Dermatology practical & conceptual最新文献

{"title":"Ultraviolet-Induced Fluorescence Dermatoscopy (UVFD) features in Porokeratosis: Findings from a Multicenter Retrospective Study.","authors":"Rosario Aguero, Marie-Chantal Caussade, Francisca Donoso, Sebastián González-Valdés, Carlos Matas, Sergio Bustos, Manuela Boleira, Natalia Salwowska, David Swanson, Bengu Nisa Akay, Ashfaq A Marghoob, Paweł Pietkiewicz, Cristian Navarrete-Dechent","doi":"10.5826/dpc.1601a6054","DOIUrl":"10.5826/dpc.1601a6054","url":null,"abstract":"<p><strong>Introduction: </strong>Porokeratosis is a group of keratinization disorders characterized by the histopathological presence of the cornoid lamella, a hallmark feature across all subtypes. The clinical diagnosis of porokeratosis can be challenging due to its similarity to other dermatological conditions. While polarized light dermatoscopy (PLD) enhances diagnostic accuracy, certain features remain difficult to identify. Ultraviolet-induced fluorescence dermatoscopy (UVFD) is a novel imaging technique that may improve the visualization of porokeratosis features, particularly the peripheral keratin rim.</p><p><strong>Objectives: </strong>This study aimed to assess the diagnostic utility of UVFD compared with PLD in identifying the dermatoscopic features of porokeratosis.</p><p><strong>Methods: </strong>In this retrospective study, dermatologists from five institutions in Chile, Brazil, Poland, and the United States contributed with dermatoscopic images of porokeratosis cases. Both PLD and UVFD images were obtained for each lesion. Two independent investigators evaluated each lesion in PLD and UVFD for the presence of peripheral keratin rim, rim continuity, central scaling, follicular plugs, vascular structures, and photodamaged surrounding skin. A third investigator reviewed discrepancies. Frequencies and means were calculated. McNemar's chi-square was used for comparison.</p><p><strong>Results: </strong>A total of 136 lesions from 35 patients with biopsy-proven porokeratosis were analyzed. UVFD significantly improved the visualization of the peripheral keratin rim (95.6% vs. 66.2% in PLD; P<0.001) and increased identification rates for central scaling, follicular plugs, and interrupted rims. PLD remained superior for detecting vascular structures(P<0.001).</p><p><strong>Conclusions: </strong>UVFD enhances the visualization of key dermatoscopic features of porokeratosis, particularly the peripheral keratin rim and other keratin-related structures.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue Lesions in Dermoscopy: A Practical Guide to Risk Stratification and Management.","authors":"Giuseppe Argenziano, Camila Scharf, Eugenia Veronica Di Brizzi, Giulia Briatico, Maria Maddalena Nicoletti, Gabriella Brancaccio","doi":"10.5826/dpc.1601a6995","DOIUrl":"10.5826/dpc.1601a6995","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Risk-Scoring Classifier for the Diagnosis and Management of Atypical Melanocytic Lesions of the Palms: the iDScore_palmar Model.","authors":"Linda Tognetti, Sofia Lo Conte, Chiara Miracapillo, Aimilios Lallas, Elvira Moscarella, Roberta Giuffrida, John Paoli, Emi Dika, Ignazio Stanganelli, Serena Magi, Maria Concetta Fargnoli, Caterina Longo, Gianluca Nazzaro, Paolo Broganelli, Francesco Lacarrubba, Mariano Suppa, Jean-Luc Perrot, Philipp Tschandl, Elisa Cinotti, Simone Leonardelli, Gennaro Cataldo, Gabriele Cevenini, Pietro Rubegni, Alessandra Cartocci","doi":"10.5826/dpc.1601a6487","DOIUrl":"10.5826/dpc.1601a6487","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunocompromised Cutaneous District-A Case of Tattoo-Associated Warts.","authors":"Venkatesan Vijay, Manobalan Karunanandhan, Yogindher Singh","doi":"10.5826/dpc.1601a5580","DOIUrl":"10.5826/dpc.1601a5580","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"If Diffuse Hyperpigmentation is Present with Signs of Sepsis in a Newborn, Think of Congenital Chikungunya.","authors":"Bilkhiwal Ekalavya, Ajit B Janagond, Charki Siddu, Kurra Chidvitha","doi":"10.5826/dpc.1601a6031","DOIUrl":"10.5826/dpc.1601a6031","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of Systemic Therapy on Inflammatory Markers and Disease Severity in Patients with Pemphigus.","authors":"José Eduardo Pérez-Nieto, Escandón-Pérez Sabrina, Alexa María Flores-Leonel, Ana Laura Ramírez-Terán, Berumen-Glinz Cristina, María Elisa Vega-Memije","doi":"10.5826/dpc.1601a5746","DOIUrl":"10.5826/dpc.1601a5746","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Health Behavior in Chronic Spontaneous Urticaria: Internet and Social Media Use Patterns.","authors":"Melek Aslan Kayıran, Betül Şerbetçi, Hasan Aksoy","doi":"10.5826/dpc.1601a5756","DOIUrl":"10.5826/dpc.1601a5756","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic spontaneous urticaria (CSU) is a prevalent dermatological condition leading to frequent visits to primary care, emergency departments, and dermatology clinics worldwide. Its chronic relapsing nature, accompanied by angioedema, shortness of breath, and intense pruritus, drives patients to seek information and treatment.