Frontiers in NutritionPub Date : 2025-01-28eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1536024
Shuxin Ying, Hongyan Ding, Yanjin Chen, Su Zheng
{"title":"Association of oxidative balance score with all-cause and cardiovascular mortality in overweight and obese.","authors":"Shuxin Ying, Hongyan Ding, Yanjin Chen, Su Zheng","doi":"10.3389/fnut.2025.1536024","DOIUrl":"10.3389/fnut.2025.1536024","url":null,"abstract":"<p><strong>Background: </strong>The oxidative balance score (OBS) combines diverse dietary components with lifestyle factors to comprehensively evaluate oxidative stress. The investigation focuses on the link between the OBS and mortality outcomes, including cardiovascular and all-cause deaths, in overweight and obese individuals.</p><p><strong>Methods: </strong>The analysis utilized data from the National Health and Nutrition Examination Survey (NHANES), covering the period from 1999 to 2018. Mortality information, categorized into all-cause and cardiovascular deaths, was gathered from the National Death Index (NDI). Kaplan-Meier survival analysis, along with multivariate Cox regression and restricted cubic spline (RCS) modeling, were utilized to explore the link between OBS and mortality risks. Subgroup analysis and sensitivity analysis were used to assess the robustness of the results and possible effect modifiers. Mediation analysis identifies pathways through which the independent variable affects the dependent variable.</p><p><strong>Results: </strong>In this study, 26,219 participants with overweight or obesity were enrolled, with an average age of 49.8 ± 17.4 years. During a median follow-up duration of 115 months, 2,239 participants (8.5%) died, including 837 (3.2%) from cardiovascular disease. According to Kaplan-Meier analysis, mortality was highest among participants in the lowest OBS quartile (Q1) and lowest among those in the highest quartile (Q4). Participants in the fourth OBS quartile experienced a 21.7% decrease in the risk of mortality from all causes and a 29.5% decrease in cardiovascular mortality risk, according to fully adjusted results, compared to those in the first quartile. These results were validated through subgroup analyses. The analysis of RCS revealed a notable inverse association between OBS and mortality outcomes. Mediation analysis indicates that white blood cell count (WBC) and gamma-glutamyl transferase (GGT) serve as significant mediators in the association between OBS and mortality risk.</p><p><strong>Conclusion: </strong>Elevated levels of OBS were strongly linked to reduced potential for both cardiovascular and all-cause mortality among individuals who are overweight or obese.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1536024"},"PeriodicalIF":4.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-28eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1509232
Jiong Wang, Jiqing Du, Minxiu Wang, Mengyun Jin, Zhihua Tang, Yuqin Mao
{"title":"Global, regional, and national burden of NAFLD in youths and young adults aged 15-39 years, 1990-2021, its attributable risk factors, and projections to 2035: a systematic analysis of the Global Burden of Disease Study 2021.","authors":"Jiong Wang, Jiqing Du, Minxiu Wang, Mengyun Jin, Zhihua Tang, Yuqin Mao","doi":"10.3389/fnut.2025.1509232","DOIUrl":"10.3389/fnut.2025.1509232","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD) is a significant health burden in youths and young adults, and the trend toward younger onset of NAFLD is alarming. Utilizing data from the Global Burden of Disease (GBD) 2021 study, this study assessed the burden and trends of NAFLD in youths and young adults aged 15-39 from 1990 to 2021 and extracted data from this study on the incidence, prevalence, death, and disability-adjusted life-years (DALYs) rates of NAFLD. We evaluated the global temporal trend of NAFLD from 1990 to 2021 with estimated annual percentage change (EAPC) and age-standardized rate (ASR). The Bayesian age-period-cohort (BAPC) model was used to predict future trends of the NAFLD burden to 2035. We found that the global burden of NAFLD in youths and young adults has risen steadily from 1990 to 2021, and projects to increase to 2035, which places enormous pressure on society. To alleviate this burden, implementing measures targeting risk factors such as glycemic control and smoking cessation is necessary.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1509232"},"PeriodicalIF":4.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-28eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1541427
Wanjun Yin, Lei Zhang, Peng Zhu
