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Future microbiology最新文献

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A tale of endurance: bats, viruses and immune dynamics. 耐力的故事：蝙蝠、病毒和免疫动态。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-22 DOI: 10.2217/fmb-2023-0233
Apoorva, Sunit K Singh
{"title":"A tale of endurance: bats, viruses and immune dynamics.","authors":"Apoorva, Sunit K Singh","doi":"10.2217/fmb-2023-0233","DOIUrl":"https://doi.org/10.2217/fmb-2023-0233","url":null,"abstract":"The emergence of highly zoonotic viral infections has propelled bat research forward. The viral outbreaks including Hendra virus, Nipah virus, Marburg virus, Ebola virus, Rabies virus, Middle East respiratory syndrome coronavirus, SARS-CoV and the latest SARS-CoV-2 have been epidemiologically linked to various bat species. Bats possess unique immunological characteristics that allow them to serve as a potential viral reservoir. Bats are also known to protect themselves against viruses and maintain their immunity. Therefore, there is a need for in-depth understanding into bat-virus biology to unravel the major factors contributing to the coexistence and spread of viruses.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140677066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repurposing approved drugs as potential efflux pump inhibitors in multidrug-resistant Pseudomonas aeruginosa. 将已获批准的药物作为潜在的外排泵抑制剂重新用于耐多药铜绿假单胞菌。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2023-0208
Gláucia Morgana de Melo Guedes, V. C. Pereira, A. Freitas, Paulo Roberto Honório de Souza, Aura Lucia Chacon Parra, Jaiane Alves Brasil, Rodrigo Fonseca de Medeiros Guedes, Paulo César Pereira de Sousa, R. A. Aguiar Cordeiro, M. F. Gadelha Rocha, J. C. Costa Sidrim, Débora de Souza Collares Maia Castelo Branco
{"title":"Repurposing approved drugs as potential efflux pump inhibitors in multidrug-resistant Pseudomonas aeruginosa.","authors":"Gláucia Morgana de Melo Guedes, V. C. Pereira, A. Freitas, Paulo Roberto Honório de Souza, Aura Lucia Chacon Parra, Jaiane Alves Brasil, Rodrigo Fonseca de Medeiros Guedes, Paulo César Pereira de Sousa, R. A. Aguiar Cordeiro, M. F. Gadelha Rocha, J. C. Costa Sidrim, Débora de Souza Collares Maia Castelo Branco","doi":"10.2217/fmb-2023-0208","DOIUrl":"https://doi.org/10.2217/fmb-2023-0208","url":null,"abstract":"Aim: To evaluate the action of promethazine, fluoxetine and carbonyl cyanide 3-chlorophenylhydrazone as efflux pump inhibitors (EPIs) against multidrug-resistant Pseudomonas aeruginosa. Methods: The effect of the compounds was evaluated in planktonic cells and bacterial biofilms. Accumulation tests were performed with ethidium bromide to prove their action as EPIs. Then, they were associated with antimicrobials. Results: Effect on planktonic cells and biofilms was found. Assays with ethidium bromide indicate their action as EPIs. Significant reductions in the metabolic activity of biofilms were observed after the association with the antimicrobials, especially for meropenem. Conclusion: It is possible to prove the action of these compounds as EPIs for P. aeruginosa and demonstrate the relevance of efflux pumps in antimicrobial resistance.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial resistance of genital mycoplasmas recovered from nonpregnant women in Greece: trends over the last 15 years. 希腊非孕妇生殖器支原体的抗菌药耐药性：过去 15 年的趋势。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2023-0238
V. Koumaki, A. Chasiakou, M. Kantzanou, A. Tsakris, S. Baka
{"title":"Antimicrobial resistance of genital mycoplasmas recovered from nonpregnant women in Greece: trends over the last 15 years.","authors":"V. Koumaki, A. Chasiakou, M. Kantzanou, A. Tsakris, S. Baka","doi":"10.2217/fmb-2023-0238","DOIUrl":"https://doi.org/10.2217/fmb-2023-0238","url":null,"abstract":"Aim: To study antimicrobial susceptibilities of genital mycoplasmas recovered from endocervical samples of reproductive-age, nonpregnant women (n = 8,336). Materials & methods: For isolation and susceptibility testing, the Mycoplasma IST2 kit was used. Results: As many as 2093 samples were positive for mycoplasmas. The vast majority (>96%) of Ureaplasma urealyticum remained susceptible to tetracycline, doxycycline, josamycin and pristinamycin, whereas susceptibility rates to azithromycin and fluoroquinolones were significantly decreased. Mycoplasma hominis exhibited high susceptibility rates to doxycycline, pristinamycin and josamycin (98.1-100%), while susceptibilities to tetracycline and fluoroquinolones were considerably lower. Conclusion: Doxycycline remained highly potent for treating mycoplasmas; nevertheless, susceptibilities to other antimicrobials were significantly diminished.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial activity of corydalis saxicola bunting total alkaloids against Porphyromonas gingivalis in vitro. 苣荬菜总生物碱对牙龈卟啉单胞菌的体外抗菌活性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2023-0165
