Frontiers in Nutrition最新文献

{"title":"Effects of one-week intake of different edible oils on the urinary proteome of rats.","authors":"Yan Su, Youhe Gao","doi":"10.3389/fnut.2025.1571846","DOIUrl":"10.3389/fnut.2025.1571846","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of different edible oils on the rat body, we analyzed alterations in the urinary proteome and post-translational modifications (PTMs) following a one-week intake of olive oil, butter, lard, hydrogenated vegetable oil, and rapeseed oil.</p><p><strong>Methods: </strong>Thirty male Wistar rats (7 weeks old, ~200 g) were randomly allocated into six groups (<i>n</i> = 5 per group). Group A served as the control group, while groups B-F were administered different edible oils. The daily intakes were calculated, respectively, according to the \"2015-2020 Dietary Guidelines for Americans\" and the \"Dietary Guidelines for Chinese Residents.\" Urine samples collected after 1 week were analyzed using label-free quantitative proteomics via LC-MS/MS. Differentially expressed proteins and differential post-translational modifications in the urinary proteome were screened for functional analysis.</p><p><strong>Results: </strong>All edible oil groups exhibited significant alterations in metabolic pathways, with distinct proteomic profiles observed across oil types, but there were few common differentially expressed proteins among different groups. In addition, the olive oil group and the butter group were enriched with many biological pathways related to the nervous system, and the rapeseed oil group produced more differentially expressed proteins and biological pathways related to immunity.</p><p><strong>Conclusion: </strong>The urinary proteome of rats showed significant changes after one-week intake of edible oils, and the effects of various edible oils on the rat urinary proteome were different from each other. This effect is comprehensive and multi-dimensional at the level of the rat body. The changes in post-translational modifications of the proteome were relatively small.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1571846"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of antibiotic associated diarrhea induced gut microbiota disorder by using <i>Dictyophora indusiata</i> water-insoluble polysaccharides in C57BL/6J mice.","authors":"Yong Lai, Qifan Zhang, Maohan Xu, Xiurong Guo, Quan Zhou, Qiuyu Liu, Huiling Deng, Can Song","doi":"10.3389/fnut.2025.1607365","DOIUrl":"10.3389/fnut.2025.1607365","url":null,"abstract":"<p><strong>Background: </strong>A healthy gut depends on a balance of commensal and probiotic bacteria, and prolonged and inappropriate clinical use of antibiotics can cause an imbalance in the gut flora, resulting in antibiotic-associated diarrhea (AAD). Macrofungal polysaccharides are rich in bioactivities and have attracted much attention for their good performance in anti-inflammatory, antioxidant, anti-obesity and anti-tumor properties. Therefore, we explored the role of <i>Dictyophora indusiata</i> water-insoluble polysaccharides (DIPY) in modulating the gut flora to improve AAD.</p><p><strong>Methods: </strong>We initially prepared the water-insoluble polysaccharides derived from <i>Dictyophora indusiata</i>. Subsequently, by comprehensively evaluating multiple parameters including the body weight, dietary patterns, cecal histomorphological characteristics, intestinal microbiota composition, concentrations of short-chain fatty acids (SCFAs), and the levels of inflammatory factors in the antibiotic-associated diarrhea (AAD) model animals, we delved into both the action mechanisms of these polysaccharides and their impacts on the intestinal flora and metabolites within C57BL/6J mice.</p><p><strong>Results: </strong>Our results showed that DIPY effectively ameliorated AAD in mice by modulating the intestinal flora, increasing microbial diversity, the Shannon and Ace index was significantly higher in the DIPY group than in the NR group after the DIPY intervention (<i>p</i> < 0.001). Also, compared with the NR group, DIPY increasing the relative abundance of <i>Parasutterella</i> and <i>Blautia</i>, increasing the production of acetic acid (<i>p</i> < 0.001), and decreasing the levels of LPS, MCP-1, TNF-<i>α</i>, and IL-6 (<i>p</i> < 0.05) which attenuating inflammatory responses.</p><p><strong>Conclusion: </strong>This study demonstrated that DIPY has intestinal prebiotic function, which provides a basis for further development of functional products for the treatment of AAD.