Future microbiology最新文献_第8页

Proteomic alterations associated with the formation of monocyte extracellular trap induced by Candida albicans hyphae. 与白色念珠菌菌丝诱导的单核细胞胞外陷阱的形成有关的蛋白质组变化。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.2217/fmb-2023-0029

Xian Wu, Liying Sun, Lei Huang, Chenwei Huang, Kuixia Sun, Haixia Li

引用次数: 0

Detection of Yersinia enterocolitica, Shigella spp. and Salmonella spp. in Rattus norvegicus captured from Tehran, Iran. 在伊朗德黑兰捕获的鼠中检测到小肠结肠耶尔森菌、志贺氏菌属和沙门氏菌属。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0138

Taher Azimi, Sina Nasrollahian, Sahar Sabour, Nahal Hadi, Leila Azimi, Fatemeh Fallah, Mohammed Reza Pourmand

引用次数: 0

Manganese(II), copper(II) and silver(I) complexes containing 1,10-phenanthroline/1,10-phenanthroline-5,6-dione against Candida species. 含 1,10-菲罗啉/1,10-菲罗啉-5,6-二酮的锰(II)、铜(II)和银(I)配合物对念珠菌的作用。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI: 10.2217/fmb-2023-0212

Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos

{"title":"Manganese(II), copper(II) and silver(I) complexes containing 1,10-phenanthroline/1,10-phenanthroline-5,6-dione against Candida species.","authors":"Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos","doi":"10.2217/fmb-2023-0212","DOIUrl":"10.2217/fmb-2023-0212","url":null,"abstract":"Background: New chemotherapeutics are urgently required to treat Candida infections caused by drug-resistant strains. Methods: The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate complexed with Mn(II), Cu(II) and Ag(I) were evaluated against ten different Candida species. Results: Proliferation of Candida albicans, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida kefyr, Candida krusei, Candida lusitaniae, Candida parapsilosis and Candida tropicalis was inhibited by three of six Cu(II) (MICs 1.52-21.55 μM), three of three Ag(I) (MICs 0.11-12.74 μM) and seven of seven Mn(II) (MICs 0.40-38.06 μM) complexes. Among these [Mn2(oda)(phen)4(H2O)2][Mn2(oda)(phen)4(oda)2].4H2O, where oda = octanedioic acid, exhibited effective growth inhibition (MICs 0.4-3.25 μM), favorable activity indexes, low toxicity against Vero cells and good/excellent selectivity indexes (46.88-375). Conclusion: [Mn2(oda)(phen)4(H2O)2][Mn2(oda)(phen)4(oda)2].4H2O represents a promising chemotherapeutic option for emerging, medically relevant and drug-resistant Candida species.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"385-395"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of PD-1 and immune cells in HSV infection and latency. PD-1 和免疫细胞在 HSV 感染和潜伏期中的作用。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.2217/fmb-2023-0151

Liqiong Ding

引用次数: 0

Biosensors for the detection of pathogenic bacteria: current status and future perspectives. 用于检测致病细菌的生物传感器：现状与未来展望。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0182

Yalcin Dicle, Murat Karamese

引用次数: 0

Interaction with lipopolysaccharide is key to efficacy of tryptophan- and arginine-rich α-melanocyte-stimulating hormone analogs against Gram-negative bacteria. 与脂多糖的相互作用是富含色氨酸和精氨酸的α-黑色素细胞刺激素类似物对革兰氏阴性菌有效的关键。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2023-12-21 DOI: 10.2217/fmb-2023-0080

Kanchan Tiwari, Priya Patel, Aftab H Mondal, Kasturi Mukhopadhyay

{"title":"Interaction with lipopolysaccharide is key to efficacy of tryptophan- and arginine-rich α-melanocyte-stimulating hormone analogs against Gram-negative bacteria.","authors":"Kanchan Tiwari, Priya Patel, Aftab H Mondal, Kasturi Mukhopadhyay","doi":"10.2217/fmb-2023-0080","DOIUrl":"10.2217/fmb-2023-0080","url":null,"abstract":"Aim: In order to search for novel antibacterial therapeutics against Gram-negative bacteria, the antibacterial efficacies and mechanism of action of tryptophan- and arginine-rich α-melanocyte-stimulating hormone analogs were investigated. Materials & methods: We performed a killing assay to determine their efficacy; fluorescence, microscopic studies were used to understand their mechanism and peptide-lipopolysaccharide interaction. A checkerboard assay was used to find the effective combination of peptide and antibiotics. Results: Ana-peptides displayed good killing activity against Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Their strong interaction with lipopolysaccharide damaged the bacterial membranes and led to their subsequent death. Ana-5, the highest cationic and hydrophobic analog, emerged as the most potent peptide, showing synergistic action with rifampicin and erythromycin. Conclusion: Ana-5 can be presented as an important therapeutic candidate against bacterial infections.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"195-211"},"PeriodicalIF":3.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of isavuconazole antifungal medicine to treat mold infections in Asia and the Western Pacific region: a plain language summary. 使用异戊康唑抗真菌药物治疗亚洲和西太平洋地区霉菌感染:简单的语言总结。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.2217/fmb-2023-0191

