Dermatology practical & conceptual最新文献

{"title":"Frequency and Correlation of Peripheral and Tissue Eosinophilia with Clinical Manifestations in Patients with Bullous Pemphigoid.","authors":"Bahareh Abtahi-Naeini, Farhad Zare-Mehrjerdi, Zabihollah Shahmoradi, Fereshte Rastegarnasab, Mojtaba Akbari, Azadeh Zolfaghari, Asiyeh Heidari, Fateme Mohaghegh","doi":"10.5826/dpc.1403a169","DOIUrl":"10.5826/dpc.1403a169","url":null,"abstract":"<p><strong>Introduction: </strong>Bullous pemphigoid (BP) is an autoimmune disease involving the sub-epidermal layer. Eosinophilia may play a role in the pathogenesis of BP.</p><p><strong>Objectives: </strong>We aimed to investigate the correlation between dermal or peripheral eosinophilia with clinical presentations in patients with BP.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 108 BP patients from January 2010 to September 2019. Clinical data were recovered. Skin biopsies were re-evaluated, and the Bullous Pemphigoid Disease Area Index (BPDAI) severity score was calculated. Finally, the relationship between clinical features of BP and dermal or peripheral eosinophilia was analyzed.</p><p><strong>Results: </strong>A total number of 108 patients were included in this study. Thirty-five were excluded due to our exclusion criteria. Finally, data from 73 patients were analyzed. Fifty-seven point five percent of the population was female. There was a significant direct correlation (r = 0.33) between BPDAI severity score and tissue eosinophilia (P = 0.03). No significant relationship was found between BPDAI severity score and peripheral eosinophilia (P = 0.52). There were significant positive correlations between tissue eosinophilia with absolute serum eosinophil count (P = 0.002; r = 0.49) and percentage (P < 0.0001; r = 0.89).</p><p><strong>Conclusions: </strong>This study revealed significant relationships between tissue eosinophilia and BP severity. These findings could be useful in clinical practice. The possible role of eosinophils in BP clinical features should be considered as a promising help for better diagnosis and treatment.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucosal Cancers Arising in Potentially Malignant Lesions of the Oral Mucosa Are Marjolin Ulcers: New Insights Into Old Concepts.","authors":"Nycolle Louise Guedes, Silvia Vanessa Lourenço, Marcello Menta Simonsen Nico","doi":"10.5826/dpc.1403a210","DOIUrl":"10.5826/dpc.1403a210","url":null,"abstract":"<p><strong>Introduction: </strong>Several disparate mucocutaneous diseases present oral mucosal lesions that have been classically labeled as \"pre-cancerous\", \"pre-malignant\", or \"potentially malignant\". These include oral lichen planus, dyskeratosis congenita, tertiary syphilitic glossitis chronic graft-versus-host-disease, and oral discoid lupus erythematosus. There is much confusion in literature regarding the real malignant potential of these oral lesions in relation to the incidence of squamous cell carcinoma.</p><p><strong>Objectives: </strong>We tried to unify the occurrence of squamous cell carcinoma in some oral mucosal diseases into the classic concept of \"Marjolin ulcer\".</p><p><strong>Methods: </strong>We analyzed the most relevant published evidence of the occurrence of squamous cell carcinoma arising in oral lichen planus, dyskeratosis congenita, tertiary syphilitic glossitis chronic graft-versus-host-disease, and oral discoid lupus erythematosus, and tried to establish a logical link between them.</p><p><strong>Results: </strong>Reported cases of squamous cell carcinoma occurring in oral lesions of these diseases seem to appear in old standing, scarring lesions.</p><p><strong>Conclusions: </strong>Oral lichen planus, dyskeratosis congenita, tertiary syphilitic glossitis, chronic graft-versushost-disease, and oral discoid lupus erythematosus are not \"pre-malignant diseases\", their long-lasting mucosal scars are prone to the development of squamous cell carcinomas. In this sense, this tumor can be considered a mucosal type of Marjolin ulcer.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Youth Sun Safety Educational Program.","authors":"Yazmeen Tembunde, Madeline Brown, Murielle Tembunde, Bernard Cohen","doi":"10.5826/dpc.1403a133","DOIUrl":"10.5826/dpc.1403a133","url":null,"abstract":"<p><strong>Introduction: </strong>Sun protection early in life is necessary to prevent skin cancer. Therefore, youth sun safety education is imperative. However, such programs have often failed to bring about behavioral change in youths.