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1607365"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between neutrophil percentage to albumin ratio and progression-free survival and overall survival in colorectal cancer patients: a retrospective cohort study.","authors":"Hailun Xie, Lishuang Wei, Shuangyi Tang, Jialiang Gan","doi":"10.3389/fnut.2025.1589854","DOIUrl":"10.3389/fnut.2025.1589854","url":null,"abstract":"<p><strong>Background: </strong>The neutrophil percentage-to-albumin ratio (NPAR) is a promising indicator for predicting outcomes in various cancers. However, its prognostic value in colorectal cancer (CRC) is still underexplored. This study aimed to investigate the relationship between NPAR and progression-free survival (PFS) as well as overall survival (OS) in CRC patients.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study involving 1,339 CRC patients who underwent surgical resection. The Kaplan-Meier method was utilized to plot survival curves for PFS and OS. Cox proportional hazards regression analysis assessed the relationship between NPAR and survival outcomes. The nomograms that included NPAR and other significant prognostic factors were developed to predict 1-, 3-, and 5-year survival rates.</p><p><strong>Results: </strong>Patients with high NPAR (≥1.62) experienced significantly worse PFS and OS compared to those with low NPAR (<1.62) (PFS: 47.4% vs. 63.1%, <i>p</i> < 0.001; OS: 50.1% vs. 65.9%, <i>p</i> < 0.001). Compared to other relevant markers, NPAR exhibited strong prognostic predictive efficacy. Multivariate Cox regression analysis identified high NPAR as an independent predictor of poor PFS (hazard ratio [HR] = 1.671, 95% Confidence Interval [CI]: 1.142-2.444, <i>p</i> = 0.008) and OS (HR = 2.697, 95% CI: 1.761-4.130, <i>p</i> < 0.001). The NPAR-based nomograms demonstrated high predictive accuracy and received favorable evaluations in the internal validation cohort.</p><p><strong>Conclusion: </strong>Preoperative NPAR is a promising indicator for predicting PFS and OS in CRC patients. The NPAR-based nomogram offers a practical tool for personalized survival prediction and may assist in clinical decision-making.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1589854"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of maternal organic food consumption and diet quality during pregnancy on offspring's risk of inflammatory bowel disease: findings from a Danish National Birth Cohort Study.","authors":"Olivia Mariella Anneberg, Sjurdur Frodi Olsen, Anne Vinkel Hansen, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Tine Jess, Maiara Brusco De Freitas","doi":"10.3389/fnut.2025.1632729","DOIUrl":"10.3389/fnut.2025.1632729","url":null,"abstract":"<p><strong>Background: </strong>This study explores associations of maternal organic food consumption and diet quality during pregnancy with pediatric-onset inflammatory bowel disease (IBD) risk in offspring, including Crohn's disease (CD) and ulcerative colitis (UC).</p><p><strong>Methods: </strong>Pregnant mothers and their offspring were enrolled in the Danish National Birth Cohort, a nationwide prospective cohort study, in 1996-2002. In gestational week 30, telephone interviews assessed overall maternal organic food consumption during pregnancy. In gestational week 25, a food frequency questionnaire assessed maternal diet during the previous 4 weeks, including six different organic food types (eggs, dairy, meat, fruit, vegetables, and cereals). A Healthy Eating Index evaluated maternal diet quality based on adherence to Danish official dietary guidelines. Offspring with pediatric-onset IBD (≤18 years) were identified in national patient registries. Cox regression explored associations of maternal organic food consumption and diet quality during pregnancy with offspring's risk of pediatric-onset IBD, CD, and UC.</p><p><strong>Results: </strong>The study included 60,274 singleton mother-child pairs, of which 168 children developed pediatric-onset IBD. Frequent maternal organic food consumption during pregnancy was not significantly associated with offspring's IBD risk (HR: 0.63; 95% CI: 0.33-1.19). However, frequent organic food consumption during pregnancy, particularly organic eggs and dairy, lowered offspring's risk of CD (HR: 0.40; 95% CI: 0.17-0.94), but not UC (HR: 1.11; 95% CI: 0.41-3.00). Maternal diet quality during pregnancy was not significantly associated with offspring's risk of IBD (HR: 0.99; 95% CI: 0.97-1.01), CD, and UC.