Future microbiology最新文献_第7页

Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice. 肠道菌群和衍生的粪便代谢物的变化可能在他克莫司诱导的小鼠糖尿病中发挥作用。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-22 DOI: 10.1080/17460913.2024.2444761

Minyan Qian, Zhenwei Jiang, Caomei Xu, Liying Wang, Nan Hu

{"title":"Changes in the gut microbiota and derived fecal metabolites may play a role in tacrolimus-induced diabetes in mice.","authors":"Minyan Qian, Zhenwei Jiang, Caomei Xu, Liying Wang, Nan Hu","doi":"10.1080/17460913.2024.2444761","DOIUrl":"10.1080/17460913.2024.2444761","url":null,"abstract":"Aims: A notable scarcity of research has focused on examining alterations in gut microbiota and its metabolites within tacrolimus (TAC)-induced diabetes models.Methods: Tacrolimus-induced changes in glucose and lipid metabolism indices were analyzed through different routes of administration. The potential role of gut microbiota and its metabolites in TAC-induced diabetes was investigated using 16S rRNA sequencing and non-targeted metabolomics.Results: After intraperitoneal(ip) and oral(po) administration of TAC, the α-diversity index of gut microbiota was significantly increased. The gut microbiota of the three groups of mice was significantly separated, and there were significant changes in composition and functional genes. Fecal metabolites changed significantly after TAC administration by different routes, and 53 metabolites (38 down-regulated and 15 up-regulated) were identified (CON vs. TACip). Similarly, 29 metabolites (8 down-regulated and 21 up-regulated) were identified (CON vs. TACpo). KEGG pathway analysis identified 4 and 13 significantly altered metabolic pathways, respectively. Correlation analysis suggested that microbiota and metabolites were involved in the pathogenesis of TAC-induced diabetes.Conclusion: This study investigated the alterations in gut microbiota and fecal metabolites in TAC-induced diabetic mice and evaluated the correlation between these changes. These findings provide valuable insights into potential biomarkers in the development of TAC-induced diabetes.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"237-246"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First case report of Corynebacterium minutissimum septic arthritis associated with an indwelling device. 微型棒状杆菌脓毒性关节炎与留置器相关的第一例报告。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1080/17460913.2024.2444160

Samiha Akkaya, Yusuf Emre Ozdemir, Esra Ensaroglu, Ergun Cetin, Hayat Kumbasar Karaosmanoglu

{"title":"First case report of Corynebacterium minutissimum septic arthritis associated with an indwelling device.","authors":"Samiha Akkaya, Yusuf Emre Ozdemir, Esra Ensaroglu, Ergun Cetin, Hayat Kumbasar Karaosmanoglu","doi":"10.1080/17460913.2024.2444160","DOIUrl":"10.1080/17460913.2024.2444160","url":null,"abstract":"Corynebacterium minutissimum usually presents with erythrasma, a macular rash, but rarely it can cause extracutaneous infections such as endocarditis, peritonitis, pyelonephritis, and catheter-related bloodstream infections. Here, we present the first case of septic arthritis caused by C. minutissimum and a literature review of invasive C. minutissimum infections. The diagnosis was confirmed by the patient's clinical findings and microbiological examination of the joint fluid. Considering the patients hemodialysis catheter and the pathogenic nature of the C. minutissimum, we strongly suspected a catheter-related infection. Clinical and laboratory follow-ups showed consistent improvement with treatment, characterized by reduced pain, swelling, and localized warmth in the left knee, along with a significant decline in acute-phase reactants. The patient achieved full recovery following a four-week course of antibiotics and catheter removal. Our report emphasizes the importance of not disregarding the isolation of non-diphtheria Corynebacterium from appropriately collected sterile samples in symptomatic patients, particularly those with indwelling devices. Based on this case report, clinicians should consider the rare possibility of this microorganism being the cause of septic arthritis.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"183-188"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Effectiveness of Ivermectin-Based Multidrug Therapy in Severely Hypoxic, Ambulatory COVID-19 Patients. 撤回声明：以伊维菌素为基础的多种药物治疗重症缺氧门诊COVID-19患者的有效性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-09 DOI: 10.1080/17460913.2025.2451540

引用次数: 0

Biosensing technology for detection and assessment of pathogenic microorganisms. 用于检测和评估病原微生物的生物传感技术。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1080/17460913.2024.2417621

