Frontiers in Nutrition最新文献

{"title":"Propolis supplementation on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis of randomized controlled trials.","authors":"Hossein Bahari, Mostafa Shahraki Jazinaki, Mohsen Aliakbarian, Mohammad Rashidmayvan, Haniyeh Golafrouz, Iman Rahnama, Rozita Khodashahi, Mahsa Malekahmadi","doi":"10.3389/fnut.2025.1542184","DOIUrl":"https://doi.org/10.3389/fnut.2025.1542184","url":null,"abstract":"<p><strong>Background: </strong>Although a large number of trials have observed the anti-inflammatory properties of propolis, the currently available research remains controversial regarding its beneficial health effects. Hence, the purpose of this study was to examine the effect of propolis on inflammatory and oxidative stress markers in adults.</p><p><strong>Methods: </strong>A comprehensive search was performed in Scopus, Web of Science, and PubMed/Medline to find relevant randomized controlled trials (RCTs) until January 2024. The overall effect sizes were calculated using the random-effects model and expressed as weighted mean differences (WMD) with a 95% confidence interval (CI). The possible heterogeneity between included trials was assessed by performing Cochran's Q test.</p><p><strong>Results: </strong>In total, 27 trials with 29 treatment arms were eligible for inclusion in this review. This meta-analysis revealed that propolis consumption led to a significant decrease in C-reactive protein (CRP) (WMD: -1.23; 95%CI: -1.76, -0.69; <i>p</i> < 0.001), Interleukin-6 (IL-6) (WMD: -1.52; 95%CI: -2.10, -0.93; <i>p</i> < 0.001), Tumor necrosis factor-α (WMD: -1.15; 95%CI: -1.75, -0.55; <i>p</i> < 0.001), and Monocyte chemoattractant protein-1 (MCP-1) (WMD: -35.33; 95%CI: -50.28, -20.37; <i>p</i> < 0.001), and a significant increase in total antioxidant capacity (TAC) (WMD: 0.32; 95%CI: 0.12, 0.51; <i>p</i> = 0.001), Glutathione (GSH) (WMD: 4.71; 95%CI: 3.17, 6.25; p < 0.001), and Glutathione peroxidase (GPx) (WMD: 44.75; 95%CI: 5.10, 84.40; <i>p</i> = 0.02). However, there were no significant effects on IL-10, IL-2, IL-8, pro-oxidant-antioxidant balance (PAB), malondialdehyde (MDA), and superoxide dismutase (SOD) in comparison to the control group.</p><p><strong>Conclusion: </strong>Propolis supplementation appears effective in reducing inflammation and oxidative stress by enhancing antioxidant capacity and reducing specific inflammatory markers. However, variations in study designs, dosages, and participant characteristics contribute to the heterogeneity of results. Further well-designed RCTs are needed to confirm these findings and determine the optimal dosage and long-term effects. Given its potential anti-inflammatory and antioxidant properties, propolis may serve as a complementary approach in managing inflammation-related conditions, though its clinical application requires further validation.</p><p><strong>Systematic review registration: </strong>https://clinicaltrials.gov/, identifier CRD42023474033.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1542184"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study.","authors":"Mingkai Li, Chenyang Li, Le Cheng, Chenhui Lv, Lushan Xue, Cheng Zhang, Ziping Bai, Xi Wang, Shuangzhi Chen, Qinfei Guo, Yafei Zhao, Haifeng Zhao","doi":"10.3389/fnut.2025.1581610","DOIUrl":"https://doi.org/10.3389/fnut.2025.1581610","url":null,"abstract":"<p><strong>Background: </strong>Biological aging, a fundamental process affecting health and longevity, is pivotal to understanding the physiological decline associated with aging. Serum vitamin D3 deficiency and cognitive impairment are common health issues among older adults. However, the joint associations of serum vitamin D levels and cognitive impairment with biological aging remain poorly understood. This study aims to evaluate the independent and combined associations of serum vitamin D3 and cognitive impairment with biological aging in older adults.</p><p><strong>Methods: </strong>This cross-sectional study included adults aged 60 years and older from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). Biological aging was measured using Phenotypic Age calculated from biomarkers. Cognitive performance was assessed using the Centre for the Establishment of a Registry for Alzheimer's Disease (CERAD) test, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). Multivariable regression and restricted cubic spline models were used to examine the relationships between serum 25(OH)D3 levels, cognitive performance, and biological aging.