乳铁蛋白及其衍生功能片段的协同作用是防治粘液瘤病的一种有前途的治疗剂。

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-07-02 Epub Date: 2024-06-21 DOI:10.1080/17460913.2024.2352263

Surabhi Pandit, Anamika Singh, Jiya Singh, Immaculata Xess, Tej P Singh, Gagandeep Singh, Pradeep Sharma, Sujata Sharma

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引用次数: 0

摘要

目的：目前，我们拥有的抗真菌剂种类有限。我们迫切需要发现有效、安全且价格合理的新型抗真菌剂。材料与方法：本研究报告了本地乳铁蛋白（LF）及其功能片段 CLF、RR6 和 LFcin 对三种常见粘菌的抗粘菌作用。使用棋盘格技术分析了 LF 与两性霉素 B、异武康唑和泊沙康唑等抗真菌剂的协同作用。结果显示使用片段处理后，三种粘菌均表现出抑制作用。棋盘试验证实，原生 LF 与两性霉素 B 联合使用时，对粘菌的协同作用最佳：这些结果凸显了原生 LF 对粘菌的潜在治疗价值。

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Synergistic action of lactoferrin and its derived functional fragments as a promising therapeutic agent in combating mucormycosis.

Aim: Currently, we have limited armamentarium of antifungal agents against Mucorales. There is an urgent need to discover novel antifungal agents that are effective, safe and affordable. Materials & methods: In this study, the anti-Mucorale action of native lactoferrin (LF) and its functional fragments CLF, RR6 and LFcin against three common Mucorale species are reported. The synergistic action of LF with antifungal agents like amphotericin B, isavuconazole and posaconazole was analyzed using checkerboard technique. Results: All the three mucor species showed inhibition when treated with fragments. The checkerboard assay confirmed that native LF showed the best synergistic action against Mucorales in combination with Amphotericin B. Conclusion: These results highlight the potential therapeutic value of native LF against Mucorales.

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.