Sakshi Sinha, Lata Sheo Bachan Upadhyay

{"title":"Biosensing technology for detection and assessment of pathogenic microorganisms.","authors":"Sakshi Sinha, Lata Sheo Bachan Upadhyay","doi":"10.1080/17460913.2024.2417621","DOIUrl":"10.1080/17460913.2024.2417621","url":null,"abstract":"At present, the prevalence of infectious diseases is rising annually, making it an important risk factor for human health that should not be neglected. Consequently, infection control and prevention have become even more important. The key to determining and designing the most effective anti-infectious medication depends upon the immediate and accurate identification of the causative agent. The standard techniques used for routine infection screening and surveillance tests are shifting toward biosensors. Furthermore, biosensors are projected to be employed for microbiological detection to satisfy the higher accuracy required for clinical diagnosis. This is because of their compact size, real-time monitoring and ability to analyze large sample numbers with less sophistication and manpower requirement, which have allowed them to develop quickly with extensive uses. Biosensors have multiple applications in food safety, environmental surveillance, drug sensing and national security because they offer several advantages such as quick response, outstanding sensitivity, remarkable selectivity, high degree of accuracy and precision, ease of use and affordable price. This review highlights the performance aspects of recently developed biosensors for the detection of infectious bacteria and viruses in biological and environmental samples and emphasizes the significance of nanotechnology in signal amplification for enhanced biosensor performance and dependability.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"57-72"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biliary tract infections caused by Enterococcus gallinarum and Escherichia coli: a rare case report. 由胆囊肠球菌和大肠埃希菌引起的胆道感染：罕见病例报告。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1080/17460913.2024.2417597

Cuilin He, Long Chen, Liangsong Zhao, Haixia Lin, Maozhu Liu, Enqiang Chen

{"title":"Biliary tract infections caused by Enterococcus gallinarum and Escherichia coli: a rare case report.","authors":"Cuilin He, Long Chen, Liangsong Zhao, Haixia Lin, Maozhu Liu, Enqiang Chen","doi":"10.1080/17460913.2024.2417597","DOIUrl":"10.1080/17460913.2024.2417597","url":null,"abstract":"Enterococcus gallinarum (E. gallinarum), an opportunistic pathogen with intrinsic resistance to vancomycin, has rarely been reported as a predominant pathogen responsible for biliary tract infections. Here, we report a case of biliary tract infections caused by E. gallinarum and Escherichia coli (E. coli) in a 57-year-old Chinese woman with symptoms of upper abdomen pain for 10 days. The patient initially received empiric treatment with cefmetazole but failed to improve. Subsequently, bile cultures identified E. gallinarum and E. coli, and cefmetazole was switched to linezolid and meropenem based on drug susceptibility testing. After 10 days of antibiotic therapy, the patient successfully recovered and was discharged from the hospital. The findings of this case remind us that E. gallinarum may be the causative factor of biliary tract infections, and timely identification of the causative organism and appropriate antibiotic treatment is important for optimal patient recovery.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"5-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new N-acylhydrazone oxadiazole derivative with activity against mycobacteria. 一种具有抗分枝杆菌活性的新型 N-酰腙噁二唑衍生物。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.1080/17460913.2024.2412439

Izabella Ventura Souza, Maria Luiza Fróes da Motta Dacome, Andrew Matheus Frederico Rozada, Jonathan Sanches Rosa, Eloisa Gibin Sampiron, Deisiany Gomes Ferreira, Gisele Freitas Gauze, Melyssa Fernanda Norman Negri, Regiane Bertin de Lima Scodro, Rosilene Fressatti Cardoso, Katiany Rizzieri Caleffi-Ferracioli

{"title":"A new N-acylhydrazone oxadiazole derivative with activity against mycobacteria.","authors":"Izabella Ventura Souza, Maria Luiza Fróes da Motta Dacome, Andrew Matheus Frederico Rozada, Jonathan Sanches Rosa, Eloisa Gibin Sampiron, Deisiany Gomes Ferreira, Gisele Freitas Gauze, Melyssa Fernanda Norman Negri, Regiane Bertin de Lima Scodro, Rosilene Fressatti Cardoso, Katiany Rizzieri Caleffi-Ferracioli","doi":"10.1080/17460913.2024.2412439","DOIUrl":"10.1080/17460913.2024.2412439","url":null,"abstract":"Aim: To evaluate the anti-Mycobacterium tuberculosis (Mtb) potential of the hybrid oxadiazol-4-methoxynaphthalene (6n) derived from N-acylhydrazone (4k).Materials & methods: The study determined the minimal inhibitory concentration of (6n) against Mtb H37Rv and Mtb clinical isolates, potential combination of (6n) with anti-tuberculosis drugs and carried out time kill curve assay of Mtb H37Rv. Additional contribution for the analysis of (6n) was explored by in silico pharmacokinetics, and in vitro and in vivo cytotoxicity determinations.Results: The newly synthesized molecule (6n) demonstrated anti-Mtb activity, low cytotoxicity and selectivity for Mtb.Conclusion: The derivative (6n) emerges as a potential anti-TB drug candidate.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"33-44"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted enzymes delivered by liposomes could address an unmet need in mycobacterial respiratory infections. 脂质体递送的靶向酶可以解决分枝杆菌呼吸道感染的未满足需求。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-12-08 DOI: 10.1080/17460913.2024.2423558