</p><p><strong>Results: </strong>After adjusting for all covariates, individuals in the highest quartile of cognitive performance had a reduced risk of biological aging compared to those in the lowest quartile (CERAD: OR 0.91; 95% CI, 0.57-1.46; AFT: OR 0.48; 95% CI, 0.29-0.82; DSST: OR 0.43; 95% CI, 0.24-0.77). A U-shaped relationship was observed between serum 25(OH)D3 levels and biological aging. Combined analyses revealed that individuals with both low serum 25(OH)D3 and low cognitive performance had the highest risk of biological aging across all cognitive tests (CERAD: OR 1.43; 95% CI, 1.02-1.98; AFT: OR 1.70; 95% CI, 1.24-2.32; DSST: OR 1.67; 95% CI, 1.22-2.27). Notably, in the DSST, individuals with normal serum 25(OH)D3 levels and normal cognitive performance showed a reduction in Phenotypic Age by 2.40 years (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>In older adults, low serum 25(OH)D3 levels combined with low cognitive performance are strongly associated with an increased risk of biological aging.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1581610"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early adolescent offspring rats.","authors":"Linxi Qian, Tao Zheng, Bowen Zhao, Weiye Wang, Yifan Wu","doi":"10.3389/fnut.2025.1566182","DOIUrl":"https://doi.org/10.3389/fnut.2025.1566182","url":null,"abstract":"<p><strong>Introduction: </strong>Postpartum sleep disturbances in women are common and can significantly affect maternal mental health and breastfeeding. However, the impact of sleep disruptions in lactating mothers on the neurological and cognitive development of their offspring has not been explored.</p><p><strong>Materials and methods: </strong>Female Sprague-Dawley rats were subjected to chronic maternal sleep interruptions (MSI) during lactation. The offspring were divided into four groups: control, MSI, and MSI with low-dose (5 mg/kg·day) or high-dose (25 mg/kg·day) oleamide (ODA) supplementation. Behavioral performance was assessed using the Morris Water Maze (MWM). Neurogenesis and neuroinflammatory markers in the hippocampus were analyzed through immunohistochemistry, Western blotting, and Q-PCR. Levels of endocannabinoids (eCBs) were measured in maternal milk and offspring brain tissues, along with the expression of eCBs-regulating enzymes in offspring brain tissues. NE-4C cells were used to examine the effects of milk from sleep-disrupted dams on neural function.</p><p><strong>Results: </strong>Offspring exposed to MSI showed increased escape latency, travel distance, and poor performance in the MWM probe test, indicating impaired spatial learning and memory. MSI also decreased neurogenesis markers and increased neuroinflammatory markers in the hippocampus. High-dose ODA supplementation restored behavioral performance, reduced neuroinflammation, and normalized eCBs levels and enzyme expression in the offspring's hippocampus. Additionally, MSI altered eCBs composition in maternal milk, particularly lowering ODA and 2-AG levels. <i>In vitro</i>, milk from MSI dams inhibited BDNF secretion and reduced anti-inflammatory cytokine expression in NE-4C cells.</p><p><strong>Conclusion: </strong>MSI during lactation disrupts eCBs signaling and induces neuroinflammation in the offspring, impairing neurodevelopment. Neonatal ODA supplementation may offer a promising intervention to mitigate the cognitive deficits and brain changes induced by MSI during lactation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1566182"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary inflammatory index with gynecological cancers in NHANES 2011-2018.","authors":"Chen Chen, Mengyu Zheng, Xing Dong, Pei Zhang, Zhuo Bao, Yushan Cao, Yixuan Liu, Jinxiang Yan, Yongzhen Guo, Xianxu Zeng","doi":"10.3389/fnut.2025.1560987","DOIUrl":"https://doi.org/10.3389/fnut.2025.1560987","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the association between the Dietary Inflammatory Index (DII) and the risk of gynecological cancers using data collected from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2018.