</p><p><strong>Objectives: </strong>We evaluate a sun safety educational program's effectiveness in improving elementary school students' knowledge of sun safety, confidence in their ability to explain the importance of sun protection, and their understanding of sunscreen labels.</p><p><strong>Methods: </strong>A 1.5-hour program was conducted for the fourth-grade students. Forty-five of the 53 students participated in the study and completed the pre- and post-surveys, a response rate of 84%. These surveys were identical, consisting of four questions rated on a Likert scale to assess changes in the students' knowledge, confidence, and understanding regarding sun protection.</p><p><strong>Results: </strong>The students overall had a statistically significant increase in their knowledge of sun safety and sun protective measures, confidence in their ability to explain the importance of sun protection, and their understanding of sunscreen labels.</p><p><strong>Conclusions: </strong>In alignment with the current literature, this study demonstrates the importance of school-based sun safety programs and notably shows that such programs can increase youths' understanding of sunscreen labels and confidence in explaining the importance of sun protection. It is our hope that the program will cause increased practice of sun protective behaviors among the students. Further research is needed to determine how effective such programs are in increasing the practice of sun protective behaviors in youths.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Vivo Demonstration of the Eruptive Behavior of an Atypical Spitz Tumor.","authors":"Amalia Luna, Natalia Castrejón, Sebastian Podlipnik, Josep Malvehy, Susana Puig, Cristina Carrera","doi":"10.5826/dpc.1403a196","DOIUrl":"10.5826/dpc.1403a196","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Multiple Sclerosis in Vitiligo Patients and Their First-Degree Relatives: Two Diseases with Similarities in Pathogenesis and Treatment.","authors":"Mohammadreza Kavyani, Vahideh Lajevardi, Maryam Ghiasi, Maryam Daneshpazhooh, Sama Heidari, Amir Teimourpour, Kamran Balighi","doi":"10.5826/dpc.1403a103","DOIUrl":"10.5826/dpc.1403a103","url":null,"abstract":"<p><strong>Introduction: </strong>Vitiligo is a common pigmentation disorder manifested by white macules and patches. It is accompanied by some autoimmune and neurological diseases. Recently, it has been suggested that multiple sclerosis (MS) is more common in vitiligo patients and that they have a higher risk of developing MS during their lifetime.</p><p><strong>Objectives: </strong>In this study, we aimed to determine the prevalence of MS in patients with vitiligo and their first-degree relatives and compare it with the prevalence in the population.</p><p><strong>Methods: </strong>In this cross-sectional study, data were consecutively collected from patients referred to Razi Hospital from March 2020 to December 2021.</p><p><strong>Results: </strong>Seven hundred and nine patients with vitiligo participated in this study, and 15 reported a history of MS (2.12%, 95% confidence interval [CI] 1.06%-3.17%). This rate was significantly higher than the prevalence of MS in the average population of Tehran (P < 0.001). Of the 2886 first-degree relatives of the patients, 10 had MS (0.35%, 95%CI 0.13&-0.56%), which was higher than the prevalence of MS, yet not statistically significant.</p><p><strong>Conclusions: </strong>A significant association between vitiligo and MS was observed, which should be of clinical and therapeutic importance. However, the prevalence of MS in first-degree relatives of vitiligo patients was higher than the average rate, yet not statistically significant.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Polarized and Non-Polarized Light in the Dermoscopic Assessment of Amelanotic Melanoma: A Teaching Case.","authors":"Vittorio Tancredi, Pierfrancesco Benvenuto, Luca Damiani, Camila Scharf, Elvira Moscarella, Giuseppe Argenziano","doi":"10.5826/dpc.1403a208","DOIUrl":"10.5826/dpc.1403a208","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Promise of Hyaluronidase in Systemic Sclerosis: A Systematic Review.","authors":"Anika Pulumati, Rachel Lin, Scott A Elman","doi":"10.5826/dpc.1403a163","DOIUrl":"10.5826/dpc.1403a163","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic sclerosis, also known as scleroderma, is a chronic disease marked by autoimmune-mediated damage to connective tissues leading to vascular damage, tissue injury, and fibrosis. Effective treatment for this condition has remained difficult; however, a promising therapeutic option for patients with systemic sclerosis has emerged as hyaluronidase.