16sRNA and internal transcribed spacer sequencing was performed preceded by quantitative PCR and enzyme-linked immunosorbent assay tests. Analyses were done using R and Cytoscape software. <b>Results:</b> Significant differences were observed in the Abundance-based Coverage Estimator (ACE) index between control and peri-implantitis samples. Basidiomycota was the dominant fungal species, while Firmicutes dominated the bacteria. The most abundant fungal and bacterial species were 's_unclassified g <i>Apiotrichum</i>' and 's_unclassified g <i>Streptococcus</i>', respectively. <i>Dothiorella</i> was strongly associated with immunoglobulin G levels, with positive correlations between specific microorganisms and peri-implantitis in Q-PCR. <b>Conclusion:</b> Our findings have significant clinical implications, suggesting specific fungal and bacterial taxa roles in peri-implant inflammation.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"397-411"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disinformation and trust in vaccines in the era of artificial intelligence: the necessity of implementing statistical recommendations. 人工智能时代的虚假信息与疫苗信任：实施统计建议的必要性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.2217/fmb-2024-0004
Michal Ordak
{"title":"Disinformation and trust in vaccines in the era of artificial intelligence: the necessity of implementing statistical recommendations.","authors":"Michal Ordak","doi":"10.2217/fmb-2024-0004","DOIUrl":"10.2217/fmb-2024-0004","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"293-295"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Staphylococcus aureus effects of natural antimicrobial peptides and the underlying mechanisms. 天然抗菌肽的抗金黄色葡萄球菌作用及其内在机制。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/fmb-2023-0168
Xueqi Chen, Jiuli Yang, Chang Qu, Qian Zhang, Shujuan Sun, Lihong Liu
{"title":"Anti-<i>Staphylococcus aureus</i> effects of natural antimicrobial peptides and the underlying mechanisms.","authors":"Xueqi Chen, Jiuli Yang, Chang Qu, Qian Zhang, Shujuan Sun, Lihong Liu","doi":"10.2217/fmb-2023-0168","DOIUrl":"10.2217/fmb-2023-0168","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> can cause localized infections such as abscesses and pneumonia, as well as systemic infections such as bacteremia and sepsis. Especially, methicillin-resistant <i>S. aureus</i> often presents multidrug resistance, which becomes a major clinical challenge. One of the most common reasons for methicillin-resistant <i>S. aureus</i> antibiotic resistance is the presence of biofilms. Natural antimicrobial peptides derived from different species have shown effectiveness in combating <i>S. aureus</i> biofilms. In this review, we summarize the inhibitory activity of antimicrobial peptides against <i>S. aureus</i> planktonic cells and biofilms. We also summarize the possible inhibitory mechanisms, involving cell adhesion inhibition, membrane fracture, biofilm disruption and DNA disruption. We believe this can provide the basis for further research against <i>S. aureus</i> biofilm-associated infections.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"355-372"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine for the eradication of Helicobacter pylori: recent advances, challenges and future perspective. 根除幽门螺旋杆菌的纳米药物：最新进展、挑战和未来展望。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI: 10.2217/fmb-2023-0189
Aakriti Garg, Sonali Karhana, Mohd A Khan
{"title":"Nanomedicine for the eradication of <i>Helicobacter pylori</i>: recent advances, challenges and future perspective.","authors":"Aakriti Garg, Sonali Karhana, Mohd A Khan","doi":"10.2217/fmb-2023-0189","DOIUrl":"10.2217/fmb-2023-0189","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics. Challenges include biocompatibility, stability, scalability and personalized therapies. Despite obstacles, nanomedicine's potential for reshaping <i>H. pylori</i> eradication is significant and showcased in this review focusing on benefits, limitations and future prospects of nanomedicine-based strategies.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"431-447"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a machine learning model to predict risk of development of COVID-19-associated mucormycosis. 开发机器学习模型，预测 COVID-19 相关粘孢子虫病的发病风险。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.2217/fmb-2023-0190
Rajashri Patil, Sahjid Mukhida, Jyoti Ajagunde, Uzair Khan, Sameena Khan, Nageswari Gandham, Chanda Vyawhare, Nikunja K Das, Shahzad Mirza
{"title":"Development of a machine learning model to predict risk of development of COVID-19-associated mucormycosis.","authors":"Rajashri Patil, Sahjid Mukhida, Jyoti Ajagunde, Uzair Khan, Sameena Khan, Nageswari Gandham, Chanda Vyawhare, Nikunja K Das, Shahzad Mirza","doi":"10.2217/fmb-2023-0190","DOIUrl":"10.2217/fmb-2023-0190","url":null,"abstract":"<p><p><b>Aim:</b> The study aimed to identify quantitative parameters that increase the risk of rhino-orbito-cerebral mucormycosis, and subsequently developed a machine learning model that can anticipate susceptibility to developing this condition. <b>Methods:</b> Clinicopathological data from 124 patients were used to quantify their association with COVID-19-associated mucormycosis (CAM) and subsequently develop a machine learning model to predict its likelihood. <b>Results:</b> Diabetes mellitus, noninvasive ventilation and hypertension were found to have statistically significant associations with radiologically confirmed CAM cases. <b>Conclusion:</b> Machine learning models can be used to accurately predict the likelihood of development of CAM, and this methodology can be used in creating prediction algorithms of a wide variety of infections and complications.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"297-305"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats. 铁前列素-1能改善脂肪肝肝移植大鼠的预后并调节其肠道微生物群。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0133
Mengshu Yuan, Yuxin Wang, Xiaorong Tian, Weiping Zheng, Huaiwen Zuo, Xinru Zhang, Hongli Song
{"title":"Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats.","authors":"Mengshu Yuan, Yuxin Wang, Xiaorong Tian, Weiping Zheng, Huaiwen Zuo, Xinru Zhang, Hongli Song","doi":"10.2217/fmb-2023-0133","DOIUrl":"10.2217/fmb-2023-0133","url":null,"abstract":"<p><p><b>Aims:</b> To investigate the effects of Ferrostatin-1 (Fer-1) on improving the prognosis of liver transplant recipients with steatotic liver grafts and regulating gut microbiota in rats. <b>Methods:</b> We obtained steatotic liver grafts and established a liver transplantation model. Recipients were divided into sham, liver transplantation and Fer-1 treatment groups, which were assessed 1 and 7 days after surgery (n = 6). <b>Results & conclusion:</b> Fer-1 promotes recovery of the histological structure and function of steatotic liver grafts and the intestinal tract, and improves inflammatory responses of recipients following liver transplantation. Fer-1 reduces gut microbiota pathogenicity, and lowers iron absorption and improves fat metabolism of recipients, thereby protecting steatotic liver grafts.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"413-429"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trichosporon spp.: what's new? Trichosporon spp.：有什么新发现？
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-18 DOI: 10.2217/fmb-2023-0281
Yasmim Passos Lima, Vanessa Cordeiro Dias
{"title":"<i>Trichosporon</i> spp.: what's new?","authors":"Yasmim Passos Lima, Vanessa Cordeiro Dias","doi":"10.2217/fmb-2023-0281","DOIUrl":"10.2217/fmb-2023-0281","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"373-375"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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