{"title":"The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status.","authors":"Wanjun Yin, Lei Zhang, Peng Zhu","doi":"10.3389/fnut.2025.1541427","DOIUrl":"10.3389/fnut.2025.1541427","url":null,"abstract":"<p><strong>Background: </strong>Given the ease of access to ambient temperature, it may be a more practical guide than the UVB index. However, the association between gestational temperature and vitamin D level in newborns remains unclear. Our study aims to explore this association and the necessity of maternal vitamin D supplementation when ambient temperature is less than a specific value.</p><p><strong>Methods: </strong>Based on a birth cohort study, we measured cord blood concentrations of 25(OH)D in 1419 neonates from January to September 2008 in Hefei, a new first-tier city in China. The daily mean temperature of Hefei was obtained from the China Meteorological Data Sharing Service System. Individual information on sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes was collected prospectively.</p><p><strong>Results: </strong>The best-fit relationship was observed in the regression model using a quadratic function to describe the association between the ambient temperature of the eighth gestational month (29-32 gestational weeks) and cord blood 25(OH)D concentrations (<i>R</i> <sup>2</sup> = 0.358, <i>p</i> < 0.001). Ambient temperatures of 10 and 24.5°C were linked to the cutoff of vitamin D inadequacy (<50 nmol/L) and deficiency (<30 nmol/L) in cord blood, respectively. For maternal exposure to an ambient temperature of ≥24.5°C in the eighth gestational month, vitamin D supplementation during pregnancy failed to significantly enhance neonatal vitamin D concentrations. In contrast, for maternal exposure to ambient temperature of <10°C, maternal vitamin D supplementation was significantly associated with elevated 25(OH)D concentrations in cord blood.</p><p><strong>Conclusion: </strong>Gestational ambient temperature may be an ideal predictor for infant vitamin D status screening. Maternal exposure to an ambient temperature of less than 10°C is a critical index in the eighth gestational month, which may determine the onset of vitamin D supplementation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1541427"},"PeriodicalIF":4.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-28eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1555875
Daniel Adrian Gârdan, Paweł Bryła, Ionel Dumitru, Iuliana Petronela Gârdan
{"title":"Editorial: Industry and individuals: branding, labelling, and marketing of food products.","authors":"Daniel Adrian Gârdan, Paweł Bryła, Ionel Dumitru, Iuliana Petronela Gârdan","doi":"10.3389/fnut.2025.1555875","DOIUrl":"10.3389/fnut.2025.1555875","url":null,"abstract":"","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1555875"},"PeriodicalIF":4.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-27eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1510563
Shuang Li, Shuangjiang Li, Linjing Guan, Mingjuan Li, Jiahui Zhao, Min Wu, Qiuyun Li, Hui Li, Guoqing Ouyang, Guangdong Pan
{"title":"Burden of NASH related liver cancer from 1990 to 2021 at the global, regional, and national levels.","authors":"Shuang Li, Shuangjiang Li, Linjing Guan, Mingjuan Li, Jiahui Zhao, Min Wu, Qiuyun Li, Hui Li, Guoqing Ouyang, Guangdong Pan","doi":"10.3389/fnut.2025.1510563","DOIUrl":"10.3389/fnut.2025.1510563","url":null,"abstract":"<p><strong>Background: </strong>The global burden of non-alcoholic steatohepatitis (NASH)-related liver cancer (NRLC) is increasing, making NASH the fastest-growing cause of liver cancer worldwide. This study presents a comprehensive analysis of NRLC burden at the global, regional, and national levels, further categorized by age, sex, and sociodemographic index (SDI).</p><p><strong>Method: </strong>Data on NRLC from the Global Burden of Disease, Injuries, and Risk Factors (GBD) study 2021 were downloaded at global, regional, and national levels. The numbers and age-standardized rates (ASRs) of incidence, mortality, and disability-adjusted life years (DALYs) were analyzed to quantify the global burden of NRLC. Additionally, percentage changes in ASRs were used to identify trends in NRLC from 1990 to 2021.</p><p><strong>Results: </strong>Globally, both the number of cases and ASRs for NRLC increased between 1990 and 2021. In 2021, there were 42,291 new cases, 40,925 deaths, and 995,475 DALYs attributed to NRLC. East Asia, South Asia, and Southeast Asia reported the highest absolute case numbers, while Western, Southern, and Eastern Sub-Saharan Africa exhibited the highest ASRs. From 1990 to 2021, Australasia, Southern Latin America, and High-income North America showed the most significant increases in NRLC incidence. Nationally, Mongolia, Gambia, and Mozambique exhibited the highest ASR in 2021.The greatest percentage increases in ASIR occurred in Australia, the United Kingdom, and New Zealand between 1990 and 2021. NRLC incidence rates were higher in men and increased with age, peaking at 80-89 years. Similar patterns were observed for NRLC-related deaths and DALYs. Regionally, ASRs initially declined but then increased as SDI rose. At the national level, ASRs consistently decreased with higher SDI.</p><p><strong>Conclusion: </strong>This study highlights the substantial burden of NRLC at global, regional, and national levels. Males and older individuals bear a higher disease burden, and considerable variation exists across different regions and countries. These findings provide critical insights for formulating effective strategies to prevent and manage NRLC.