Wenli Ye, Jiaxuan Wu, Qiaozhi Jiang, Zhiheng Su, Haiqing Liao, Zhenmin Liu, Renchuan Tao, Xiangzhi Yong
{"title":"Antibacterial activity of corydalis saxicola bunting total alkaloids against Porphyromonas gingivalis in vitro.","authors":"Wenli Ye, Jiaxuan Wu, Qiaozhi Jiang, Zhiheng Su, Haiqing Liao, Zhenmin Liu, Renchuan Tao, Xiangzhi Yong","doi":"10.2217/fmb-2023-0165","DOIUrl":"https://doi.org/10.2217/fmb-2023-0165","url":null,"abstract":"Aim: To investigate the antibacterial effects of Corydalis Saxicola bunting total alkaloid (CSBTA) on Porphyromonas gingivalis. Methods: SEM, chemical staining, RT-qPCR and ELISA were used to detect effects of CSBTA on P. gingivalis. Results: CSBTA treatment caused shrinkage and rupture of P. gingivalis morphology, decreased biofilm density and live bacteria in biofilm, as well as reduced mRNA expression of virulence genes hagA, hagB, kgp, rgpA and rgpB of P. gingivalis. Furthermore, NOK cells induced by CSBTA-treated P. gingivalis exhibited lower IL-6 and TNF-α expression levels. Conclusion: CSBTA is able to kill free P. gingivalis, disrupt the biofilm and weaken the pathogenicity of P. gingivalis. It has the potential to be developed as a drug against P. gingivalis infection.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascorbic acid as a modulator of inflammatory response against Candida albicans. 抗坏血酸是抗白色念珠菌炎症反应的调节剂。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2023-0188
Noala Vicensoto Moreira Milhan, Aline da Graça Sampaio, C. Y. Koga-Ito, Angela Bruzzaniti
{"title":"Ascorbic acid as a modulator of inflammatory response against Candida albicans.","authors":"Noala Vicensoto Moreira Milhan, Aline da Graça Sampaio, C. Y. Koga-Ito, Angela Bruzzaniti","doi":"10.2217/fmb-2023-0188","DOIUrl":"https://doi.org/10.2217/fmb-2023-0188","url":null,"abstract":"Aim: To evaluate the behavior of oral keratinocytes in the presence of Vitamin C (Vit C) and its anti-inflammatory potential. Materials & methods: Oral keratinocytes were initially exposed to 0.1-2.5 mM of Vit C and the metabolic activity and cell migration were evaluated using MTS assay and Ibidi culture inserts, respectively. After, the cells were challenged with Candida albicans and inflammatory markers were analyzed by qPCR. Results: The treatment was not cytotoxic, and the highest concentrations increased the metabolic activity at 24 h. Vit C delayed the cell migration at 48 and 72 h. Interestingly, it downregulated the genes IL-8 and IL-1β. Conclusion: Vit C could be an interesting adjuvant to anti-fungal treatment due to its anti-inflammatory potential.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metagenomic next-generation sequencing for the diagnosis of neurobrucellosis. 用于诊断神经布鲁氏菌病的下一代元基因组测序。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2023-0177
Wen Li, Ying He, Yanyan Li, Xiaona Li, Ting Bian, Tingting Liu, Xuedong Liu, Wen Jiang
{"title":"Metagenomic next-generation sequencing for the diagnosis of neurobrucellosis.","authors":"Wen Li, Ying He, Yanyan Li, Xiaona Li, Ting Bian, Tingting Liu, Xuedong Liu, Wen Jiang","doi":"10.2217/fmb-2023-0177","DOIUrl":"https://doi.org/10.2217/fmb-2023-0177","url":null,"abstract":"Objective: This study investigates the application of metagenomic next-generation sequencing (mNGS) in the diagnosis of neurobrucellosis (NB). Methods: We retrospectively analyzed patients diagnosed with NB who underwent cerebrospinal fluid (CSF) mNGS testing in Xijing Hospital from 2015 to 2021. Results: Among the 20 individuals included in the study, the serum rose bengal test was positive in 11 out of 16 cases, serum agglutination test was positive in 13 out of 16 cases, CSF culture was positive in 6 out of 11 cases, and CSF mNGS tests were positive in 18 out of 20 cases. Conclusion: CSF mNGS demonstrates superior sensitivity; therefore, it is recommended to collect CSF for mNGS testing prior to antibiotic therapy when NB is suspected.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Akkermansia muciniphila improves gastric cancer treatment by modulating the immune microenvironment. Akkermansia muciniphila 可通过调节免疫微环境改善胃癌治疗。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2023-0210
Jia-hui Fang, Huizhong Zhang, Xiaodong Zhang, Xiaolong Lu, Junjie Liu, Haiyang Li, Jianxin Huang
