Frontiers in Nutrition最新文献

{"title":"Correction: Appetite measures as correlates of clinical response in mood disorders treated with ketamine: systematic review.","authors":"Jakub Słupski, Agnieszka Mechlińska, Adam Włodarczyk, Aleksander Kwaśny, Joanna Szarmach, Anita Słupska, Wiesław Jerzy Cubała","doi":"10.3389/fnut.2025.1699569","DOIUrl":"https://doi.org/10.3389/fnut.2025.1699569","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnut.2025.1616859.].</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1699569"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.","authors":"Kuo-Chuan Hung, Ting-Sian Yu, Chih-Wei Hsu, Yi-Chen Lai, Ping-Heng Tan, Yao-Tsung Lin, Li-Kai Wang, Chien-Ming Lin, I-Wen Chen","doi":"10.3389/fnut.2025.1653151","DOIUrl":"10.3389/fnut.2025.1653151","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a major global health challenge, with diabetic kidney disease (DKD) representing one of its most serious complications. Although zinc deficiency is common in diabetes, large-scale clinical evidence on its role as a predictor of new-onset DKD is limited.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the TriNetX Analytics Network Platform to analyze patients aged ≥18 years who underwent zinc testing (2010-2023). Patients were classified into zinc deficiency (serum zinc <70 μg/dL) and control groups (70-120 μg/dL). After 1:1 propensity score matching, we analyzed the risk of new-onset DKD at two-year follow-up. The secondary outcomes included the risks of all-cause mortality, acute kidney injury (AKI), chronic kidney disease (CKD), poor glycemic control (HbA1c ≥ 7%), and ophthalmic complications.</p><p><strong>Results: </strong>The final matched cohort included 20,470 patients (10,235 per group) with a mean age of 54 years. Zinc deficiency was associated with a 42% increased risk of new-onset DKD (hazard ratio [HR] 1.42, 95% confidence interval [CI]: 1.20-1.68, <i>p</i> < 0.001). Additional significant associations included all-cause mortality (HR: 1.65, 95% CI: 1.40-1.95, <i>p</i> < 0.001), AKI (HR: 1.47, 95% CI: 1.27-1.69, <i>p</i> < 0.001), and CKD development (HR: 1.18, 95% CI: 1.02-1.37, <i>p</i> = 0.028). No significant associations were observed with poor glycemic control or ophthalmic complications. Subgroup analyses showed stronger associations in patients with diabetes duration <5 years (HR 1.65, 95% CI: 1.35-2.02, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Zinc deficiency is an independent predictor of new-onset DKD and adverse outcomes in T2DM, particularly in early disease. These findings support zinc deficiency as a potential biomarker for risk stratification and highlight the need for prospective studies to evaluate whether zinc supplementation can reduce risk.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1653151"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbial signatures associated with the Indian lean MASLD phenotype.","authors":"Priyankar Dey","doi":"10.3389/fnut.2025.1673517","DOIUrl":"10.3389/fnut.2025.1673517","url":null,"abstract":"<p><p>Lean Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) is a substantial challenge in India, manifesting in individuals with normal BMI and indicative of a <i>'metabolically obese normal weight</i>' phenotype. This review delineates the unique gut microbial signatures that characterize Indian lean MASLD, distinguishing it from obese MASLD. Principal modifications encompass substantial decreases in <i>Faecalibacterium</i> (particularly <i>F. prausnitzii</i>), <i>Ruminococcus</i>, <i>Lactobacillus</i>, <i>Lachnospira</i>, and <i>Subdoligranulum</i>, alongside an increase in pro-inflammatory <i>Escherichia-Shigella</i>. Dysbiotic patterns in India are influenced by factors such as fiber-deficient diets rich in refined carbohydrates, visceral obesity, insulin resistance, and genetic predispositions, including the PNPLA3 rs738409 polymorphism. Microbial alterations can contribute to disease by compromising gut barrier integrity, facilitating endotoxemia, and affecting the generation of beneficial metabolites. The combination signature of increased <i>Escherichia-Shigella</i> and decreased <i>Lachnospira/Subdoligranulum</i> exhibits significant diagnostic accuracy for detecting lean MASLD in the Indian population. These findings highlight lean MASLD as a mechanistically unique condition necessitating customized diagnostic and treatment approaches beyond standard weight management.