Future microbiology最新文献_第6页

A rare case of granulomatous mastitis by Brucella species. 一例罕见的布鲁氏菌引起的肉芽肿性乳腺炎。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-16 DOI: 10.1080/17460913.2024.2429263

Necati Mumcu, Yusuf Emre Ozdemir

引用次数: 0

Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis. 寄生虫与微生物群的相互作用：创新性干预恰加斯病、利什曼病和蛔虫病的途径。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1080/17460913.2024.2431417

Juan David Ramírez, Sergio Castañeda, Jill Weatherhead, Cristina Poveda

{"title":"Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis.","authors":"Juan David Ramírez, Sergio Castañeda, Jill Weatherhead, Cristina Poveda","doi":"10.1080/17460913.2024.2431417","DOIUrl":"10.1080/17460913.2024.2431417","url":null,"abstract":"Parasitic infections are a major global health challenge, driven in part by complex interactions between parasites, host microbiota, and immune responses. Recent advances in microbiome research highlight the critical role of microbiota in influencing disease outcomes and treatment effectiveness. This review examines how changes in the microbiota impact parasite transmission, disease progression, and responses to treatment, focusing on key parasitic diseases such as Chagas disease, leishmaniasis, and ascariasis. The microbiota can either exacerbate or mitigate disease severity, depending on its composition, providing critical insights for novel therapeutic strategies. Emerging approaches discussed include the use of targeted probiotics, prebiotics, and microbiota-modulating drugs to influence parasite dynamics and enhance conventional therapies. The review also explores the potential of integrating microbiota knowledge into vaccine design and immunotherapy, aiming to develop vaccines that elicit stronger immune responses and identify new therapeutic targets. A multidisciplinary approach is essential for translating these findings into effective clinical solutions, with future research focusing on validating microbiota-based interventions in clinical settings. In conclusion, the interaction between microbiota and parasitic infections presents a promising avenue for innovative therapies, with the potential to significantly improve global health outcomes.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"149-161"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of extracts and isolated compounds Trichilia catigua against clinically relevant candida species. 毛毛菌提取物及分离化合物对临床相关念珠菌的活性研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-22 DOI: 10.1080/17460913.2024.2444163

Mariane Roberta Ritter, Daniella Renata Faria, Franciele Abigail Vilugron Rodrigues, Danielle Lazarin-Bidóia, Daniela Cristina de Medeiros Araújo, Flavio Augusto Vicente Seixas, Érika Seki Kioshima, João Carlos Palazzo de Mello

{"title":"Activity of extracts and isolated compounds Trichilia catigua against clinically relevant candida species.","authors":"Mariane Roberta Ritter, Daniella Renata Faria, Franciele Abigail Vilugron Rodrigues, Danielle Lazarin-Bidóia, Daniela Cristina de Medeiros Araújo, Flavio Augusto Vicente Seixas, Érika Seki Kioshima, João Carlos Palazzo de Mello","doi":"10.1080/17460913.2024.2444163","DOIUrl":"10.1080/17460913.2024.2444163","url":null,"abstract":"Objectives: To evaluate the in vitro antifungal activity of extracts and compounds from Trichilia catigua against clinically relevant Candida species, notably Candida glabrata, and investigate possible mechanisms of action using electron microscopy and in silico techniques.Methods: Extracts and fractions of T. catigua were obtained through turboextraction and partitioning, while the isolated compounds were previously purified. The ethyl acetate fraction (EAF) was characterized by HPLC. Antifungal activity against C. glabrata was evaluated through MIC tests, synergism was assessed via checkerboard assays, and structural changes were analyzed via electron microscopy. Molecular docking was performed to identify potential targets of action.Results: The EAF and isolated compounds (cinchonains and procyanidin B2) exhibited significant activity against C. glabrata, with MICs of 9.76 µg/mL (EAF) and 3.9 µg/mL (cinchonains Ia and Ib). Cinchonain Ib combined with epicatechin or procyanidin B2 displayed synergistic effects, particularly with amphotericin B. Microscopy analysis revealed cell membrane damage, and reverse docking analysis suggested that the compounds may target an enzyme essential to the metabolic processes of C. glabrata.Conclusions: The findings suggest that compounds isolated from T. catigua hold considerable potential for developing new antifungal agents against Candida species, particularly C. glabrata, with promising safety and synergistic profiles.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"227-235"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural polymicrobial Staphylococcus aureus-Pseudomonas aeruginosa interactions and antimicrobial resistance in ex vivo cornea model. 体外角膜模型中金葡萄球菌-铜绿假单胞菌相互作用的超微结构和抗菌药耐药性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1080/17460913.2024.2417617

