囊性纤维化患者感染非结核分枝杆菌的分子机制分析。

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-05-03 DOI:10.2217/fmb-2023-0237

Qihuang Chen, Jin Li

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引用次数: 0

摘要

目的：本研究旨在探讨囊性纤维化（CF）并发非结核分枝杆菌（NTM）感染的分子机制。材料与方法：从 GEO 数据库下载囊性纤维化合并非结核分枝杆菌感染患者的表达谱。交叉分析得出了 78 个与非结核分枝杆菌感染 CF 相关的基因。研究了蛋白质-蛋白质相互作用（PPI）网络和枢纽基因的功能。结果发现了五个枢纽基因（PIK3R1、IL1A、CXCR4、ACTN1、PFN1），它们主要富集在肌动蛋白相关的生物过程和通路中。调控枢纽基因的转录因子 RELA、JUN、NFKB1 和 FOS 可调控 IL1A 的表达，而其他 21 个转录因子可调控 CXCR4 的表达。结论总之，本研究可为了解非结核菌感染 CF 的机制提供新的视角。

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Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis.

Aim: This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. Materials & methods: Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. Results: Five hub genes (PIK3R1, IL1A, CXCR4, ACTN1, PFN1) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors RELA, JUN, NFKB1 and FOS that regulated hub genes modulated IL1A expression, while 21 other transcription factors regulated CXCR4 expression. Conclusion: In summary, this study may provide new insights into the mechanisms of CF with NTM infection.

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.