Frontiers in Nutrition最新文献

{"title":"Malícia honey (<i>Mimosa quadrivalvis</i> L.) produced by the jandaíra bee (<i>Melipona subnitida</i> D.) shows antioxidant activity via phenolic compound action in obese rats.","authors":"Maria Luiza Rolim Bezerra, Mirela Gouveia-Nhanca, Maria Letícia da Veiga Dutra, Kamila Sabino Batista, Alana Natalícia Vasconcelos de Araújo, Marcos Dos Santos Lima, Mateus Duarte Ribeiro, Alexandre Sergio Silva, Adriano Francisco Alves, Tatiana Colombo Pimentel, Marciane Magnani, Jailane de Souza Aquino","doi":"10.3389/fnut.2025.1524642","DOIUrl":"10.3389/fnut.2025.1524642","url":null,"abstract":"<p><strong>Background and aims: </strong>Obesity is a disease associated with increased oxidative stress in humans and animals, and consumption of antioxidant compounds such as polyphenols can minimise it. These compounds are abundant in malícia (<i>Mimosa quadrivalvis</i> L.) honey produced by stingless bees. This study aimed to evaluate whether administration of <i>Mimosa quadrivalvis</i> L. honey to obese rats could reduce oxidative stress in vital organs through phenolic compound action.</p><p><strong>Methods: </strong>Wistar rats (228 ± 14.69 g) were randomly divided into two groups: a healthy group (HG, <i>n</i> = 20) fed a control diet and an obese group (OG, <i>n</i> = 20) fed a cafeteria diet for the initial 8 weeks. After this period, these groups were again randomised into four subgroups: healthy (HG, <i>n</i> = 10), obese (OG, <i>n</i> = 10), healthy with malícia honey administration (1,000 mg/kg; HGH, <i>n</i> = 10), and obese with malícia honey administration (1,000 mg/kg; OGH, <i>n</i> = 10) for the final 8 weeks fed the previously mentioned diets. The rats were euthanised at the end of the experiment to collect brain, gut, kidney, and liver tissues to evaluate parameters related to oxidative stress and phenolic profile.</p><p><strong>Results: </strong>The administration of malícia honey reduced energy intake and weight gain in the OGH in comparison to the OG. Total antioxidant capacity increased in the brain, liver, and gut in both groups treated with honey compared to respective controls. Lipid peroxidation decreased in the brain, gut, and kidney of the OGH. Both treated groups showed elevated phenolic compound deposition, including catechin, procyanidins, and flavonoids, across all organs. Specifically, the brain in the OGH showed greater procyanidin B2 and gallic acid deposition; the liver showed increased procyanidin B1 and B2, epicatechin, and myricetin concentrations; the gut showed higher procyanidin B2 and kaempferol 3-glucoside concentrations; and the kidneys had increased catechin, procyanidin B1 and B2, and gallic acid deposition compared to the OG.</p><p><strong>Conclusion: </strong>Histologically, the OGH displayed reduced neuronal damage and prevention of hepatic steatosis induced by the cafeteria diet. Malícia honey effectively reduced oxidative stress via modulation of phenolic compounds in the brain, gut, kidney, and liver of cafeteria diet-induced obese rats.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1524642"},"PeriodicalIF":4.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between advanced lung cancer inflammation index and all-cause and cause-specific mortality among asthma patients: a cohort study.","authors":"Tu-Lei Tian, Xiang-Kun Qu, Hong-Bo Zhang, Cun-Cun Wang, Qing-Qing Yuan, Jing Xia, Li-Fang Cao, Kui Liu","doi":"10.3389/fnut.2025.1519271","DOIUrl":"10.3389/fnut.2025.1519271","url":null,"abstract":"<p><strong>Background: </strong>The advanced lung cancer inflammation index (ALI), which reflects both inflammation and nutritional status, has an uncertain role in predicting outcomes for asthma patients. This study aimed to evaluate the association between ALI and mortality from all causes, as well as specific causes including cardiovascular disease (CVD) and cancer-related mortality, among individuals with asthma.</p><p><strong>Methods: </strong>We analyzed data from 4,829 asthma patients who participated in the U.S. National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Cox proportional hazards models were used to assess the relationship between ALI and both all-cause and cause-specific mortality, adjusting for demographic and clinical variables. Additionally, restricted cubic spline models were applied to explore potential nonlinear trends, while segmented Cox models were used to identify threshold effects. A competing risk model further examined the independent association of ALI with CVD mortality.</p><p><strong>Results: </strong>Over a median follow-up of 7.83 years, a total of 582 deaths from all causes, 151 cardiovascular-related deaths, and 125 cancer-related deaths were recorded. An L-shaped association was observed between ALI and both all-cause and CVD mortality, with thresholds identified at 82.02 for all-cause mortality and 58.40 for CVD mortality. Compared to the lowest quartile of ALI (Q1), patients in the highest quartile (Q4) had a 49% lower risk of all-cause mortality (hazard ratio [HR] 0.51, 95% confidence interval [CI] 0.40-0.66) and a 51% reduction in CVD mortality (HR 0.49, 95% CI 0.29-0.83). This protective effect was further confirmed by the competing risk model. No significant association between ALI and cancer mortality was observed (HR 1.01, 95% CI 0.98-1.03).