Future microbiology最新文献_第6页

Biliary tract infections caused by Enterococcus gallinarum and Escherichia coli: a rare case report. 由胆囊肠球菌和大肠埃希菌引起的胆道感染：罕见病例报告。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1080/17460913.2024.2417597

Cuilin He, Long Chen, Liangsong Zhao, Haixia Lin, Maozhu Liu, Enqiang Chen

{"title":"Biliary tract infections caused by Enterococcus gallinarum and Escherichia coli: a rare case report.","authors":"Cuilin He, Long Chen, Liangsong Zhao, Haixia Lin, Maozhu Liu, Enqiang Chen","doi":"10.1080/17460913.2024.2417597","DOIUrl":"10.1080/17460913.2024.2417597","url":null,"abstract":"Enterococcus gallinarum (E. gallinarum), an opportunistic pathogen with intrinsic resistance to vancomycin, has rarely been reported as a predominant pathogen responsible for biliary tract infections. Here, we report a case of biliary tract infections caused by E. gallinarum and Escherichia coli (E. coli) in a 57-year-old Chinese woman with symptoms of upper abdomen pain for 10 days. The patient initially received empiric treatment with cefmetazole but failed to improve. Subsequently, bile cultures identified E. gallinarum and E. coli, and cefmetazole was switched to linezolid and meropenem based on drug susceptibility testing. After 10 days of antibiotic therapy, the patient successfully recovered and was discharged from the hospital. The findings of this case remind us that E. gallinarum may be the causative factor of biliary tract infections, and timely identification of the causative organism and appropriate antibiotic treatment is important for optimal patient recovery.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"5-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new N-acylhydrazone oxadiazole derivative with activity against mycobacteria. 一种具有抗分枝杆菌活性的新型 N-酰腙噁二唑衍生物。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.1080/17460913.2024.2412439

Izabella Ventura Souza, Maria Luiza Fróes da Motta Dacome, Andrew Matheus Frederico Rozada, Jonathan Sanches Rosa, Eloisa Gibin Sampiron, Deisiany Gomes Ferreira, Gisele Freitas Gauze, Melyssa Fernanda Norman Negri, Regiane Bertin de Lima Scodro, Rosilene Fressatti Cardoso, Katiany Rizzieri Caleffi-Ferracioli

{"title":"A new N-acylhydrazone oxadiazole derivative with activity against mycobacteria.","authors":"Izabella Ventura Souza, Maria Luiza Fróes da Motta Dacome, Andrew Matheus Frederico Rozada, Jonathan Sanches Rosa, Eloisa Gibin Sampiron, Deisiany Gomes Ferreira, Gisele Freitas Gauze, Melyssa Fernanda Norman Negri, Regiane Bertin de Lima Scodro, Rosilene Fressatti Cardoso, Katiany Rizzieri Caleffi-Ferracioli","doi":"10.1080/17460913.2024.2412439","DOIUrl":"10.1080/17460913.2024.2412439","url":null,"abstract":"Aim: To evaluate the anti-Mycobacterium tuberculosis (Mtb) potential of the hybrid oxadiazol-4-methoxynaphthalene (6n) derived from N-acylhydrazone (4k).Materials & methods: The study determined the minimal inhibitory concentration of (6n) against Mtb H37Rv and Mtb clinical isolates, potential combination of (6n) with anti-tuberculosis drugs and carried out time kill curve assay of Mtb H37Rv. Additional contribution for the analysis of (6n) was explored by in silico pharmacokinetics, and in vitro and in vivo cytotoxicity determinations.Results: The newly synthesized molecule (6n) demonstrated anti-Mtb activity, low cytotoxicity and selectivity for Mtb.Conclusion: The derivative (6n) emerges as a potential anti-TB drug candidate.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"33-44"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted enzymes delivered by liposomes could address an unmet need in mycobacterial respiratory infections. 脂质体递送的靶向酶可以解决分枝杆菌呼吸道感染的未满足需求。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-12-08 DOI: 10.1080/17460913.2024.2423558

Jason W Holder, Richard A Slayden

引用次数: 0

Microbiome and bladder cancer: the role of probiotics in treatment. 微生物组与膀胱癌：益生菌在治疗中的作用。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1080/17460913.2024.2414671

Leila Dadgar-Zankbar, Maryam Mokhtaryan, Elnaz Bafandeh, Zahra Javanmard, Parisa Asadollahi, Taleih Darbandi, Roghayeh Afifirad, Shirin Dashtbin, Atieh Darbandi, Roya Ghanavati

