Frontiers in Nutrition最新文献

{"title":"Enhanced antibacterial potential of exopolysaccharide-stabilized spice oil emulsions against foodborne pathogens.","authors":"Jahnavi Kumari Singh, Steve Djiazet, Palanisamy Bruntha Devi, Horliane Nzali Ghomdim, G Bhanuprakash Reddy, Digambar Kavitake, Prathapkumar Halady Shetty","doi":"10.3389/fnut.2025.1624274","DOIUrl":"https://doi.org/10.3389/fnut.2025.1624274","url":null,"abstract":"<p><p>Exopolysaccharides (EPSs) from lactic acid bacteria (LAB) are known to have diverse applications in food and pharmaceuticals due to their functional properties. Emulsification is one of the important potentials of microbial polysaccharides, revealing its role as a natural emulsifier. In this study, glucan has been explored for emulsification with spice oils from <i>Xylopia aethiopica</i> (Xae), <i>Monodora myristica</i> (Mm), and <i>Fagara lepreuri</i> (Fl) Cameroon underutilized spices. Emulsifying ability, turbidity, emulsion droplet size, and micrographs of glucan-based spice oil emulsion were studied. The effect of sonication has been studied on droplet size and morphology of the emulsions. Sonication treatment has improved the emulsion stability by converting the larger emulsion droplets into smaller ones. The results of the disk diffusion assay confirmed antibacterial activity of emulsions, exhibiting high antibacterial efficiencies against food pathogens <i>Listeria monocytogenes</i> 1143, <i>Shewanella putrefaciens</i> 8104, and <i>Salmonella enterica</i> 950. This study underscores the potential of EPS as a natural emulsifying agent in food preservation, pharmaceuticals, and antimicrobial applications.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1624274"},"PeriodicalIF":4.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> characterization of amino acid digestibility and fermentative properties of a specific hydrolyzed yeast, and its <i>in vivo</i> effects on growth performance and fecal microbiota in weanling piglets.","authors":"Fernando Bravo de Laguna, Caroline S Achard, Lysiane Dunière, Elsa Parmentier, Katia Helmja, Bruno Bertaud, Pierre Lebreton, David Saornil, Eric Chevaux, Mathieu Castex, Emmanuelle Apper","doi":"10.3389/fnut.2025.1596561","DOIUrl":"10.3389/fnut.2025.1596561","url":null,"abstract":"<p><p>Weaning is a stressful event that is often accompanied by anorexia, risk of diarrhea, and development of intestinal disorders, making it crucial to provide highly digestible and palatable diets. Novel functional protein sources are being developed to be included in diets fed to weanling pigs. We evaluated <i>in vitro</i> and <i>in vivo</i> the properties of a recently developed hydrolyzed yeast protein source (Yela ProSecure; YPS; Lallemand SAS, Blagnac, France). The objectives were (1) to evaluate <i>in vitro</i> amino acids (AA) digestibility; (2) to assess, <i>in vitro,</i> the impact of the product's insoluble fraction (YPSi) on the fermentative activity of piglet fecal microbiota; and (3) to test the effects of two inclusion levels (2.5 and 6%) on growth performance and fecal microbiota in weanling piglets. The total AA availability after 3 h of digestion was 76.6%, reaching 89.8% after 48 h. YPSi induced high gas and short-chain fatty acids production. In the <i>in vivo</i> experiment, a significant difference in body weight was observed on day 18 (<i>p</i> < 0.001) post-weaning and on day 40 (<i>p</i> < 0.05), with piglets in both YPS treatments being heavier than control piglets. A higher average daily feed intake was observed between weaning and day 18 (<i>p</i> < 0.01) and overall (<i>p</i> < 0.05) in both YPS treatments, and an improved feed conversion ratio was observed in both YPS treatments between weaning and day 18 (<i>p</i> < 0.001). Moreover, YPS significantly modulated the fecal microbiota composition after 2 days and 16 days of treatment, whereas no lasting effect was evidenced on day 40, namely after 19 days of withdrawal from the diet. Lower relative abundance (RA) of <i>Campylobacterota</i> (<i>p</i> adj. < 0.05) was evidenced in YPS groups compared to the control group. Furthermore, several members of the <i>Lactobacillaceae</i> family, annotated as <i>L. amylovorus</i>, <i>L. mucosae,</i> or <i>L. reuteri,</i> as well as <i>Faecalibacterium prausnitzii</i>, showed higher RA in YPS groups. To conclude, adding YPS to the diet of weanling piglets increased growth performance, probably due to nutrient absorption in the small intestine and its functional role on gut microbiota. Those results suggest complex interconnections between host and microbiota and emphasize the need to consider the holobiont theory when formulating a diet.