Sanchita Mitra, Nagapriya Banka, Soumyava Basu, Tirupathi Rao

{"title":"Ultrastructural polymicrobial Staphylococcus aureus-Pseudomonas aeruginosa interactions and antimicrobial resistance in ex vivo cornea model.","authors":"Sanchita Mitra, Nagapriya Banka, Soumyava Basu, Tirupathi Rao","doi":"10.1080/17460913.2024.2417617","DOIUrl":"10.1080/17460913.2024.2417617","url":null,"abstract":"Aim: To investigate antagonistic interactions among pathogens, in ex vivo donor corneas infected with monomicrobial or polymicrobial combinations of antibiotic susceptible and resistant clinical isolates of Staphylococcus aureus (MSSA, MRSA) and Pseudomonas aeruginosa (S-PA, MDR-PA).Materials & methods: Scanning electron microscopy and antimicrobial susceptibility testing (AST, broth microdilution for minimum inhibitory and bactericidal concentrations [MIC/MBC]) pre-and post-polymicrobial interactions, in infected donor corneas.Results: MSSA lost viability with S-PA/MDR-PA, while MRSA formed larger cells, biofilm and lower MIC (teicoplanin) with S-PA, but lost viability with MDR-PA. S-PA had lower MIC (ceftazidime, meropenem, chloramphenicol) with MSSA, and lower MBC (cefoperazone, ciprofloxacin) and fewer cells with MRSA. MDR-PA had abundant cells and no change in AST with MSSA or MRSA.Conclusion: Significant antagonistic interactions occur in ocular polymicrobial infections, affecting antibiotic susceptible isolates more than resistant ones.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"117-135"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A plain language summary of the STRIVE and ReSTORE studies, which tested if rezafungin is effective and as safe as caspofungin at treating people with candidaemia and invasive candidiasis. 对STRIVE和ReSTORE研究的简单语言总结，该研究测试了rezafungin在治疗念珠菌血症和侵袭性念珠菌病方面是否与caspofungin一样有效和安全。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1080/17460913.2024.2426387

George R Thompson, Alex Soriano, Oliver A Cornely, Jalal A Aram, Peter G Pappas

引用次数: 0

Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid. 精氨酸与氟化物和甘油磷酸钙的结合：浓度和对生物膜液体的影响。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI: 10.1080/17460913.2024.2411921

Marina Lins Miranda, Karina Borges Salomão, Alberto Carlos Botazzo Delbem, Marcelle Danelon, Elis Rodrigues Oliveira Barbosa, Caio Sampaio, Lucas Arrais Campos, Fernanda Lourenção Brighenti

{"title":"Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid.","authors":"Marina Lins Miranda, Karina Borges Salomão, Alberto Carlos Botazzo Delbem, Marcelle Danelon, Elis Rodrigues Oliveira Barbosa, Caio Sampaio, Lucas Arrais Campos, Fernanda Lourenção Brighenti","doi":"10.1080/17460913.2024.2411921","DOIUrl":"10.1080/17460913.2024.2411921","url":null,"abstract":"Aim: To study the influence of varying concentrations of arginine (Arg) combined with fluoride (F) and/or calcium glycerophosphate (CaGP) on biofilms.Materials & methods: Biofilms were analyzed for acidogenicity, microbial viability and Ca, F and inorganic phosphorus (P) concentrations.Results: For total bacteria, the lowest viability was found in F-containing groups, regardless of the arginine concentrations and presence of CaGP. For aciduric bacteria, no significant differences were found among arginine concentrations in the presence of F. For MS, arginine concentrations did not influence MS viability in the presence of fluoride and CaGP only decreased viability at 3.2% Arg concentration. The arginine-treated groups showed the lowest acidogenicity. For ion concentrations in biofilms, CaGP showed the highest values for P; Arg+F for F; and CaGP/Arg+CaGP for Ca.Conclusion: Different concentrations of arginine did not affect the microbial viability or acidogenicity of biofilms. Moreover, 0.8% Arg did not increase ion concentration in biofilm fluid.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"201-212"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of MPT-64 protein in pleural tuberculosis cases by magnetic bead-gold nanoparticle-PCR amplified immunoassay. 磁珠-金纳米颗粒- pcr扩增免疫分析法检测胸膜结核患者MPT-64蛋白。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI: 10.1080/17460913.2024.2432179

Aishwarya Soni, Kiran Nehra, Bhawna Dahiya, Anam Rais, Tulika Prasad, Anjum Gahlaut, Vikas Raj, Reetu Sheoran, Aparna Parmar, Promod K Mehta