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1510563"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank.","authors":"Lili Pan, Zhengrong Xu, Yining Li, Guoen Cai, Haibing Gao, Shenglong Lin","doi":"10.3389/fnut.2025.1537855","DOIUrl":"10.3389/fnut.2025.1537855","url":null,"abstract":"<p><strong>Background: </strong>Chronic liver diseases (CLD) continue to pose a significant global burden, potentially exacerbated by pro-inflammatory diets. This study explores the relationship between the Dietary Inflammatory Index (DII), a measure of dietary inflammatory potential, and CLD risk.</p><p><strong>Methods: </strong>Utilizing data from the UK Biobank cohort, we assessed the dietary information and calculated the DII for each participant. Cox proportional hazards models and Fine-Gray competing risk models were employed to evaluate the association between DII and CLD incidence, adjusting for potential confounders.</p><p><strong>Results: </strong>Our analysis included 121,329 participants with a median follow-up of 604.43 weeks, during which 4,018 developed CLD. A higher DII, indicating a more inflammatory diet, was associated with a 16% increased risk of CLD [hazard ratio (HR) = 1.162, <i>P</i> = 0.001], with each unit increase in DII elevating the risk by 3.3% (HR: 1.033, <i>P</i> < 0.001). A significant linear association between DII and CLD was observed. Competing risk analyses, which accounted for cirrhosis, liver cancer, and death, supported these findings. Subgroup analyses confirmed the robustness of the DII's association across various demographic and lifestyle factors. Moreover, a higher DII was positively associated with the progression of CLD to cirrhosis. Sensitivity analyses, including energy-adjusted DII and typical dietary DII, reinforced our results. Additionally, adherence to anti-inflammatory dietary patterns, as indicated by higher Healthy Eating Index 2020 and Mediterranean Diet Score values, was inversely associated with CLD risk.</p><p><strong>Conclusion: </strong>Our study highlights the potential benefits of adopting anti-inflammatory diets as a strategy for the prevention and management of CLD. Comprehensive dietary interventions may play a pivotal role in mitigating the global burden of CLD.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1537855"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-27eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1528184
Shuzhi Zhang, Jingjing Guo, Shikun Suo, Li Ju, Zhaoqiang Jiang, Pingshuan Dong, Yanli Wang, Yali Dang, Laijing Du
{"title":"<i>In vitro</i> gastrointestinal digestion simulation screening of novel ACEI peptides from broccoli: mechanism in high glucose-induced VSMCs dysfunction.","authors":"Shuzhi Zhang, Jingjing Guo, Shikun Suo, Li Ju, Zhaoqiang Jiang, Pingshuan Dong, Yanli Wang, Yali Dang, Laijing Du","doi":"10.3389/fnut.2025.1528184","DOIUrl":"10.3389/fnut.2025.1528184","url":null,"abstract":"<p><p>Many natural angiotensin-converting enzyme inhibitory (ACEI) peptides have been widely studied. However, their stability <i>in vivo</i> is poor in most cases. In this study, peptides were initially digested from broccoli <i>in vitro</i>, and absorption was simulated by Caco2 cells transport and then analyzed by Peptideomics and molecular docking. Subsequently, the mechanisms were verified using a high glucose-induced vascular smooth muscle cells (VSMCs) dysfunction model. Results showed that ACEI activity of broccoli crude peptide increased by 70.73 ± 1.42% after digestion. The enzymatic hydrolysates of crude broccoli peptides before and after digestion were detected by HPLC. The digested crude peptides were highly stable (with a stability level > 90%) in the intestine and possessed a strong absorptive potential. Five peptides with high stability and strong permeability were first identified, including HLEVR, LTEVR, LEHGF, HLVNK, and LLDGR, which exhibited high activity with IC<sub>50</sub> values of 3.19 ± 0.23 mM, 17.07 ± 1.37 mM, 0.64 ± 0.02 mM, 0.06 ± 0.01 mM, and 2.81 ± 0.12 mM, respectively. When the VSMCs model was exposed to Ang II, the expressions of PCNA, MMP2, and Bcl2 were increased, while the expression of BAX was inhibited. When the VSMCs was exposed to high glucose (HG), the Ang II concentration significantly increased. This indicates that HG elevated Ang II levels. Finally, five peptides significantly attenuated Ang II-induced VSMCs proliferation and migration by down-regulating AT1R expression and inhibiting ERK and p38 MAPK phosphorylation. Notably, in exploring VSMCs dysfunction on a high glucose-induced model, ACEI peptides resulted in down-regulation of ACE and up-regulation of ACE2 expression. Therefore, it can be further referenced for the functional food against hypertension and cardiovascular diseases.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1528184"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-27eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1535226
Mengjie He, Lichun Huang, Yan Zou, Peiwei Xu, Danting Su, Dong Zhao, Dan Han, Ronghua Zhang
