Frontiers in Nutrition最新文献

{"title":"Prevalence, risk factors, impact and management of constipation among adults in Urumqi, China: a cross-sectional survey.","authors":"Lingyun Shi, Li Shi, Minghui Wei, Mengke Zhang, Yuan Zhang, Jiaxue Li, Palida Maimaiti","doi":"10.3389/fnut.2024.1451527","DOIUrl":"10.3389/fnut.2024.1451527","url":null,"abstract":"<p><p>Constipation, a prevalent gastrointestinal disorder, significantly impacts quality of life. This study aimed to investigate the prevalence, risk factors, and implications of constipation in Urumqi City. A cross-sectional survey was conducted from July to August 2023, involving 1,386 participants aged 20-80 years. Data were collected via a self-administered questionnaire, with constipation severity assessed using the Patient Assessment of Constipation Symptoms (PAC-SYM) scale. Key findings indicated that various factors, including residing in rural areas, outdoor work, and sleep disorders, were positively correlated with higher PAC-SYM scores. Conversely, higher daily water intake and certain dietary patterns showed negative correlations. Additionally, increased constipation severity was associated with greater physiological strain and psychosocial concerns (all <i>p</i> < 0.05), emphasizing the disorder's profound effect on quality of life. These findings underscore the need for comprehensive management strategies in Urumqi, considering its diverse lifestyle and dietary factors.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1451527"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life undernutrition in the great Chinese famine and the risk of early natural menopause: a retrospective cohort study in Western China.","authors":"Xiaoyang Xu, Yong Zhang, Xiaoya Qi","doi":"10.3389/fnut.2024.1432707","DOIUrl":"10.3389/fnut.2024.1432707","url":null,"abstract":"<p><strong>Purpose: </strong>Early age of menopause may increase the risk of fracture, cardiovascular diseases, and all-cause mortality. This study aimed to investigate the relation between early-life undernutrition in the Great Chinese Famine and the risk of early natural menopause.</p><p><strong>Methods: </strong>A famine exposure retrospective cohort was established during 2017-2018. Postmenopausal women who were born on 01 October 1956-30 September 1964 and came to the hospital for routine health examinations were candidates for the study. Famine time was defined from 1 January 1959 to 31 December 1961. Three types of early-life famine exposure status were determined by the participant's date of birth. Natural menopause age below 45 was defined as early menopause. The association between early-life famine exposure status and the risk of early natural menopause was confirmed by multiple logistic regression.</p><p><strong>Result: </strong>A total of 3,337 participants born around famine were included in this study. The prevalence of early menopause was 13.1, 10.0, and 8.3% for those born before, during, and after the famine, respectively. The multiple logistic regression showed that women born before famine significantly increased the risk of early menopause compared to non-exposure (born after famine) (the fully adjusted OR = 1.463, 95%CI = 1.049-2.042). The fetal famine exposure did not significantly increase the risk of early menopause (the fully adjusted OR = 1.244, 95%CI = 0.878-1.764).</p><p><strong>Conclusion: </strong>Long-term early childhood famine exposure, which caused chronic undernutrition at young ages, increased the risk of early menopause. Early lifetime undernutrition can be recognized as an adverse factor in female reproductive development and aging. This cohort study further confirmed the hypothesis of developmental origins of health and disease from the aspect of women's reproductive health. Further mechanism study is warranted.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1432707"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary food hygiene practice and associated factors among mothers with children aged 6-23 months in Dessie Zuria, South Wollo Zone, Amhara, Ethiopia, 2023.","authors":"Alemayehu Tesfaye Addis, Yeshimebet Ali Dawed, Geleta Mussa Yimer, Yonas Fissha Adem","doi":"10.3389/fnut.2024.1465008","DOIUrl":"10.3389/fnut.2024.1465008","url":null,"abstract":"<p><strong>Background: </strong>Implementing appropriate complementary food hygiene practices is essential to lower the incidence of food-borne disease and malnutrition in children. However, this aspect is often overlooked in resource-limited settings, and information regarding these practices is not fully available and is not assessed enough. Therefore, this study aimed to assess complementary food hygiene practices and their associated factors in Dessie Zuria, South Wollo Zone, Amhara, Ethiopia, in 2023.