Frontiers in Nutrition最新文献

{"title":"Coenzyme Q10 modulates the immunity by enhancing mononuclear macrophage, NK cell activity, and regulating gut microbiota.","authors":"Yajun Liang, Yang Han, Ling Xiao, Yupeng Su, Tongen Bao, Xia Ji, Longgang Jia, Jing Zhang","doi":"10.3389/fnut.2025.1504831","DOIUrl":"https://doi.org/10.3389/fnut.2025.1504831","url":null,"abstract":"<p><strong>Introduction: </strong>Coenzyme Q10 (CoQ10), an important fat-soluble, bioactive molecule that predominantly found in the inner mitochondrial membrane, is widely used in functional food and health food raw materials, which has garnered considerable attention due to its potential role in immunoregulation. However, the intrinsic mechanism of CoQ10 on immunity, and the relationship to the gut microbiota have not been elucidated.</p><p><strong>Methods: </strong>Here, we conducted a series of <i>in vivo</i> experiments with the aim of comprehensively exploring the effect of CoQ10 on both cellular and humoral immune functions, and on gut microbiota communities in mice.</p><p><strong>Results: </strong>CoQ10 showed negligible impact on both mouse body weight fluctuations and tissue indices, but enhanced the mouse body immunity by elevating the carbon clearance ability and natural killer (NK) cellular viability. 16S rRNA gene sequencing revealed that administration of CoQ10 modulated the structure and composition of the gut microbiota in mice, notably by enhancing the abundance of <i>Lactobacillus, Limosilactobacillus</i>, and decreasing the abundance of <i>Paramuribaculum</i> species.</p><p><strong>Discussion: </strong>This work makes a contribution to the application of CoQ10 as an immunomodulator in the biological, pharmaceutical and health care product industries.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1504831"},"PeriodicalIF":4.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the dietary index for gut microbiota with sleep disorder among US adults: the mediation effect of dietary inflammation index.","authors":"Yingying Li, Fang Pan, Xiaofei Shen","doi":"10.3389/fnut.2025.1528677","DOIUrl":"https://doi.org/10.3389/fnut.2025.1528677","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have confirmed the relationship between gut microbiota and sleep disorders, characterized by the persistent inability to achieve adequate sleep, with dietary composition playing a key role in maintaining microbiota homeostasis. Our study aims to explore the relationship between the newly proposed Dietary Index for Gut Microbiota (DI-GM) and sleep disorders, as well as whether the Dietary Inflammatory Index (DII) mediates this relationship.</p><p><strong>Methods: </strong>This study is based on data from 30,406 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, a cross-sectional survey that represents the U.S. adult population. We used multivariable logistic regression models to examine the relationship between DI-GM and sleep disorders. Subgroup interaction analyses were conducted to assess the stability of the results. Mediation analysis was employed to explore the effect of the Dietary Inflammatory Index (DII) on the relationship between DI-GM and sleep disorders.</p><p><strong>Results: </strong>The DI-GM score was significantly negatively correlated with sleep disorders. After adjusting for covariates, each unit increase in DI-GM was associated with a 5% reduction in the prevalence of sleep disorders (<i>p</i> < 0.001). Additionally, there was a trend toward a decrease in the prevalence of sleep disorders with increasing DI-GM (trend <i>p</i> < 0.05). Dose-response curve analysis revealed a linear relationship between DI-GM and sleep disorders, with higher DI-GM scores being associated with lower prevalence of sleep disorders. DII was positively correlated with sleep disorders (<i>p</i> < 0.001) and decreased as DI-GM increased (<i>β</i> = -0.37, <i>p</i> < 0.001). Mediation analysis showed that DII significantly mediated the relationship between DI-GM and sleep disorders, with a mediation proportion of 27.36% (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The results of this study indicate that the DI-GM score was significantly negatively correlated with sleep disorders. A higher DI-GM score is associated with a lower incidence of sleep disorders, while the DII significantly mediated the relationship between DI-GM and sleep disorders. Specifically, an increase in DII may attenuate the protective effect of DI-GM on sleep disorders.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1528677"},"PeriodicalIF":4.