Dermatology practical & conceptual最新文献_第2页

Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis. 成人特应性皮炎患者维生素 D 受体多态性、紧密连接蛋白与临床特征之间的关系

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a214

Teresa Grieco, Elisa Moliterni, Giovanni Paolino, Camilla Chello, Alvise Sernicola, Colin Gerard Egan, Fabrizio Nannipieri, Santina Battaglia, Marina Accoto, Erika Tirotta, Silvia Trasciatti, Silvano Bonaretti, Simona Nencioni, Elena Biasci, Giovanni Pellacani, Stefano Calvieri

{"title":"Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.","authors":"Teresa Grieco, Elisa Moliterni, Giovanni Paolino, Camilla Chello, Alvise Sernicola, Colin Gerard Egan, Fabrizio Nannipieri, Santina Battaglia, Marina Accoto, Erika Tirotta, Silvia Trasciatti, Silvano Bonaretti, Simona Nencioni, Elena Biasci, Giovanni Pellacani, Stefano Calvieri","doi":"10.5826/dpc.1403a214","DOIUrl":"10.5826/dpc.1403a214","url":null,"abstract":"Introduction: Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD).Methods: From 43 adult AD patients, VDR polymorphisms were genotyped from peripheral blood samples using polymerase chain reaction-restriction fragment length polymorphism. VDR, occludin, claudin-1 and ZO-1 protein expression from skin lesion biopsies were assessed by immunohistochemistry.Results: The A1012G heterozygous VDR polymorphism exhibited a lower odds ratio (OR) for juvenile AD onset (OR: 0.046, 95% CI 0.004-0.51, p=0.012). In contrast, the presence of ≥2 homozygous VDR polymorphisms were significantly associated with positive skin prick test (SPT) (10/20, 50%) vs. negative SPT (1/23, 4.3%; p=0.0003). The most highly expressed TJ proteins in lesions of AD patients were claudin-1 and zonulin-1 (ZO-1), while VDR and occludin were less prevalent. A significant correlation was observed between ZO-1 expression and a body mass index ≥30 kg/m2 (OR: 12.1, 95% CI 1.06-137.9, p=0.045). Claudin-1 expression was associated with a positive SPT (OR: 8.23, 95% CI 1.04-65.5, p=0.046) and serum 25(OH)D levels were negatively correlated with ZO-1 expression (rho= -0.43, p=0.0058).Conclusion: This study provides novel insights into the relationship between VDR gene polymorphisms, VDR, TJ protein expression, and clinical features in adult AD patients, highlighting a significant role of vitamin D in the pathophysiology of this disease.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Facial Hair Whorls in a Child. 一名儿童的双侧面部毛发卷曲。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a136

Vincenzo Piccolo, Ramon Grimalt, Julia Nowowiejska, Mario Cutrone

引用次数: 0

Dermoscopic Findings in Juvenile Colloid Milium. 幼年胶样丘疹的皮肤镜检查结果

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a197

Karama Sboui, Noureddine Litaiem, Soumaya Rammeh, Faten Zeglaoui

引用次数: 0

Does a Tattoo Protect Against Chronic Spontaneous Urticaria? An Unusual Finding. 纹身能预防慢性自发性荨麻疹吗？一个不寻常的发现

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a172

Kinga Bojahr, Agata Sztramska, Weronika Zysk, Agata Rolewicz, Jan Romantowski, Marta Chełmińska

引用次数: 0

Efficacy of Fractional Versus Fully Ablative CO₂ Laser for Distolateral Onychomycosis: Experience With 20 Patients. 点阵式与完全烧蚀式 CO2 激光治疗远侧甲癣的疗效：20例患者的经验。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a121

Laura Gnesotto, Bianca Maria Piraccini, Michela Starace, Luigi Naldi, Guido Mioso, Andrea Sechi

{"title":"Efficacy of Fractional Versus Fully Ablative CO2 Laser for Distolateral Onychomycosis: Experience With 20 Patients.","authors":"Laura Gnesotto, Bianca Maria Piraccini, Michela Starace, Luigi Naldi, Guido Mioso, Andrea Sechi","doi":"10.5826/dpc.1403a121","DOIUrl":"10.5826/dpc.1403a121","url":null,"abstract":"Introduction: Oral antifungals are the treatment choice for onychomycosis, and topical therapies are favored in cases of limited nail involvement. Recently, carbon dioxide (CO2) laser treatment has emerged as an option to enhance the effectiveness of topical therapies.Objectives: Our objective was to compare the efficacy of fractional ablative and fully ablative CO2 laser treatments for distolateral subungual onychomycosis affecting a single toenail and caused by dermatophytes.Methods: The records of 10 patients treated with a single fully ablative CO2 session were matched with those of 10 patients who underwent a single CO2 fractional treatment. All had previously failed topical antifungal lacquers and were discharged with the prescription of topical ciclopirox nail lacquer (8%) for 3 months.Results: The clinical response rates were 80% for the fully ablative group and 60% for the fractional group. Additionally, the mean reduction in Onychomycosis Severity Index from baseline to 8.6±1.6 weeks after treatment completion was 6.9±5.4 in the fully ablative group and 3.6±6.6 in the fractional group. The relapse rate among responders was 12.5% in the fully ablative and 33.3% in the fractional group after a mean follow-up time of 29.4±2.3 weeks.Conclusions: Fractional and fully ablative CO2 laser in combination with ciclopirox lacquer could increase the response rate in onychomycosis resistant to topical antifungals when systemic therapy is contraindicated or not yet pursued. Fully ablative mode therapy is significantly more effective than fractional (P < 0.05). Further studies are needed to identify prognostic response factors and assess the long-term effectiveness of CO2 laser treatment.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients. 评估脱发症患者血清炎症标志物及其与治疗反应的关系