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study design was conducted from 17 April to 18 May 2023, among 366 mothers with children aged 6-23 months. Dessie Zuria was purposively selected, and a systematic random sampling technique was used to recruit study participants. Data were collected using pretested and structured questionnaires. Finally, the data were entered using EPI-info and then exported to SPSS version 26. Bivariable and multivariable logistic regression analyses were used to identify factors associated with complementary feeding hygiene practices. Both crude odds ratios (COR) and adjusted odds ratios (AOR) with a 95% confidence level (CI) were computed, and a <i>p</i>-value of <0.05, in the final model, was considered statistically significant.</p><p><strong>Results: </strong>The proportion of households practicing complementary food hygiene was 22.22%. Factors associated with these practices included access to media such as television or radio (AOR = 10.51, 95% CI: 2.8, 39.28), starting complementary feeding before 6 months (AOR = 2.01, 95% CI: 1.05, 3.84), and the child's age being 6 to 11 months (AOR = 0.25, 95% CI: 0.08, 0.7).</p><p><strong>Conclusion: </strong>The prevalence of complementary food hygiene practices was poor. Healthcare professionals should promote starting breastfeeding at the age of 6 months. In addition, media companies ought to make an effort to create a positive social and cultural environment that encourages complementary feeding practices for young children.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1465008"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor human milk: the influence of processing technologies on its nutritional and microbial composition.","authors":"Ruth Conboy-Stephenson, R Paul Ross, Alan L Kelly, Catherine Stanton","doi":"10.3389/fnut.2024.1468886","DOIUrl":"10.3389/fnut.2024.1468886","url":null,"abstract":"<p><p>Human milk is regarded as the gold standard nutrition for newborn infants, providing all nutrients required for adequate growth and development from birth to 6 months. In addition, human milk is host to an array of bioactive factors that confer immune protection to the newborn infant. For this reason, the supply of human milk is crucial for premature, seriously ill, or low birth weight infants (<1,500 g). When a mother's own milk is unavailable, donor human milk is the recommended alternative by the World Health Organization. Prior to consumption, donor human milk undergoes pasteurization to ensure the eradication of bacterial agents and prevent the transfer of potentially pathogenic organisms. Currently, Holder Pasteurization, a heat-based treatment, is the widely adopted pasteurization technique used by milk banks. Holder pasteurization has demonstrated degradative effects on some of milk's biologically active factors, thus depleting critical bioactive agents with known functional, protective, and beneficial properties, ultimately reducing the immunoprotective value of donor human milk. As a result, alternative strategies for the processing of donor human milk have garnered much interest. These include thermal and non-thermal techniques. In the current review, we describe the effects of Holder pasteurization and alternative milk processing technologies on the nutritional and bioactive properties of milk. In addition, the capacity of each technique to ensure microbial inactivation of milk is summarized. These include the most extensively studied, high-temperature short-time and high-pressure processing, the emerging yet promising techniques, microwave heating and UV-C irradiation, and the lesser studied technologies, thermoultrasonication, retort processing, pulsed electric field, and gamma irradiation. Herein, we collate the findings of studies, to date, to allow for greater insight into the existing gaps in scientific knowledge. It is apparent that the lack of a cohesive standardized approach to human milk processing has resulted in contrasting findings, preventing a direct comparative analysis of the research. We conclude that donor human milk is a unique and valuable resource to the health sector, and although substantial research has been completed, persistent data disparities must be overcome to ensure optimal nutrition for the vulnerable newborn preterm infant group, in particular.