</p><p><strong>Objectives: </strong>We conducted a systemic review of the available literature to describe the therapeutic usage of hyaluronidase in systemic sclerosis.</p><p><strong>Methods: </strong>We conducted a comprehensive review on PubMed and Embase, using the terms: \"hyaluronidase\" AND \"scleroderma,\" as well as \"hyaluronidase\" AND \"systemic sclerosis.\" Our criteria for inclusion were English-written articles published between 2013 and 2023. Only studies conducted on human subjects or in vitro on human cell lines were included. We excluded articles that did not discuss therapeutic use as well as articles that focused on medical conditions other than systemic sclerosis.</p><p><strong>Results: </strong>Ten articles were included in our review. Overall, intradermal hyaluronidase showed improvement in systemic sclerosis-associated microstomia via increased oral aperture with minimal side effects. Treatment protocol and outcome measured differed per case, however, multiple rounds of injections were necessary in all treatment courses. In some studies, a plateauing effect for hyaluronidase was seen after 3-5 months of injections.</p><p><strong>Conclusions: </strong>Case studies and case series have demonstrated hyaluronidase effectiveness in treating systemic sclerosis-associated microstomia, however, more research using larger sample sizes, standardized protocols, and specific outcomes such be conducted.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Point Checklist Dermoscopy for Melanoma Screening: Experience in Medical Students New to Dermatology.","authors":"Aldo Ibani, Diego Aragón-Caqueo, Monserrat Naveiro, Felipe Sánchez, Daniela Ríos, Javiera Medina, Antonio Guglielmetti","doi":"10.5826/dpc.1403a211","DOIUrl":"10.5826/dpc.1403a211","url":null,"abstract":"<p><strong>Introduction: </strong>Early detection of melanoma and optimal referral to the specialist starts in primary care. Medical education is usually deficient in training general physicians in early detection and risk management for most skin malignancies. A three-point dermoscopy checklist is used as a screening tool for differentiating malignant and benign pigmented lesions in non-expert clinicians using dermoscopy.</p><p><strong>Objectives: </strong>To evaluate the impact of brief medical training on the three-point dermoscopy algorithm in third-year medical students new to dermatology and to determine the levels of sensitivity and specificity to differentiate malignant and benign pigmented lesions.</p><p><strong>Methods: </strong>Optional dermoscopy lecture for third-year medical students new to dermatology in the context of general medical semiology courses, with case discussion and evaluation of 50 dermoscopy cases (25 benign and 25 malignant). Students were asked to classify malignant versus benign pathology based on the three-point dermoscopy algorithm discussed. Sensitivity, specificity, and predictive values were calculated according to the students' responses.</p><p><strong>Results: </strong>Sixty-five students provided 3250 responses. Malignant pathology was misclassified as benign in 154 responses, while benign pathology was misclassified as malignant in 668 responses. Sensitivity and specificity for differentiating malignant lesions were 89.70% and 61.99%, respectively. Moderate interobserver agreement was found (Kappa value = 0.50; [CI: 0.47-0.54]).</p><p><strong>Conclusion: </strong>When evaluating melanocytic lesions, the focus of primary healthcare and general medical education should emphasize the correct determination of malignant or benign pathology. Teaching the three-point dermoscopy rule to medical students new to dermatology yields satisfactory levels of sensitivity and specificity, comparable to general physicians.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Sirolimus 0.1% as Off-Label Treatment of Kaposi's Sarcoma.","authors":"Vittorio Tancredi, Gaetano Licata, Dario Buononato, Maria Pia Boccellino, Giuseppe Argenziano, Caterina Mariarosaria Giorgio","doi":"10.5826/dpc.1403a201","DOIUrl":"10.5826/dpc.1403a201","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV Dermoscopy as a Diagnostic Tool to Differentiate Between Pediculosis and Piedra Branca.","authors":"Bianca Spina Papaleo, Gustavo de Sá Menezes Carvalho, Guilherme Camargo Julio Valinoto, John Verrinder Veasey","doi":"10.5826/dpc.1403a144","DOIUrl":"10.5826/dpc.1403a144","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}