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1673517"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of healthy eating index score and n-3 fatty acid intake with cardiovascular diseases incidence and lipid biomarkers in Alberta's tomorrow project cohort.","authors":"Reihane Taheri, Olivia Weaver, Ming Ye, Jennifer E Vena, Jeffrey A Johnson, Donna Vine, Dean Eurich, Spencer D Proctor","doi":"10.3389/fnut.2025.1630126","DOIUrl":"10.3389/fnut.2025.1630126","url":null,"abstract":"<p><strong>Introduction: </strong>Unhealthy diet and dyslipidemia are major risk factors for cardiovascular disease (CVD). Studies have shown an inverse association between greater n-3 fatty acid (FA) intake and reduced dyslipidemia and CVD risk. We aimed to assess the association of the healthy eating index (HEI) score and n-3 FA intake with CVD incidence and non-fasting RC in the Alberta's Tomorrow Project (ATP) cohort.</p><p><strong>Methods: </strong>This is a prospective study on a subset of ATP study participants (<i>n</i> = 23,248), with the mean age of 50.2 (35-69) years, 36% male and 64% female, and no history of cancer or CVD in Alberta, Canada. Dietary intake was assessed using the Canadian Diet History Questionnaire (CDHQ), from which the Canadian HEI-2005 score and total n-3 FA intake were calculated. Lipid panel markers were measured from non-fasting blood samples, and CVD was defined using the International Statistical Classification of Diseases and Related Health Problems from linked administrative health records. The Cox proportional hazard model, linear regression, and logistic regression were used to assess the association of dietary intakes with CVD incidence, and lipid biomarkers.</p><p><strong>Results: </strong>The mean follow-up was 13.9 years. For every 1 unit increase in the HEI score, the adjusted Hazard Ratio (HR) of developing CVD decreased [HR: 0.98 (95% confidence interval (CI) 0.97-0.98), 0.99 (95%CI 0.98-0.99), and 0.97 (95%CI 0.97-0.98) in females, males, and total cohort, respectively (<i>p</i> < 0.05)]. No significant association was found between absolute n-3 FA intake (g/d) with CVD incidence. However, higher relative intake (i.e., n-3 FA as proportion of energy) increased the risk of developing CVD [HR = 1.42 (95%CI 1.1-1.84), <i>p</i> = 0.006] in males. Adjusted multivariate regression in a subset (<i>n</i> = 8,458) showed no association between n-3 FA (g/d) intake and lipid biomarkers but a significant inverse association between HEI score and non-fasting RC [coefficient: -0.006 (95%CI -0.009--0.003) for females and -0.01 (95%CI -0.018--0.005) for males], and TG levels [-0.01 (95%CI -0.015--0.006) for females and -0.01 (95%CI -0.02--0.006) for males].</p><p><strong>Discussion: </strong>Higher overall diet quality but not n-3 FA intake was associated with a lower risk of CVD incidence and non-fasting RC.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1630126"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between prognostic nutritional index and its components (albumin and lymphocyte count) and all-cause mortality in lung cancer patients: a hospital-based study with database external validation.","authors":"Zhuolin Qin, Longqian Li, Ming Hou, Cheng Wang","doi":"10.3389/fnut.2025.1649334","DOIUrl":"10.3389/fnut.2025.1649334","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the prognostic value of the Prognostic Nutritional Index (PNI), derived from serum albumin and lymphocyte count, in predicting all-cause mortality among lung cancer patients, using both a hospital-based cohort and an external validation dataset.</p><p><strong>Methods: </strong>A hospital-based retrospective cohort study was conducted, supplemented with external validation using the NHANES database. Univariate and multivariate Cox proportional hazards regression analyses were performed to assess associations between PNI, its components, and mortality. Variance inflation factor (VIF) testing was used to evaluate multicollinearity. Kaplan-Meier (KM) curves and log-rank tests were employed to compare survival across PNI tertiles. Restricted cubic spline (RCS) models were applied to examine non-linear relationships between continuous variables and mortality risk.