Dermatology practical & conceptual最新文献

{"title":"Abdominal Telangiectasia in Newborns: A Comprehensive Retrospective Review of Clinical Cases.","authors":"Tullio Brunetti, Marco Adriano Chessa, Francesco Paolo Salamone, Alessandra Gelmetti, Iria Neri","doi":"10.5826/dpc.1503a5501","DOIUrl":"10.5826/dpc.1503a5501","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondrodermatitis Nodularis Helicis: Association with Higher Risk of Multimorbidity and Mortality in Middle-Aged Individuals and Implications for Prevention. An Observational Multicenter Retrospective Case-Control Investigation in Northern Spain.","authors":"Francisco Vázquez-López, Luis Requena, Cristina Galache, Carla Díaz-Louzao, Marcos A González-López","doi":"10.5826/dpc.1503a4828","DOIUrl":"10.5826/dpc.1503a4828","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have independently linked chondrodermatitis nodularis (CN) with vascular injury, tobacco smoking, and diabetes, particularly in adult patients with early onset lesions.</p><p><strong>Objectives: </strong>To build on previous research by investigating survival and frequency of comorbidities in adult patients diagnosed with premature CN lesions (<61 years).</p><p><strong>Methods: </strong>We conducted a retrospective multicenter case-control observational study focused on individuals diagnosed with CN before the age of 61. Participants were further categorized into those diagnosed before 46 years and those diagnosed between ages 46 and 60 years. We evaluated the frequency of cancer, chronic obstructive lung disease, severe liver disease, diabetes mellitus, HIV infection, arterial disease, hypertension, dyslipidemia, multimorbidity, and tobacco smoking as well as survival rates. Statistical analysis included univariate analysis (including Holm-Bonferroni test), Kaplan-Meier plot estimation with log-rank test, and multivariate Cox analysis.</p><p><strong>Results: </strong>Patients diagnosed with CN between ages 46 and <61 years showed significantly greater multimorbidity (Holm-Bonferroni test, P=0.00007 < 0.00122) and higher mortality rates compared to controls (log-rank test, P=0.006). Multivariate Cox analysis revealed an adjusted HR of 2.75 (95% CI: 1.36-5.54, P=0.005).</p><p><strong>Conclusions: </strong>The novel finding of this retrospective multicenter study is that a diagnosis of CN in middle-aged patients could be a marker of elevated risk of systemic comorbidity and mortality. These results highlight the need for prospective studies to confirm these associations. Meanwhile, clinicians should be aware that emphasizing healthy lifestyle choices of patients with CN may have an important preventive value.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Stress, Stress Coping Strategies, and Body Image Among Facial Dermatosis.","authors":"Hazel Ezgi Kaya, İlknur Kıvanç Altunay, Aslı Aksu","doi":"10.5826/dpc.1503a5054","DOIUrl":"10.5826/dpc.1503a5054","url":null,"abstract":"<p><strong>Introduction: </strong>Considering its visible nature, facial dermatosis may result in more prominent psychosocial effects.</p><p><strong>Objectives: </strong>We aimed to compare quality of life, anxiety, depression, perceived stress, stress coping strategies, and body image in individuals with facial and trunk dermatosis.</p><p><strong>Methods: </strong>A total of 120 patients (60 with facial dermatosis, 60 with trunk dermatosis) and 60 healthy volunteers were included in the study. Demographic and clinical features were recorded, and participants were evaluated with Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS), Stress Coping Attitudes Inventory (SCAI), and Body Image Scale (BIS).</p><p><strong>Results: </strong>In trunk dermatosis patient group, the DLQI, HADS, and PSS scores were significantly higher, while the BIS scores were significantly lower than in the facial dermatosis group and the controls. Avoidance subscores of the SCAI were significantly higher in the trunk dermatosis group compared to the facial dermatosis group. Acceptance/Cognitive Restructuring subscore of the SCAI was found to be higher in the facial dermatosis than the trunk dermatosis group (P=0.037). Linear regression analysis revealed that the most important determinant of DLQI was HADS-Anxiety score (β=0.271, P=0.023) and one of the most important determinant of the PSS score was HADS-Anxiety score (β= 0.426, P<0.001).</p><p><strong>Conclusion: </strong>Patients with trunk dermatosis experienced more stress, anxiety, depression, and distortion of body perception, and the impact on quality of life was more pronounced. This situation was thought to be related to the fact that patients with facial dermatosis used positive coping strategies, while negative strategies were more common in patients with trunk dermatosis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Zonulin and Its Role in Rosacea Pathogenesis: A Comprehensive Estimation Study.","authors":"Fatma H Shabaka, Laila A Rashed, Mona S Ali, Aya A Salama","doi":"10.5826/dpc.1503a5027","DOIUrl":"10.5826/dpc.1503a5027","url":null,"abstract":"<p><strong>Introduction: </strong>Rosacea is a chronic inflammatory skin disorder distinguished by recurrent episodes of inflammatory papules, persistent erythema, facial flushing, pustules, and telangiectasia. Any disturbance in the gut microbiome could influence the immune system equilibrium in rosacea by releasing zonulin, leading to increased intestinal permeability and the passage of many microbes into the circulation, causing inflammation.