Frontiers in Nutrition最新文献

{"title":"Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.","authors":"Saeid Mohseni, Ali Tavakoli, Hamid Ghazipoor, Neda Pouralimohamadi, Roghayeh Zare, Thomas Rampp, Maryam Shayesteh, Mehdi Pasalar","doi":"10.3389/fnut.2025.1494351","DOIUrl":"10.3389/fnut.2025.1494351","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory Bowel Disease (IBD), encompassing Crohn disease (CD) and ulcerative colitis (UC), presents complex challenges in management due to dysregulated immune responses and genetic predispositions. This study explored the potential of curcumin as an adjunctive therapy in IBD, assessing its efficacy and safety through a systematic review of clinical trials to enhance treatment strategies and outcomes.</p><p><strong>Methods: </strong>To identify placebo-controlled randomized clinical trials on curcumin treatment in IBD, databases such as Medline/PubMed, Scopus, Embase, Web of Knowledge, and Google Scholar were searched till May 2024. Inclusion criteria focused on RCTs comparing curcumin with placebo in IBD patients, with data extraction and analysis conducted using established methodologies and tools for comprehensive synthesis and assessment of study findings.</p><p><strong>Results: </strong>In this meta-analysis, 13 placebo-controlled RCTs on curcumin treatment in IBD were included after screening 362 records and conducting a full-text review. Most trials focused on UC patients and were published post-2010, utilizing oral curcumin with varying dosages and durations. The analysis showed curcumin's significant efficacy in achieving clinical remission and response in UC patients, with heterogeneity observed. Adverse events and withdrawal rates did not significantly differ between curcumin and placebo groups. In CD patients, curcumin did not show superiority over placebo for clinical and endoscopic remission.</p><p><strong>Conclusion: </strong>The findings highlight curcumin's potential as a treatment for UC but indicate inconclusive results for CD, emphasizing the need for further research. The multifaceted mechanisms of curcumin's efficacy in IBD involve anti-inflammatory, antioxidant, microbiota modulatory, and immune-regulating properties. Further research is warranted to enhance understanding and treatment efficacy.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567247.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1494351"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases.","authors":"Sathish Kumar Perumal, Madan Kumar Arumugam, Natalia A Osna, Karuna Rasineni, Kusum K Kharbanda","doi":"10.3389/fnut.2025.1478542","DOIUrl":"10.3389/fnut.2025.1478542","url":null,"abstract":"<p><p>Chronic liver disease is defined by persistent harm to the liver that might result in decreased liver function. The two prevalent chronic liver diseases are alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD). There is ample evidence that the pathogenesis of these two chronic liver diseases is closely linked to gastrointestinal dysfunctions that alters the gut-liver crosstalk. These alterations are mediated through the imbalances in the gut microbiota composition/function that combined with disruption in the gut barrier integrity allows for harmful gut microbes and their toxins to enter the portal circulation and reach the liver to elicit an inflammatory response. This leads to further recruitment of systemic inflammatory cells, such as neutrophils, T-cells, and monocytes into the liver, which perpetuate additional inflammation and the development of progressive liver damage. Many therapeutic modalities, currently used to prevent, attenuate, or treat chronic liver diseases are aimed at modulating gut dysbiosis and improving intestinal barrier function. Betaine is a choline-derived metabolite and a methyl group donor with antioxidant, anti-inflammatory and osmoprotectant properties. Studies have shown that low betaine levels are associated with higher levels of organ damage. There have been several publications demonstrating the role of betaine supplementation in preventing the development of ALD and MASLD. This review explores the protective effects of betaine through its role as a methyl donor and its capacity to regulate the protective gut microbiota and maintain intestinal barrier integrity to prevent the development of these chronic liver diseases. Further studies are needed to enhance our understanding of its therapeutic potential that could pave the way for targeted interventions in the management of not only chronic liver diseases, but other inflammatory bowel diseases or systemic inflammatory conditions.