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1468886"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farmed blue mussels (<i>Mytilus edulis</i>)-a nutrient-dense resource retaining nutritional value through processing.","authors":"Hanne Bjerknes, Edel O Elvevoll, Monica Alterskjær Sundset, Andreas Langdal, Karl-Erik Eilertsen","doi":"10.3389/fnut.2024.1443229","DOIUrl":"10.3389/fnut.2024.1443229","url":null,"abstract":"<p><p>This study investigated how farmed blue mussels (<i>Mytilus edulis</i>) can optimize human nutrient intake. A particular focus was on assessing nutrient preservation during steaming and freeze-drying, processes that could deplete nutrients. The study compared the content of essential amino acids and fatty acids in steamed and freeze-dried blue mussels to the nutritional needs of humans and farmed Atlantic salmon (<i>Salmo salar</i>). Additionally, it assessed the ethyl acetate method versus the traditional, more toxic Folch method for lipid extraction from blue mussels. Both steaming and freeze-drying effectively preserved essential amino acids and fatty acids in blue mussels. A 100 g serving of steamed blue mussels contributes from 26.8 ± 0.78% (Phe) to 54.9 ± 1.66% (Thr) of the daily recommended intake of essential amino acids (EAA). For steamed freeze-dried blue mussels, over 100% of the recommended intake is met for all EAA and as much as 243% for threonine. The 100 g serving will also provide 271 mg eicosapentaenoic acid (EPA; 20:5n-3) and 220 mg docosahexaenoic acid (DHA; 22:6n-3), thus covering the required intake of n-3 long-chain polyunsaturated fatty acids for adults as well as the recommended intake for pregnant and lactating women. Mussels are non-fed filter feeders that generally provide these nutrients with significantly lower environmental footprints, measured as global warming, eutrophication, and acidification, compared to farmed Atlantic salmon. Blue mussels can also be a valuable feed ingredient for farmed Atlantic salmon. Finally, it was demonstrated that the ethyl acetate method is not suited for lipid extraction from blue mussels, as the lipid yield was only half compared to the lipid yield using the Folch method.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1443229"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health associated with increased prevalence of childhood malnutrition in Africa.","authors":"Samuel Faraday Saidu, Ramona Ann Danielson","doi":"10.3389/fnut.2024.1456089","DOIUrl":"10.3389/fnut.2024.1456089","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood malnutrition remains a critical public health concern in Africa, with significant long-term consequences for children's growth, development, and overall health.</p><p><strong>Methods: </strong>This study examined the association between the prevalence of underweight and stunting of children <5 and six social determinants of health. Data were taken from publicly available data sources. After data quality criteria were met, data were analyzed for 50 African countries using descriptive statistics and one-way ANOVA. A quartile analysis was performed on each predictor variable. Countries were also analyzed according to five subregions.</p><p><strong>Results: </strong>The average prevalence of children <5 who were underweight was 14.5% and who were stunted was 26.8%. There were significant differences by region in the prevalence of underweight but not stunting, and in average access to basic sanitation services, basic drinking-water services, literacy rate, and HAQ index. The quartile analysis indicated basic sanitation services, prevalence of open defecation, basic drinking-water services, literacy rate, HAQ Index, and Political Stability Score were statistically significantly associated (<i>p</i> < 0.05) with underweight, while all of these except open defecation were associated (<i>p</i> < 0.05) with stunting.</p><p><strong>Discussion: </strong>This study emphasizes the variations in underweight and stunting prevalence, but also demonstrates patterns among how the risk for these child malnutrition outcomes are distributed. The results offer a multifaceted understanding of factors influencing childhood malnutrition. By focusing on key underlying social determinants of health, substantial improvements in nutritional outcomes may be achieved, ultimately enhancing the health and well-being of children across the African continent.