Trichosporon asahii: emerging challenges in pathogenesis and drug resistance.

IF 2.5 4区 生物学 Q3 MICROBIOLOGY
Future microbiology Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI:10.1080/17460913.2025.2457858
Hanzhao Zhang, Jingping Zhang
{"title":"<i>Trichosporon asahii</i>: emerging challenges in pathogenesis and drug resistance.","authors":"Hanzhao Zhang, Jingping Zhang","doi":"10.1080/17460913.2025.2457858","DOIUrl":null,"url":null,"abstract":"<p><p><i>Trichosporon asahii</i> (<i>T. asahii</i>) is an opportunistic pathogenic fungus that often causes severe infections in immunosuppressed patients. Among <i>Trichosporon</i> species, <i>T. asahii</i> is the most pathogenic and lethal species. Current research faces challenges related to unknown pathogenic mechanisms, complex resistance mechanisms, insufficiently rapid and accurate diagnostic methods, and insufficient research on susceptibility to infection. These issues need to be explored in depth. This review summarizes research progress on the origin and classification of <i>T. asahii</i>, its virulence factors and pathogenic mechanisms, epidemiological characteristics, infection modes, diagnostic methods, drug treatment options, and drug resistance mechanisms. Traditional culture combined with molecular biology techniques, such as polymerase chain reaction and gene sequencing, has improved the accuracy and speed of detection. Treatment relies mainly on azole antifungal drugs and amphotericin B; however, patients are facing the problem of drug resistance. New techniques, such as gene knockout and gene sequencing, have identified resistance mechanisms, thus supporting the development of novel antifungal drugs. In summary, an in-depth study of <i>T. asahii</i> will aid in developing more effective diagnostic and therapeutic methods and improve patient prognosis.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":" ","pages":"333-343"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938978/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2025.2457858","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/27 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Trichosporon asahii (T. asahii) is an opportunistic pathogenic fungus that often causes severe infections in immunosuppressed patients. Among Trichosporon species, T. asahii is the most pathogenic and lethal species. Current research faces challenges related to unknown pathogenic mechanisms, complex resistance mechanisms, insufficiently rapid and accurate diagnostic methods, and insufficient research on susceptibility to infection. These issues need to be explored in depth. This review summarizes research progress on the origin and classification of T. asahii, its virulence factors and pathogenic mechanisms, epidemiological characteristics, infection modes, diagnostic methods, drug treatment options, and drug resistance mechanisms. Traditional culture combined with molecular biology techniques, such as polymerase chain reaction and gene sequencing, has improved the accuracy and speed of detection. Treatment relies mainly on azole antifungal drugs and amphotericin B; however, patients are facing the problem of drug resistance. New techniques, such as gene knockout and gene sequencing, have identified resistance mechanisms, thus supporting the development of novel antifungal drugs. In summary, an in-depth study of T. asahii will aid in developing more effective diagnostic and therapeutic methods and improve patient prognosis.

朝日毛丝虫病:发病机制和耐药性的新挑战。
朝日毛霉(T.朝日)是一种机会致病性真菌,经常引起免疫抑制患者严重感染。在毛丝虫病种中,朝日毛丝虫病是致病性和致死率最高的一种。目前的研究面临着致病机制未知、耐药机制复杂、诊断方法不够快速准确、感染易感性研究不足等挑战。这些问题需要深入探讨。本文综述了日本血吸虫的起源和分类、毒力因素和致病机制、流行病学特征、感染方式、诊断方法、药物治疗选择、耐药机制等方面的研究进展。传统培养与聚合酶链反应和基因测序等分子生物学技术相结合,提高了检测的准确性和速度。治疗主要依靠唑类抗真菌药物和两性霉素B;然而,患者正面临着耐药性的问题。基因敲除和基因测序等新技术已经确定了耐药机制,从而支持了新型抗真菌药物的开发。总之,深入研究朝日肠杆菌将有助于开发更有效的诊断和治疗方法,改善患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Future microbiology
Future microbiology 生物-微生物学
CiteScore
4.90
自引率
3.20%
发文量
134
审稿时长
6-12 weeks
期刊介绍: Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信