Association between magnesium depletion score and prevalence and all-cause mortality of psoriasis among the US population.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1598688

Lin Qi, Xian Yang

{"title":"Association between magnesium depletion score and prevalence and all-cause mortality of psoriasis among the US population.","authors":"Lin Qi, Xian Yang","doi":"10.3389/fnut.2025.1598688","DOIUrl":null,"url":null,"abstract":"Background: Magnesium plays a key role in the physiopathologic process of psoriasis. The recently proposed magnesium depletion score (MDS) represents a comprehensive index for assessing magnesium status. However, the effect of MDS on psoriasis remains to be elucidated. This study aimed to evaluate the possible association between MDS and psoriasis prevalence and mortality.Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) of adult participants. The multivariable logistic regression analysis was employed to assess the relationship between MDS and psoriasis prevalence. Restricted cubic splines (RCS) were utilized to investigate the dose-response correlation. Furthermore, Cox regression analysis was performed to determine the relationship between MDS and all-cause mortality in psoriasis patients. Furthermore, we conducted subgroup and sensitivity analyses to verify the validity and consistency of these results.Results: This study enrolled 17,883 eligible participants. After excluding individuals without follow-up information, 64 all-cause deaths were observed among 505 patients with psoriasis. In the weighted multivariable logistic regression model, individuals with an MDS ≥ 3 had a 1.75-fold greater risk of psoriasis compared with those with an MDS of 0 (OR = 1.75; 95% CI: 1.05-2.92; p < 0.05). RCS analysis revealed a positive linear relationship between MDS and psoriasis prevalence (P for nonlinear = 0.145). Additionally, Cox regression analysis demonstrated that MDS was positively associated with all-cause mortality (HR = 1.39; 95% CI: 1.04-1.87; p < 0.05). Subgroup analyses indicated that these findings remained consistent across different subgroups.Conclusion: MDS is associated with an increased prevalence and all-cause mortality from psoriasis among American adults. Early detection and management for MDS may reduce the risk of psoriasis and improving its prognosis.","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1598688"},"PeriodicalIF":4.0000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460096/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1598688","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Magnesium plays a key role in the physiopathologic process of psoriasis. The recently proposed magnesium depletion score (MDS) represents a comprehensive index for assessing magnesium status. However, the effect of MDS on psoriasis remains to be elucidated. This study aimed to evaluate the possible association between MDS and psoriasis prevalence and mortality.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) of adult participants. The multivariable logistic regression analysis was employed to assess the relationship between MDS and psoriasis prevalence. Restricted cubic splines (RCS) were utilized to investigate the dose-response correlation. Furthermore, Cox regression analysis was performed to determine the relationship between MDS and all-cause mortality in psoriasis patients. Furthermore, we conducted subgroup and sensitivity analyses to verify the validity and consistency of these results.

Results: This study enrolled 17,883 eligible participants. After excluding individuals without follow-up information, 64 all-cause deaths were observed among 505 patients with psoriasis. In the weighted multivariable logistic regression model, individuals with an MDS ≥ 3 had a 1.75-fold greater risk of psoriasis compared with those with an MDS of 0 (OR = 1.75; 95% CI: 1.05-2.92; p < 0.05). RCS analysis revealed a positive linear relationship between MDS and psoriasis prevalence (P for nonlinear = 0.145). Additionally, Cox regression analysis demonstrated that MDS was positively associated with all-cause mortality (HR = 1.39; 95% CI: 1.04-1.87; p < 0.05). Subgroup analyses indicated that these findings remained consistent across different subgroups.

Conclusion: MDS is associated with an increased prevalence and all-cause mortality from psoriasis among American adults. Early detection and management for MDS may reduce the risk of psoriasis and improving its prognosis.

查看原文本刊更多论文

镁耗尽评分与美国人群中牛皮癣患病率和全因死亡率之间的关系

背景：镁在银屑病的生理病理过程中起关键作用。最近提出的镁消耗评分（MDS）是评估镁状态的综合指标。然而，MDS对银屑病的影响仍有待阐明。本研究旨在评估MDS与牛皮癣患病率和死亡率之间的可能关联。方法：本研究利用了美国国家健康与营养调查（NHANES）成人参与者的数据。采用多变量logistic回归分析评估MDS与银屑病患病率的关系。采用限制性三次样条（RCS）研究剂量-反应相关性。此外，进行Cox回归分析以确定MDS与银屑病患者全因死亡率之间的关系。此外，我们进行了亚组分析和敏感性分析，以验证这些结果的有效性和一致性。结果：本研究纳入了17883名符合条件的参与者。在排除无随访信息的个体后，505例牛皮癣患者中有64例全因死亡。在加权多变量logistic回归模型中，MDS ≥ 3的个体患牛皮癣的风险是MDS为0的个体的1.75倍（OR = 1.75;95% CI: 1.05-2.92； p 非线性的p = 0.145）。此外，Cox回归分析显示MDS与全因死亡率呈正相关（HR = 1.39;95% CI: 1.04-1.87; p ）结论：MDS与美国成年人银屑病患病率和全因死亡率增加有关。MDS的早期发现和管理可以降低银屑病的风险，改善其预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.