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the efficacy and impact of neutropenic diet in pediatric hematology patients: a longitudinal cohort study on adherence, clinical outcomes, and socioeconomic factors.","authors":"Amitabh Singh, Neetu Kushwaha, Raja Srishwan, Shamsuz Zaman, Noreen Grace George, Raj Kamal, Sandeep Kumar Swain, Manpreet Kaur, Fouzia Siraj, Saurabh Sharma, Baseer Noor, Prashant Prabhakar, Bhavika Rishi, Aroonima Misra","doi":"10.3389/fnut.2025.1533734","DOIUrl":"https://doi.org/10.3389/fnut.2025.1533734","url":null,"abstract":"<p><strong>Background and aim: </strong>A neutropenic diet aims to reduce hospitalizations from febrile neutropenia and sepsis in pediatric hematology patients during chemotherapy. This study aimed to evaluate its effectiveness in improving mortality, morbidity, and overall outcomes while considering limitations, adherence rates, and its impact on hospital admissions and culture positivity.</p><p><strong>Method: </strong>A prospective 18-month observational study was conducted on pediatric hematology patients in a pediatric department at a tertiary care center. Using a baseline questionnaire at the introduction of a neutropenic diet, the study assessed the clinical history, diagnosis, clinicopathological parameters, dietary recommendations, and socio-demographic data of the patients. Patients were followed up for up to 1 year to evaluate diet adherence, outcomes, mortality, and morbidity, as indicated by hospital admissions for febrile neutropenia.</p><p><strong>Results: </strong>An analysis involving 100 patients was conducted to assess adherence to a neutropenic diet and its ramifications on clinical outcomes over a period of 18 months. Initial follow-up data were accessible for 83 patients, revealing an adherence rate of 66%, which subsequently declined to 57% following a 6-month interval. Patients were categorized as compliant or non-compliant, but no correlation was found between adherence and febrile admissions, sepsis, hospitalizations, or mortality. Among compliant patients, 62% showed sepsis signs, though only 19% had positive blood cultures in the whole study group. Non-adherence was linked to demographic factors such as large family size, financial constraints, and limited resources. The neutropenic diet showed minimal impact on morbidity and mortality.</p><p><strong>Conclusion: </strong>Our study does not support the strict adherence to the neutropenic diet, as there is no evidence of reduced infections and the dietary adherence also imposes an undue financial burden on patients. Instead, focusing on the safe acquisition of food, food processing, and proper hand cleanliness will probably provide superior protection against infection.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1533734"},"PeriodicalIF":4.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum calcium levels and the risk of sarcopenia in young adults: insights from NHANES 2011-2018.","authors":"Junliang Jiang, Ge Chen, Yonggang Li, Qinggang Zhao, Zhong Chen","doi":"10.3389/fnut.2025.1526879","DOIUrl":"https://doi.org/10.3389/fnut.2025.1526879","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia, the accelerated loss of muscle mass and function, is commonly associated with aging, especially in older adults. While low serum calcium has been linked to muscle loss in individuals over 50, its relationship with sarcopenia in younger adults (20-60 years) is unclear. This study examines this association using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018.</p><p><strong>Methods: </strong>This population-based, cross-sectional study analyzed participants aged 20-60 from NHANES 2011-2018. Individuals with missing data were excluded. Sarcopenia was assessed using appendicular skeletal muscle (ASM) measured by dual-energy X-ray absorptiometry, defined by ASM/BMI or ASM/Weight. Multiple logistic regression and stratified analyses were used to explore the correlation between serum calcium levels and sarcopenia prevalence.</p><p><strong>Results: </strong>Among 7,309 adults, 578 (7.91%) had sarcopenia by ASM/BMI and 1,363 (18.65%) by ASM/Weight. Higher serum calcium levels were significantly associated with a lower risk of sarcopenia (ASM/BMI: OR 0.07, 95% CI 0.02-0.20; ASM/Weight: OR 0.09, 95% CI 0.04-0.19). The trend was consistent across age, gender, education, poverty income ratio, and race, with some exceptions.</p><p><strong>Conclusion: </strong>This study highlights a negative association between serum calcium and sarcopenia risk in young and middle-aged adults, suggesting that calcium interventions could be beneficial in preventing sarcopenia in this population. However, the cross-sectional design precludes any inference of causality, and further longitudinal studies are warranted to confirm these findings.