Dermatology practical & conceptual最新文献

{"title":"Abdominal Telangiectasia in Newborns: A Comprehensive Retrospective Review of Clinical Cases.","authors":"Tullio Brunetti, Marco Adriano Chessa, Francesco Paolo Salamone, Alessandra Gelmetti, Iria Neri","doi":"10.5826/dpc.1503a5501","DOIUrl":"10.5826/dpc.1503a5501","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondrodermatitis Nodularis Helicis: Association with Higher Risk of Multimorbidity and Mortality in Middle-Aged Individuals and Implications for Prevention. An Observational Multicenter Retrospective Case-Control Investigation in Northern Spain.","authors":"Francisco Vázquez-López, Luis Requena, Cristina Galache, Carla Díaz-Louzao, Marcos A González-López","doi":"10.5826/dpc.1503a4828","DOIUrl":"10.5826/dpc.1503a4828","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have independently linked chondrodermatitis nodularis (CN) with vascular injury, tobacco smoking, and diabetes, particularly in adult patients with early onset lesions.</p><p><strong>Objectives: </strong>To build on previous research by investigating survival and frequency of comorbidities in adult patients diagnosed with premature CN lesions (<61 years).</p><p><strong>Methods: </strong>We conducted a retrospective multicenter case-control observational study focused on individuals diagnosed with CN before the age of 61. Participants were further categorized into those diagnosed before 46 years and those diagnosed between ages 46 and 60 years. We evaluated the frequency of cancer, chronic obstructive lung disease, severe liver disease, diabetes mellitus, HIV infection, arterial disease, hypertension, dyslipidemia, multimorbidity, and tobacco smoking as well as survival rates. Statistical analysis included univariate analysis (including Holm-Bonferroni test), Kaplan-Meier plot estimation with log-rank test, and multivariate Cox analysis.</p><p><strong>Results: </strong>Patients diagnosed with CN between ages 46 and <61 years showed significantly greater multimorbidity (Holm-Bonferroni test, P=0.00007 < 0.00122) and higher mortality rates compared to controls (log-rank test, P=0.006). Multivariate Cox analysis revealed an adjusted HR of 2.75 (95% CI: 1.36-5.54, P=0.005).</p><p><strong>Conclusions: </strong>The novel finding of this retrospective multicenter study is that a diagnosis of CN in middle-aged patients could be a marker of elevated risk of systemic comorbidity and mortality. These results highlight the need for prospective studies to confirm these associations. Meanwhile, clinicians should be aware that emphasizing healthy lifestyle choices of patients with CN may have an important preventive value.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Stress, Stress Coping Strategies, and Body Image Among Facial Dermatosis.","authors":"Hazel Ezgi Kaya, İlknur Kıvanç Altunay, Aslı Aksu","doi":"10.5826/dpc.1503a5054","DOIUrl":"10.5826/dpc.1503a5054","url":null,"abstract":"<p><strong>Introduction: </strong>Considering its visible nature, facial dermatosis may result in more prominent psychosocial effects.</p><p><strong>Objectives: </strong>We aimed to compare quality of life, anxiety, depression, perceived stress, stress coping strategies, and body image in individuals with facial and trunk dermatosis.</p><p><strong>Methods: </strong>A total of 120 patients (60 with facial dermatosis, 60 with trunk dermatosis) and 60 healthy volunteers were included in the study. Demographic and clinical features were recorded, and participants were evaluated with Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS), Stress Coping Attitudes Inventory (SCAI), and Body Image Scale (BIS).</p><p><strong>Results: </strong>In trunk dermatosis patient group, the DLQI, HADS, and PSS scores were significantly higher, while the BIS scores were significantly lower than in the facial dermatosis group and the controls. Avoidance subscores of the SCAI were significantly higher in the trunk dermatosis group compared to the facial dermatosis group. Acceptance/Cognitive Restructuring subscore of the SCAI was found to be higher in the facial dermatosis than the trunk dermatosis group (P=0.037). Linear regression analysis revealed that the most important determinant of DLQI was HADS-Anxiety score (β=0.271, P=0.023) and one of the most important determinant of the PSS score was HADS-Anxiety score (β= 0.426, P<0.001).</p><p><strong>Conclusion: </strong>Patients with trunk dermatosis experienced more stress, anxiety, depression, and distortion of body perception, and the impact on quality of life was more pronounced. This situation was thought to be related to the fact that patients with facial dermatosis used positive coping strategies, while negative strategies were more common in patients with trunk dermatosis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Zonulin and Its Role in Rosacea Pathogenesis: A Comprehensive Estimation Study.","authors":"Fatma H Shabaka, Laila A Rashed, Mona S Ali, Aya A Salama","doi":"10.5826/dpc.1503a5027","DOIUrl":"10.5826/dpc.1503a5027","url":null,"abstract":"<p><strong>Introduction: </strong>Rosacea is a chronic inflammatory skin disorder distinguished by recurrent episodes of inflammatory papules, persistent erythema, facial flushing, pustules, and telangiectasia. Any disturbance in the gut microbiome could influence the immune system equilibrium in rosacea by releasing zonulin, leading to increased intestinal permeability and the passage of many microbes into the circulation, causing inflammation.