</p><p><strong>Conclusion: </strong>In this large prospective cohort study, we show that maternal organic food consumption, particularly eggs and dairy, during pregnancy may lower offspring's risk of pediatric-onset CD, but not UC.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1632729"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the composite dietary antioxidant index and cardiovascular-kidney-metabolic syndrome among U.S. adults: evidence from NHANES 2007-2018.","authors":"Qiuming He, Fan Hu, Wanhui Wei, Jie Li, Yang Yu, Heng Zhang","doi":"10.3389/fnut.2025.1600651","DOIUrl":"10.3389/fnut.2025.1600651","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome is a major public health issue worldwide. However, direct evidence on dietary modulators in CKM syndrome is lacking. This study aimed to explore the association between the Composite Dietary Antioxidant Index (CDAI) and advanced CKM syndrome using National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.</p><p><strong>Methods: </strong>Advanced CKM syndrome (Stage 3-4) was defined using 2023 AHA criteria. CDAI was calculated from averaged 24-h dietary recalls for six antioxidants (vitamins A/C/E, zinc, selenium, carotenoids). Weighted multivariable logistic regression adjusted for sociodemographics, lifestyle, and metabolic factors. Multinomial logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI), adjusting for potential confounders. Furthermore, restricted cubic splines (RCS) were applied to investigate any possible nonlinear relationships between CDAI and CKM syndrome in the study.</p><p><strong>Results: </strong>This study included 11,073 adults aged 20 years and older, with a mean age of 48 years and a gender distribution of 52.75% female and 47.25% male. Multivariate logistic regression with full adjustment for covariates showed that higher CDAI scores were inversely associated with advanced CKM syndrome. Specifically, compared to the lowest quartile, the highest quartile of CDAI scores had an OR of 0.70 (95% CI: 0.49-0.98). A nonlinear negative correlation was identified by the RCS (<i>p</i> for nonlinearity = 0.031). In both the subgroup and sensitivity analysis, this relationship was still present.</p><p><strong>Conclusion: </strong>Higher CDAI scores are correlated with decreased odds of advanced CKM syndrome, suggesting that an antioxidant-rich diet may be associated with a lower likelihood of advanced CKM syndrome. Understanding these correlations could contribute to the development of preventive strategies and intervention measures for CKM syndrome. However, prospective studies are needed to confirm these associations and explore their clinical relevance.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1600651"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenylalanine modulates casein synthesis in bovine mammary epithelial cells by influencing amino acid transport and protein synthesis pathways.","authors":"Yuanyuan Xing, Yixuan Luo, Mei Sun, Jing Yang, Shaoxiong Lin, Xiaojia Mu, Xiaoyu Niu, Dabiao Li, Yuanyuan Liu","doi":"10.3389/fnut.2025.1598191","DOIUrl":"10.3389/fnut.2025.1598191","url":null,"abstract":"<p><p>The efficiency of phenylalanine (Phe) utilization for milk protein synthesis in dairy cows is limited, and its uptake and metabolic mechanisms in the mammary tissue remaining unclear. This study investigated the effects of Phe availability (0.07, 0.14, 0.28, and 0.56 mM) on amino acid metabolism and casein synthesis in bovine mammary epithelial cells (BMECs) cultured for 24 h. Results showed that α_S1-casein, <i>β</i>-casein, and <i>κ</i>-casein expression peaked at 0.14 mM Phe (<i>p</i> < 0.05). At this optimal concentration, amino acid transporters (<i>SLC7A5</i>, <i>SLC7A8</i>, and <i>SLC38A2</i>) were upregulated, corresponding with enhanced uptake of Met, Ile, His, and Arg (<i>p</i> < 0.05). The mammalian target of rapamycin (mTOR) signaling pathway was activated as evidenced by increased phosphorylation of P70 S6 kinase (P70S6K) and mTOR (<i>p</i> < 0.05), while the general control nonderepressible 2 (GCN2) pathway was suppressed through reduced eukaryotic initiation factor 2α (eIF2α) phosphorylation (<i>p</i> < 0.05). As Phe concentration increased, its net uptake increased linearly (<i>P_linear</i>  < 0.05) while uptake efficiency decreased linearly (<i>P_linear</i>  < 0.05). High Phe concentration (0.56 mM) inhibited