</p><p><strong>Results: </strong>In the hospital cohort, univariate Cox analysis revealed significant associations between PNI (HR = 0.89, 95% CI: 0.85-0.93, <i>p</i> < 0.01), albumin (HR = 0.88, 95% CI: 0.86-0.92, <i>p</i> < 0.01), lymphocyte count (HR = 0.60, 95% CI: 0.50-0.80, <i>p</i> < 0.01), and mortality. After multivariate adjustment and VIF testing (all VIF < 5), PNI remained an independent predictor of mortality. KM curves showed significant survival differences across PNI tertiles (log-rank <i>p</i> < 0.001). RCS analysis indicated a non-linear relationship between PNI and mortality risk (<i>p</i> for nonlinear = 0.007). External validation using NHANES data consistently supported the association between PNI and mortality, with significant survival differences in KM analysis (log-rank <i>p</i> = 0.011) and a non-linear trend in RCS.</p><p><strong>Conclusion: </strong>PNI and its components-albumin and lymphocyte count-are significantly associated with all-cause mortality in lung cancer patients. PNI demonstrates promise as a practical and reproducible prognostic indicator, potentially aiding in risk stratification and clinical decision-making.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1649334"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a predictive equation for resting energy expenditure in pediatric patients with oncological diagnosis.","authors":"Alda Daniela García-Guzmán, Sandra Nayeli Becerra-Morales, Beatriz Adriana Pinzón-Navarro, Daffne Danae Baldwin-Monroy, Marta Zapata-Tarres, Liliana Velasco-Hidalgo, Azalia Avila-Nava, Rocío Del Socorro Cárdenas-Cardos, Karla Maldonado-Silva, Martha Guevara-Cruz, Isabel Medina-Vera","doi":"10.3389/fnut.2025.1656975","DOIUrl":"10.3389/fnut.2025.1656975","url":null,"abstract":"<p><strong>Background and aim: </strong>Pediatric cancer is a significant health concern, particularly in low- and middle-income countries with lower cure rates. The nutritional status of these patients is crucial because malnutrition, whether due to a deficiency or excess of energy, can negatively impact treatment response and long-term outcomes. Since resting energy expenditure (REE) is a key parameter for planning appropriate nutritional support, accurate assessment is essential. However, the most precise methods, such as indirect calorimetry (IC), are not always available, leading to predictive equations based on easily accessible variables. These equations may be inaccurate if they are not specifically designed for children with cancer. Therefore, this study presents an equation to estimate REE in pediatric patients with oncological diagnosis and to compare the accuracy of this equation with those of previous equations developed in different pediatric populations to assess its utility in a clinical population.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted in pediatric patients aged 6 to <18 years with a recent oncological diagnosis. After diagnosis, anthropometric measurements were taken, nutritional status was assessed, body composition was determined using bioelectrical impedance, and REE was measured through IC.</p><p><strong>Results: </strong>A total of 226 pediatric participants were evaluated, of whom 203 were included in the final analysis. The majority had solid tumors (68.5%), followed by leukemia (20.2%) and brain tumors (11.3%). Significant differences in anthropometric and biochemical variables were observed among the different diagnoses, with patients with brain tumor having lower REE/kg of body weight. Two new REE prediction equations specific to this population were developed: the INP-simple model, which is based on basic clinical variables, and the INP-Morpho model, which includes body composition. Both new INP equations showed less bias in REE estimation (114.8, 95% CI: -408, 638) than traditional equations, including the Harris-Benedict (-133.6, 95% CI: -671.5, 404.2), FAO (-178.8, 95% CI: -683.9, 326.3), Schofield (-185.4, 95% CI: -697.6, 326.8), IOM (-201, 95% CI: -761.7, 359.7), Oxford (-110.6, 95% CI: -661.4, 440.1), Kaneko (-135.6, 95% CI: -652.5, 381.4) and Müller (-162.6, 95% CI: -715.1, 389.9) equations but not the Molnár equation (-82.3, 95% CI: -741.3, 576.7).