希腊 COVID-19 大流行期间的艰难梭菌感染流行病学。

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI:10.1080/17460913.2024.2358653

Theodoros Karampatakis, Eleni Kandilioti, Helen Katsifa, Anna Nikopoulou, Celine Harmanus, Katerina Tsergouli, Ed Kuijper, Melina Kachrimanidou

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引用次数: 0

摘要

目的：旨在强调COVID-19大流行期间希腊一家三级医院艰难梭菌感染（CDI）的发病率和流行病学。研究方法开展一项单中心前瞻性队列观察研究（2021 年 10 月至 2022 年 4 月）。从住院病人粪便样本中培养出 125 株艰难梭菌分离株，并通过 PCR 对毒素 A（ccdA）、毒素 B（ccdB）、二元毒素（ccdtA 和 cdtB）基因以及ccdC 的调控基因进行筛查。结果CDI 感染率增至每 10,000 个住院日 13.1 例。最常见的 PCR 核型包括与 RT027 相关的高致病性 RT181（73.6%）、推测为高致病性的 RT126（8.0%）和毒素 A 阴性的 RT017（7.2%）。结论虽然 CDI 发病率大幅上升，但 CDI 流行病学保持稳定。

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Clostridioides difficile infection epidemiology during the COVID-19 pandemic in Greece.

Aim: The aim was to highlight the incidence and epidemiology of C. difficile infections (CDI) in a tertiary Greek hospital during the COVID-19 pandemic.Methods: A single-center prospective observational cohort study was conducted (October 2021 until April 2022). 125 C. difficile isolates were cultured from hospitalized patients stool samples and screened by PCR for toxin A (tcdA), toxin B (tcdB), binary toxin (cdtA and cdtB) genes and the regulating gene of tcdC.Results: The incidence of CDI increased to 13.1 infections per 10,000 bed days. The most common PCR ribotypes identified included hypervirulent RT027-related RT181 (73.6%), presumably hypervirulent RT126 (8.0%) and toxin A negative RT017 (7.2%).Conclusion: Although the incidence of CDI increased significantly, the CDI epidemiology remained stable.

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.