{"title":"Akkermansia muciniphila improves gastric cancer treatment by modulating the immune microenvironment.","authors":"Jia-hui Fang, Huizhong Zhang, Xiaodong Zhang, Xiaolong Lu, Junjie Liu, Haiyang Li, Jianxin Huang","doi":"10.2217/fmb-2023-0210","DOIUrl":"https://doi.org/10.2217/fmb-2023-0210","url":null,"abstract":"Background: Gut microbiota is pivotal in tumor occurrence and development, and there is a close relationship between Akkermansia muciniphila (AKK) and cancer immunotherapy. Methods: The effects of AKK and its outer membrane proteins on gastric cancer (GC) were evaluated in vitro and in vivo using cell counting kit-8 assay, flow cytometry, western blotting, ELISA, immunohistochemistry and immunofluorescence. Results: AKK outer membrane protein facilitated apoptosis of GC cells and exerted an immunostimulatory effect (by promoting M1 polarization of macrophages, enhancing expression of cytotoxic T-lymphocyte-related cytokines and suppressing that of Treg-related cytokines). Additionally, AKK and its formulation could inhibit tumor growth of GC and enhance the infiltration of immune cells in tumor tissues. Conclusion: AKK could improve GC treatment by modulating the immune microenvironment.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JN.1: ongoing considerations of the shifting landscape of SARS-CoV-2 variants. JN.1：对不断变化的 SARS-CoV-2 变异情况的持续考虑。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-17 DOI: 10.2217/fmb-2024-0010
Soumya Basu, Titirsha Kayal, Ponoop Prasad Patro, Amit Patnaik
{"title":"JN.1: ongoing considerations of the shifting landscape of SARS-CoV-2 variants.","authors":"Soumya Basu, Titirsha Kayal, Ponoop Prasad Patro, Amit Patnaik","doi":"10.2217/fmb-2024-0010","DOIUrl":"https://doi.org/10.2217/fmb-2024-0010","url":null,"abstract":"","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel automated AIMLAM for diagnosis of Mycobacterium tuberculosis. 用于诊断结核分枝杆菌的新型自动化 AIMLAM。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-04-09 DOI: 10.2217/fmb-2024-0025
Ruixia Liang, Jiankang Li, Hongmei Shi, Wu Han, Zhao Chang
{"title":"Novel automated AIMLAM for diagnosis of Mycobacterium tuberculosis.","authors":"Ruixia Liang, Jiankang Li, Hongmei Shi, Wu Han, Zhao Chang","doi":"10.2217/fmb-2024-0025","DOIUrl":"https://doi.org/10.2217/fmb-2024-0025","url":null,"abstract":"Aim: A rapid and precise diagnostic method is crucial for timely intervention and management of tuberculosis. The present study compared the diagnostic accuracy of a novel lipoarabinomannan (LAM) antigen test, AIMLAM, for tuberculosis in urine samples. Methodology: The study subjected 106 TB suspects to smear microscopy, MGIT, GeneXpert and AIMLAM. Results: Among 106, smear microscopy identified 36 as positive (33%) (sensitivity; 70.93%, 95% CI (60.14-80.22%), while MGIT showed 38 positive (36.8%). GeneXpert detected 59 positives (sensitivity; 96.83, 95% CI (89.00-99.61%)). AIMLAM declared 61 as positive (57.5%) (sensitivity; 100.00, 95% CI (94.13-100.00%) and 45 as negative (42.5%). Conclusion: Overall, AIMLAM demonstrated better diagnostic accuracy than GeneXpert Assay, smear microscopy and MGIT liquid culture in urine samples.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140727287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria. 含有头孢他啶和妥布霉素的 Zein 纳米粒子：对革兰氏阴性菌的抗菌活性。
IF 3.1 4区 生物学
Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/fmb-2023-0147
Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães
{"title":"Zein nanoparticles containing ceftazidime and tobramycin: antibacterial activity against Gram-negative bacteria.","authors":"Luís Aa Campos, Azael Fs Neto, Maria Cs Noronha, João Vo Santos, Marton Ka Cavalcante, Maria Cab Castro, Valéria Ra Pereira, Isabella Mf Cavalcanti, Nereide S Santos-Magalhães","doi":"10.2217/fmb-2023-0147","DOIUrl":"10.2217/fmb-2023-0147","url":null,"abstract":"<p><p><b>Aims:</b> This work describes the encapsulation of ceftazidime and tobramycin in zein nanoparticles (ZNPs) and the characterization of their antibacterial and antibiofilm activities against Gram-negative bacteria. <b>Materials & methods:</b> ZNPs were synthesized by nanoprecipitation. Cytotoxicity was assessed by MTT assay and antibacterial and antibiofilm assays were performed by broth microdilution and violet crystal techniques. <b>Results:</b> ZNPs containing ceftazidime (CAZ-ZNPs) and tobramycin (TOB-ZNPs) showed drug encapsulation and thermal stability. Encapsulation of the drugs reduced their cytotoxicity 9-25-fold. Antibacterial activity, inhibition and eradication of biofilm by CAZ-ZNPs and TOB-ZNPs were observed. There was potentiation when CAZ-ZNPs and TOB-ZNPs were combined. <b>Conclusion:</b> CAZ-ZNPs and TOB-ZNPs present ideal physical characteristics for <i>in vivo</i> studies of antibacterial and antibiofilm activities.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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