Future microbiology最新文献_第8页

Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study. 肠道双歧杆菌与移植失败之间的因果关系：孟德尔随机研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2417608

Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li

{"title":"Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study.","authors":"Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li","doi":"10.1080/17460913.2024.2417608","DOIUrl":"10.1080/17460913.2024.2417608","url":null,"abstract":"Aim: Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure.Materials & methods: A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.Results: The abundance of Bifidobacteriaceae demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] p = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW p > 0.200). Notably, a higher intestinal abundance of Bifidobacteriaceae corresponded to a decreased risk of transplant failure. Bifidobacteriaceae instrumental variables were enriched in pathways related to synapses and membranes.Conclusion: The Bifidobacteriaceae may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"23-31"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella. 来自灰飞虱的抗隐球菌多肽：在三维细胞培养物和灰飞虱中的毒性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2421632

Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida

{"title":"Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella.","authors":"Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida","doi":"10.1080/17460913.2024.2421632","DOIUrl":"10.1080/17460913.2024.2421632","url":null,"abstract":"Aim: This work aimed to test peptides against the planktonic and biofilm form of Cryptococcus spp. and in vitro toxicity using three-dimensional (3D) cells characterized and evaluate in vivo toxicity in Galleria mellonella.Materials & methods: Susceptibility tests were conducted on the planktonic form and biofilm formation. The toxicity of the peptides was evaluated in lung and brain cells in monolayer (2D) and 3D mono- and co-culture, in addition to in vivo analysis with G. mellonella.Results: Susceptibility values ranged from 31.25 to over 250 µg/ml with a fungicidal profile. Regarding toxicity, the PepM2 peptide was not toxic in 3D culture (500 µg/ml). G. mellonella, showed a survival rate of more than 85% In assays with brain and lung cell lines, concentrations ranged from 4 × 104 to 4 × 103 cells/well for brain cells and 1 × 103 cells/well for lung cells. Cocultures used 1 × 105 brain and 1 × 103 lung cells.Conclusion: This study shows that the peptides have great potential against cryptococcosis, and all spheroids were characterized as having a spheroidal and compact structure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"11-21"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area. 元基因组下一代测序在布鲁氏菌病诊断中的应用：来自非流行区的五个病例。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1080/17460913.2024.2363632

Xuan Zhang, Xinfei Yao, Huixin Chen, Dongsheng Han, Meifang Yang

引用次数: 0

Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp. 芒果苷可增强抗真菌药物对氟康唑耐药念珠菌属的活性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2366627

Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva

{"title":"Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp.","authors":"Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva","doi":"10.1080/17460913.2024.2366627","DOIUrl":"10.1080/17460913.2024.2366627","url":null,"abstract":"Aim: To evaluate the antifungal activity of mangiferin against Candida spp. resistant to fluconazole.Materials & methods: The antifungal activity of mangiferin was assessed using broth microdilution and its interaction with azoles and amphotericin B was evaluated by checkerboard. The activity of mangiferin against Candida spp. biofilms was assessed using the MTT colorimetric assay and its possible mechanism of action was evaluated using flow cytometry.Results: Mangiferin showed activity against Candida albicans, Candida tropicalis and Candida parapsilosis resistant to fluconazole and showed synergism with azoles and amphotericin B. Mangiferin increased the activity of antifungals against Candida biofilms and caused depolarization of the mitochondrial membrane and externalization of phosphatidylserine, suggesting apoptosis.Conclusion: mangiferin combined with antifungals has potential against Candida spp.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1157-1170"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: accuracy required in data entry when using machine learning techniques to predict risk of disease. 致编辑的信：使用机器学习技术预测疾病风险时对数据录入准确性的要求。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2353525

Akash Korat, Dhaval Dobariya, Imtiyaz Bavaliya, Vikram Mali

引用次数: 0

Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan. 对从萨斯喀彻温省血液透析患者身上分离出的隧道式血液透析导管进行微生物分析。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-16 DOI: 10.1080/17460913.2024.2359879