</p><p><strong>Objectives: </strong>We aimed to estimate the serum zonulin levels in cases with rosacea compared with healthy controls. Some fecal bacteria were investigated in an attempt to find a relationship between gut microbiome and rosacea.</p><p><strong>Methods: </strong>This case-control study was performed on 42 participants aged above 18 years: 21 patients with a clinical diagnosis of rosacea approved by dermoscopy and 21 healthy individuals as controls. The serum zonulin level was estimated by the enzyme-linked immunosorbent assay technique, and some gut microbiomes were investigated using real-time quantitative PCR.</p><p><strong>Results: </strong>There was a statistically significantly higher serum zonulin level in rosacea cases than in controls. There was a statistically significant elevation in Bacteroides and Lactobacillus gut microbiomes in rosacea patients compared to controls, while there was no statistically significant increase in Fusobacterium microbiome in patients. Zonulin levels did not show a significant correlation with gut microbiome.</p><p><strong>Conclusions: </strong>Serum zonulin measurement can be used as a discriminating marker between rosacea and healthy controls, due to getting a specific cut-off point in ROC analysis with the highest specificity and sensitivity (100% and 100%, respectively). Gut microbial dysbiosis could play a valuable role in the disease pathogenesis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopy of Acne Agminata in Fair and Dark Skin.","authors":"Noemi Plozner, Irene D'Odorico, Enrico Pegolo, Giuseppe Stinco, Enzo Errichetti","doi":"10.5826/dpc.1503a5568","DOIUrl":"10.5826/dpc.1503a5568","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Findings of Mucosal Pemphigus Vulgaris: Clinical Correlation and Diagnostic Value.","authors":"Zeynep Karaca Ural, Merva Hatun Erkayman, Zeynep Utlu, Handan Bilen, Özgür Yörük","doi":"10.5826/dpc.1503a5870","DOIUrl":"10.5826/dpc.1503a5870","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris (PV) is an autoimmune bullous disease that usually starts on the oral mucosa, but it can affect all mucosal surfaces. There are limited data about endoscopic otorhinolaryngological examination of patients with PV.</p><p><strong>Objective: </strong>To assess the prevalence of nasal, pharyngeal, and laryngeal involvement in patients with PV and to determine its correlation with clinical symptoms.</p><p><strong>Methods: </strong>Thirty-four patients with pemphigus vulgaris were questioned for rhinorrhea, epistaxis, hoarseness, and throat pain. All patients' nasal, oral, hypopharyngeal, and laryngeal mucosa were then examined endoscopically by the same otolaryngologist, and mucosal lesion localizations were noted. The association between symptoms and lesion localization was assessed using the chi-squared test.</p><p><strong>Results: </strong>The study included 34 patients, 14 (41.2%) males and 20 (58.8%) females; 32 (94.1%) patients had oral mucosal involvement. Nasal, hypopharyngeal, and laryngeal involvement were detected in 52.9%, 58.8%, and 55.9% of cases, respectively. Endoscopic examination revealed lesions in areas other than the oral mucosa in 30 patients, with 24 (70.6%) exhibiting symptoms related to these regions. Nasal bleeding was a significant symptom of nasal involvement (P=0.006), whereas nasal obstruction was not (P=0.388). Throat pain was significantly associated with hypopharyngeal involvement (P=0.003), while hoarseness showed marginal significance (P=0.05). No significant association was found between laryngeal or tonsillar involvement and any symptom.</p><p><strong>Conclusion: </strong>The study demonstrates that a significant proportion of pemphigus vulgaris patients have silent mucosal involvement. This suggests that symptom-based evaluations may be insufficient and that systematic endoscopic screening could play a critical role in PV management.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Reflectance Confocal Microscopy for Detecting Cutaneous Metastasis in Breast Cancer.","authors":"Nilay Duman, Banu Yaman, Göktürk Oraloğlu, Işıl Kararaslan","doi":"10.5826/dpc.1503a5624","DOIUrl":"10.5826/dpc.1503a5624","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Blue Straggler Stars a Hidden Clue? Intriguing Discovery in Pityriasis Rubra Pilaris Under UV-Induced Fluorescence Dermoscopy.","authors":"Divya Madonna Dsouza, Jacintha Martis, M Ramesh Bhat, Michelle Serene Fernandes, Rochelle Cheryl Monteiro, Jyothi Jayaraman","doi":"10.5826/dpc.1503a5295","DOIUrl":"10.5826/dpc.1503a5295","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Cutaneous Metastasis in Clear Cell Renal Carcinoma.","authors":"Amanda do Carmo Gusmão, Carollina Cecim De Souza, Luciana Pantaleão, Isadora Ortiz Cantarino Pereira da Silva, Bruno de Souza Bianchi Reis, Carlos Arthur de Figueiredo Athayde","doi":"10.5826/dpc.1503a5440","DOIUrl":"10.5826/dpc.1503a5440","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Eyelash Poliosis with Raccoon Erythema and Hypopigmentation-Contact Follicular Leukoderma.","authors":"Shreya K Gowda, Ritika Dhakad, Somesh Gupta","doi":"10.5826/dpc.1503a5235","DOIUrl":"10.5826/dpc.1503a5235","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}