</p><p><strong>Methods: </strong>The data for this study were obtained from NHANES, conducted between 2011 and 2018, and included a total of 8,380 women. To examine the association between the Dietary Inflammatory Index and gynecological cancers, weighted multivariable logistic regression analyses were performed, using DII both as a continuous variable and as a categorical variable divided into tertiles. Subgroup analyses stratified by DII and gynecological cancer characteristics were conducted to further explore this association. Additionally, restricted cubic spline (RCS) analysis was applied to evaluate potential non-linear relationships between DII and gynecological cancer risk.</p><p><strong>Results: </strong>Among the 8,380 women included in the analysis, the mean age was 47.02 (SD: 16.91) years, and 196 participants self-reported a diagnosis of gynecological cancer. In fully adjusted models, DII was significantly positively associated with the prevalence of gynecological cancer, whether analyzed as a continuous variable (OR = 1.15, 95% CI: 1.00-1.33, <i>p</i> = 0.046) or as a categorical variable (highest tertile compared to the lowest tertile: OR = 2.14, 95% CI: 1.14-4.04, <i>p</i> = 0.021, p for trend = 0.021). Restricted cubic spline analysis confirmed a linear relationship between DII and gynecological cancer risk (p for non-linear association = 0.1984). Subgroup analyses revealed a significant interaction effect with smoking status (p for interaction = 0.037).</p><p><strong>Conclusion: </strong>Our findings suggest that higher DII scores are positively associated with an increased risk of gynecological cancer. These results contribute to the existing literature and underscore the need for further validation through larger prospective cohort studies.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1560987"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of protein intake in maintaining muscle mass composition among elderly females suffering from sarcopenia.","authors":"Izwa Ishaq, Sana Noreen, Patrick Maduabuchi Aja, Ayomide Victor Atoki","doi":"10.3389/fnut.2025.1547325","DOIUrl":"https://doi.org/10.3389/fnut.2025.1547325","url":null,"abstract":"<p><p>Dietary protein is crucial in preserving muscle mass and promoting long-term bone health, particularly in aging populations. The novelty of this study lies in evaluating the impact of varying protein intake levels (0.8 vs. 1.2 g/kg b.w/d) on muscle mass composition in elderly females suffering from sarcopenia. For this purpose, in this research trial, a total of 126 participants (60-75 years) were enrolled and equally divided into two groups: normal protein intake (0.8 g/kg b.w/d) and moderately high protein intake (1.2 g/kg b.w/d) for 12 weeks. The effects of dietary protein were assessed using anthropometric measurements, magnetic resonance imaging (MRI), handgrip, and knee flexion tests with baseline and post-intervention comparisons. Statistical analysis was conducted using SPSS, employing paired sample t-test at a significance level of <i>p</i> < 0.05. Results indicated a significant improvement in muscle mass composition with moderately high protein intake. Anthropometric parameters, including body mass (83.51 ± 4.23 kg) and waist circumference (113.90 ± 10.82 cm), showed notable enhancement in the moderately higher protein group. Muscle function and imaging assessments, such as handgrip strength and knee flexion, demonstrated improved functionality. MRI-derived measurements of the muscle composition of the calf (141.23 ± 4.87 MCSA, mm² × 10⁴) and thigh (258.04 ± 7.26 MCSA, mm² × 10⁴) further confirmed the positive impact of increased protein intake. The study concluded that a moderately high protein diet effectively supports muscle health in elderly females with sarcopenia. Therefore, an adequate protein intake may serve as a strategic nutritional intervention to mitigate muscle loss and improve overall physical function in aging women.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1547325"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of mixed tempeh with soy tempeh on cognitive function in older people.","authors":"Yuda Turana, Yvonne Suzy Handajani, Tati Barus, Kevin Kristian, Elvina Theodoraliu, Ika Suswanti","doi":"10.3389/fnut.2025.1551211","DOIUrl":"https://doi.org/10.3389/fnut.2025.1551211","url":null,"abstract":"<p><strong>Introduction: </strong>Antioxidants may help alleviate cognitive impairment in older adults, which is often caused by oxidative stress. This research focuses on developing tempeh enriched with antioxidant-rich ingredients, including sunflower seeds, pumpkin seeds, and adzuki beans, to enhance its neuroprotective properties. This study is the first to investigate the effectiveness of mixed tempeh in reducing cognitive decline.