amino acid transporter expression and reduced uptake of Leu, Pro, and Tyr (<i>p</i> < 0.05). Additionally, Phe-to-Tyr conversion was dynamically regulated, with phenylalanine hydroxylase (PAH) activity inhibited at 0.07 mM Phe (<i>p</i> < 0.05) but enhanced at higher concentrations, concurrent with reduced exogenous Tyr uptake (<i>p <</i> 0.05). These findings show that casein synthesis in BMECs is optimal at 0.14 mM Phe, coinciding with enhanced expression of amino acid transporters and activation of protein synthesis pathways. In contrast, higher Phe concentrations (0.56 mM) are associated with reduced amino acid utilization efficiency. These observations suggest potential mechanisms by which Phe concentration may regulate milk protein synthesis in dairy cows.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1598191"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioprospecting and mechanistic insights of <i>Trichoderma</i> spp. for suppression of <i>Ganoderma</i>-induced basal stem rot in oil palm.","authors":"M Amrutha Lakshmi, M Indraja, Udai B Singh, A R N S Subanna, G K Challa, Ritu Mawar, W P Dauda","doi":"10.3389/fnut.2025.1582047","DOIUrl":"10.3389/fnut.2025.1582047","url":null,"abstract":"<p><strong>Purpose: </strong>Basal stem rot (BSR), with <i>Ganoderma</i> spp. as the principal causative agent, is an important oil palm disease, leading to significant stand loss and reduced yield potential. The use of antagonistic fungi, particularly <i>Trichoderma</i> spp., offers a sustainable approach to disease suppression through hyperparasitism, antibiosis, and rhizosphere competence. However, strain-dependent variability in antagonistic potential necessitates the selection of the most efficacious isolates for integrated BSR management. Here we show that <i>T. afroharzianum</i> exhibits superior antagonism against <i>Ganoderma</i> spp., in dual culture, inverted plate assay as well as cellfiltrate assays.</p><p><strong>Methods: </strong>From 50 Trichoderma isolates screened, 12 highly mycoparasitic strains (>80% <i>Ganoderma</i> suppression) were selected. To enhance applicability under field conditions, the selected strains were further evaluated against co-occurring soil-borne pathogens commonly associated with oil palm decline.</p><p><strong>Results: </strong><i>T</i>. <i>afroharzianum</i> exhibited hydrolytic enzyme secretion (chitinase, cellulase, and pectinase), solubilized key macronutrients, and suppressed multiple soil-borne phytopathogens including <i>Rhizoctonia solani, R. bataticola, Fusarium solani, Lasiodeplodia theobromae Colletotrichum gleosporoides</i> and <i>Curvularia lunata</i>. A tailored <i>Trichoderma</i> consortium achieved 61.94% disease suppression, reduced foliar and bole severity by 48.59 and 20.22%, respectively, and increased plant height (47.59 ± 2.52 cm) and shoot fresh weight (15.83 ± 0.80 g).</p><p><strong>Implications/conclusion: </strong>These findings establish <i>T. afroharzianum</i> as a promising biocontrol agent for BSR suppression through multiple mechanisms, including competitive exclusion and pathogen inhibition. The results support its potential for field deployment as part of an integrated, climate-resilient disease management strategy in oil palm cultivation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1582047"},"PeriodicalIF":4.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the unseen: nutritional interventions as a key to combat frailty.","authors":"Luya Shi, Xijiang Tian, Yih Bongsook, Jiameng Chen","doi":"10.3389/fnut.2025.1575922","DOIUrl":"10.3389/fnut.2025.1575922","url":null,"abstract":"<p><strong>Background: </strong>Frailty and malnutrition have emerged as critical public health issues amidst global population aging. Malnutrition not only significantly contributes to frailty but also intensifies its clinical symptoms, severely affecting the quality of life and health outcomes in older adults. Research in this field has accelerated in recent years; however, a comprehensive analysis of key research trends and hotspots remains absent. This study employs bibliometric methods to systematically analyze core themes and emerging research directions related to nutritional status and frailty in older adults, identifying potential research frontiers and guiding future development.</p><p><strong>Methods: </strong>A comprehensive search was conducted in the Web of Science Core Collection (WoSCC) database on November 6, 2024, using keywords relevant to frailty and nutrition status in older adults. Bibliometric analyses and knowledge mapping were performed using CiteSpace, VOSviewer, and R software.