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1596561"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between an inflammatory diet index and nonunion: a prospective study of 172,839 UK biobank participants.","authors":"Jiemao Su, Wenxuan Fan, Keyu Kong, Yifan Wang, Zanjing Zhai, Jingwei Zhang, Minghao Jin, Yansong Qi, Yongsheng Xu","doi":"10.3389/fnut.2025.1640259","DOIUrl":"10.3389/fnut.2025.1640259","url":null,"abstract":"<p><strong>Purposes: </strong>This study utilizes prospective cohort data from the UK Biobank to investigate the association between the energy-adjusted dietary inflammation index (E-DII) and the development of fracture nonunion.</p><p><strong>Methods: </strong>In this study, COX regression was used to analyze the correlation between E-DII and nonunion. Among 172,839 participants free of prior nonunion at baseline, 2,341 (1.4%) developed nonunion during a median follow-up of 14.2 years. E-DII scores, calculated from five separate 24-h dietary recall assessments, were used to quantify dietary inflammatory potential, with higher values indicating pro-inflammatory patterns.</p><p><strong>Results: </strong>Multivariable-adjusted analyses revealed that participants with anti-inflammatory dietary patterns (E-DII < -1) exhibited a significantly elevated risk of impaired fracture healing compared to those with pro-inflammatory diets (E-DII > 1), yielding an adjusted hazard ratio (HR) of 1.89 (95% CI: 1.45-3.11). A nonlinear U-shaped dose-response relationship was identified, with the nadir of nonunion risk observed at E-DII values between 0.3 and 1.2. Conversely, values outside this range were associated with progressively higher risks. Transcriptomic profiling identified differential expression of 35 inflammation-related genes-including CD3E and CX3CR1-significantly downregulated in nonunion cases compared to controls. These genes are functionally enriched in pathways governing immune response regulation and leukocyte activation.</p><p><strong>Conclusion: </strong>These findings propose that a moderately pro-inflammatory dietary pattern may confer protection against impaired bone healing, whereas both strongly anti-inflammatory and excessively pro-inflammatory diets were associated with compromised healing outcomes. Based on these results, tailored dietary strategies designed to optimize inflammatory homeostasis during fracture recovery are recommended to enhance clinical outcomes.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1640259"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumer preferences for evaluative front-of-package nutrition labels: evidence from a choice experiment in China.","authors":"Minda Yang, Shi Min, Trung Thanh Nguyen","doi":"10.3389/fnut.2025.1563341","DOIUrl":"10.3389/fnut.2025.1563341","url":null,"abstract":"<p><p>This study examines consumer preferences, behaviors, and willingness to pay (WTP) for evaluative front-of-package (FOP) nutrition labels in China, with a particular focus on the role of information provision in influencing consumer behavior. A choice experiment was conducted involving ham sausages with different evaluative nutrition labels, including the Health Star Rating and Nutrition Score System, among 998 participants from five representative cities in China. The choice experiment also incorporates an information intervention to assess its impact on consumers' choice. A random parameter logit model was employed to estimate consumers preferences and WTP for the different evaluative FOP labels. The results show that consumers exhibit a higher preference for ham sausages with evaluative FOP nutrition labels compared to those without any labels. The Nutrition Score System emerges as the most preferred labeling format. Furthermore, under information intervention, consumers exhibit the highest WTP for evaluative FOP labels, with 2.47 yuan for the Health Star Rating (124% premium) and 2.77 yuan for the Nutrition Score System (138% premium). These findings suggest a substantial demand among Chinese consumers for evaluative FOP nutrition labels and underscore the importance of providing related information to enhance consumer acceptance and promote healthier food-choice behavior.