</p><p><strong>Objective: </strong>This study aimed to investigate CSU patients' Internet usage habits, including their search terms, trusted sources, and whether they share this information with their physicians.</p><p><strong>Methods: </strong>A survey was conducted among 80 patients at a tertiary hospital's urticaria outpatient clinic. Data collected included sociodemographic characteristics, urticaria activity scores, dermatology life quality indexes, and Internet and social media usage patterns related to CSU.</p><p><strong>Results: </strong>Of the 80 patients, 73.8% had researched CSU online, with significantly higher usage among younger, single patients with lower educational levels and shorter disease duration. Google was the most used platform (84.7%), followed by Instagram and YouTube (25.4% each). General information about CSU was the primary search term (76.3%). Notably, 21.3% attempted to contact doctors via social media, a behavior less common among patients using omalizumab. Approximately 75% did not share their findings with their physicians. Additionally, 58.8% expressed a desire for dermatologists to provide more online information about CSU.</p><p><strong>Conclusions: </strong>CSU patients frequently research their condition online but often conceal this from their doctors. Attempts to contact physicians via social media were lower among omalizumab users, possibly due to regular follow-ups. Enhancing dermatological follow-up and online educational resources could improve patient engagement and treatment adherence.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand, Foot, and Mouth Disease As An Unusual Cutaneous Viral Infection Post-Rituximab: A Rare Observation.","authors":"Paridhi Vaidh, Debasmita Behera, Chinmoy Raj, Farheen Begum","doi":"10.5826/dpc.1601a6075","DOIUrl":"10.5826/dpc.1601a6075","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Safety of IL-17 Inhibitors in Psoriasis and Psoriatic Arthritis: A 12-Month Retrospective Cohort Evaluation Using the FIB-4 Index.","authors":"Umut Bakay, Tugba Izci Duran, Ozge Sevil Karstarli Bakay, Rahime Ekmekcioglu","doi":"10.5826/dpc.1601a6746","DOIUrl":"10.5826/dpc.1601a6746","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic immune-mediated diseases frequently associated with metabolic dysfunction-associated steatotic liver disease (MASLD). Interleukin-17 (IL-17) contributes to both psoriatic inflammation and hepatic fibrogenesis. However, long-term real-world data on the hepatic safety of IL-17 inhibitors remain limited.</p><p><strong>Objectives: </strong>To evaluate longitudinal changes in hepatic fibrosis risk using the Fibrosis-4 (FIB-4) index in PsO and PsA patients treated with IL-17 inhibitors and to assess concurrent trends in skin activity and liver enzymes in a dual-center, retrospective cohort.</p><p><strong>Methods: </strong>Adults with PsO ± PsA who received secukinumab or ixekizumab for ≥12 months at two tertiary centers were retrospectively analyzed. FIB-4 index, liver enzymes (AST, ALT, GGT), and Psoriasis Area and Severity Index (PASI) were assessed at baseline, 3, 6, and 12 months. Patients with chronic liver disease, hepatotoxic drug exposure, or incomplete follow-up were excluded.</p><p><strong>Results: </strong>A total of 123 patients (mean age 45.2 ± 11.7 years; 59.3% male; 79.7% with PsA) were included. Median baseline FIB-4 was 1.06 (IQR 0.84-1.32); 17.9% of patients were in the intermediate-high risk category. FIB-4 values and risk distribution remained stable over 12 months (P=0.76). Liver enzyme levels did not change significantly, and no hepatotoxic event occurred. Median PASI improved from 12.3 (IQR 7.9-18.7) to 1.1 (IQR 0.5-2.2) at month 12 (P<0.001), with 68.1% of patients achieving PASI ≤1. There was no correlation between changes in PASI and FIB-4 (ρ= -0.08; P=0.27).</p><p><strong>Conclusions: </strong>IL-17 inhibitors provided substantial clinical efficacy and stable hepatic fibrosis risk over 12 months, including among patients with intermediate-high baseline FIB-4. These findings support the hepatic safety of IL-17 blockade in psoriatic disease and highlight the importance of routine fibrosis monitoring in metabolic-risk populations.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Features of Solitary Leukemia Cutis in a Patient with Chronic Lymphocytic Leukemia.","authors":"Umberto Santaniello, Francesco Cavallo, Luca Conti, Paolo Fava, Simone Ribero, Pietro Quaglino","doi":"10.5826/dpc.1601a6065","DOIUrl":"10.5826/dpc.1601a6065","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}