Michael A Pfaller, Cecilia G Carvalhaes, Paul R Rhomberg, Mariana Castanheira

{"title":"Use of isavuconazole antifungal medicine to treat mold infections in Asia and the Western Pacific region: a plain language summary.","authors":"Michael A Pfaller, Cecilia G Carvalhaes, Paul R Rhomberg, Mariana Castanheira","doi":"10.2217/fmb-2023-0191","DOIUrl":"10.2217/fmb-2023-0191","url":null,"abstract":"What is this summary about?: Molds are types of fungus that can invade humans. It can cause a disease called invasive mold infection (IMI) and make people sick or cause death. This is a summary of a study that looked at mold samples collected from people in Asia and the Western Pacific region to check if an antifungal medicine called isavuconazole (ISC) can stop the growth of or kill these molds.What were the results?: One type of mold known as Aspergillus or type 1 molds, was more common than other molds. Antifungal medicines including ISC, posaconazole, voriconazole, and itraconazole slowed or stopped the growth of the type 1 molds. ISC was very active in slowing or stopping the growth of this mold. Other molds, known as non-Aspergillus or type 2 mold, were less common. The antifungals medicines mentioned above were able to slow or stop the growth of some but not all of the type 2 molds.What do the results of the study mean?: ISC stopped the growth of most type 1 molds and was as good as the other antifungal medicines against type 2 molds.What is the purpose of this plain language summary?: The purpose of this plain language summary is to help you to understand the findings from recent research. The results of this study may differ from those of other studies. Health professionals should make treatment decisions based on all available evidence not on the results of a single study.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"173-180"},"PeriodicalIF":2.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenols and their nanoformulations as potential antibiofilm agents against multidrug-resistant pathogens. 多酚类化合物及其纳米制剂作为潜在的抗生物膜剂，可对抗耐多药病原体。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-02-02 DOI: 10.2217/fmb-2023-0175

Modawy Em Elkhalifa, Muhammad Ashraf, Alshebli Ahmed, Assad Usman, Alashary Ae Hamdoon, Mohammed A Elawad, Meshari G Almalki, Osama F Mosa, Laziz N Niyazov, Muhammad Ayaz

引用次数: 0

Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 inhibit HIF-1α-mediated glycolysis of colon cancer. 副酸乳杆菌 PC-H1 的细胞外囊泡抑制 HIF-1α 介导的结肠癌糖酵解。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI: 10.2217/fmb-2023-0144

Yangqian Shi, Chunliang Zhang, Wanyu Cao, Luyi Li, Kaili Liu, Hanyue Zhu, Fikadu Balcha, Yong Fang

{"title":"Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 inhibit HIF-1α-mediated glycolysis of colon cancer.","authors":"Yangqian Shi, Chunliang Zhang, Wanyu Cao, Luyi Li, Kaili Liu, Hanyue Zhu, Fikadu Balcha, Yong Fang","doi":"10.2217/fmb-2023-0144","DOIUrl":"10.2217/fmb-2023-0144","url":null,"abstract":"Aims: Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 have antiproliferative activity of colon cells, but the effect on glycolytic metabolism of cancer cell remains enigmatic. The authors investigated how Lacticaseibacillus paracasei extracellular vesicles (LpEVs) inhibit the growth of colon cancer cells by affecting tumor metabolism. Materials & methods: HCT116 cells were treated with LpEVs and then differentially expressed genes were analyzed by transcriptome sequencing, the sequencing results were confirmed in vivo and in vitro. Results: LpEVs entered colon cancer cells and inhibited their growth. Transcriptome sequencing revealed differentially expressed genes were related to glycolysis. Lactate production, glucose uptake and lactate dehydrogenase activity were significantly reduced after treatment. LpEVs also reduced HIF-1α, GLUT1 and LDHA expression. Conclusion: LpEVs exert their antiproliferative activity of colon cancer cells by decreasing HIF-1α-mediated glycolysis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"227-239"},"PeriodicalIF":3.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial therapy using VIS plus water-filtered infrared-A as an alternative method to treat oral diseases. 使用 VIS 加水过滤红外线-A 作为治疗口腔疾病的替代方法进行抗菌治疗。

IF 3.1 4区生物学

Future microbiology Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.2217/fmb-2023-0127

Sara Bernardi, Davide Gerardi, Sibylle Bartsch, Guido Macchiarelli, Elmar Hellwig, Ali Al-Ahmad

引用次数: 0