</p><p><strong>Objectives: </strong>We aimed to estimate the serum zonulin levels in cases with rosacea compared with healthy controls. Some fecal bacteria were investigated in an attempt to find a relationship between gut microbiome and rosacea.</p><p><strong>Methods: </strong>This case-control study was performed on 42 participants aged above 18 years: 21 patients with a clinical diagnosis of rosacea approved by dermoscopy and 21 healthy individuals as controls. The serum zonulin level was estimated by the enzyme-linked immunosorbent assay technique, and some gut microbiomes were investigated using real-time quantitative PCR.</p><p><strong>Results: </strong>There was a statistically significantly higher serum zonulin level in rosacea cases than in controls. There was a statistically significant elevation in Bacteroides and Lactobacillus gut microbiomes in rosacea patients compared to controls, while there was no statistically significant increase in Fusobacterium microbiome in patients. Zonulin levels did not show a significant correlation with gut microbiome.</p><p><strong>Conclusions: </strong>Serum zonulin measurement can be used as a discriminating marker between rosacea and healthy controls, due to getting a specific cut-off point in ROC analysis with the highest specificity and sensitivity (100% and 100%, respectively). Gut microbial dysbiosis could play a valuable role in the disease pathogenesis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopy of Acne Agminata in Fair and Dark Skin.","authors":"Noemi Plozner, Irene D'Odorico, Enrico Pegolo, Giuseppe Stinco, Enzo Errichetti","doi":"10.5826/dpc.1503a5568","DOIUrl":"10.5826/dpc.1503a5568","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Findings of Mucosal Pemphigus Vulgaris: Clinical Correlation and Diagnostic Value.","authors":"Zeynep Karaca Ural, Merva Hatun Erkayman, Zeynep Utlu, Handan Bilen, Özgür Yörük","doi":"10.5826/dpc.1503a5870","DOIUrl":"10.5826/dpc.1503a5870","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris (PV) is an autoimmune bullous disease that usually starts on the oral mucosa, but it can affect all mucosal surfaces. There are limited data about endoscopic otorhinolaryngological examination of patients with PV.</p><p><strong>Objective: </strong>To assess the prevalence of nasal, pharyngeal, and laryngeal involvement in patients with PV and to determine its correlation with clinical symptoms.</p><p><strong>Methods: </strong>Thirty-four patients with pemphigus vulgaris were questioned for rhinorrhea, epistaxis, hoarseness, and throat pain. All patients' nasal, oral, hypopharyngeal, and laryngeal mucosa were then examined endoscopically by the same otolaryngologist, and mucosal lesion localizations were noted. The association between symptoms and lesion localization was assessed using the chi-squared test.</p><p><strong>Results: </strong>The study included 34 patients, 14 (41.2%) males and 20 (58.8%) females; 32 (94.1%) patients had oral mucosal involvement. Nasal, hypopharyngeal, and laryngeal involvement were detected in 52.9%, 58.8%, and 55.9% of cases, respectively. Endoscopic examination revealed lesions in areas other than the oral mucosa in 30 patients, with 24 (70.6%) exhibiting symptoms related to these regions. Nasal bleeding was a significant symptom of nasal involvement (P=0.006), whereas nasal obstruction was not (P=0.388). Throat pain was significantly associated with hypopharyngeal involvement (P=0.003), while hoarseness showed marginal significance (P=0.05). No significant association was found between laryngeal or tonsillar involvement and any symptom.</p><p><strong>Conclusion: </strong>The study demonstrates that a significant proportion of pemphigus vulgaris patients have silent mucosal involvement. This suggests that symptom-based evaluations may be insufficient and that systematic endoscopic screening could play a critical role in PV management.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Reflectance Confocal Microscopy for Detecting Cutaneous Metastasis in Breast Cancer.","authors":"Nilay Duman, Banu Yaman, Göktürk Oraloğlu, Işıl Kararaslan","doi":"10.5826/dpc.1503a5624","DOIUrl":"10.5826/dpc.1503a5624","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.","authors":"Mohamed J Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Suhas Ballal, Shilpa Sharma, J Guntaj, G V Siva Prasad, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad","doi":"10.5826/dpc.1503a5333","DOIUrl":"10.5826/dpc.1503a5333","url":null,"abstract":"<p><strong>Introduction: </strong>The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.