Jason W Holder, Richard A Slayden

引用次数: 0

Microbiome and bladder cancer: the role of probiotics in treatment. 微生物组与膀胱癌：益生菌在治疗中的作用。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1080/17460913.2024.2414671

Leila Dadgar-Zankbar, Maryam Mokhtaryan, Elnaz Bafandeh, Zahra Javanmard, Parisa Asadollahi, Taleih Darbandi, Roghayeh Afifirad, Shirin Dashtbin, Atieh Darbandi, Roya Ghanavati

{"title":"Microbiome and bladder cancer: the role of probiotics in treatment.","authors":"Leila Dadgar-Zankbar, Maryam Mokhtaryan, Elnaz Bafandeh, Zahra Javanmard, Parisa Asadollahi, Taleih Darbandi, Roghayeh Afifirad, Shirin Dashtbin, Atieh Darbandi, Roya Ghanavati","doi":"10.1080/17460913.2024.2414671","DOIUrl":"10.1080/17460913.2024.2414671","url":null,"abstract":"Bladder cancer (BCa) remains a significant global health challenge, with increasing interest in the role of the bladder microbiome in its pathogenesis, progression and treatment outcomes. The complex relationship between bladder cancer and the microbiome, as well as the potential impact of probiotics on treatment effectiveness, is currently under investigation. Research suggests that the microbiota may influence BCa recurrence prevention and enhance the efficacy of the Bacillus Calmette-Guérin (BCG) vaccine. Recent studies reveal differences in the bladder microbiome between individuals without bladder cancer and those with the disease. In the healthy bladder, Streptococcus and Lactobacillus are consistently identified as the most prevalent genera. However, in men, the predominant bacterial genera are Staphylococcus, Corynebacterium and Streptococcus, while in women with bladder cancer, Gardnerella and Lactobacillus are dominant. Probiotics, particularly Lactobacillus spp., can exhibit anti-tumor properties by competing with pathogenic strains involved in carcinogenesis or by producing regulatory substances. They regulate cancer signaling, induce apoptosis, inhibit mutagenic activity, downregulate oncogene expression, induce autophagy, inhibit kinases, reactivate tumor suppressors and prevent metastasis. These mechanisms have shown promising results in both preclinical and some clinical studies.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"73-90"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series. 脊髓神经囊虫病患者的治疗效果：已发表病例和系列病例的系统回顾。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.1080/17460913.2024.2428526

Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal

{"title":"Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series.","authors":"Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal","doi":"10.1080/17460913.2024.2428526","DOIUrl":"10.1080/17460913.2024.2428526","url":null,"abstract":"Aims: Spinal neurocysticercosis is a rare central nervous system infection caused by the larval form of the Taenia solium. Due to its rarity, most knowledge is derived from isolated case reports. This review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease's clinical presentation and treatment outcomes.Methods: Following PRISMA guidelines, a comprehensive search was performed across various databases. The review included case reports, case series, and observational studies, and it is registered with PROSPERO (CRD42024496957).Results: This review analyzed 206 spinal neurocysticercosis cases (from 171 published reports). Symptoms persisted for one week to six months in 49% of cases, and common presentations included paraparesis/quadriparesis (61.7%) and neck/limb/back pain (40.8%). CSF abnormalities were observed in 23.8%. Thoracic involvement was most frequent (39.3%), followed by cervical (27.2%). Neurocysticercosis lesions in other regions, primarily the brain, were found in 18.9%. Differential diagnoses included spinal cord tumors (13.1%). Treatment often involved surgery alone (32%) or with cysticidal drugs (45.6%), with a 91.3% improvement rate, indicating favorable outcomes.Conclusions: Spinal neurocysticercosis primarily affects the thoracic and cervical regions. Most patients respond well to medical therapy; surgery is mainly for progressive neurological deficits.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"45-56"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study. 肠道双歧杆菌与移植失败之间的因果关系：孟德尔随机研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2417608

Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li

{"title":"Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study.","authors":"Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li","doi":"10.1080/17460913.2024.2417608","DOIUrl":"10.1080/17460913.2024.2417608","url":null,"abstract":"Aim: Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure.Materials & methods: A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.Results: The abundance of Bifidobacteriaceae demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] p = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW p > 0.200). Notably, a higher intestinal abundance of Bifidobacteriaceae corresponded to a decreased risk of transplant failure. Bifidobacteriaceae instrumental variables were enriched in pathways related to synapses and membranes.Conclusion: The Bifidobacteriaceae may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"23-31"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0