Dermatology practical & conceptual最新文献

{"title":"Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful?","authors":"Camila Scharf, Aleksandra A Stefaniak, Mario Vaccaro, Francesco Borgia, Federico Vaccaro, Fabrizio Chirico, Andrea Battisti, Valentino Valentini, Giuseppe Argenziano","doi":"10.5826/dpc.1502a4796","DOIUrl":"10.5826/dpc.1502a4796","url":null,"abstract":"<p><strong>Introduction: </strong>Erosive pustular dermatosis of the scalp (EPDS) presents as a rare and challenging skin disorder marked by erosions, pustules, and crusted lesions on the scalp. Diagnosing EPDS is complex, often mimicking other dermatological conditions like actinic keratosis (AK), basal cell carcinoma (BCC), or squamous cell carcinoma (SCC). Therapeutic challenges arise from EPDS's chronic, relapsing nature, which requires long-term management.</p><p><strong>Objective: </strong>This study aimed to identify and compare dermoscopic features of EPDS mimicking SCC of the scalp to improve diagnostic accuracy and support non-invasive differentiation.</p><p><strong>Methods: </strong>A retrospective descriptive study, conducted in two Italian dermatological centers from 2017 to 2023, included 43 patients initially diagnosed with SCC of the scalp that was afterwards confirmed as EPDS through either histology or clinical evaluation and follow-up. Clinical and dermoscopic criteria were evaluated. A comparison of dermoscopical criteria with the same number of confirmed SCC of the scalp was performed.</p><p><strong>Results: </strong>A total of 43 patients were included, predominantly male (42:1). Androgenetic alopecia was present in 65% of cases, predominantly in the parietal area (44%). Hairpin and dotted vessels, along with white and combined lesion colors, were strongly associated with SCC, while polymorphic and branched vessels, orange tones, and targetoid hair follicles predominated in EPDS.</p><p><strong>Conclusions: </strong>EPDS poses diagnostic and therapeutic challenges due to its unique features and elusive etiology. Distinguishing SCC from EPDS is crucial to avoid unnecessary treatments; dermoscopy can serve as an instrument in this process.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Foot Skin Nodules in Children: Talar Callosities in 7 Patients and Differential Diagnosis.","authors":"Mario Cutrone, Ramon Grimalt, Dirk Van Gysel, Julia Nowowiejska, Vincenzo Piccolo","doi":"10.5826/dpc.1502a4872","DOIUrl":"10.5826/dpc.1502a4872","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologic and Non-Biologic Therapies for Scalp Psoriasis: A Network Meta-analysis of Randomized Controlled Trials.","authors":"Hargun Kaur, Tara Behroozian, Rafael Paolo Lansang, Saverio Caini, Chiara Doccioli, Mohannad Abu-Hilal","doi":"10.5826/dpc.1502a4793","DOIUrl":"10.5826/dpc.1502a4793","url":null,"abstract":"<p><strong>Introduction: </strong>Scalp psoriasis affects up to 80% of patients with plaque-type psoriasis and is often resistant to topical and conventional systemic agents. There is a lack of consensus on a \"gold standard\" treatment.</p><p><strong>Objective: </strong>This comprehensive review and network meta-analysis aimed to compare the efficacy and safety of studied interventions.</p><p><strong>Methods: </strong>The Ovid MEDLINE(R), Embase, and Cochrane databases were searched from 01 January 2000 to 05 October 2022. All English-language randomized controlled trials evaluating an intervention for scalp psoriasis were included if they reported one of the following clinical outcomes: Psoriasis Scalp Severity Index (PSSI), scalp Physician Global Assessment (ScPGA), scalp-specific Investigator or Physician Global Assessment (IGA/PGA), and Total Sign Score (TSS), and adverse events. A random effects network meta-analysis was performed where possible, and network plots were generated.</p><p><strong>Results: </strong>Of 1,046 studies identified, 35 met the inclusion criteria, with seven in the PSSI analysis and 16 in the IGA analysis. All interventions led to an improvement in all outcomes when compared to placebo in the PSSI and PGA/IGA. For the PSSI response, secukinumab 300 mg every four weeks (Q4W) was the most effective (SUCRA 0.991). For the PGA/IGA response, bimekizumab 320 mg Q4W was the most effective (SUCRA 0.975).