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1526879"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose tissue characteristics as a new prognosis marker of patients with locally advanced head and neck cancer.","authors":"Larissa Ariel Oliveira Carrilho, Fabiana Lascala Juliani, Rafaella Caroline de Lellis Moreira, Livia Dias Guerra, Fernanda Silva Santos, Daniela Morais de Holanda Padilha, Sandra Regina Branbilla, Vivian Naomi Horita, Davi Magalhães Leite Novaes, Lígia Macedo Antunes-Correa, Carmem Silvia Passos Lima, Maria Carolina Santos Mendes, José Barreto Campello Carvalheira","doi":"10.3389/fnut.2025.1472634","DOIUrl":"https://doi.org/10.3389/fnut.2025.1472634","url":null,"abstract":"<p><strong>Background: </strong>Patients with head and neck cancer (HNC) are at increased risk of malnutrition due to the presence of tumor and treatments. Body composition is a prognostic factor in these patients. However, the relationship between adipose tissue characteristics and survival in HNC is still unclear.</p><p><strong>Objective: </strong>To evaluate the associations of adiposity, the radiodensity of adipose tissue and muscularity with the prognosis of patients with locally advanced HNC undergoing to chemoradiotherapy.</p><p><strong>Methods: </strong>This retrospective study included 132 patients diagnosed with locally advanced HNC. Body composition assessment was performed using computed tomography (CT) images at the level of the third cervical vertebra (C3). The total adipose tissue radiodensity (TATR), the total adipose tissue index (TATI) and skeletal muscle index (SMI) were evaluated. The primary outcome was overall survival (OS).</p><p><strong>Results: </strong>Patients in the highest TATI tertile had a lower risk of mortality when compared to those in the lowest tertile, HR: 0.56, 95% confidence Interval (CI): 0.32-0.96; <i>p</i> = 0.039. The highest TATR tertile was not associated with death. Patients with greater adiposity had a higher median survival compared to patients with medium and lower TATI (<i>p</i> = 0.0193). Individuals with lower TATI had lower energy intake than patients with higher TATI (<i>p</i> = 0.03). Additionally, patients with low muscularity had worse OS in the multivariable analysis (HR: 1.77, 95% CI: 1.01-3.07; <i>p</i> = 0.044).</p><p><strong>Conclusion: </strong>In patients with locally advanced HNC, our findings underscore the significance of elevated adiposity, beyond maintained muscularity, as independent protective factors for overall survival. Our study highlights the critical importance of assessing body composition and initiating early nutritional interventions to improve the prognosis of these patients.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1472634"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination and food consumption: association with Post-Acute COVID-19 Syndrome in Brazilian adults (CUME Study).","authors":"Marlise Lima Brandão, Helen Hermana Miranda Hermsdorff, Arieta Carla Gualandi Leal, Josefina Bressan, Adriano Marçal Pimenta","doi":"10.3389/fnut.2025.1549747","DOIUrl":"https://doi.org/10.3389/fnut.2025.1549747","url":null,"abstract":"<p><strong>Background: </strong>Post-Acute COVID-19 Syndrome (PACS) is an important sequalae of COVID-19. Then, our objective was to analyze the risk and protective factors for PACS in Brazilian adults participating in the Cohort of Universities of Minas Gerais (CUME Study), with emphasis on COVID-19 vaccination and food consumption.</p><p><strong>Methods: </strong>In this sub-study, we included 2,065 participants of CUME Study who answered the baseline questionnaire in 2016 or 2018 or 2020 or 2022, and the follow-up COVID-19/PACS-specific questionnaire in 2023. PACS diagnosis was based on self-reporting of continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. To estimate the risk and protective factors for PACS, hierarchical multivariate statistical analysis was conducted using the Cox regression technique, producing two models: (1) focusing on consumption of macro and micronutrients; (2) focusing on consumption of food groups.</p><p><strong>Results: </strong>After a median of 5.5 years of follow-up, 54.4% of the participants reported PACS. When we analyzed the consumption of macro and micronutrients, higher intake of proteins (HR: 1.36; 95% CI: 1.06-1.74-4th quartile) and lipids (HR: 1.23; 95% CI: 1.02-1.48-4th quartile) were risk factors for PACS. On the other hand, higher intake of vitamin C (HR: 0.78; 95% CI: 0.64-0.94-4th quartile), vitamin D (HR: 0.81; 95% CI: 0.67-0.99-4th quartile), and zinc (HR: 0.66; 95% CI: 0.52-0.83-4th quartile) were protective factors for the outcome (model 1). When we analyzed the consumption of food groups, higher intake of eggs (HR: 1.59; 95% CI: 1.34-1.89-4th quartile) increased the risk of PACS, whereas, respectively, higher and intermediate consumption of white meat (HR: 0.84; 95% CI: 0.71-1.00-4th quartile) and vegetables (HR: 0.81; 95% CI: 0.67-0.99-2nd quartile; HR: 0.81; 95% CI: 0.67-0.99-3rd quartile) decreased the risk of the outcome (model 2). In both models, pre-infection COVID-19 vaccination was a protective factor for PACS.