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Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella. 来自灰飞虱的抗隐球菌多肽：在三维细胞培养物和灰飞虱中的毒性。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2421632
Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida
{"title":"Peptides from <i>Galleria mellonella</i> against <i>Cryptococcus</i> spp: toxicity in three-dimensional cell cultures and <i>G. mellonella</i>.","authors":"Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida","doi":"10.1080/17460913.2024.2421632","DOIUrl":"10.1080/17460913.2024.2421632","url":null,"abstract":"<p><p><b>Aim:</b> This work aimed to test peptides against the planktonic and biofilm form of <i>Cryptococcus</i> spp. and <i>in vitro</i> toxicity using three-dimensional (3D) cells characterized and evaluate <i>in vivo</i> toxicity in <i>Galleria mellonella</i>.<b>Materials & methods:</b> Susceptibility tests were conducted on the planktonic form and biofilm formation. The toxicity of the peptides was evaluated in lung and brain cells in monolayer (2D) and 3D mono- and co-culture, in addition to <i>in vivo</i> analysis with <i>G. mellonella</i>.<b>Results:</b> Susceptibility values ranged from 31.25 to over 250 µg/ml with a fungicidal profile. Regarding toxicity, the PepM2 peptide was not toxic in 3D culture (500 µg/ml). <i>G. mellonella</i>, showed a survival rate of more than 85% In assays with brain and lung cell lines, concentrations ranged from 4 × 10<sup>4</sup> to 4 × 10<sup>3</sup> cells/well for brain cells and 1 × 10<sup>3</sup> cells/well for lung cells. Cocultures used 1 × 10<sup>5</sup> brain and 1 × 10<sup>3</sup> lung cells.<b>Conclusion:</b> This study shows that the peptides have great potential against cryptococcosis, and all spheroids were characterized as having a spheroidal and compact structure.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"11-21"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area. 元基因组下一代测序在布鲁氏菌病诊断中的应用：来自非流行区的五个病例。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1080/17460913.2024.2363632
Xuan Zhang, Xinfei Yao, Huixin Chen, Dongsheng Han, Meifang Yang
{"title":"Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area.","authors":"Xuan Zhang, Xinfei Yao, Huixin Chen, Dongsheng Han, Meifang Yang","doi":"10.1080/17460913.2024.2363632","DOIUrl":"10.1080/17460913.2024.2363632","url":null,"abstract":"<p><p>Metagenomic next-generation sequencing (mNGS) in diagnosis of human brucellosis is comparatively unexplored. This report details five human brucellosis cases diagnosed using mNGS based on Illumina sequencing platform, comprising three females and two males, four with epidemiological exposure. In cases 1 and 2, plasma mNGS results showed one positive and one negative for <i>Brucella melitensis</i>, and subsequent blood cultures were both positive. Cases 3, 4 and 5 involved spinal brucellosis, some with paravertebral abscesses. mNGS from infectious tissue samples successfully detected <i>Brucella</i>, with read counts ranging between 30 and 1314, yet cultures were negative in cases 4 and 5. Following antibiotic and surgical treatments, all patients showed clinical improvement. This report shows mNGS testing enhances the detection sensitivity of brucellosis diagnosis.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1111-1117"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp. 芒果苷可增强抗真菌药物对氟康唑耐药念珠菌属的活性。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2366627
Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva
{"title":"Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant <i>Candida</i> spp.","authors":"Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva","doi":"10.1080/17460913.2024.2366627","DOIUrl":"10.1080/17460913.2024.2366627","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the antifungal activity of mangiferin against <i>Candida</i> spp. resistant to fluconazole.<b>Materials & methods:</b> The antifungal activity of mangiferin was assessed using broth microdilution and its interaction with azoles and amphotericin B was evaluated by checkerboard. The activity of mangiferin against <i>Candida</i> spp. biofilms was assessed using the MTT colorimetric assay and its possible mechanism of action was evaluated using flow cytometry.<b>Results:</b> Mangiferin showed activity against <i>Candida albicans, Candida tropicalis</i> and <i>Candida parapsilosis</i> resistant to fluconazole and showed synergism with azoles and amphotericin B. Mangiferin increased the activity of antifungals against <i>Candida</i> biofilms and caused depolarization of the mitochondrial membrane and externalization of phosphatidylserine, suggesting apoptosis.<b>Conclusion:</b> mangiferin combined with antifungals has potential against <i>Candida</i> spp.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1157-1170"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: accuracy required in data entry when using machine learning techniques to predict risk of disease. 致编辑的信：使用机器学习技术预测疾病风险时对数据录入准确性的要求。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2353525
Akash Korat, Dhaval Dobariya, Imtiyaz Bavaliya, Vikram Mali