</p><p><strong>Conclusions: </strong>Several systemic therapies are superior to placebo in improving clinical outcomes, with secukinumab 300 mg Q4W and bimekizumab 320 mg Q4W deemed the most effective among biologic agents analyzed. Efforts to enhance research standardization, including head-to-head trials with standardized outcome measures, diverse patient recruitment, and long-term follow-up, are crucial next steps in assessing treatment efficacy and adverse events.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Response to Imiquimod for the Treatment of Lentigo Maligna Assessed With Digital Dermoscopy.","authors":"Luisina Caliani, Gabriel Salerni","doi":"10.5826/dpc.1502a5425","DOIUrl":"10.5826/dpc.1502a5425","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanoma on Chronically Sun-Damaged Skin: Deciphering Gene Expression Signatures.","authors":"Alejandra Avila, Varsha Thakur, Natalie Vincent, Pilar Valencia, Mecker G Möller, Rimpi Khurana, Guo Yan, Jennifer C Tang, Barbara Bedogni, Natalia Jaimes","doi":"10.5826/dpc.1502a4952","DOIUrl":"10.5826/dpc.1502a4952","url":null,"abstract":"<p><strong>Introduction: </strong>Melanoma of the skin is responsible for most skin cancer-related deaths. It is well known that exposure to ultraviolet radiation is the most common and modifiable risk factor for melanoma. Melanomas arising on chronically sun-damaged skin (CSDS) have shown a higher mutational burden.</p><p><strong>Objectives: </strong>To analyze skin samples of patients with melanoma on CSDS to identify possible gene expression signatures that may contribute to melanomagenesis.</p><p><strong>Methods: </strong>This experimental observational analysis, conducted at the Dermatology Melanoma and Pigmented Lesion Clinic at University of Miami Hospitals/Sylvester Comprehensive Cancer Center, Miami, Florida, included a total of 10 patients over 18 years of age with a recent diagnosis of melanoma on CSDS. For each patient, two skin samples were obtained using a 2-mm punch (one from CSDS within 2 cm of the primary melanoma, another from sun-protected skin). Skin samples were sent to the Sylvester Onco-genomics Shared Resource (OGSR) for library preparation and RNA sequencing. Main outcome was the identification of differentially expressed genes between CSDS and non-CSDS of patients with a recent diagnosis of melanoma.</p><p><strong>Results: </strong>A total of four skin samples met the necessary quality standards for molecular analyses. Significant differences were observed between the CSDS and non-CSDS samples. Pathways involved in inflammation (e.g., IL-17 signaling), immune responses (e.g., ABC transporters), and oxidative phosphorylation were overexpressed in CSDS.</p><p><strong>Conclusions: </strong>CSDS can be an adequate milieu for the development and progression of melanoma. CSDS reveals overexpression of pathways involved in inflammation, immune responses, and oxidative phosphorylation, all of which may facilitate interactions between the skin microenvironment and melanocytes/melanoma cells, predisposing to melanoma development and progression.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant Nevi Regression Associated with Multiple Non-Metastatic Cutaneous Melanomas: A Case Report.","authors":"Mislav Mokos, Mirna Šitum, Davor Tomas, Sunčica Andrea Rogan, Marija Buljan","doi":"10.5826/dpc.1502a4912","DOIUrl":"10.5826/dpc.1502a4912","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Nasal Mucociliary Activity in Patients with Psoriasis Vulgaris.","authors":"Mehmet Akif Dündar, Selami Aykut Temiz, İsmail Hakkı Tunçez, Elif Emre, Sadettin Emre, Recep Dursun","doi":"10.5826/dpc.1502a5014","DOIUrl":"10.5826/dpc.1502a5014","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis, a chronic inflammatory dermatological condition, is marked by recurring periods of activity and quiescence. This persistent inflammation contributes to a range of associated health issues. The respiratory system relies on nasal mucociliary clearance as a fundamental defense mechanism. Mucociliary transport dysfunction is frequently observed in chronic inflammatory states.