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1478542"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ultra-processed foods with phenotypic age acceleration in US adults: a mediation analysis of body mass index in the NHANES.","authors":"Weiliang Kong, Yilian Xie, Mengyuan Cen, Kunlong Xiong","doi":"10.3389/fnut.2025.1485456","DOIUrl":"10.3389/fnut.2025.1485456","url":null,"abstract":"<p><strong>Background: </strong>The rising intake of ultra-processed foods (UPFs) has been linked to adverse health outcomes, yet its impact on aging acceleration remains unclear.</p><p><strong>Objective: </strong>This study aimed to examine the association between the percentage of total daily calories (%Kcal) and grams (%Gram) from UPFs and phenotypic age acceleration (PhenoAgeAccel).</p><p><strong>Methods: </strong>Data from 12,079 adults in the NHANES 2005-2010 cycles were analyzed. The relationship between UPFs intake and PhenoAgeAccel was assessed using multivariable linear regression and restricted cubic splines, with adjustments for relevant covariates. The mediating role of body mass index (BMI) was also explored.</p><p><strong>Results: </strong>A significant positive linear association was observed between UPFs intake (%Gram) and PhenoAgeAccel, with the highest quartile showing an increase of 0.60 (95% CI: 0.15, 1.05; <i>p</i> for trend = 0.039), but no association was found between UPFs intake (%Kcal) and PhenoAgeAccel. Mediation analysis indicated that BMI mediated 27.5% of the association between UPFs intake (%Gram) and PhenoAgeAccel. Sensitivity analyses confirmed the robustness of the results.</p><p><strong>Conclusion: </strong>Higher intake of UPFs intake (%Gram) is positively associated with PhenoAgeAccel, with BMI playing a significant mediating role.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1485456"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between estimated glucose disposal rate and metabolic syndrome: a cross-sectional analysis of the National Health and Nutrition Examination Survey.","authors":"Kaide Xia, Shuai Jin, Guifang Chen, Haiwang Zhang, Qiao Zhang","doi":"10.3389/fnut.2025.1544582","DOIUrl":"10.3389/fnut.2025.1544582","url":null,"abstract":"<p><p>Metabolic syndrome (MS) is a complex metabolic disorder that is often closely associated with the development of chronic diseases such as cardiovascular disease and diabetes. This study aimed to explore the relationship between estimated glucose metabolic rate (eGDR) and MS. The correlation between eGDR levels and the prevalence of metabolic syndrome was analyzed here based on data from the National Health and Nutrition Examination Survey from 2005 to 2020. The study sample consisted of 63,131 adult participants, and the results showed that lower eGDR levels were significantly associated with a higher prevalence of metabolic syndrome. Further regression analyses showed that eGDR acted as a protective factor and that the risk of MS significantly decreased as its level increased. Subgroup analyses showed that this trend held across gender, age, and BMI categories, and that the protective effect of eGDR was weaker in the higher BMI group. Based on the nonlinear relationship between subjects' eGDR levels and MS prevalence, RCS analyses further confirmed a significant correlation between lower eGDR levels and increased risk of MS. In conclusion, the present study suggests that eGDR levels could serve as a potential biomarker for predicting metabolic syndrome, providing new perspectives for early screening and intervention of MS.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1544582"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of ALT, AST and ALT/AST ratio with metabolically unhealthy obesity in the elderly.","authors":"Yuhan Shao, Hailong Zhu, Xin Chen, Enqiang Feng, Chen Chen, Zhugang Shao, Xiaojing Li, Li Liu","doi":"10.3389/fnut.2025.1513029","DOIUrl":"10.3389/fnut.2025.1513029","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to clarify the effects of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and ALT/AST ratio on metabolically unhealthy obese (MUHO) and to estimate the predictors of MUHO in the elderly.