{"title":"Letter to the editor: accuracy required in data entry when using machine learning techniques to predict risk of disease.","authors":"Akash Korat, Dhaval Dobariya, Imtiyaz Bavaliya, Vikram Mali","doi":"10.1080/17460913.2024.2353525","DOIUrl":"10.1080/17460913.2024.2353525","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1109-1110"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan. 对从萨斯喀彻温省血液透析患者身上分离出的隧道式血液透析导管进行微生物分析。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-16 DOI: 10.1080/17460913.2024.2359879
Murugesan Sivaranjani, Haley Sanderson, Chinenye R Nnajide, Anna Martens-Koop, Joseph M Blondeau, Rodrick Stryker, Aaron P White
{"title":"Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan.","authors":"Murugesan Sivaranjani, Haley Sanderson, Chinenye R Nnajide, Anna Martens-Koop, Joseph M Blondeau, Rodrick Stryker, Aaron P White","doi":"10.1080/17460913.2024.2359879","DOIUrl":"10.1080/17460913.2024.2359879","url":null,"abstract":"<p><p><b>Aim:</b> To compare the microbial communities inside hemodialysis catheters from symptomatic and asymptomatic patients to determine their differences.<b>Materials & methods:</b> Catheters (<i>n</i> = 41) were removed from patients in the Saskatchewan Health Authority over an 18-month period. The catheter section inside the body was flushed and the contents were evaluated using culture-dependent and culture-independent analysis.<b>Results:</b> All catheters were colonized by bacteria, with considerable overlap between groups based on microbial communities and the individual species detected. More Gram-negative species were detected by sequencing, whereas predominantly Gram-positive strains were cultured. Antibiotic resistance and biofilm formation was widespread and not correlated with either catheter group.<b>Conclusion:</b> Common pathogens were detected in each set of catheters, therefore predicting infections based on the microbiology is difficult.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":"19 13","pages":"1129-1144"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting fire with fire: using infectious agents to treat persistent infection. 以毒攻毒：使用传染性制剂治疗顽固性感染。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1080/17460913.2024.2363728
Maha Albukhari, Maria Bagies, Tanya Lizbeth, Shyamasundaran Kottilil
{"title":"Fighting fire with fire: using infectious agents to treat persistent infection.","authors":"Maha Albukhari, Maria Bagies, Tanya Lizbeth, Shyamasundaran Kottilil","doi":"10.1080/17460913.2024.2363728","DOIUrl":"10.1080/17460913.2024.2363728","url":null,"abstract":"<p><p>Infectious diseases lead to significant morbidity and mortality. Often, resolution of the acute stage of the disease leads to microbial persistence, resulting in chronic debilitating disease. Management of persistent infections frequently requires lifelong therapy with antimicrobial agents. These infections could be chronic viral infections like HIV, hepatitis B or chronic bacterial persistent infections like prosthetic joint infections caused by multi-drug resistant organisms. Bacteriophages have been designed specifically to target recalcitrant bacterial infections, such as prosthetic joint infections with varying success. In this review, we describe the historic evolution of scenarios and risks associated with innovative therapy using infectious agents to treat other persistent infections.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1177-1184"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SUBA-itraconazole in the treatment of systemic fungal infections. 治疗全身性真菌感染的 SUBA-伊曲康唑。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2362128
Jennifer Liu, Kees A Vanderwyk, Monica A Donnelley, George R Thompson Iii
{"title":"SUBA-itraconazole in the treatment of systemic fungal infections.","authors":"Jennifer Liu, Kees A Vanderwyk, Monica A Donnelley, George R Thompson Iii","doi":"10.1080/17460913.2024.2362128","DOIUrl":"10.1080/17460913.2024.2362128","url":null,"abstract":"<p><p>Conventional itraconazole (c-ITZ) can be used for a variety of fungal infections although variable absorption has been a significant limitation. Super-bioavailable itraconazole (SUBA-ITZ) is a novel formulation that overcomes absorption concerns by utilizing a polymer-matrix to disperse active drug and facilitate dissolution. The pH-driven matrix allows concurrent proton pump inhibitor administration without significant effects on drug concentrations. The enhanced bioavailability of SUBA-ITZ allows for lower dosing, while achieving similar serum concentrations as c-ITZ and SUBA-ITZ is now US FDA approved in the treatment of blastomycosis, histoplasmosis and aspergillosis. Common side effects of SUBA-ITZ include gastrointestinal disorders, peripheral edema and drug-induced hypertension. Given the significant differences in pharmacokinetics between the formulations, c-ITZ and SUBA-ITZ capsules are not considered interchangeable. It is important to note that drug errors may occur when transitioning a patient from one formulation to another.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1171-1175"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori infection delays neutrophil apoptosis and exacerbates inflammatory response. 幽门螺杆菌感染会延缓中性粒细胞凋亡并加剧炎症反应。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1080/17460913.2024.2360798