</p><p><strong>Conclusion: </strong>ALI was significantly and inversely associated with all-cause and CVD mortality in asthma patients, particularly when ALI values were below 82.02 and 58.40, respectively, where the risk of mortality was substantially lower. These findings suggest that ALI may have clinical utility in assessing prognosis for asthma patients, especially in terms of cardiovascular risk evaluation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1519271"},"PeriodicalIF":4.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-related behaviors of rural (Asaase Kooko) and peri-urban (Kaadjanor) households in Ghana.","authors":"Prince Kwabena Osei, Megan A McCrory, Matilda Steiner-Asiedu, Edward Sazonov, Mingui Sun, Wenyan Jia, Tom Baranowski, Gary Frost, Benny Lo, Alex Kojo Anderson","doi":"10.3389/fnut.2025.1523793","DOIUrl":"10.3389/fnut.2025.1523793","url":null,"abstract":"<p><strong>Background: </strong>\"Food-related behaviors\" range widely and include food acquisition, storage, cooking, meal sharing, eating practices, among others. Food-related behaviors can influence nutritional status and health outcomes, and likely vary between rural and peri-urban households; however, there is limited documentation on such differences.</p><p><strong>Objective: </strong>To assess food-related behaviors of rural and peri-urban households in Ghana to inform the design and implementation of a field study to validate passive wearable camera technologies for dietary assessment.</p><p><strong>Methods: </strong>This was a cross-sectional qualitative study in rural (Asaase Kokoo) and peri-urban (Kaadjanor) communities, Ghana. Forty key informants (20 rural and 20 peri-urban) were interviewed about their household food-related behaviors. All interviews were audio-recorded and transcribed verbatim by professional transcribers, and manually coded using the directed content analysis approach.</p><p><strong>Results: </strong>All but three key informants were mothers, who were also the main food preparers for their households. The mean (SD) ages of female key informants were 35.5 (19.8) years in rural households and 38.9 (19.2) years in peri-urban households. The ages of two male key informants in rural households were 45 and 60 years, and the age of the only male key informant in a peri-urban household was 53 years. The most prevalent occupation in rural households was farming, while in per-urban households, blue-collar jobs (e.g., beauticians, sales personnel, and commercial drivers) were the main occupations. Farming was the main source of food in rural households, whereas buying food from local markets and grocery stores was the main source of food in peri-urban households. Some in rural and peri-urban households reported that husbands received preferential treatment by being served first with larger meal portions after food preparation in the home. Few key informants in rural households reported that meal-sharing patterns were based on ages of household members, with adults usually served more food than children.</p><p><strong>Conclusion: </strong>The meal-sharing patterns and eating practices reported in some rural and peri-urban households could potentially impact the nutrition and health of children. Our findings suggest the need for nutrition education for mothers to provide adequate and nutrient-rich foods to support optimal child growth and development.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1523793"},"PeriodicalIF":4.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering proteome variations and concomitant quality changes of different drying methods <i>Cordyceps sinensis</i> by 4D-DIA structural proteomics.","authors":"Mengjun Xiao, Chuyu Tang, Tao Wang, Min He, Yuling Li, Xiuzhang Li","doi":"10.3389/fnut.2025.1463780","DOIUrl":"10.3389/fnut.2025.1463780","url":null,"abstract":"<p><strong>Introduction: </strong><i>Cordyceps sinensis</i> is a fungus, serves dual purposes as both a medicinal herb and a food source. Due to its high water content, fresh <i>Cordyceps sinensis</i> is difficult to preserve, necessitating the drying necessary to process <i>Cordyceps sinensis</i>.</p><p><strong>Methods: </strong>Using 4D-DIA proteomics, researchers analyzed the proteome profiles of fresh <i>Cordyceps sinensis</i> (CK) under three different drying conditions: vacuum freeze-drying (FD), oven-drying (OD), and air-drying (AD). In addition, it was found that the protein and free sulfhydryl content of <i>Cordyceps sinensis</i> decreased significantly and the disulfide bond content increased after different drying methods.