</p><p><strong>Objective: </strong>We aimed to determine the relationship between psoriasis and concomitant clinical conditions and nasal mucociliary clearance time (NMCT).</p><p><strong>Method: </strong>We conducted a study to evaluate NMCTin 34 individuals diagnosed with psoriasis and a control group of 35 healthy individuals.</p><p><strong>Results: </strong>Our results revealed a statistically significant prolongation of NMCT in the psoriasis group (11.26 ± 2 minutes) compared to the control group (9.2 ± 1.85 minutes, P<0.001). Moreover, a positive correlation was identified between NMCT and both the duration of psoriasis and the Psoriasis Area and Severity Index (PASI). This suggests that impaired nasal mucociliary clearance in individuals with psoriasis, especially those with more severe disease, may elevate their vulnerability to infections of the sinuses and nasal passages.</p><p><strong>Conclusion: </strong>This highlights the need to consider strategies for enhancing mucociliary function in this patient population.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Lymphangioma Circumscriptum.","authors":"Xinxin Lei, Ke Bian, Bo Xie","doi":"10.5826/dpc.1502a5343","DOIUrl":"10.5826/dpc.1502a5343","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Features of Eccrine Poromas in Diverse Skin Phototypes: A Retrospective Study of 26 Cases.","authors":"Bengu Nisa Akay, Handan Merve Erol Mart, Aylin Okcu Heper","doi":"10.5826/dpc.1502a5071","DOIUrl":"10.5826/dpc.1502a5071","url":null,"abstract":"<p><strong>Introduction: </strong>Eccrine poroma (EP) is a benign adnexal tumor. Establishing a definitive diagnosis based on clinical and dermoscopic findings can be challenging.</p><p><strong>Objectives: </strong>The aim of this study was to perform a comprehensive analysis of the dermoscopic features of pigmented, hypopigmented, and nonpigmented variants of EP and to compare these dermoscopic features in patients with dark and light Fitzpatrick skin phototypes.</p><p><strong>Methods: </strong>A total of 26 cases of histopathologically confirmed EP were included. Each case was categorized as pigmented, hypopigmented, or nonpigmented based on the melanin content within the lesion. Patients were classified according to their Fitzpatrick skin phototypes. Dermoscopic images were subjected to revised pattern analysis, and the results were compared with the existing literature.</p><p><strong>Results: </strong>Regarding Fitzpatrick skin phototype, four (15.4%), 11 (42.3%), six (23.1%), and five (19.2%) patients had Fitzpatrick skin phototypes II, III, IV, and V, respectively. Of the cases, 17 (65.4%) were classified as nonpigmented, three (11.5%) as hypopigmented, and six (23.1%) as pigmented EP. All pigmented EP cases occurred in patients with dark skin and were located on non-acral sites. Polymorphic vascular pattern, branched vessels with rounded endings, linear-irregular vessels, interlacing white areas around vessels, and collarettes were more frequently observed in patients with light skin. In contrast, clod vessels, coiled vessels, white lines, ulceration, fiber sign, scales, and structureless areas were more common in patients with dark skin.</p><p><strong>Conclusions: </strong>This study underscores the significant dermoscopic diversity observed in EP, revealing distinct patterns based on pigmentation and Fitzpatrick skin phototypes.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Disseminated Mucormycosis by Cunninghamella in Newly Diagnosed Acute Myeloid Leukemia: Case Report and Diagnostic Challenges.","authors":"Sebastián González-Valdés, Magdalena Vial, Renate Steffen, Mauricio Lechuga","doi":"10.5826/dpc.1502a5016","DOIUrl":"10.5826/dpc.1502a5016","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}