Synergistic effects of Mediterranean diet combined with phytosterol-based supplements and omega-3 fatty acids on lipid profiles: a pilot study in menopausal women.

Abstract

Objectives: Menopause marks the cessation of ovarian function, preceded by perimenopause, a transitional phase characterized by hormonal fluctuations and metabolic changes, including dyslipidemia. Therefore, a targeted nutritional approach is essential. In this retrospective, observational, pilot study, we evaluated the impact of a Mediterranean-based dietary regimen supplemented with specific natural compounds on lipid profiles and body composition in perimenopausal and menopausal women with hypercholesterolemia.

Methods: An individual dietary plan based on the Mediterranean diet, supplemented with a phytosterol-based formula containing bergamot, prickly pear extract, and vitamin B1, was recommended for each study participant. Additionally, omega-3 fatty acid supplementation was recommended due to its well-documented benefits in reducing cardiovascular disease risk factors, including elevated lipid levels. Lipid profile, body composition, and anthropometric values were recorded and carefully analyzed.

Results: Our findings indicated that this combined dietary approach significantly improved lipid profiles, as evidenced by reductions in total cholesterol, low-density lipoprotein cholesterol, and triglycerides and by an increment in high-density lipoprotein cholesterol values. Furthermore, the dietary plan positively impacted overall body composition and morphometric parameters.

Conclusion: These preliminary findings suggest that a personalized, nutritionally targeted approach may be an effective non-pharmacological strategy for managing cardiovascular and metabolic risk factors during the menopausal transition and postmenopausal period. Further large-scale, controlled studies are warranted to confirm these results and explore long-term outcomes.