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1456089"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waist-to-hip ratio and nonalcoholic fatty liver disease: a clinical observational and Mendelian randomization analysis.","authors":"Weining Xie, Yan Hong, Xinrong Chen, Shujuan Wang, Fan Zhang, Xiaoling Chi","doi":"10.3389/fnut.2024.1426749","DOIUrl":"10.3389/fnut.2024.1426749","url":null,"abstract":"<p><strong>Background: </strong>Obesity often coincides with non-alcoholic fatty liver disease (NAFLD), yet a significant portion of NAFLD patients exhibit normal body mass index (BMI) but have abdominal obesity. Recognizing this discrepancy, we aimed to delve deeper into this phenomenon through observational studies coupled with two-sample Mendelian randomization (MR) analysis, with waist-to-hip ratio (WHR) serving as the indicator for abdominal obesity. Our objective was to ascertain whether WHR correlates with an increased risk of NAFLD development.</p><p><strong>Methods: </strong>This study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 to examine the association between WHR and NAFLD through weighted multivariate logistic regression models. On this basis, subgroup analyses were performed to further explore the correlation between WHR and NAFLD. Subsequently, a two-sample MR analysis was conducted using genome-wide association studies (GWAS) data to investigate the potential causal relationship between WHR and NAFLD. Sensitivity analyses were also employed to ensure the robustness of our findings.</p><p><strong>Results: </strong>A total of 3,732 eligible participants were included in the analysis. Weighted multivariable-adjusted logistic regression models revealed a positive association between WHR and the risk of NAFLD (Q2vsQ1: OR = 1.94 [95% CI: 1.55-2.44]; Q3vsQ1: OR = 2.08 [95% CI: 1.51-2.85]; Q4vsQ1: OR = 3.70 [95% CI: 2.13-6.43], <i>p</i> < 0.05). The results of the subgroup analysis suggested that there was an interaction in the correlation between WHR and NAFLD in normal weight, overweight, and obese populations (<i>p</i> < 0.05). The RCS curves indicated that there was a nonlinear relationship between WHR and NAFLD in populations with BMI in the normal versus obese categories. Furthermore, MR analysis provided additional support for the causal relationship between WHR and NAFLD. Using inverse variance weighting (IVW), the MR analysis yielded an OR of 2.062 (95% CI: 1.680-2.531, <i>p</i><0.05). Consistent results were obtained with the other four MR methods, all supporting the same direction of causality. Sensitivity analyses were performed to assess the robustness of the findings (<i>p</i> > 0.5), further reinforcing the reliability of the observed associations.</p><p><strong>Conclusion: </strong>WHR elevation heightens the susceptibility to NAFLD.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1426749"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Effect and potential mechanism of <i>Lactobacillus plantarum</i> Q7 on hyperuricemia <i>in vitro</i> and <i>in vivo</i>.","authors":"","doi":"10.3389/fnut.2024.1517030","DOIUrl":"https://doi.org/10.3389/fnut.2024.1517030","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3389/fnut.2022.954545.].</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1517030"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry.","authors":"Xin Zhou, Wenbin Zheng, Wen Kong, Tianshu Zeng","doi":"10.3389/fnut.2024.1429603","DOIUrl":"10.3389/fnut.2024.1429603","url":null,"abstract":"<p><strong>Purpose: </strong>Previous observational studies about the link between dietary factors and diabetic microvascular complications (DMCs) is controversial. Thus, we systemically assessed the potential causal relationship between diet and DMCs risk using Mendelian randomization (MR) methods.</p><p><strong>Methods: </strong>We used genome-wide association studies (GWAS) statistics to estimate the causal effects of 17 dietary patterns on three common DMCs in European. Summary statistics on dietary intakes were obtained from the UK biobank, and data on DMCs [diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic neuropathy (DNP)] were obtained from the FinnGen Consortium. A two-sample MR (TSMR) was conducted to explore the causal relationships of dietary habits with DMCs. In addition, multivariable MR analysis (MVMR) was performed to adjust for traditional risk factors for eating habits, and evaluated the direct or indirect effects of diet on DMCs.