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1563341"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the extraction, antioxidant and prebiotic activity of the polysaccharides from the fruits of <i>Phyllanthus emblica</i> L.","authors":"Haotian Huang, Xiaobo Zhou, Mengge Sun, Jiajie Chen, Tao Tan, Dongsheng Yang","doi":"10.3389/fnut.2025.1607077","DOIUrl":"10.3389/fnut.2025.1607077","url":null,"abstract":"<p><strong>Introduction: </strong>Polysaccharides extracted from the fruits of <i>Phyllanthus emblica</i> L. (PEP) have demonstrated various bioactivities, including antioxidant and prebiotic effects. This study aimed to optimize the extraction of PEP using ultrasonic microwave synergistic extraction (UMSE) and evaluate its bioactivities.</p><p><strong>Methods: </strong>The UMSE process was optimized using response surface methodology (RSM) to identify the most efficient extraction conditions. Antioxidant capacity was evaluated through DPPH, ABTS, and hydroxyl radical scavenging assays, alongside total reducing capacity measurements. For prebiotic activity, the ability of PEP to promote the growth of <i>Lactobacillus casei, Lactobacillus acidophilus</i>, and <i>Lactobacillus plantarum</i> was compared with that of standard prebiotics. Changes in pH and lactic acid production in the culture medium were also monitored.</p><p><strong>Results: </strong>Optimal UMSE parameters included microwave power (370 W), ultrasonic power (340 W), extraction time (25 minutes), and a solid-liquid ratio of 1:6.5 g/mL. These conditions achieved an extraction yield of 8.09%, aligning with the predicted value. The UMSE method showed higher extraction efficiency and sugar content compared to traditional water extraction, with a reduction in impurities. The extracted PEPs exhibited significant scavenging activity against DPPH, ABTS, and hydroxyl radicals, as well as robust total reducing capacity. Additionally, the PEPs demonstrated resistance to hydrolysis by artificial saliva and gastric juice, suggesting their ability to reach the gastrointestinal tract intact. In prebiotic assays, PEP (UMSE-derived, PEP-U) stimulated the proliferation of <i>Lactobacillus</i> spp. more effectively than water-extracted PEP (PEP-W), correlating with increased lactic acid production and reduced pH in the culture medium.</p><p><strong>Discussion: </strong>These results highlight the dual bioactivity of PEP as both an antioxidant and prebiotic, suggesting its potential as a functional food ingredient for promoting gut health and oxidative balance.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1607077"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites.","authors":"Pei Xiao, Ting Song, Xiao Lu Li, Yong Mei Xiao, Rui Xue Wang, Fei Fei Song, Dan Li, Ai Hua Zhang, Ying Wang, Ting Zhang","doi":"10.3389/fnut.2025.1579668","DOIUrl":"10.3389/fnut.2025.1579668","url":null,"abstract":"<p><strong>Background: </strong>Although dietary fiber is widely recommended for preventing and treating functional constipation (FC), clinical trial evidence remains limited and the efficacy has not been sufficiently tested in children.</p><p><strong>Purpose: </strong>This study aimed to evaluate the effects of dietary fiber on FC symptoms, while identifying modulations in gut microbiota and associated metabolic changes.</p><p><strong>Results: </strong>Between January 1, 2024, and June 1, 2024, a total of 60 patients diagnosed with FC were enrolled in the study across three centers; however, 54 children completed the study. The final cohort consisted of 28 boys and 26 girls, aged 6 to 12 years (mean age: 8.4 ± 1.8 years). Following the dietary fiber intervention, a significant increase in the frequency of complete spontaneous bowel movements (CSBMs) was observed, accompanied by improved stool consistency. Scores for abdominal pain, bloating, and straining showed significant reductions. After 4 weeks of dietary fiber treatment, both richness and diversity of gut microbiota were significantly enhanced. At the genus level, the relative abundances of <i>Lachnospiraceae_ND3007_group</i>, <i>Lactococcus</i>, <i>Prevotella</i>, and <i>Anaerofustis</i> significantly increased, whereas <i>Enterobacter</i>, <i>DTU089</i>, and <i>Sutterella</i> showed significant decreases. Metabolic analysis revealed significant profile alterations. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis identified metabolite-associated pathways, including steroid hormone biosynthesis, alpha-linolenic acid metabolism, and nucleotide metabolism. Pearson correlation analysis established correlations among dietary fiber, gut microbiota, metabolites, and constipation relief. No significant adverse effects were observed.</p><p><strong>Conclusion: </strong>In conclusion, our findings indicate that dietary fiber alleviates constipation and is accompanied by intervention-specific alterations in gut microbiota and metabolites. This research elucidates the interrelationships between constipation, gut microbiota, and metabolites. These insights may enhance our understanding of the pathogenic mechanisms of FC and provide novel therapeutic perspectives.</p><p><strong>Clinical trials registration: </strong>ChiCTR2400084125.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1579668"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of a galactoglucan from <i>Pleurotus citrinopileatus</i> in constipation: modulation of aquaporin signaling and intestinal barrier.","authors":"Yi Gao, Lan Deng, Yuanyuan Chen, Peiyou Qin, Yuanyuan Zhao, Xiaoyan Zhao, Wei Liu, Dan Wang, Shuang Zhao","doi":"10.3389/fnut.2025.1635487","DOIUrl":"10.3389/fnut.2025.1635487","url":null,"abstract":"<p><strong>Introduction: </strong>Constipation is a prevalent gastrointestinal disorder demanding effective therapeutic strategies. This study investigated the therapeutic potential of <i>Pleurotus citrinopileatus</i> polysaccharide (PCP-g), a novel galactoglucan, against sucralfate-induced constipation murine model, focusing on intestinal motility, fecal parameters, aquaporin signaling, and gut microbiota modulation.</p><p><strong>Methods: </strong>PCP-g was purified from <i>P. citrinopileatus</i> and its physicochemical properties were characterized. To evaluate the effects of PCP, the research utilized intestinal motility assays, fecal analysis, and <i>in vitro</i> fermentation. The role of Aquaporin 3 (AQP3) in constipation, especially regarding the PKA - phosphorylation mechanism, was investigated. The influence of PCP-g on PKA, phosphorylated PKA, AQP3, and tight junction proteins were examined at both the mRNA and protein levels.</p><p><strong>Results: </strong>PCP-g was identified as a homogeneous galactoglucan with a molecular weight of 7.49 × 10³ kDa, characterized by a backbone consisting of 1→4-linked glucose (Glcp) and branches of mannose (Manp) and Glcp. The composition of PCP-g includes Glc, Gal, Man, L-Fuc, Rha, GlcA, and Ara, in a molar ratio of 1.00:0.16:0.13:0.01:0.006:0.005:0.006. The oral administration of PCP-g resulted in a significant reduction in constipation symptoms, as indicated by an increase in fecal water content, normalization of pellet formation, enhancement of total fecal mass, decreased latency to the first stool, and improved intestinal propulsion. Furthermore, PCP-g was found to elevate the production of short-chain fatty acids (SCFAs) while simultaneously reducing intestinal gas. Mechanistically, PCP-g suppressed the PKA-dependent phosphorylation of AQP3, leading to the downregulation of AQP3 overexpression and enhanced colonic epithelial permeability. Concurrently, PCP-g reduced the expression of tight junction proteins ZO-1 and Occludin, contributing to the increase in fecal water content.</p><p><strong>Discussion: </strong>PCP-g effectively alleviates constipation by enhancing intestinal motility and fecal hydration. It modulates the PKA-AQP3 signaling pathway to improve colonic water permeability and positively influences the gut environment through the generation of SCFAs. These findings suggest that PCP-g may serve as a promising therapeutic candidate for the treatment of constipation, operating through aquaporin signaling and the regulation of the gut environment. The study advocates for further clinical trials and highlights the potential of edible mushroom polysaccharides in the management of constipation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1635487"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of prognostic nutritional index with all-cause mortality and cardiovascular mortality: a nationwide population-based cohort study.","authors":"Ce Zhou, You Zhou, TingYue Wang, Yun Wang, XiuYi Liang, Xin Kuang","doi":"10.3389/fnut.2025.1530452","DOIUrl":"10.3389/fnut.2025.1530452","url":null,"abstract":"<p><strong>Background: </strong>The prognostic nutritional index (PNI) has shown prognostic value in various diseases, but its association with mortality in the general population remains unclear.