</p><p><strong>Results and discussion: </strong>A total of 3762 proteins were identified, showing variations between groups and high protein content. In the control groups consisting of fresh <i>Cordyceps sinensis</i> samples and the three drying methods, FD. vs CK exhibited the fewest differentially abundant proteins, with the majority being upregulated. On the other hand, CK vs OD displayed the greatest amount of distinct proteins, with a significant rise in both up-regulated and down-regulated proteins. Analysis of KEGG indicated that the distinct proteins were predominantly concentrated in pathways like the ribosome, synthesis of coenzymes, and metabolism of amino sugar and nucleotide sugar. Notably, there was a significant overlap between ribosome and ribosome biogenesis in eukaryotes pathways. The process of drying <i>Cordyceps sinensis</i> resulted in a significant upregulation of the expression of proteins linked to various metabolic pathways. This observation suggests that the drying treatment might activate or enhance certain biochemical processes within the organism, potentially influencing its overall metabolic activity. This finding highlights the importance of post-harvest dry methods on the biochemical properties of <i>Cordyceps sinensis</i>, which could have implications for its nutritional and medicinal value.This study provides a theoretical basis for the realization of <i>Cordyceps sinensis</i> resource utilization and storage methods, and provides theoretical support for guaranteeing the sustainable development of <i>Cordyceps sinensis</i> resources.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1463780"},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between visceral adipose tissue and osteoarthritis among older adults: evidence from the NHANES 1999-2018.","authors":"Wei Huang, Yin-Sheng Xiao, Yu-Hang Zou, Lu-Qun Zhong, Gui-Qiong Huang","doi":"10.3389/fnut.2025.1526377","DOIUrl":"10.3389/fnut.2025.1526377","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess any possible links between visceral fat accumulation and an elevated prevalence of osteoarthritis (OA) in the elderly.</p><p><strong>Methods: </strong>3,779 subjects aged 65 years or older from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were finally included, of whom 516 had OA. The identification of patients diagnosed with OA was conducted using questionnaire data. The visceral adiposity index (VAI) was computed utilizing body mass index (BMI), waist circumference (WC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C). To investigate the relationship between VAI and OA, weighted multivariable logistic regression analysis, restricted cubic spline (RCS), subgroup analyses, and interaction tests were carried out.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that the increase in VAI is accompanied by an increased prevalence of OA after fully correcting for variables. The top quartile of VAI had a prevalence that was 110% higher than the lowest quartile. A non-linear positive correlation between VAI and OA was found in the RCS.</p><p><strong>Conclusion: </strong>This study suggests a potential correlation between elevated VAI and increased prevalence of OA in older adults, and that lowering VAI may have an impact on the prevalence of OA.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1526377"},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: A global analysis of portion size recommendations in food-based dietary guidelines.","authors":"Fanny Salesse, Alison L Eldridge, Tsz Ning Mak, Eileen R Gibney","doi":"10.3389/fnut.2025.1548350","DOIUrl":"https://doi.org/10.3389/fnut.2025.1548350","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnut.2024.1476771.].</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1548350"},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the Healthy Eating Index in a multicultural population: introduction of Adaptive Component Scoring.","authors":"David L Katz, Lauren Q Rhee, Dina L Aronson","doi":"10.3389/fnut.2025.1511230","DOIUrl":"10.3389/fnut.2025.1511230","url":null,"abstract":"<p><p>The United States, and many modern nations, represent assemblies of many cultural groups. Such groups are often influenced, sometimes profoundly, by the culinary traditions of their countries of origin, resulting in a diversity of cultural dietary patterns. Such patterns all derive key elements of nutritional quality from essential food groups-such as vegetables and fruits-but vary in their inclusion of \"discretionary\" food groups, such as dairy. The application of robust, validated, and standardized diet quality scoring is important in nutrition research, and in the food-as-medicine movement at large if what is being \"managed\" is to be measured. While robustly validated, the Healthy Eating Index is closely aligned with the <i>Dietary Guidelines for Americans</i>, and thus may not readily account for all multicultural dietary variations. Other diet quality metrics account for deviation from the prevailing American dietary pattern, but none does so in a way that expressly adapts to food components included or excluded so that \"credit\" for nutritional quality is appropriately assigned in all cases using a standard metric. In this context, we introduce and explain Adaptive Component Scoring as applied to the Healthy Eating Index in the service of advancing fair and universal diet quality scoring. Implications for nutrition research and food-as-medicine initiatives are briefly enumerated.