Future microbiology最新文献_第9页

Targeted enzymes delivered by liposomes could address an unmet need in mycobacterial respiratory infections. 脂质体递送的靶向酶可以解决分枝杆菌呼吸道感染的未满足需求。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-12-08 DOI: 10.1080/17460913.2024.2423558

Jason W Holder, Richard A Slayden

引用次数: 0

Microbiome and bladder cancer: the role of probiotics in treatment. 微生物组与膀胱癌：益生菌在治疗中的作用。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1080/17460913.2024.2414671

Leila Dadgar-Zankbar, Maryam Mokhtaryan, Elnaz Bafandeh, Zahra Javanmard, Parisa Asadollahi, Taleih Darbandi, Roghayeh Afifirad, Shirin Dashtbin, Atieh Darbandi, Roya Ghanavati

{"title":"Microbiome and bladder cancer: the role of probiotics in treatment.","authors":"Leila Dadgar-Zankbar, Maryam Mokhtaryan, Elnaz Bafandeh, Zahra Javanmard, Parisa Asadollahi, Taleih Darbandi, Roghayeh Afifirad, Shirin Dashtbin, Atieh Darbandi, Roya Ghanavati","doi":"10.1080/17460913.2024.2414671","DOIUrl":"10.1080/17460913.2024.2414671","url":null,"abstract":"Bladder cancer (BCa) remains a significant global health challenge, with increasing interest in the role of the bladder microbiome in its pathogenesis, progression and treatment outcomes. The complex relationship between bladder cancer and the microbiome, as well as the potential impact of probiotics on treatment effectiveness, is currently under investigation. Research suggests that the microbiota may influence BCa recurrence prevention and enhance the efficacy of the Bacillus Calmette-Guérin (BCG) vaccine. Recent studies reveal differences in the bladder microbiome between individuals without bladder cancer and those with the disease. In the healthy bladder, Streptococcus and Lactobacillus are consistently identified as the most prevalent genera. However, in men, the predominant bacterial genera are Staphylococcus, Corynebacterium and Streptococcus, while in women with bladder cancer, Gardnerella and Lactobacillus are dominant. Probiotics, particularly Lactobacillus spp., can exhibit anti-tumor properties by competing with pathogenic strains involved in carcinogenesis or by producing regulatory substances. They regulate cancer signaling, induce apoptosis, inhibit mutagenic activity, downregulate oncogene expression, induce autophagy, inhibit kinases, reactivate tumor suppressors and prevent metastasis. These mechanisms have shown promising results in both preclinical and some clinical studies.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"73-90"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series. 脊髓神经囊虫病患者的治疗效果：已发表病例和系列病例的系统回顾。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.1080/17460913.2024.2428526

Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal

{"title":"Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series.","authors":"Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal","doi":"10.1080/17460913.2024.2428526","DOIUrl":"10.1080/17460913.2024.2428526","url":null,"abstract":"Aims: Spinal neurocysticercosis is a rare central nervous system infection caused by the larval form of the Taenia solium. Due to its rarity, most knowledge is derived from isolated case reports. This review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease's clinical presentation and treatment outcomes.Methods: Following PRISMA guidelines, a comprehensive search was performed across various databases. The review included case reports, case series, and observational studies, and it is registered with PROSPERO (CRD42024496957).Results: This review analyzed 206 spinal neurocysticercosis cases (from 171 published reports). Symptoms persisted for one week to six months in 49% of cases, and common presentations included paraparesis/quadriparesis (61.7%) and neck/limb/back pain (40.8%). CSF abnormalities were observed in 23.8%. Thoracic involvement was most frequent (39.3%), followed by cervical (27.2%). Neurocysticercosis lesions in other regions, primarily the brain, were found in 18.9%. Differential diagnoses included spinal cord tumors (13.1%). Treatment often involved surgery alone (32%) or with cysticidal drugs (45.6%), with a 91.3% improvement rate, indicating favorable outcomes.Conclusions: Spinal neurocysticercosis primarily affects the thoracic and cervical regions. Most patients respond well to medical therapy; surgery is mainly for progressive neurological deficits.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"45-56"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella. 来自灰飞虱的抗隐球菌多肽：在三维细胞培养物和灰飞虱中的毒性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2421632

Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida

{"title":"Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella.","authors":"Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida","doi":"10.1080/17460913.2024.2421632","DOIUrl":"10.1080/17460913.2024.2421632","url":null,"abstract":"Aim: This work aimed to test peptides against the planktonic and biofilm form of Cryptococcus spp. and in vitro toxicity using three-dimensional (3D) cells characterized and evaluate in vivo toxicity in Galleria mellonella.Materials & methods: Susceptibility tests were conducted on the planktonic form and biofilm formation. The toxicity of the peptides was evaluated in lung and brain cells in monolayer (2D) and 3D mono- and co-culture, in addition to in vivo analysis with G. mellonella.Results: Susceptibility values ranged from 31.25 to over 250 µg/ml with a fungicidal profile. Regarding toxicity, the PepM2 peptide was not toxic in 3D culture (500 µg/ml). G. mellonella, showed a survival rate of more than 85% In assays with brain and lung cell lines, concentrations ranged from 4 × 104 to 4 × 103 cells/well for brain cells and 1 × 103 cells/well for lung cells. Cocultures used 1 × 105 brain and 1 × 103 lung cells.Conclusion: This study shows that the peptides have great potential against cryptococcosis, and all spheroids were characterized as having a spheroidal and compact structure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"11-21"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study. 肠道双歧杆菌与移植失败之间的因果关系：孟德尔随机研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2417608

Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li

{"title":"Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study.","authors":"Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li","doi":"10.1080/17460913.2024.2417608","DOIUrl":"10.1080/17460913.2024.2417608","url":null,"abstract":"Aim: Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure.Materials & methods: A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.Results: The abundance of Bifidobacteriaceae demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] p = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW p > 0.200). Notably, a higher intestinal abundance of Bifidobacteriaceae corresponded to a decreased risk of transplant failure. Bifidobacteriaceae instrumental variables were enriched in pathways related to synapses and membranes.Conclusion: The Bifidobacteriaceae may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"23-31"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area. 元基因组下一代测序在布鲁氏菌病诊断中的应用：来自非流行区的五个病例。

IF 2.4 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1080/17460913.2024.2363632

Xuan Zhang, Xinfei Yao, Huixin Chen, Dongsheng Han, Meifang Yang

引用次数: 0

Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp. 芒果苷可增强抗真菌药物对氟康唑耐药念珠菌属的活性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2366627

Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva

{"title":"Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp.","authors":"Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva","doi":"10.1080/17460913.2024.2366627","DOIUrl":"10.1080/17460913.2024.2366627","url":null,"abstract":"Aim: To evaluate the antifungal activity of mangiferin against Candida spp. resistant to fluconazole.Materials & methods: The antifungal activity of mangiferin was assessed using broth microdilution and its interaction with azoles and amphotericin B was evaluated by checkerboard. The activity of mangiferin against Candida spp. biofilms was assessed using the MTT colorimetric assay and its possible mechanism of action was evaluated using flow cytometry.Results: Mangiferin showed activity against Candida albicans, Candida tropicalis and Candida parapsilosis resistant to fluconazole and showed synergism with azoles and amphotericin B. Mangiferin increased the activity of antifungals against Candida biofilms and caused depolarization of the mitochondrial membrane and externalization of phosphatidylserine, suggesting apoptosis.Conclusion: mangiferin combined with antifungals has potential against Candida spp.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1157-1170"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: accuracy required in data entry when using machine learning techniques to predict risk of disease. 致编辑的信：使用机器学习技术预测疾病风险时对数据录入准确性的要求。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2353525

Akash Korat, Dhaval Dobariya, Imtiyaz Bavaliya, Vikram Mali

引用次数: 0

Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan. 对从萨斯喀彻温省血液透析患者身上分离出的隧道式血液透析导管进行微生物分析。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-16 DOI: 10.1080/17460913.2024.2359879

Murugesan Sivaranjani, Haley Sanderson, Chinenye R Nnajide, Anna Martens-Koop, Joseph M Blondeau, Rodrick Stryker, Aaron P White

{"title":"Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan.","authors":"Murugesan Sivaranjani, Haley Sanderson, Chinenye R Nnajide, Anna Martens-Koop, Joseph M Blondeau, Rodrick Stryker, Aaron P White","doi":"10.1080/17460913.2024.2359879","DOIUrl":"10.1080/17460913.2024.2359879","url":null,"abstract":"Aim: To compare the microbial communities inside hemodialysis catheters from symptomatic and asymptomatic patients to determine their differences.Materials & methods: Catheters (n = 41) were removed from patients in the Saskatchewan Health Authority over an 18-month period. The catheter section inside the body was flushed and the contents were evaluated using culture-dependent and culture-independent analysis.Results: All catheters were colonized by bacteria, with considerable overlap between groups based on microbial communities and the individual species detected. More Gram-negative species were detected by sequencing, whereas predominantly Gram-positive strains were cultured. Antibiotic resistance and biofilm formation was widespread and not correlated with either catheter group.Conclusion: Common pathogens were detected in each set of catheters, therefore predicting infections based on the microbiology is difficult.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":"19 13","pages":"1129-1144"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fighting fire with fire: using infectious agents to treat persistent infection. 以毒攻毒：使用传染性制剂治疗顽固性感染。

IF 2.4 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1080/17460913.2024.2363728

Maha Albukhari, Maria Bagies, Tanya Lizbeth, Shyamasundaran Kottilil

引用次数: 0