</p><p><strong>Methods: </strong>19,812 individuals aged 65 years and older from a health check-up in Qingdao, China in 2021 were chosen as subjects in the current study. Binary logistic regression models were performed to evaluate the relationship between ALT, AST, ALT/AST ratio and MUHO. Receiver operating characteristic (ROC) analysis was performed to estimate the predictive value of ALT, AST and ALT/AST ratio for the diagnosis of MUHO.</p><p><strong>Results: </strong>The risks for MUHO increased across quartiles of ALT level and ALT/AST ratio in both genders. The adjusted odds ratios (ORs) for MUHO in the highest quartile of ALT were 3.20-fold higher than the reference quartile in men and 3.05-fold higher in women. Compared with the first quartile of ALT/AST ratio, the adjusted ORs for MUHO in the highest quartile were 3.64 (95% CI: 3.17-4.19) in men and 3.60 (95% CI: 3.11-4.16) in women, respectively. In ROC curve analysis for predicting MUHO, the area under the ROC curve (AUC) values were 0.63 (<i>p</i> < 0.001) for ALT and 0.64 (<i>p</i> < 0.001) for ALT/AST ratio in men, and 0.62 (<i>p</i> < 0.001) for ALT and 0.64 (<i>p</i> < 0.001) for ALT/AST ratio in women. However, AST was not significantly associated with MUHO both in men and in women (<i>p</i>>0.05).</p><p><strong>Conclusion: </strong>ALT and ALT/AST ratio might be considered as two simple and reliable diagnostic indicators for MUHO in the elderly.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1513029"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication <i>in vitro</i>.","authors":"Zhanding Cui, Jinlong Liu, Jinlong Wang, Jing Zhang, Yimei Cao, Kun Li, Zhixun Zhao, Hong Yuan, Xingwen Bai, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Dong Li, Qiang Zhang, Zaixin Liu, Kai Li, Tong Xu, Zengjun Lu","doi":"10.3389/fnut.2024.1501685","DOIUrl":"10.3389/fnut.2024.1501685","url":null,"abstract":"<p><p>This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains <i>in vitro</i>, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1501685"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural and hormonal mechanisms of appetite regulation during eating.","authors":"Xurui Sun, Binghan Liu, Yuan Yuan, Ying Rong, Rui Pang, Qiu Li","doi":"10.3389/fnut.2025.1484827","DOIUrl":"https://doi.org/10.3389/fnut.2025.1484827","url":null,"abstract":"<p><p>Numerous animal and clinical studies have demonstrated that the arcuate nucleus of the hypothalamus, a central regulator of appetite, plays a significant role in modulating feeding behavior. However, current research primarily focuses on long-term dietary changes and their effects on the body, with limited investigation into neuroendocrine dynamics during individual meals across diverse populations. In contrast to long-term dietary adjustments, directives for dietary behavior during a specific meal are more actionable, potentially enhancing patient adherence and achieving better outcomes in dietary behavior interventions. This review aimed to explore the neural pathways and endocrine changes activated by gastrointestinal expansion and variations in blood nutrient levels during a single meal, with the goal of informing dietary behavior guidance.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1484827"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fiber from burdock root ameliorates functional constipation in aging rats by regulating intestinal motility.","authors":"Liya Mo, Kaiyang Ma, Ying Li, Jiangfeng Song, Qiqi Song, Ling Wang","doi":"10.3389/fnut.2025.1550880","DOIUrl":"10.3389/fnut.2025.1550880","url":null,"abstract":"<p><p>Functional constipation is a common gastrointestinal health issue among the aging population. Dietary fiber supplementation is widely recognized as a first-line strategy for constipation. However, the effectiveness of dietary fiber in practical applications remains unsatisfactory, and dietary fibers from different sources are believed to possess varying physiological activities in alleviating constipation. Burdock root is a vegetable rich in dietary fiber. In this study, loperamide was used to induce functional constipation in aged rats. Doses of 3 mg/kg·bw·day and 1.5 mg/kg·bw·day of dietary fiber from burdock root were used to intervene in functional constipation in aged rats. Research indicated that dietary fiber from burdock root enhanced intestinal motility to ameliorate functional constipation in aging rats. This effect may involve several mechanisms, including repairing the intestinal barrier, regulating intestinal hormones, and providing anti-inflammation and antioxidation. Our findings provide a theoretical basis for the potential mechanism by which burdock root dietary fiber can ameliorate functional constipation. It is expected to serve as a natural functional food to combat functional constipation in the aging population.