</p><p><strong>Objectives: </strong>A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p><p><strong>Methods: </strong>In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.</p><p><strong>Results: </strong>Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.</p><p><strong>Conclusions: </strong>Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Rosacea on Keratinocyte Skin Cancers: A Prospective Case-Control Study of Basal and Squamous Cell Carcinoma Risk.","authors":"Aslı Aksu, Ayşenur Demir, Hatice Günay, Pinar Ozdemir Cetinkaya, Birgul Ozkesici Kurt, Hazel Ezgi Kaya, İlknur Kıvanç Altunay, Deniz Altınel","doi":"10.5826/dpc.1503a5264","DOIUrl":"10.5826/dpc.1503a5264","url":null,"abstract":"<p><strong>Introduction: </strong>The full range of cutaneous comorbidities associated with keratinocyte skin cancers remains to be elucidated.</p><p><strong>Objectives: </strong>We aimed to examine other skin diseases in patients with keratinocyte cancer (KC) and to reveal potential associations between them.</p><p><strong>Methods: </strong>Included in the study were 200 patients with KC and 200 disease-free controls. To identify any additional concomitant dermatological conditions, all study groups underwent examination by two dermatologists.</p><p><strong>Results: </strong>In patients with KC, 87.5% were diagnosed with basal cell carcinoma and 13.5% were diagnosed with squamous cell carcinoma. There was no statistically significant difference between the two groups regarding sunscreen use habits (P =0.284). Patients with KC exhibited a significantly elevated odds ratio (OR) for the presence of rosacea (OR 5.13, 95% CI: 3.2-8.3, P=0.000) and especially erythematotelangiectatic rosacea (ETR) subtype (OR 5.03, 95% CI: 3.1-8.2, P=0.000). An Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the efficacy of rosacea in differentiating between the control group and patients with KC. The sensitivity, specificity, negative predictive value, and positive predictive value for rosacea were 45.5%, 86%, 61.2%, and 76.5%, respectively (AUC 0.658, 95% CI: 0.604-0.711, P=0.000), while for ETR it was 44%, 86.5%, 60.7%, and 76.5%, respectively (AUC 0.653, 95% CI: 0.599-0.706, P=0.000). The presence of rosacea demonstrated a significant efficacy in differentiating patients with KC from the control group in all localizations (P< 0.05).</p><p><strong>Conclusion: </strong>The risk of rosacea in patients with KC, particularly those with the ETR subtype, was found to be significantly elevated, irrespective of age, sex, or localization.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Vascular Patterns in Skin Lesions with LC-OCT and Dermoscopy with a Tridimensional Perspective: A Pilot Study.","authors":"Clément Lenoir, Mariano Suppa, Susana Puig, Véronique Del Marmol, Raquel Albero, Llucia Also, Carmen Orte Cano, Gwendoline Diet, Margot Fontaine, Linda Tognetti, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, Josep Malvehy, Javiera Perez-Anker","doi":"10.5826/dpc.1503a5297","DOIUrl":"10.5826/dpc.1503a5297","url":null,"abstract":"<p><strong>Introduction: </strong>Vascular patterns play a crucial role in the diagnosis and differentiation of skin lesions by providing insight into underlying pathology and aid in distinguishing between benign and malignant lesions. While dermoscopy has proven valuable for visualizing these vascular structures, line-field confocal optical coherence tomography (LC-OCT) offers high-resolution, 3-dimensional (3D) imaging of the skin, potentially providing detailed visualization of vascular architecture and new insights into their projection in dermoscopy.</p><p><strong>Objectives: </strong>This pilot study aimed to investigate the correlation between vascular patterns in skin lesions with LC-OCT and dermoscopy and explored tridimensional imaging in assessing microvascular architecture.</p><p><strong>Methods: </strong>A cohort of patients with 14 diverse skin lesions showing typical dermoscopic vascular patterns were examined using dermoscopy and LC-OCT. LC-OCT images were analyzed, and manual segmentation with tridimensional reconstruction of the vascular structures was performed. The correlation between these vascular structures and their dermoscopic projection was then assessed qualitatively.</p><p><strong>Results: </strong>LC-OCT demonstrated a strong visual correlation with dermoscopy in identifying vascular patterns, offering additional depth and 3D details of the intricate relationship between skin micro-architecture and the development of specific vascular patterns in skin lesions.</p><p><strong>Conclusions: </strong>LC-OCT correlates with dermoscopy in vascular pattern analysis in skin lesions. The added advantage of 3D imaging helped us understand the way vascular structures are formed in skin lesions depending on their micro-architecture. LC-OCT could potentially play a significant role in precisely assessing the vascular environment of skin lesions. Further studies are necessary to assess how this could provide clinical value for diagnosing or monitoring skin lesions.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}