</p><p><strong>Results: </strong>Between 2005 and 2024, 2,357 publications on frailty and nutrition status in older adults were produced by 13,080 researchers from 3,987 institutions across 88 countries. The volume of publications has shown a consistent upward trajectory over the past two decades (R² = 0.84), with projections indicating a continued increase, peaking at 315 publications by 2033. This sustained growth underscores the field's significance and ongoing research interest. Early research has centered on the \"home-living elderly\" demographic, while current investigations have shifted focus from molecular biology, genetics, and health nursing to more clinical and medical domains. Key areas of emphasis now include nutrition and dietetics, geriatrics, oncology, and pharmacology. Emerging research hotspots involve the early identification and management of malnutrition to reduce frailty-related health risks and improve health outcomes and quality of life for older adults. Notable trends include the keywords \"prediction,\" \"nutritional assessment MNA,\" \"intervention,\" and \"infection.\"</p><p><strong>Conclusion: </strong>This bibliometric analysis offers a comprehensive examination of the research evolution, hotspots, and emerging frontiers in frailty and nutrition status among older adults over the past two decades. The findings provide an objective overview of the academic landscape, offering valuable insights for future research, resource allocation, and policymaking.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1575922"},"PeriodicalIF":4.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency and polycystic ovary syndrome: an opinion and positioning article.","authors":"Gao Song","doi":"10.3389/fnut.2025.1602472","DOIUrl":"10.3389/fnut.2025.1602472","url":null,"abstract":"","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1602472"},"PeriodicalIF":4.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D status among apparently healthy individuals in the UAE: a systematic review.","authors":"Maitha Abdulla Alshamsi, Wafeeqa Fatima, Maitha Tareq Al Teneiji, Suresh Kumar Srinivasamurthy","doi":"10.3389/fnut.2025.1604819","DOIUrl":"10.3389/fnut.2025.1604819","url":null,"abstract":"<p><strong>Background/objectives: </strong>Vitamin D deficiency is a global health concern, particularly in regions with abundant sunlight, such as the UAE. This study aims to systematically review and meta-analyze available data on vitamin D levels in apparently healthy individuals in the UAE, categorizing findings by demographic factors, including age, gender, and ethnicity. The goal is to assess the extent of deficiency and identify potential contributing factors.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines. PubMed and SCOPUS databases were searched for studies reporting serum vitamin D levels in healthy individuals in the UAE. Eligible studies included cross-sectional, retrospective, prospective, and comparative designs. Data were extracted and analyzed, with vitamin D levels categorized as deficient, insufficient, or normal. Study quality was assessed using a modified Newcastle-Ottawa scale for single-arm studies.</p><p><strong>Results: </strong>A total of 35 studies involving 28,260 participants were included. Reported vitamin D levels ranged from 5.2 ± 2.8 ng/mL to 42.5 ± 19.5 ng/mL. The pooled mean (SD) for adults above 18 years was 17.63 ng/mL (95% CI: 14.28 to 20.99) indicating widespread deficiency. Among participants, 65% were female, 34% were male, and 1% were infants. Severe deficiency was noted in infants and children, though limited studies focused on these groups.</p><p><strong>Conclusion: </strong>Despite high sunlight exposure, vitamin D deficiency is prevalent in the UAE, likely due to cultural clothing practices, limited outdoor activities, darker skin pigmentation, and dietary insufficiencies. Further research on vulnerable populations is needed. Variations in assay methods used across studies (e.g., RIA, ECLIA, LC-MS/MS) may have influenced reported vitamin D levels and contributed to heterogeneity in findings.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024587972, Identifier, CRD42024587972.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1604819"},"PeriodicalIF":4.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}