</p><p><strong>Conclusion: </strong>Children with cancer often have energy expenditure levels that differ from the recommended values, increasing their risk of malnutrition or obesity. Predictive equations specifically developed for this population may offer improved accuracy for estimating REE in clinical settings, although external validation is still needed.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1656975"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking altitude and child growth: evidence from a multi-altitude study in Tibet.","authors":"Shubin Shao, Xiaowei Ma, Dawa Wangyai, Jian Wang, Agudamu, Yang Zhang","doi":"10.3389/fnut.2025.1648246","DOIUrl":"10.3389/fnut.2025.1648246","url":null,"abstract":"<p><strong>Objective: </strong>High-altitude environments have long been linked to growth deficits in children, often attributed to chronic hypoxia. Yet, emerging evidence from better-resourced highland communities suggests that socioeconomic and infrastructural factors may be equally or more influential. This study evaluated growth and nutritional disparities among Tibetan children across altitudes and assess the continued relevance of the altitude-growth paradigm.</p><p><strong>Methods: </strong>A repeated cross-sectional study in 2019 and 2024 surveyed 28 schools in Qamdo, Tibet (3200-4,500 m), collecting anthropometric and lung function data from 8,230 children (47.4% boys) aged 6-17 years. Regional growth standards were updated using GAMLSS. Logistic regression examined associations of age, sex, and altitude with stunting, underweight, and overweight, using girls and ~3,200 m as the reference groups.</p><p><strong>Results: </strong>In 2024, adolescent height approached national norms, with marked gains since 2019. Stunting (12.3%) and underweight (9.2%) remained prevalent. Compared to ~3,200 m, children at ~3,600 m had higher odds of stunting (OR 6.10, 95% CI 4.94-7.58) and underweight (OR 9.03, 95% CI 7.05-11.63), while >4,000 m showed smaller increases (stunting OR 3.43; underweight OR 4.63). Boys had greater odds of stunting (OR 1.16, 95% CI 1.02-1.33) and underweight (OR 1.34, 95% CI 1.15-1.56) than girls. Body mass index rose in 2024 but remained below national averages; body fat was consistently lower.</p><p><strong>Conclusion: </strong>Non-linear altitude effects and catch-up growth under improved conditions suggest altitude is an indirect risk factor mediated by modifiable socioeconomic constraints, challenging deterministic altitude-growth models and supporting targeted nutrition and infrastructure policies.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1648246"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrient inadequacy in Europe: the overlooked role of food supplements in health resilience.","authors":"Samantha Christie, David Crooks, Rowena Thomson-Selibowitz, Ashley Green-Woolard, Konstantinos Mantantzis","doi":"10.3389/fnut.2025.1686365","DOIUrl":"10.3389/fnut.2025.1686365","url":null,"abstract":"<p><p>Micronutrient inadequacy is a significant issue in Europe, partly driven by an evolving food landscape. Food supplements play a critical role in offsetting these gaps, particularly in vulnerable groups, and contribute to the overall health resilience, wellbeing, and productivity across the life-course and population. However, both the extent and impact of micronutrient insufficiency and the essential role of food supplements remain underrecognized in public health, clinical training, and practice. We examine the reasons behind this widespread under-acknowledgment, along with selected evidence demonstrating the tangible benefits of food supplements in bridging micronutrient gaps and fostering health resilience. We discuss the health policy implications of incorporating food supplements into public health strategies to enhance nutritional status, help reduce the risk of chronic diseases, improve workforce productivity, and reduce healthcare costs across Europe. Ultimately, we call for an integrated approach to nutrition policy that fully recognizes and utilizes the value of food supplements in supporting a healthier and more resilient European population.