Murugesan Sivaranjani, Haley Sanderson, Chinenye R Nnajide, Anna Martens-Koop, Joseph M Blondeau, Rodrick Stryker, Aaron P White

{"title":"Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan.","authors":"Murugesan Sivaranjani, Haley Sanderson, Chinenye R Nnajide, Anna Martens-Koop, Joseph M Blondeau, Rodrick Stryker, Aaron P White","doi":"10.1080/17460913.2024.2359879","DOIUrl":"10.1080/17460913.2024.2359879","url":null,"abstract":"Aim: To compare the microbial communities inside hemodialysis catheters from symptomatic and asymptomatic patients to determine their differences.Materials & methods: Catheters (n = 41) were removed from patients in the Saskatchewan Health Authority over an 18-month period. The catheter section inside the body was flushed and the contents were evaluated using culture-dependent and culture-independent analysis.Results: All catheters were colonized by bacteria, with considerable overlap between groups based on microbial communities and the individual species detected. More Gram-negative species were detected by sequencing, whereas predominantly Gram-positive strains were cultured. Antibiotic resistance and biofilm formation was widespread and not correlated with either catheter group.Conclusion: Common pathogens were detected in each set of catheters, therefore predicting infections based on the microbiology is difficult.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":"19 13","pages":"1129-1144"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fighting fire with fire: using infectious agents to treat persistent infection. 以毒攻毒：使用传染性制剂治疗顽固性感染。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.1080/17460913.2024.2363728

Maha Albukhari, Maria Bagies, Tanya Lizbeth, Shyamasundaran Kottilil

引用次数: 0

SUBA-itraconazole in the treatment of systemic fungal infections. 治疗全身性真菌感染的 SUBA-伊曲康唑。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2362128

Jennifer Liu, Kees A Vanderwyk, Monica A Donnelley, George R Thompson Iii

引用次数: 0

Helicobacter pylori infection delays neutrophil apoptosis and exacerbates inflammatory response. 幽门螺杆菌感染会延缓中性粒细胞凋亡并加剧炎症反应。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1080/17460913.2024.2360798

Yu Song, Peng Liu, Xi Qi, Xiao-Lin Shi, Yu-Shan Wang, Dong Guo, Hong Luo, Zong-Jun Du, Ming-Yi Wang

{"title":"Helicobacter pylori infection delays neutrophil apoptosis and exacerbates inflammatory response.","authors":"Yu Song, Peng Liu, Xi Qi, Xiao-Lin Shi, Yu-Shan Wang, Dong Guo, Hong Luo, Zong-Jun Du, Ming-Yi Wang","doi":"10.1080/17460913.2024.2360798","DOIUrl":"10.1080/17460913.2024.2360798","url":null,"abstract":"Aim: Understanding molecular mechanisms of Helicobacter pylori (H. pylori)-induced inflammation is important for developing new therapeutic strategies for gastrointestinal diseases.Materials & methods: We designed an H. pylori-neutrophil infection model and explored the effects of H. pylori infection on neutrophils.Results: H. pylori infected neutrophils showed a low level of apoptosis. H. pylori stimulation activated the NACHT/LRR/PYD domain-containing protein 3 (NLRP3)-gasdermin-D (GSDMD) pathway for interleukin (IL)-1β secretion. However, IL-1β secretion was not completely dependent on GSDMD, as inhibition of autophagy significantly reduced IL-1β release, and autophagy-related molecules were significantly upregulated in H. pylori-infected neutrophils.Conclusion: Therefore, H. pylori infection inhibits neutrophils apoptosis and induces IL-1β secretion through autophagy. These findings may be utilized to formulate therapeutic strategies against H. pylori mediated chronic gastritis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1145-1156"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clostridioides difficile infection epidemiology during the COVID-19 pandemic in Greece. 希腊 COVID-19 大流行期间的艰难梭菌感染流行病学。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1080/17460913.2024.2358653

Theodoros Karampatakis, Eleni Kandilioti, Helen Katsifa, Anna Nikopoulou, Celine Harmanus, Katerina Tsergouli, Ed Kuijper, Melina Kachrimanidou

引用次数: 0