{"title":"Microbiome and bladder cancer: the role of probiotics in treatment.","authors":"Leila Dadgar-Zankbar, Maryam Mokhtaryan, Elnaz Bafandeh, Zahra Javanmard, Parisa Asadollahi, Taleih Darbandi, Roghayeh Afifirad, Shirin Dashtbin, Atieh Darbandi, Roya Ghanavati","doi":"10.1080/17460913.2024.2414671","DOIUrl":"10.1080/17460913.2024.2414671","url":null,"abstract":"Bladder cancer (BCa) remains a significant global health challenge, with increasing interest in the role of the bladder microbiome in its pathogenesis, progression and treatment outcomes. The complex relationship between bladder cancer and the microbiome, as well as the potential impact of probiotics on treatment effectiveness, is currently under investigation. Research suggests that the microbiota may influence BCa recurrence prevention and enhance the efficacy of the Bacillus Calmette-Guérin (BCG) vaccine. Recent studies reveal differences in the bladder microbiome between individuals without bladder cancer and those with the disease. In the healthy bladder, Streptococcus and Lactobacillus are consistently identified as the most prevalent genera. However, in men, the predominant bacterial genera are Staphylococcus, Corynebacterium and Streptococcus, while in women with bladder cancer, Gardnerella and Lactobacillus are dominant. Probiotics, particularly Lactobacillus spp., can exhibit anti-tumor properties by competing with pathogenic strains involved in carcinogenesis or by producing regulatory substances. They regulate cancer signaling, induce apoptosis, inhibit mutagenic activity, downregulate oncogene expression, induce autophagy, inhibit kinases, reactivate tumor suppressors and prevent metastasis. These mechanisms have shown promising results in both preclinical and some clinical studies.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"73-90"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series. 脊髓神经囊虫病患者的治疗效果：已发表病例和系列病例的系统回顾。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.1080/17460913.2024.2428526

Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal

{"title":"Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series.","authors":"Ravindra Kumar Garg, Imran Rizvi, Harish Nigam, Shweta Pandey, Ravi Uniyal","doi":"10.1080/17460913.2024.2428526","DOIUrl":"10.1080/17460913.2024.2428526","url":null,"abstract":"Aims: Spinal neurocysticercosis is a rare central nervous system infection caused by the larval form of the Taenia solium. Due to its rarity, most knowledge is derived from isolated case reports. This review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease's clinical presentation and treatment outcomes.Methods: Following PRISMA guidelines, a comprehensive search was performed across various databases. The review included case reports, case series, and observational studies, and it is registered with PROSPERO (CRD42024496957).Results: This review analyzed 206 spinal neurocysticercosis cases (from 171 published reports). Symptoms persisted for one week to six months in 49% of cases, and common presentations included paraparesis/quadriparesis (61.7%) and neck/limb/back pain (40.8%). CSF abnormalities were observed in 23.8%. Thoracic involvement was most frequent (39.3%), followed by cervical (27.2%). Neurocysticercosis lesions in other regions, primarily the brain, were found in 18.9%. Differential diagnoses included spinal cord tumors (13.1%). Treatment often involved surgery alone (32%) or with cysticidal drugs (45.6%), with a 91.3% improvement rate, indicating favorable outcomes.Conclusions: Spinal neurocysticercosis primarily affects the thoracic and cervical regions. Most patients respond well to medical therapy; surgery is mainly for progressive neurological deficits.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"45-56"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study. 肠道双歧杆菌与移植失败之间的因果关系：孟德尔随机研究。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2417608

Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li

{"title":"Causal associations between gut Bifidobacteriaceae and transplant failure: a Mendelian randomization study.","authors":"Han Yan, Gongbin Lan, Qi Peng, Wei Zhang, Ying Wang, Xi Li","doi":"10.1080/17460913.2024.2417608","DOIUrl":"10.1080/17460913.2024.2417608","url":null,"abstract":"Aim: Transplant rejection and failure are the primary causes of shortened lifespan in transplant patients and are closely associated with the status of the human immune system. Gut microbiota have the capacity to modulate the human immune system. However, it remains unclear whether any gut microbiota can influence the risk of transplant failure.Materials & methods: A Mendelian randomization study was conducted to explore the causal relationship between gut microbiota and transplant failure. This study utilized three Genome-Wide Association Study results focusing on the gut microbiome, transplant failure and transplantation status. Single nucleotide polymorphisms that were strongly associated with gut microbiota abundance were selected as instrumental variables.Results: The abundance of Bifidobacteriaceae demonstrated a significant causal relationship with transplant failure (inverse variance weighted [IVW] p = 0.049, OR = 0.658, 95% CI: 0.433-0.998), but was not related to the risk of transplantation status (IVW p > 0.200). Notably, a higher intestinal abundance of Bifidobacteriaceae corresponded to a decreased risk of transplant failure. Bifidobacteriaceae instrumental variables were enriched in pathways related to synapses and membranes.Conclusion: The Bifidobacteriaceae may play a crucial role in the mechanism of transplant failure. These study results contribute to elucidating the mechanisms underlying transplant failure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"23-31"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella. 来自灰飞虱的抗隐球菌多肽：在三维细胞培养物和灰飞虱中的毒性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/17460913.2024.2421632

Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida

{"title":"Peptides from Galleria mellonella against Cryptococcus spp: toxicity in three-dimensional cell cultures and G. mellonella.","authors":"Marcos William De Lima Gualque, Carolina Orlando Vaso, Kelvin Sousa Dos Santos, Mariana Cristina Galeane, Paulo César Gomes, Mario Sérgio Palma, Maria José Soares Mendes Giannini, Andrei Moroz, Ana Marisa Fusco Almeida","doi":"10.1080/17460913.2024.2421632","DOIUrl":"10.1080/17460913.2024.2421632","url":null,"abstract":"Aim: This work aimed to test peptides against the planktonic and biofilm form of Cryptococcus spp. and in vitro toxicity using three-dimensional (3D) cells characterized and evaluate in vivo toxicity in Galleria mellonella.Materials & methods: Susceptibility tests were conducted on the planktonic form and biofilm formation. The toxicity of the peptides was evaluated in lung and brain cells in monolayer (2D) and 3D mono- and co-culture, in addition to in vivo analysis with G. mellonella.Results: Susceptibility values ranged from 31.25 to over 250 µg/ml with a fungicidal profile. Regarding toxicity, the PepM2 peptide was not toxic in 3D culture (500 µg/ml). G. mellonella, showed a survival rate of more than 85% In assays with brain and lung cell lines, concentrations ranged from 4 × 104 to 4 × 103 cells/well for brain cells and 1 × 103 cells/well for lung cells. Cocultures used 1 × 105 brain and 1 × 103 lung cells.Conclusion: This study shows that the peptides have great potential against cryptococcosis, and all spheroids were characterized as having a spheroidal and compact structure.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"11-21"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities. 高危人群结核性脑膜炎的系统回顾：死亡率和诊断差异。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-10-03 DOI: 10.1080/17460913.2024.2366604

Andressa Lorena Ieque, Carolina Trevisolli Palomo, Deborah de Castro Moreira, Jean Eduardo Meneguello, Letícia Sayuri Murase, Lincoln Luís Silva, Vanessa Pietrowski Baldin, Katiany Rizzieri Caleffi-Ferracioli, Vera Lucia Dias Siqueira, Rosilene Fressatti Cardoso, Jorge Juarez Vieira Teixeira, Regiane Bertin De Lima Scodro

引用次数: 0

Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area. 元基因组下一代测序在布鲁氏菌病诊断中的应用：来自非流行区的五个病例。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1080/17460913.2024.2363632

Xuan Zhang, Xinfei Yao, Huixin Chen, Dongsheng Han, Meifang Yang

引用次数: 0

Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp. 芒果苷可增强抗真菌药物对氟康唑耐药念珠菌属的活性。

IF 2.5 4区生物学

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/17460913.2024.2366627

Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva

{"title":"Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida spp.","authors":"Thais Lima Ferreira, Amanda Cavalcante Leitão, Lisandra Juvêncio da Silva, Livia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sarah Alves Barbosa, João Batista de Andrade Neto, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva","doi":"10.1080/17460913.2024.2366627","DOIUrl":"10.1080/17460913.2024.2366627","url":null,"abstract":"Aim: To evaluate the antifungal activity of mangiferin against Candida spp. resistant to fluconazole.Materials & methods: The antifungal activity of mangiferin was assessed using broth microdilution and its interaction with azoles and amphotericin B was evaluated by checkerboard. The activity of mangiferin against Candida spp. biofilms was assessed using the MTT colorimetric assay and its possible mechanism of action was evaluated using flow cytometry.Results: Mangiferin showed activity against Candida albicans, Candida tropicalis and Candida parapsilosis resistant to fluconazole and showed synergism with azoles and amphotericin B. Mangiferin increased the activity of antifungals against Candida biofilms and caused depolarization of the mitochondrial membrane and externalization of phosphatidylserine, suggesting apoptosis.Conclusion: mangiferin combined with antifungals has potential against Candida spp.","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"1157-1170"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0