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1686365"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the CIPA nutritional screening tool in over 30,000 hospitalized patients: a retrospective study (2014-2022).","authors":"Javier García Fernández, José Pablo Suárez-Llanos, Cristina Lorenzo González, Elena Márquez Mesa, María Araceli García Núñez, Maria Demelza Farrais Luis, Manuel Enrique Fuentes Ferrer","doi":"10.3389/fnut.2025.1648228","DOIUrl":"10.3389/fnut.2025.1648228","url":null,"abstract":"<p><strong>Introduction: </strong>Malnutrition is a well-established negative prognostic factor in hospitalized patients, contributing to increased morbidity and mortality. The CIPA (Control of Food Intake, Protein, and Anthropometry) screening tool was developed to identify patients at nutritional risk and to predict adverse clinical outcomes across both surgical and non-surgical populations. This study aimed to evaluate the prognostic value of the CIPA tool in routine clinical practice by analyzing its association with key clinical outcomes since its implementation at our center in 2014.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of inpatients screened with the CIPA tool between 2014 and 2022 in a tertiary care hospital. The association between CIPA screening results and clinical outcomes-including 3- and 6-month mortality, early hospital readmission, and length of stay-was assessed, with a particular focus on patients with active oncological disease. Regression analyses were adjusted for age, sex, admitting department, and type of admission.</p><p><strong>Results: </strong>A total of 30,581 patients were included, of whom 31.4% screened positive for malnutrition using the CIPA tool. CIPA-positive patients had significantly higher mortality at 3 months (adjusted OR 3.02; 95% CI: 2.78-3.30; <i>p</i> < 0.001) and at 6 months (adjusted OR 2.69; 95% CI: 2.49-2.91; <i>p</i> < 0.001). They also exhibited increased rates of early readmission (adjusted OR 1.43; 95% CI: 1.34-1.53; <i>p</i> < 0.001) and a longer median hospital stay (<i>β</i> = 0.25; 95% CI: 0.23-0.27; <i>p</i> < 0.001).</p><p><strong>Discussion: </strong>In this large, real-world cohort, the CIPA nutritional screening tool was a robust predictor of poorer clinical outcomes among hospitalized patients with positive screening results. These findings support the utility of CIPA screening for early identification of high-risk patients, enabling targeted nutritional interventions to potentially mitigate adverse outcomes.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1648228"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing antioxidant activity and quality of <i>Triadica cochinchinensis</i> honey via an automated temperature-humidity controlled cabinet.","authors":"Huizhi Jiang, Weixuan Chen, Wujun Jiang, Feng Liu, Xiaobo Wu, Weiyu Yan, Xujiang He, Zhijiang Zeng","doi":"10.3389/fnut.2025.1641551","DOIUrl":"10.3389/fnut.2025.1641551","url":null,"abstract":"<p><p>Honey, a key beekeeping product, is rich in antioxidants and bioactive compounds, offering antimicrobial, anti-inflammatory and health-promoting properties. The water content of honey is directly correlated with its quality. However, <i>Triadica cochinchinensis</i> honey (TCH), produced in high humidity regions, is frequently at risk of fermentation and spoilage due to excessive water content. A dewatering method using an automated, temperature- and humidity-controlled honey cabinet was applied to address this issue and investigate its effects on TCH. After 96 h of treatment, the water content of TCH capped honeycombs effectively reduced to below 18%. Meanwhile, most physicochemical parameters, volatile compounds and chemical compositions largely remained unchanged, thereby preserving their nutritional value and flavor. Moreover, phenolics and flavonoids levels significantly increased by 15.83 and 25.42%, respectively, thereby enhancing the honey's antioxidant capacity. Our results indicated that this method can significantly enhance maturity and improve the quality of TCH, providing reference value for other honey produced in high humidity regions. The utilization of honey cabinets can enhance the market value of honey in these regions, and consumers can benefit from higher-quality honey with greater biological activity.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1641551"},"PeriodicalIF":4.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}