{"title":"Detection of postpartum women anemia and its impact on their offspring in Zhejiang Province, China.","authors":"Mengjie He, Lichun Huang, Yan Zou, Peiwei Xu, Danting Su, Dong Zhao, Dan Han, Ronghua Zhang","doi":"10.3389/fnut.2025.1535226","DOIUrl":"10.3389/fnut.2025.1535226","url":null,"abstract":"<p><strong>Background: </strong>Information on the prevalence of postpartum women anemia is scarce in China, as well as its impact on their offspring. This study aimed to explore the influencing factors of anemia and the impact on the offspring.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 977 women within 2 years postpartum in 10 sites from 2016 to 2017 in Zhejiang Province, China. Information on demographics, nutrient supplementation and diet was collected. Whole blood hemoglobin, serum ferritin and transferrin receptor were assessed for all women and whole blood hemoglobin was assessed in offspring. The multivariate logistic regression was used to assess the determinants of anemia and the impact on the offspring by calculating odds ratio (OR) and its 95% confidence interval (95%CI).</p><p><strong>Results: </strong>Among 977 participants, 144 (14.74%) had anemia. Regression analysis showed that women intaking iron supplements during pregnancy (0.549, 0.350 ~ 0.860), and intaking sufficient red meat (0.647, 0.437 ~ 0.958) had lower rates of anemia, while women wo had anemia during pregnancy (2.754, 1.844 ~ 4.113 for mild anemia, and 3.815, 1.564 ~ 9.309 for moderate or severe anemia), had postpartum over 7 months (1.717, 1.112 ~ 2.650), with abnormal serum ferritin (11.931, 4.846 ~ 29.379) and excessive transferrin receptor levels (1.817, 1.050 ~ 3.145) had higher rates of anemia. Moreover, maternal anemia significantly increases the rate of anemia in offsprings, with ORs being 1.456 (0.994 ~ 2.133) for mild anemia, and 2.961 (1.242 ~ 7.058) for moderate or severe anemia, respectively.</p><p><strong>Conclusion: </strong>The status of anemia in postpartum women was severe and its impact on the anemia of their offspring should be noted. It is highly necessary to strengthen the regular monitoring of hemoglobin levels in pregnant and postpartum women, as well as implement targeted dietary interventions and suggest to intake dietary supplements if necessary.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1535226"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation.","authors":"Lianling Xu, Kaixuan Zeng, Zuoyue Duan, Jing Liu, Yan Zeng, Miao Zhang, You Yang, Qulian Guo, Yanling Jin, Wenjun Liu, Ling Guo","doi":"10.3389/fnut.2025.1518525","DOIUrl":"10.3389/fnut.2025.1518525","url":null,"abstract":"<p><strong>Background: </strong>Active dietary flavonoids are a promising resource for novel drug discovery. Sweet potato, a widely cultivated functional crop, is abundant in flavonoids. However, the active ingredients associated with acute myeloid leukemia (AML) treatment and their underlying mechanisms have not been reported to date.</p><p><strong>Objective: </strong>This study aims to identify novel drugs against AML from sweet potato by integrating metabolomics analysis, network pharmacology, and experimental validation.</p><p><strong>Methods: </strong>Firstly, ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed to analyze the major constituents in sweet potato. Then, nine active ingredients were selected for validation of their anti-leukemia effects. Subsequently, three of them underwent network pharmacology analyses and <i>in vitro</i> experimental verification. Finally, the anti-leukemia effect of cynaroside was further confirmed through <i>in vivo</i> experimental validation.</p><p><strong>Results: </strong>Firstly, the flavonoid content of stem, leaves, flesh, and peel from 13 sweet potato cultivars was examined. The leaves of Nanshu 017 exhibited the highest flavonoid content of 2.27% dry weight (DW). Then, an extract derived from these leaves was employed for <i>in vitro</i> experiments, demonstrating significant inhibition of AML cell growth. Subsequently, based on the results of metabolomics analysis and network pharmacology, cynaroside, nepitrin, and yuanhuanin were identified as potential antileukemia agents present in sweet potato for the first time; while CASP3, KDR, EGFR, and SRC were recognized as pivotal targets of these three monomers against AML. Finally, the antileukemia effects of cynaroside, nepitrin, and yuanhuanin were confirmed through <i>in vitro</i> and <i>in vivo</i> experimental validation.</p><p><strong>Conclusion: </strong>In summary, sweet potato leaves extract possesses an antileukemic effect while cynaroside, nepitrin, and yuanhuanin demonstrate potential as treatments for AML.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1518525"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NutritionPub Date : 2025-01-27eCollection Date: 2025-01-01DOI: 10.3389/fnut.2025.1553149
Sunmin Park
{"title":"Editorial: Precision nutrition and nutrients: making the promise a reality.","authors":"Sunmin Park","doi":"10.3389/fnut.2025.1553149","DOIUrl":"10.3389/fnut.2025.1553149","url":null,"abstract":"","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1553149"},"PeriodicalIF":4.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}