</p><p><strong>Methods: </strong>We analyzed data from 30,741 adults in the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Cox proportional hazard models examined the association between PNI and mortality outcomes. Restricted cubic spline analyses were performed to assess non-linear relationships. Subgroup analyses were conducted to evaluate effect modifications.</p><p><strong>Results: </strong>During follow-up, higher PNI values were associated with lower all-cause mortality (HR: 0.95, 95% CI: 0.94-0.96) and cardiovascular mortality (HR: 0.94, 95% CI: 0.93-0.96). Non-linear relationships were identified with threshold effects at PNI = 50.24 for all-cause mortality and PNI = 51.50 for cardiovascular mortality. The protective associations were particularly strong among participants with liver disease (<i>P</i> for interaction < 0.001).</p><p><strong>Conclusion: </strong>Prognostic nutritional index demonstrates significant predictive value for mortality outcomes in the general U.S. adult population, with identified threshold effects. These findings suggest PNI's potential utility as a valuable risk stratification tool in clinical practice.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1530452"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and computational exploration of red date fruit vinegar: synergistic effects on cardiovascular and type 2 diabetes pathways.","authors":"Zeshan Ali, Hamad Rafique, Rana Adnan Tahir, Tania Saeed, Muhamad Amir Rasheed, Ishrat Khan, Tawfiq Alsulami, Muqadas Shahzadi, Mariam Laraib Amir, Suleiman A Althawab, Fangchao Cui","doi":"10.3389/fnut.2025.1557733","DOIUrl":"10.3389/fnut.2025.1557733","url":null,"abstract":"<p><strong>Introduction: </strong>Dates (Phoenix dactylifera), often questioned for their high sugar content, may provide anti-diabetic benefits through their phytochemicals. Date vinegar offers a potentially effective alternative with reduced sugar content and enhanced bioactivity. This study evaluated the effects of date vinegar on glycemic control and lipid profiles in adults with type 2 diabetes mellitus (T2DM) and dyslipidemia while exploring the molecular mechanisms of its bioactive compounds in managing cardiovascular diseases (CVDs) and T2DM.</p><p><strong>Methods: </strong>A 10-week randomized controlled trial assessed the clinical effects of date vinegar. Complementary experiments explored therapeutic mechanisms through computational analysis and assessed sugar reduction and bioactive preservation under varying drying conditions. Fifty adults with T2DM and dyslipidemia were randomized into two groups: 25 participants received 20 mL of date vinegar daily, while 25 received a placebo. Clinical parameters were measured, including HbA1c, LDL cholesterol, and fasting blood sugar. Computational docking and molecular dynamics simulations investigated interactions of bioactive compounds with key protein targets.</p><p><strong>Results: </strong>Significant improvements were observed: HbA1c reduced from 6.85 to 6.08%, LDL cholesterol from 121.05 to 111.09 mg/dL, and fasting blood sugar from 168.4 to 147.6 mg/dL (<i>p</i> < 0.05). Key compounds with stable protein-ligand complexes confirmed were bound to targets such as ACE, β1AR, hATRs, AR, DPP-IV, and SGLT1. Higher drying temperatures reduced sugar content to match fresh dates but compromised bioactive integrity.</p><p><strong>Conclusion: </strong>Date vinegar offers a dual target therapeutic strategy for managing T2DM and CVDs, supported by clinical and computational findings.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1557733"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Joint and independent associations of dietary vitamin intake and prevalence of cardiovascular disease in chronic kidney disease subjects: a cross-sectional analysis.","authors":"Wu Zezhi, Wang Huishu, Li Xiangming, Xie Shaoting","doi":"10.3389/fnut.2025.1631331","DOIUrl":"10.3389/fnut.2025.1631331","url":null,"abstract":"","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1631331"},"PeriodicalIF":4.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}