</p><p><strong>Results: </strong>TSMR analysis revealed that salad/raw vegetable intake (odd ratio [OR]: 2.830; 95% confidence interval [CI]: 1.102-7.267; <i>p</i> = 0.0306) and fresh fruit intake (OR: 2.735; 95% CI: 1.622-4.611; <i>p</i> = 0.0002; false discovery rate [FDR] = 0.0082) increased the risk of DR, whereas cheese intake (OR: 0.742; 95% CI: 0.563-0.978; <i>p</i> = 0.0339) and cereal intake (OR: 0.658; 95% CI: 0.444-0.976; <i>p</i> = 0.0374) decreased the risk of DR. Salad/raw vegetable (OR: 6.540; 95% CI: 1.061-40.300; <i>p</i> = 0.0430) and fresh fruit consumption (OR: 3.573; 95% CI: 1.263-10.107; <i>p</i> = 0.0164) are risk factors for DN, while cereal consumption (OR: 0.380; 95% CI: 0.174-0.833; <i>p</i> = 0.0156) is the opposite. And genetically predicted higher pork intake increased the risk of DNP (OR: 160.971; 95% CI: 8.832-2933.974; <i>p</i> = 0.0006; FDR = 0.0153). The MVMR analysis revealed that cheese intake may act as an independent protective factor for DR development. Moreover, fresh fruit intake, salad/raw vegetable intake and pork intake may be independent risk factors for DR, DN and DNP, respectively. Other causal associations between dietary habits and DMCs risk may be mediated by intermediate factors.</p><p><strong>Conclusion: </strong>This causal relationship study supports that specific dietary interventions may reduce the risk of DMCs.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1429603"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between HALP and PNI score with 1-month mortality after CABG.","authors":"Ilhan Koyuncu, Emin Koyun","doi":"10.3389/fnut.2024.1489301","DOIUrl":"10.3389/fnut.2024.1489301","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) is the most common cause of cardiovascular disease (CVD). CHD is among the most common causes of mortality and morbidity world wide. In addition, CHD is one of the most important causes of health expenditures world wide. Today, coronary artery bypass grafting (CABG) operations are a widely used surgical procedure and have an important place in the treatment of CHD. Many scoring systems have been evaluated to estimate the risk of mortality and morbidity. 30-day mortality rates after CABG have been reported as 1-4% in large-scale studies.</p><p><strong>Objectives: </strong>The aim of our study was to evaluate the relationship between 1-month mortality in patients undergoing CABG and the Hemoglobin, albumin, lymphocyte, platelet index (HALP score) and Prognostic nutritional index (PNI) calculated using laboratory data in the preoperative period.</p><p><strong>Methods and design: </strong>A total of 239 patients who underwent CABG were evaluated retrospectively. Preoperative biochemical and hemogram values, demographic characteristics, comorbidities, HALP score and PNI values of the patients were recorded. The patients were divided into two groups: Exitus group (<i>n</i> = 51) and survival group (<i>n</i> = 188). The data of the two groups were compared, mainly HALP score and PNI.</p><p><strong>Results: </strong>It was observed that 51 of 239 patients (21.3%) developed exitus during the 30-day follow-up after CABG. When demographic data are compared; advanced age, female gender, history of DM (Diabetes Mellitus), history of HL (hyperlipidemia) and smoking were found to be associated with mortality. When laboratory data are compared; high troponin levels, low hemoglobin, low lymphocyte and low albumin levels were found to be associated with mortality. Low HALP score (<i>p</i> < 0.001) and low PNI (<i>p</i> < 0.001) were also found to be associated with mortality. In univariate and multivariate regression analysis; advanced age, history of DM, HALP score and PNI were found to be independent predictors of 30-day mortality after CABG. It was determined that a cut-off value of 0.29 for the HALP score and 39.1 for PNI had found, respectively, 81 and 79% sensitivity and 82 and 80% specificity.</p><p><strong>Conclusion: </strong>Preoperatively measured HALP score and PNI can be used to predict 1-month mortality after CABG.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1489301"},"PeriodicalIF":4.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}