Association of dietary inflammatory index with gynecological cancers in NHANES 2011-2018.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1560987

Chen Chen, Mengyu Zheng, Xing Dong, Pei Zhang, Zhuo Bao, Yushan Cao, Yixuan Liu, Jinxiang Yan, Yongzhen Guo, Xianxu Zeng

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引用次数: 0

Abstract

Objective: This study aimed to analyze the association between the Dietary Inflammatory Index (DII) and the risk of gynecological cancers using data collected from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2018.

Methods: The data for this study were obtained from NHANES, conducted between 2011 and 2018, and included a total of 8,380 women. To examine the association between the Dietary Inflammatory Index and gynecological cancers, weighted multivariable logistic regression analyses were performed, using DII both as a continuous variable and as a categorical variable divided into tertiles. Subgroup analyses stratified by DII and gynecological cancer characteristics were conducted to further explore this association. Additionally, restricted cubic spline (RCS) analysis was applied to evaluate potential non-linear relationships between DII and gynecological cancer risk.

Results: Among the 8,380 women included in the analysis, the mean age was 47.02 (SD: 16.91) years, and 196 participants self-reported a diagnosis of gynecological cancer. In fully adjusted models, DII was significantly positively associated with the prevalence of gynecological cancer, whether analyzed as a continuous variable (OR = 1.15, 95% CI: 1.00-1.33, p = 0.046) or as a categorical variable (highest tertile compared to the lowest tertile: OR = 2.14, 95% CI: 1.14-4.04, p = 0.021, p for trend = 0.021). Restricted cubic spline analysis confirmed a linear relationship between DII and gynecological cancer risk (p for non-linear association = 0.1984). Subgroup analyses revealed a significant interaction effect with smoking status (p for interaction = 0.037).

Conclusion: Our findings suggest that higher DII scores are positively associated with an increased risk of gynecological cancer. These results contribute to the existing literature and underscore the need for further validation through larger prospective cohort studies.

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NHANES 2011-2018中饮食炎症指数与妇科癌症的关系

目的：本研究旨在利用2011年至2018年国家健康与营养检查调查（NHANES）收集的数据，分析膳食炎症指数（DII）与妇科癌症风险之间的关系。方法：本研究的数据来自NHANES，于2011年至2018年进行，共包括8380名女性。为了检验饮食炎症指数与妇科癌症之间的关系，进行了加权多变量logistic回归分析，使用DII作为连续变量和分类变量分为三分位数。以DII和妇科肿瘤特征分层的亚组分析进一步探讨这种关联。此外，应用限制性三次样条（RCS）分析评估DII与妇科癌症风险之间潜在的非线性关系。结果：在纳入分析的8,380名女性中，平均年龄为47.02岁（SD: 16.91）岁，196名参与者自我报告诊断为妇科癌症。在完全调整后的模型中，无论是作为一个连续变量（OR = 1.15, 95% CI: 1.00-1.33, p = 0.046）还是作为一个分类变量（最高五分位数与最低五分位数的比较：OR = 2.14, 95% CI: 1.14-4.04, p = 0.021， p为趋势值= 0.021），DII与妇科癌症的患病率显著正相关。限制性三次样条分析证实了DII与妇科癌症风险之间的线性关系（非线性关联p = 0.1984）。亚组分析显示与吸烟状况有显著的交互作用（交互作用p = 0.037）。结论：我们的研究结果表明，较高的DII评分与妇科癌症风险增加呈正相关。这些结果有助于现有文献，并强调需要通过更大的前瞻性队列研究进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.