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1550880"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational screening for novel <i>α</i>-glucosidase inhibitory peptides from <i>Chlamys nobilis</i> adductor muscle as a potential antidiabetic agent.","authors":"Haisheng Lin, Wen Wang, Lei Du, Jialong Gao, Wenhong Cao, Huina Zheng, Zhongqin Chen, Xiaoming Qin, Yuanwei Liang","doi":"10.3389/fnut.2025.1566107","DOIUrl":"10.3389/fnut.2025.1566107","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the adjuvant hypoglycemic function of enzyme hydrolyzate (EHCA) from <i>Chlamys nobilis</i> in mice and to identify <i>α</i>-glucosidase inhibitory peptides.</p><p><strong>Methods: </strong>The <i>α</i>-glucosidase inhibitory and radical scavenging ability of EHCA were determined <i>in vitro</i>, and the effects on blood glucose regulation and the antioxidant activity were evaluated <i>in vivo</i> using a mouse model. Peptides with potential <i>α</i>-glucosidase inhibitory activity were identified by LC-MS/MS and confirmed <i>in silico</i>.</p><p><strong>Results and discussion: </strong>EHCA exhibited significant <i>α</i>-glucosidase inhibitory activity and radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). <i>in vivo</i>, EHCA significantly improved the glucose tolerance of mice, reduced malondialdehyde and increased the superoxide dismutase activity in liver. Five novel peptides were identified, with Lys-Leu-Asn-Ser-Thr-Thr-Glu-Lys-Leu-Glu-Glu and Thr-Asp-Ala-Asp-His-Lys-Phe showing strong inhibitory effects on <i>α</i>-glucosidase (IC₅₀ value of 144.89 μM and 136.96 μM, respectively). The interactions between peptides and <i>α</i>-glucosidase were driven by hydrogen bonds, van der Waals forces, and hydrophobic interactions. These findings suggest that EHCA and its derived peptides could serve as potential adjuvant agents for blood glucose regulation and antioxidant activity. The identified peptides may pave the way for the development of alternative <i>α</i>-glucosidase inhibitors.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1566107"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-shaped association between fasting blood glucose and urea in a non-diabetic population.","authors":"Chenguang Wu, Zhenyan Xu, Xin Chen, Hualong Liu, Yuliang Chen, Jiaxing Huang, Teng Lu, Zixi Huang","doi":"10.3389/fnut.2025.1504855","DOIUrl":"10.3389/fnut.2025.1504855","url":null,"abstract":"<p><strong>Background: </strong>The relationship between fasting blood glucose and urea in non-diabetic individuals is still unclear. This study aimed to evaluate the association between fasting blood glucose and urea in a non-diabetic population.</p><p><strong>Methods: </strong>Data from a cohort of non-diabetic individuals were collected from the 2009 China Health and Nutrition Survey dataset. We performed smooth curve and two piecewise linear regression analyses to assess the association between fasting blood glucose and urea in this non-diabetic population.</p><p><strong>Results: </strong>Data from a total of 7,596 adult participants without diabetes were included in this study; the mean age of the participants was 50.2 years, and 46.4% were male. There was an L-shaped relationship between fasting blood glucose and urea, and the inflection point of fasting blood glucose was 4.6 mmol/L. After adjusting for potential confounders, we found a negative correlation between fasting blood glucose and urea up to the inflection point (β = -0.3, 95% CI -0.5 to -0.2, <i>P</i> < 0.001), but beyond the inflection point, this relationship disappeared (β = 0.0, 95% CI -0.1 to 0.1 <i>P</i> = 0.848). In the group with lower fasting blood glucose (fasting blood glucose <4.6 mmol/L), smoking (interaction <i>P</i> = 0.037) and alcohol consumption (interaction <i>P</i> = 0.001) influenced the relationship between fasting blood glucose and urea.</p><p><strong>Conclusions: </strong>The results suggest that lower fasting blood glucose was associated with higher urea in non-diabetic individuals with fasting blood glucose <4.6 mmol/L, revealing an L-shaped association between fasting blood glucose and urea.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1504855"},"PeriodicalIF":4.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}