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1511230"},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A step forward in enhancing the health-promoting properties of whole tomato as a functional food to lower the impact of non-communicable diseases.","authors":"Pier Giorgio Natali, Mauro Piantelli, Alessandra Sottini, Margherita Eufemi, Cristina Banfi, Luisa Imberti","doi":"10.3389/fnut.2025.1519905","DOIUrl":"10.3389/fnut.2025.1519905","url":null,"abstract":"<p><p>Nutritional interventions facilitating the consumption of natural, affordable, and environment-compatible health-promoting functional foods are a promising strategy for controlling non-communicable diseases. Given that the complex of tomato micronutrients produces healthier outcomes than lycopene, its major antioxidant component, new strategies to improve the health-supporting properties of the berry are ongoing. In this context, a whole tomato food supplement (WTFS), enriched by 2% olive wastewater containing a complex of healthy nutrients with converging biologic activities, has recently been developed, which is superior to those present in tomato commodities or obtained with whole tomato conventional processing methods. WTFS equals the antioxidant activity of N-acetyl-cysteine and interferes with multiple inflammation and cellular transformation-sustaining metabolic pathways. In interventional studies, WTFS inhibits prostate experimental tumors and improves benign prostate hypertrophy-associated symptoms with no associated side-effects. Although WTFS may be susceptible to further improvements and clinical scrutiny, its composition embodies the features of advanced functional foods to ease adherence to dietary patterns, that is, the Mediterranean diet, aimed at contrasting and mitigating the low-grade inflammation, thus being interceptive or preventive of non-communicable diseases.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1519905"},"PeriodicalIF":4.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possible effects of chili peppers on ADHD in relation to the gut microbiota.","authors":"Yinyue Li, Jing Feng, GuangYao Ding, Lin Deng, Ying He, Qiongqiong Zhang, Jianhui Wang, Xia Chen","doi":"10.3389/fnut.2025.1551650","DOIUrl":"10.3389/fnut.2025.1551650","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, which is characterized by inattention, impulsivity and hyperactivity. Although the etiology and pathogenesis of ADHD are not fully understood, existing studies have shown that it may be related to genetic factors, environmental factors, abnormal brain development, and psychosocial factors. In recent years, with the concept of microbioa-gut-brain axis (MGBA), more and more studies have begun to pay attention to the effect of gut microbiota on ADHD. Dietary structure can significantly change the diversity and abundance of gut microbiota. Therefore, dietary supplements or food additives to regulate gut microbiota have become one of the potential ways to treat ADHD. Peppers, as an important dietary component, have potential value in regulating gut microbiota. Among them, capsaicin (8-methyl N-vanillyl-6-noneamide, CAP), as a key active component of peppers, has been shown to have potential therapeutic effects on central nervous system (CNS) diseases such as Parkinson's disease, epilepsy, and depression. In addition, much attention has been paid to the beneficial effects of CAP on gut microbiota. Chili peppers contain not only CAP, but also rich in vitamin C and fatty acids, all of which may ameliorate ADHD by modulating the gut microbiota. This finding not only provides a potential treatment for ADHD, but also provides a new perspective to expand the research and clinical treatment of ADHD pathogenesis. Although current research on the potential therapeutic effects of chili peppers on ADHD is still at an early stage and requires further verification through larger-scale and more rigorous controlled studies, its potential clinical value cannot be ignored.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1551650"},"PeriodicalIF":4.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013-2020.","authors":"Mingjun Ma, Huanying Xu, Kexin Wang, Yanfen Chen, Ting Pan, Qiaoling Zhu","doi":"10.3389/fnut.2025.1493253","DOIUrl":"10.3389/fnut.2025.1493253","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, limited studies have explored the relationship between OBS and infertility.</p><p><strong>Methods: </strong>We performed a cross-sectional study including 2,664 women aged 20-45 years, based on data from the 2013-2020 National Health and Nutrition Examination Survey (NHANES). The OBS was derived from 16 dietary components and 4 lifestyle factors. We used multivariate logistic regression analysis to examine the association between OBS and infertility.</p><p><strong>Results: </strong>The analysis revealed a significant negative association between higher OBS and infertility risk, with an odds ratio (OR) of 0.98 (95% CI, 0.95-1.00) after full adjustment. Compared to the first quartile of OBS, the second, third, and fourth quartiles showed ORs of 0.71 (95% CI, 0.45-1.11), 0.79 (95% CI, 0.51-1.22), and 0.57 (95% CI, 0.35-0.92), respectively. Similarly, women in the highest dietary OBS and lifestyle OBS quartiles had a lower infertility risk compared to those in the lowest quartiles, with ORs of 0.60 (95% CI, 0.39-0.94) and 0.54 (95% CI, 0.32-0.93), respectively. Furthermore, subgroup analysis indicated that the association between the fourth quartile of OBS and infertility remained consistent, except among women with other ethnicities-including multi-racial, and college graduate or higher.</p><p><strong>Conclusion: </strong>These findings suggest that high dietary OBS and lifestyle OBS are associated with a lower risk of infertility.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1493253"},"PeriodicalIF":4.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}