</p><p><strong>Conclusion: </strong>A healthy diet, with higher consumption of white meat, vegetables and specific micronutrients (vitamin C, vitamin D, zinc), in parallel with pre-infection COVID-19 vaccination, is essential to reduce the risk of PACS.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1549747"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study.","authors":"Yi-Qi Chen, Zhen-Ya Chen, Zheng-Qi Song, Hai-Bo Liang, Yi-Jun Li, Hong Su, Hai-Ming Jin, Xue-Qin Bai","doi":"10.3389/fnut.2025.1437484","DOIUrl":"https://doi.org/10.3389/fnut.2025.1437484","url":null,"abstract":"<p><strong>Background: </strong>Spinal diseases and their associated symptoms are prevalent across all age groups, and their incidence severely affects countless individuals' quality of life. The role of daily habits in the progression of these diseases is increasingly emphasized in research. Moreover, there are reports suggesting associations between dietary factors and the onset of spinal diseases. However, the exact causal relationship between dietary factors and spinal diseases has not been fully elucidated.</p><p><strong>Methods: </strong>We obtained GWAS data on 16 dietary intake and 187 dietary likings from the UK Biobank, and GWAS data on 23 types of spinal disorders from FinnGen R10. The analysis of causal effects was conducted using the Inverse Variance Weighted (IVW) test, and to ensure robustness, MR-Egger, Weighted median, and Bayesian weighted Mendelian randomization (BWMR) were utilized to validate the direction. Sensitivity analysis was conducted using the Cochran Q test and MR-Egger intercept test. Additionally, Multivariable MR (MVMR) was employed to examine the independent effect of alcohol intake frequency.</p><p><strong>Results: </strong>In summary, our study identified statistically significant causal associations between four dietary intake and 10 dietary linkings with various spinal disorders through univariable MR, with degenerative spinal changes showing the most significant dietary influence. Alcohol intake was identified as the primary risk factor, with other risk factors including poultry intake and likings for various types of meat. Protective factors mainly included intake and liking of fruits and vegetables. Additionally, various supplementary analytical methods along with heterogeneity and pleiotropy tests have confirmed the robustness of our results. To avoid the interference of diet-related diseases, multivariable MR analysis was conducted, showing that the incidence of cervical disc disorders may be influenced by gout, diabetes, and hypertension.</p><p><strong>Conclusion: </strong>This study indicates a potential causal relationship between dietary factors and the risk of spinal disorders, providing insights for the early detection and prevention. However, the specific pathogenic mechanisms require detailed basic and clinical research in the future.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1437484"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between prebiotic, probiotic consumption and hyperuricemia in U.S. adults: a cross-sectional study from NHANES 2011-2018.","authors":"Yixuan Wang, Shiwei Li, Xin Li, Meng Wang, Bo Huang, Kailei Feng, Jingqiu Cui","doi":"10.3389/fnut.2025.1492708","DOIUrl":"https://doi.org/10.3389/fnut.2025.1492708","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to provide evidence for an association between the consumption of prebiotics and probiotics and hyperuricemia in U.S. adults.</p><p><strong>Methods: </strong>A total of 7,176 adults who participated in the National Health and Nutrition Examination Survey (NHANES) during 2011-2018 were included in the study. First, the baseline characteristics of the data were described for the weighted data, using the presence or absence of hyperuricemia as the classification criterion. Second, binary logistic regression analyses were performed to establish crude models and regression models adjusted for relevant covariates, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to explore the relationship between prebiotics, probiotic intake, and hyperuricemia. Subsequently, receiver operating characteristic (ROC) curves were plotted to assess probiotic consumption's role in the hyperuricemia prediction model. Finally, subgroup analyses were performed.</p><p><strong>Results: </strong>Participants who consumed probiotics had a lower prevalence of hyperuricemia than those who did not (3.48% vs. 6.25%, <i>p</i> = 0.082). In logistic regression analyses, prebiotics' effect on hyperuricemia was insignificant (<i>p</i> > 0.05), regardless of whether covariates were considered. In contrast, the crude model for probiotics and the adjusted model 1, which was constructed by adjusting for age, sex, and ethnicity, showed ORs less than 1 (crude model: OR = 0.54, 95% CI [0.34, 0.83], <i>p</i> = 0.008; adjusted model 1: OR = 0.54, 95% CI [0.34, 0.83], <i>p</i> = 0.008). The predictive model, including age, sex, race, body mass index (BMI), hypertension, chronic kidney disease, and probiotics, had 76.7% sensitivity and 68.0% specificity with an area under the ROC curve of 0.7886 for detecting hyperuricemia in US adults.