Yu Song, Peng Liu, Xi Qi, Xiao-Lin Shi, Yu-Shan Wang, Dong Guo, Hong Luo, Zong-Jun Du, Ming-Yi Wang
{"title":"<i>Helicobacter pylori</i> infection delays neutrophil apoptosis and exacerbates inflammatory response.","authors":"Yu Song, Peng Liu, Xi Qi, Xiao-Lin Shi, Yu-Shan Wang, Dong Guo, Hong Luo, Zong-Jun Du, Ming-Yi Wang","doi":"10.1080/17460913.2024.2360798","DOIUrl":"10.1080/17460913.2024.2360798","url":null,"abstract":"<p><p><b>Aim:</b> Understanding molecular mechanisms of <i>Helicobacter pylori</i> (<i>H. pylori</i>)-induced inflammation is important for developing new therapeutic strategies for gastrointestinal diseases.<b>Materials & methods:</b> We designed an <i>H. pylori</i>-neutrophil infection model and explored the effects of <i>H. pylori</i> infection on neutrophils.<b>Results:</b> <i>H. pylori</i> infected neutrophils showed a low level of apoptosis. <i>H. pylori</i> stimulation activated the NACHT/LRR/PYD domain-containing protein 3 (NLRP3)-gasdermin-D (GSDMD) pathway for interleukin (IL)-1β secretion. However, IL-1β secretion was not completely dependent on GSDMD, as inhibition of autophagy significantly reduced IL-1β release, and autophagy-related molecules were significantly upregulated in <i>H. pylori</i>-infected neutrophils.<b>Conclusion:</b> Therefore, <i>H. pylori</i> infection inhibits neutrophils apoptosis and induces IL-1β secretion through autophagy. These findings may be utilized to formulate therapeutic strategies against <i>H. pylori</i> mediated chronic gastritis.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1145-1156"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clostridioides difficile infection epidemiology during the COVID-19 pandemic in Greece. 希腊 COVID-19 大流行期间的艰难梭菌感染流行病学。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2358653
Theodoros Karampatakis, Eleni Kandilioti, Helen Katsifa, Anna Nikopoulou, Celine Harmanus, Katerina Tsergouli, Ed Kuijper, Melina Kachrimanidou
{"title":"<i>Clostridioides difficile</i> infection epidemiology during the COVID-19 pandemic in Greece.","authors":"Theodoros Karampatakis, Eleni Kandilioti, Helen Katsifa, Anna Nikopoulou, Celine Harmanus, Katerina Tsergouli, Ed Kuijper, Melina Kachrimanidou","doi":"10.1080/17460913.2024.2358653","DOIUrl":"10.1080/17460913.2024.2358653","url":null,"abstract":"<p><p><b>Aim:</b> The aim was to highlight the incidence and epidemiology of <i>C. difficile</i> infections (CDI) in a tertiary Greek hospital during the COVID-19 pandemic.<b>Methods:</b> A single-center prospective observational cohort study was conducted (October 2021 until April 2022). 125 <i>C. difficile</i> isolates were cultured from hospitalized patients stool samples and screened by PCR for toxin A (<i>tcdA</i>), toxin B (<i>tcdB</i>), binary toxin (<i>cdtA</i> and <i>cdtB</i>) genes and the regulating gene of <i>tcdC</i>.<b>Results:</b> The incidence of CDI increased to 13.1 infections per 10,000 bed days. The most common PCR ribotypes identified included hypervirulent RT027-related RT181 (73.6%), presumably hypervirulent RT126 (8.0%) and toxin A negative RT017 (7.2%).<b>Conclusion:</b> Although the incidence of CDI increased significantly, the CDI epidemiology remained stable.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1119-1127"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential role of Akkermansia muciniphila in liver health. Akkermansia muciniphila 对肝脏健康的潜在作用。
IF 2.5 4区 生物学
Future microbiology Pub Date : 2024-08-12 Epub Date: 2024-08-07 DOI: 10.2217/fmb-2023-0220
Min Zhang, Yang Wang, Yong Gan
{"title":"The potential role of <i>Akkermansia muciniphila</i> in liver health.","authors":"Min Zhang, Yang Wang, Yong Gan","doi":"10.2217/fmb-2023-0220","DOIUrl":"10.2217/fmb-2023-0220","url":null,"abstract":"<p><p><i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) is a 'star strain' that has attracted much attention in recent years. <i>A. muciniphila</i> can effectively regulate host metabolism, significantly affect host immune function, and play an important role in balancing host health and disease. As one of the organs most closely related to the gut (the two can communicate through the hepatic portal vein and bile duct system), liver is widely affected by intestinal microorganisms. A growing body of evidence suggests that <i>A. muciniphila</i> may alleviate liver-related diseases by improving the intestinal barrier, energy metabolism and regulating inflammation through its protein components and metabolites. This paper systematically reviews the key roles of <i>A. muciniphila</i> and its derivatives in maintaining liver health and improving liver disease.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1081-1096"},"PeriodicalIF":2.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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