</p><p><strong>Methods: </strong>This experimental study (a non-randomized controlled trial) included 57 older participants with mild cognitive impairment who did not have diabetes. The participants were divided into two groups: one consumed mixed tempeh (comprising sunflower seeds, pumpkin seeds, adzuki beans, and regular soybeans), while the other group consumed soy tempeh. Both groups were instructed to consume 100 g daily over a period of 4 months and to avoid other fermented foods. Cognitive assessments were conducted before and after the intervention to evaluate the effects of tempeh consumption.</p><p><strong>Results: </strong>The majority of participants were female (68.4%), aged over 65 years (77.2%), and had an education level of 12 years or more (59.6%). The mixed tempeh group showed improvement in three cognitive domains (global cognitive, memory, and verbal fluency) before and after the intervention, while the soy tempeh group experienced improvements in two domains (memory and visuospatial).</p><p><strong>Conclusion: </strong>The study highlights the cognitive benefits of tempeh, particularly when mixed with other nutrient-rich ingredients. The combination of sunflower seeds, pumpkin seeds, and adzuki beans in mixed tempeh provides superior neuroprotective effects than traditional soy tempeh. This research supports the idea of promoting mixed tempeh as a healthy food alternative, especially for older adults, by offering enhanced nutritional value and cognitive health benefits.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1551211"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The interaction between estimated glomerular filtration rate and dietary magnesium intake and its effect on stroke prevalence: a cross-sectional study spanning 2003-2018.","authors":"Chunhua Liu, Linan Qiu, Yuanyuan Zhang, Liping Chen, Huaqiang Wang, Huajian Lin, Yongjun Tao, Haiqin Ye","doi":"10.3389/fnut.2025.1603936","DOIUrl":"https://doi.org/10.3389/fnut.2025.1603936","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnut.2024.1395685.].</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1603936"},"PeriodicalIF":4.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of dietary nutrients on hearing loss: a systematic review and meta-analysis.","authors":"Wang Lu, Rui Tang, Xiong Jiahui, Zhang Shipeng, Guo Tao, Wang Hanyua, Xiong Feng, Xie Hui","doi":"10.3389/fnut.2025.1528771","DOIUrl":"10.3389/fnut.2025.1528771","url":null,"abstract":"<p><strong>Background: </strong>Hearing loss ranks as the third most prevalent disability globally, significantly impacting individuals and society, and imposing a substantial healthcare burden. The World Health Organization reports that over 1.5 billion people worldwide experience hearing loss, with one-third of these cases attributed to preventable factors. Recently, the influence of diet and nutrition on auditory health has garnered increasing attention.</p><p><strong>Objective: </strong>This study systematically reviews and meta-analyzes the protective effects of dietary nutrients on hearing, examining specific nutrients' impact on hearing loss and their potential biological mechanisms.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted for relevant studies up to August 2024. Following PRISMA guidelines, the systematic review was registered in PROSPERO. Included were observational studies assessing the relationship between dietary intake and hearing loss.</p><p><strong>Results: </strong>Thirty-three studies met inclusion criteria: 21 cross-sectional, 10 cohort, and 2 case-control studies. Meta-analysis revealed significant inverse associations between the intake of vitamin B2, β-carotene, carotenoids, β-cryptoxanthin, fat, protein, fiber, and fish, and the risk of hearing loss.</p><p><strong>Conclusion: </strong>Certain dietary nutrients may protect hearing health. Increasing intake of antioxidants, fiber, protein, and fish rich in unsaturated fatty acids may help preserve auditory function.Keywords: Hearing loss, dietary nutrients, systematic review, meta-analysis, antioxidants.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024572118, identifier: CRD42024572118.