{"title":"Detection of MPT-64 protein in pleural tuberculosis cases by magnetic bead-gold nanoparticle-PCR amplified immunoassay.","authors":"Aishwarya Soni, Kiran Nehra, Bhawna Dahiya, Anam Rais, Tulika Prasad, Anjum Gahlaut, Vikas Raj, Reetu Sheoran, Aparna Parmar, Promod K Mehta","doi":"10.1080/17460913.2024.2432179","DOIUrl":"10.1080/17460913.2024.2432179","url":null,"abstract":"Aim: Diagnosis of pleural tuberculosis (TB) is challenging; thus, an efficient method is urgently needed.Methods: We developed a magnetic-bead-gold nanoparticle-PCR amplified immunoassay (MB-AuNP-I-PCR, liquid system) to detect the Mycobacterium tuberculosis MPT-64 protein in pleural TB patients. AuNPs functionalized with detection antibodies/oligonucleotides were characterized by UV-vis spectroscopy, Transmission/Scanning electron microscopy, Fourier-transform infrared spectrometer, ELISA, and PCR, whereas MBs conjugated with detection antibodies were validated by magneto-ELISA/UV-vis spectroscopy.Results: We utilized the MB-AuNP-I-PCR for MPT-64 detection in 99 clinical specimens which displayed 85.2% sensitivity and 97.8% specificity to diagnose pleural TB cases. Markedly, the sensitivity achieved by MB-AuNP-I-PCR was noticeably higher (p < 0.01) than magneto-ELISA and GeneXpert.Conclusion: This is a preliminary report to diagnose pleural TB cases by MB-AuNP-I-PCR with promising results that require further corroboration in a higher number of specimens.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"107-115"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic evaluation of treating invasive aspergillosis with isavuconazole, posaconazole and voriconazole in China. 在中国使用异武康唑、泊沙康唑和伏立康唑治疗侵袭性曲霉菌病的经济评估。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2423530

Qiang Liu, Pingyu Chen, Dunming Xiao, Jingxuan Wei, Yintao Lin, Tiantian Tao, Xin Li

引用次数: 0

Streptococcus intermedius: an underestimated pathogen in brain infection? 中间链球菌：脑部感染中被低估的病原体？

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2423524

Eliza Gil, James Hatcher, Sophia de Saram, Rebecca L Guy, Theresa Lamagni, Jeremy S Brown

{"title":"Streptococcus intermedius: an underestimated pathogen in brain infection?","authors":"Eliza Gil, James Hatcher, Sophia de Saram, Rebecca L Guy, Theresa Lamagni, Jeremy S Brown","doi":"10.1080/17460913.2024.2423524","DOIUrl":"10.1080/17460913.2024.2423524","url":null,"abstract":"Streptococcus intermedius is an oral commensal organism belonging to the Streptococcus anginosus group (SAG). S. intermedius causes periodontitis as well as invasive, pyogenic infection of the central nervous system, pleural space or liver. Compared with other SAG organisms, S. intermedius has a higher mortality as well as a predilection for intracranial infection, suggesting it is likely to possess virulence factors that mediate specific interactions with the host resulting in bacteria reaching the brain. The mechanisms involved are not well described. Intracranial suppuration (ICS) due to S. intermedius infection can manifest as an abscess within the brain parenchyma, or a collection of pus (empyema) in the sub- or extra-dural space. These infections necessitate neurosurgery and prolonged antibiotic treatment and are associated with a considerable burden of morbidity and mortality. The incidence of ICS is increasing in several settings, with SAG species accounting for an increasing proportion of cases. There is a paucity of published literature regarding S. intermedius pathogenesis as well as few published genomes, hampering molecular epidemiological research. This perspective evaluates what is known about the clinical features and pathogenesis of ICS due to S. intermedius and explores hypothetical explanations why the incidence of these infections may be increasing.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"163-177"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients. 门诊病人中引起甲癣的耐多药角化溶解性皮癣菌和非皮癣菌。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-02-01 Epub Date: 2024-11-26 DOI: 10.1080/17460913.2024.2428140

Sajeda Akter, Parveen Afroz Chowdhury, Marufatuzzahan, Al Hakim, Mehejabin Nurunnahar, Md Asraful Jahan, Md Siraj Uddin, Abul Kalam Azad

{"title":"Multidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients.","authors":"Sajeda Akter, Parveen Afroz Chowdhury, Marufatuzzahan, Al Hakim, Mehejabin Nurunnahar, Md Asraful Jahan, Md Siraj Uddin, Abul Kalam Azad","doi":"10.1080/17460913.2024.2428140","DOIUrl":"10.1080/17460913.2024.2428140","url":null,"abstract":"Aims: This study identified and determined antibiograms of keratinolytic dermatophytes (DM), non-dermatophytic molds (NDM), and yeasts causing onychomycosis.Methods: Morphological, cultural, and biochemical characteristics were used to identify DM and NDM. The keratinolytic activity (KA) and antibiograms were conducted with keratin azure and the agar diffusion method, respectively. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined using the microdilution method.Results: Onychomycosis was more prevalent in males (53%) than females, toenails (57%) than fingernails, and commercial employees (40%) than other employees or unemployed. Fungal growth was observed in 92.5% nail samples. DM, NDM, and yeasts caused 46%, 35%, and 19% onychomycosis, respectively. Trichophyton rubrum and Trichophyton mentagrophytes were the common DM. Five different genus of NDM and three different yeasts were isolated. The KA of DM was 30-45% higher than that of NDM and yeasts. All fungal isolates (FI) were resistant to griseofulvin and fluconazole. However, 71%, 64%, and 36% of FI were sensitive to terbinafine hydrochloride, nystatin, and ketoconazole, respectively, while 84% of DM and 46% of NDM were multidrug-resistant. The MIC and MFC of these antifungals against FI ranged from micrograms to milligrams.Conclusion: Multidrug resistance is growing in keratinolytic DM and NDM.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"137-147"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0