</p><p><strong>Conclusion: </strong>These results suggest that probiotic consumption may reduce the incidence of hyperuricemia in the US adult population, but prebiotics have not shown the same effect.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1492708"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep behaviors and adiposity indices among U.S. adults: a cross-sectional study.","authors":"Shenghao Xu, Jie Lin, Qibo Xu, Kai Zhao, Jianlin Xiao","doi":"10.3389/fnut.2025.1526422","DOIUrl":"https://doi.org/10.3389/fnut.2025.1526422","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the relationship between sleep behaviors and adiposity indices.</p><p><strong>Methods: </strong>We analyzed NHANES data from 2011 to 2018 for adults aged 20-80, assessing BMI, waist circumference (WC), lean mass, and body fat percentage with DEXA scans and physical measurements. Sleep duration was categorized into short (<7 h), normal (7-9 h), and long (>9 h), as well as their sleep status based on questionnaires. Furthermore, we examined the interaction effects between sleep duration and sleep patterns.</p><p><strong>Results: </strong>Among 19,951 participants providing BMI and WC data, and 10,716 for lean mass and body fat percentage, short sleep duration correlated with higher BMI (β = 0.56, 95% CI: 0.36-0.76), WC (β = 0.90, 95% CI: 0.43-1.37), and lean mass (β = 0.70, 95% CI: 0.32-1.07). Individuals with sleep disorders showed increased values across all indices: BMI (β = 0.93, 95% CI: 0.72-1.13), WC (β = 2.40, 95% CI: 1.92-2.88), lean mass (β = 0.71, 95% CI: 0.30-1.12), and body fat percentage (β = 0.64, 95% CI: 0.37-0.90). No significant interaction effects were found between sleep duration and sleep disorders.</p><p><strong>Conclusion: </strong>Our findings indicate that individuals with short sleep duration and sleep disorders are likely to carry a higher weight burden, indicating potential targets for addressing obesity-related health issues.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1526422"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three lessons on diabetes for global health professionals, researchers and policy-makers from the people of Ga Mashie.","authors":"Olutobi Adekunle Sanuade, Lydia O Okoibhole, Ernestina K Dankyi, Daniel Strachan, Leonard Baatiema, Sandra Boatemaa Kushitor, Raphael B Awuah, Mawuli K Kushitor, Samuel Amon, Irene Akwo Kretchy, Daniel Arhinful, Edward Fottrell, Megan Vaughan","doi":"10.3389/fnut.2025.1534450","DOIUrl":"https://doi.org/10.3389/fnut.2025.1534450","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a leading cause of death globally, with significant burdens in low- and middle-income countries (LMICs). However, knowledge of contextual factors associated with diabetes in LMICs are limited. This study highlights three important lessons on diabetes by identifying and interpreting contextual factors related to its prevention and management within a low-income urban community in Accra, Ghana.</p><p><strong>Methods: </strong>This was a qualitative study. Data were collected through four focus group discussions (FGDs) with older adults men and women (50+ years) and 18 in-depth interviews with community stakeholders, including traditional leaders, market women, and the Ga Mashie Development Agency. Thematic analysis was conducted to identify key insights on diabetes perceptions, challenges, and cultural practices.</p><p><strong>Results: </strong>Three key themes emerged from the data: (1) Knowledge does not always translate to action. While participants had extensive knowledge of diabetes risk factors and management, they cited practical constraints that hindered their ability to make behavior changes; (2) Food is more than nutrition. Participants noted that food plays an important role in family, community, and emotional well-being, and (3) Diabetes carries dual meanings. Participants associated diabetes with both individual lifestyle behaviors (e.g., alcohol consumption and sexual activity) and broader environmental exposures (e.g., pollution and chemical contaminants in food).</p><p><strong>Conclusion: </strong>These results highlight the complexity of diabetes management in an urban poor community context, requiring more than knowledge on diabetes risk factors for behavior change. Addressing personal, communal, and environmental factors, alongside structural barriers, is essential for developing effective, sustainable diabetes management strategies in this setting.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1534450"},"PeriodicalIF":4.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}