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1528771"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Bacillus coagulans</i> BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study.","authors":"Rui Wang, Guoming Zhang, Xiaoya Wang, Zefeng Xing, Zhen Li, Lixiang Li","doi":"10.3389/fnut.2025.1542145","DOIUrl":"10.3389/fnut.2025.1542145","url":null,"abstract":"<p><strong>Introduction: </strong>Probiotic supplementation is a safe and effective way to reduce overweight and obesity by regulating the gut microbiota. The <i>Bacillus coagulans</i> strain BC99 is derived from humans and has various probiotic-related, acid resistance, bile salt resistance, and adhesion-related domains in the genome. This study aimed to assess the effects of BC99 on the gut microbiota, body weight and lipid profiles of overweight and obese individuals.</p><p><strong>Methods: </strong>A total of 66 adult individuals were randomly assigned to a probiotic group (supplemented with 5 × 10⁹ colony-forming units of BC99 per day along with 3 g of maltodextrin) and placebo group (supplemented with 3 g of maltodextrin daily) in a 1:1 ratio.</p><p><strong>Results: </strong>After 8 weeks of oral administration, BC99 intervention significantly decreased the body weight of overweight individual (<i>P</i> < 0.01). Weight loss was significantly greater in the probiotic group than in the placebo group (<i>P</i> < 0.05). No significant differences were observed in lipid profiles between two groups. The microbiota analysis revealed that BC99 intervention significantly improved the β-diversity at week 4. The genus <i>Parabacteroides</i> was negatively correlated with body weight and was found to be enriched in the BC99 group.</p><p><strong>Discussion: </strong>These findings suggest that <i>B. coagulans</i> strain BC99 could be a beneficial candidate for modulating the gut microbiota and improve body weight management for overweight individuals.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, identifier NCT06077383.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1542145"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators and barriers of wet nursing: a qualitative study with implications for emergencies.","authors":"Khadija Abdelrahmman, Bindi Borg, Karleen Gribble, Seema Mihrshahi","doi":"10.3389/fnut.2025.1456675","DOIUrl":"10.3389/fnut.2025.1456675","url":null,"abstract":"<p><strong>Introduction: </strong>Supporting recommended breastfeeding practices, including wet nursing in emergencies, is crucial to providing safe and nutritious food for infants and young children to support their health and wellbeing in critical resourced situations. However, it is only now that practical guidelines for implementing wet nursing in emergencies are being developed (by UNICEF). As there is very little literature on wet nursing in contemporary settings, this study aimed to explore current wet nursing experiences to identify the facilitators and barriers of the practice, especially in emergencies.</p><p><strong>Methods: </strong>Online semi-structured interviews were conducted from September to November 2023 with eight breastfeeding counselors and advocates. Transcripts were inductively analyzed using a reflexive thematic approach.</p><p><strong>Results: </strong>Seven themes were identified that reflect the factors affecting wet nursing. These included \"wet nursing saved lives,\" \"breastfeeding is valued,\" \"infant formula is normalized,\" \"risk of infection transmission,\" \"all stakeholders' acceptance,\" \"counseling approach,\" and \"planning for implementation.\" These results suggest that facilitators and barriers that generally affect maternal breastfeeding in emergencies also influence wet nursing. Certain obstacles may have a particular impact on wet nursing, including the risk of infection transmission, negative attitudes toward wet nursing and the need for culturally sensitive counseling to mediate wet nursing.</p><p><strong>Conclusion: </strong>Promoting wet nursing is an Infant and Young Children Feeding in Emergencies recommendation (IYCF-E) for non-breastfed infants. Implementing wet nursing programs can be in line with supporting good breastfeeding practices in emergencies. The results of this study can guide practical steps for implementing wet nursing and future investigation in different contexts.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1456675"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}