Olivia Mariella Anneberg, Sjurdur Frodi Olsen, Anne Vinkel Hansen, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Tine Jess, Maiara Brusco De Freitas
{"title":"孕期母体有机食品消费和饮食质量对后代患炎症性肠病风险的影响：来自丹麦国家出生队列研究的结果","authors":"Olivia Mariella Anneberg, Sjurdur Frodi Olsen, Anne Vinkel Hansen, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Tine Jess, Maiara Brusco De Freitas","doi":"10.3389/fnut.2025.1632729","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study explores associations of maternal organic food consumption and diet quality during pregnancy with pediatric-onset inflammatory bowel disease (IBD) risk in offspring, including Crohn's disease (CD) and ulcerative colitis (UC).</p><p><strong>Methods: </strong>Pregnant mothers and their offspring were enrolled in the Danish National Birth Cohort, a nationwide prospective cohort study, in 1996-2002. In gestational week 30, telephone interviews assessed overall maternal organic food consumption during pregnancy. In gestational week 25, a food frequency questionnaire assessed maternal diet during the previous 4 weeks, including six different organic food types (eggs, dairy, meat, fruit, vegetables, and cereals). A Healthy Eating Index evaluated maternal diet quality based on adherence to Danish official dietary guidelines. Offspring with pediatric-onset IBD (≤18 years) were identified in national patient registries. Cox regression explored associations of maternal organic food consumption and diet quality during pregnancy with offspring's risk of pediatric-onset IBD, CD, and UC.</p><p><strong>Results: </strong>The study included 60,274 singleton mother-child pairs, of which 168 children developed pediatric-onset IBD. Frequent maternal organic food consumption during pregnancy was not significantly associated with offspring's IBD risk (HR: 0.63; 95% CI: 0.33-1.19). However, frequent organic food consumption during pregnancy, particularly organic eggs and dairy, lowered offspring's risk of CD (HR: 0.40; 95% CI: 0.17-0.94), but not UC (HR: 1.11; 95% CI: 0.41-3.00). Maternal diet quality during pregnancy was not significantly associated with offspring's risk of IBD (HR: 0.99; 95% CI: 0.97-1.01), CD, and UC.</p><p><strong>Conclusion: </strong>In this large prospective cohort study, we show that maternal organic food consumption, particularly eggs and dairy, during pregnancy may lower offspring's risk of pediatric-onset CD, but not UC.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1632729"},"PeriodicalIF":4.0000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286796/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of maternal organic food consumption and diet quality during pregnancy on offspring's risk of inflammatory bowel disease: findings from a Danish National Birth Cohort Study.\",\"authors\":\"Olivia Mariella Anneberg, Sjurdur Frodi Olsen, Anne Vinkel Hansen, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Tine Jess, Maiara Brusco De Freitas\",\"doi\":\"10.3389/fnut.2025.1632729\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study explores associations of maternal organic food consumption and diet quality during pregnancy with pediatric-onset inflammatory bowel disease (IBD) risk in offspring, including Crohn's disease (CD) and ulcerative colitis (UC).</p><p><strong>Methods: </strong>Pregnant mothers and their offspring were enrolled in the Danish National Birth Cohort, a nationwide prospective cohort study, in 1996-2002. In gestational week 30, telephone interviews assessed overall maternal organic food consumption during pregnancy. In gestational week 25, a food frequency questionnaire assessed maternal diet during the previous 4 weeks, including six different organic food types (eggs, dairy, meat, fruit, vegetables, and cereals). A Healthy Eating Index evaluated maternal diet quality based on adherence to Danish official dietary guidelines. Offspring with pediatric-onset IBD (≤18 years) were identified in national patient registries. Cox regression explored associations of maternal organic food consumption and diet quality during pregnancy with offspring's risk of pediatric-onset IBD, CD, and UC.</p><p><strong>Results: </strong>The study included 60,274 singleton mother-child pairs, of which 168 children developed pediatric-onset IBD. Frequent maternal organic food consumption during pregnancy was not significantly associated with offspring's IBD risk (HR: 0.63; 95% CI: 0.33-1.19). However, frequent organic food consumption during pregnancy, particularly organic eggs and dairy, lowered offspring's risk of CD (HR: 0.40; 95% CI: 0.17-0.94), but not UC (HR: 1.11; 95% CI: 0.41-3.00). Maternal diet quality during pregnancy was not significantly associated with offspring's risk of IBD (HR: 0.99; 95% CI: 0.97-1.01), CD, and UC.</p><p><strong>Conclusion: </strong>In this large prospective cohort study, we show that maternal organic food consumption, particularly eggs and dairy, during pregnancy may lower offspring's risk of pediatric-onset CD, but not UC.</p>\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"12 \",\"pages\":\"1632729\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286796/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2025.1632729\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2025.1632729","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Impact of maternal organic food consumption and diet quality during pregnancy on offspring's risk of inflammatory bowel disease: findings from a Danish National Birth Cohort Study.
Background: This study explores associations of maternal organic food consumption and diet quality during pregnancy with pediatric-onset inflammatory bowel disease (IBD) risk in offspring, including Crohn's disease (CD) and ulcerative colitis (UC).
Methods: Pregnant mothers and their offspring were enrolled in the Danish National Birth Cohort, a nationwide prospective cohort study, in 1996-2002. In gestational week 30, telephone interviews assessed overall maternal organic food consumption during pregnancy. In gestational week 25, a food frequency questionnaire assessed maternal diet during the previous 4 weeks, including six different organic food types (eggs, dairy, meat, fruit, vegetables, and cereals). A Healthy Eating Index evaluated maternal diet quality based on adherence to Danish official dietary guidelines. Offspring with pediatric-onset IBD (≤18 years) were identified in national patient registries. Cox regression explored associations of maternal organic food consumption and diet quality during pregnancy with offspring's risk of pediatric-onset IBD, CD, and UC.
Results: The study included 60,274 singleton mother-child pairs, of which 168 children developed pediatric-onset IBD. Frequent maternal organic food consumption during pregnancy was not significantly associated with offspring's IBD risk (HR: 0.63; 95% CI: 0.33-1.19). However, frequent organic food consumption during pregnancy, particularly organic eggs and dairy, lowered offspring's risk of CD (HR: 0.40; 95% CI: 0.17-0.94), but not UC (HR: 1.11; 95% CI: 0.41-3.00). Maternal diet quality during pregnancy was not significantly associated with offspring's risk of IBD (HR: 0.99; 95% CI: 0.97-1.01), CD, and UC.
Conclusion: In this large prospective cohort study, we show that maternal organic food consumption, particularly eggs and dairy, during pregnancy may lower offspring's risk of pediatric-onset CD, but not UC.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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