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a193

Icim Komurcugil, Nermin Karaosmanoglu

{"title":"Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients.","authors":"Icim Komurcugil, Nermin Karaosmanoglu","doi":"10.5826/dpc.1403a193","DOIUrl":"10.5826/dpc.1403a193","url":null,"abstract":"Introduction: Alopecia areata is a type of non-scarring alopecia which is thought to be associated with T-cell mediated immune response.Objective: This study aimed to compare the levels of serum inflammatory markers before and after treatment in patients with alopecia areata. The study explored the utility of the systemic immune-inflammation index (SII) in assessing the severity and treatment response in alopecia areata patients.Methods: The study included 60 alopecia areata patients and 40 control patients diagnosed with tinea unguium, aged between 18 and 65 years. Sociodemographic characteristics such as age, sex, and medical history were recorded for both groups. For alopecia areata patients, serum inflammatory markers were recorded before and at the third month of treatment. Serum inflammatory markers for the control group were also recorded. Furthermore, the Severity of Alopecia Tool (SALT) score was calculated for alopecia areata patients before and at the third month of treatment.Results: The alopecia areata group had a significantly higher neutrophil-lymphocyte ratio, mean platelet volume, and SII values compared to the control group, while high-density lipoprotein (HDL) values were significantly lower. Serum inflammatory markers, assessed at the third month of treatment in the alopecia areata group, were lower, and HDL values were significantly higher compared to pre-treatment levels. A statistically significant correlation was observed between disease severity and the SII.Conclusion: The SII is a cost-effective marker that can be utilized in assessing the severity of alopecia areata and treatment response.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real Life Comparative Effectiveness of IL-23 Inhibitors in the Treatment of Moderate to Severe Psoriasis: A Multicenter Experience. IL-23抑制剂治疗中度至重度银屑病的实际疗效比较：多中心经验。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a179

Alessandro Borghi, Giulia Odorici, Federico Bardazzi, Federica Filippi, Laura Bigi, Claudia Lasagni, Marco Manfredini, Vito Di Lernia, Francesca Peccerillo, Andrea Conti, Rossana Tiberio, Francesca Satolli, Carolina Fantini, Miriam Rovesti, Massimo Gasperini, Michela Tabanelli, Simone D'Adamio, Maria Elena Flacco, Monica Corazza

引用次数: 0

Real-World Experience of Upadacitinib Dosing Reduction in Patients with Moderate Atopic Dermatitis: A Case Series Study in Taiwan. 减少中度特应性皮炎患者服用乌达帕替尼剂量的实际经验：台湾病例系列研究。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a186

Yang-Yi Chen, Chieh-Hsun Chen, Cheng-Che Eric Lan

引用次数: 0

The Difference Between SARS-CoV-2 Associated Telogen Effluvium and Telogen Effluvium Due to Other Causes. 与 SARS-CoV-2 相关的脱发与其他原因引起的脱发之间的区别。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a170

Didem Kazan, Defne Özkoca, Nazlı Dizen Namdar

{"title":"The Difference Between SARS-CoV-2 Associated Telogen Effluvium and Telogen Effluvium Due to Other Causes.","authors":"Didem Kazan, Defne Özkoca, Nazlı Dizen Namdar","doi":"10.5826/dpc.1403a170","DOIUrl":"10.5826/dpc.1403a170","url":null,"abstract":"Introduction: Telogen effluvium (TE) is a common type of non-cicatricial alopecia, and it is reported frequently in patients with SARS-CoV-2 infection.Objectives: Herein, we aimed to examine the demographic, dermoscopic, and laboratory features of the patients with SARS-CoV-2 associated TE (CATE) and compare them with TE due to other causes (TEDOC) according to these features.Methods: In this retrospective case-control study we evaluated the patients who were diagnosed with TE and were above 18 years of age between April and June 2022. The patients were divided into two groups based on their medical history and SARS-CoV-2 PCR positivity. The first group included patients with CATE and positive SARS-CoV-2 PCR test results in the last 3 months. The second group consisted of patients with TEDOC. Patients gender, age, disease duration, additional systemic disease, dermoscopic findings, and laboratory results were recorded.Results: A total of 92 patients, 86 (93.5%) females, and 6 (6.5%) males, were included in the study. CATE was detected in 52 (56.5%) patients whereas 40 (44.5%) patients had TEDOC. The mean time between the onset of SARS-CoV-2 infection and hair loss complaint was calculated as 64.8 + 25.6 days, and this time was significantly shorter than patients with TEDOC (P = 0.003). The dermoscopic evaluation showed that empty follicular openings and yellow dots were statistically higher in patients with CATE, whereas short regrowing hair were markedly higher in patients with TEDOC (P = 0.001, P = 0.001,and P = 0.001, respectively) CONCLUSIONS: CATE is characterized by excessive hair-shedding that begins sooner after infection than classic TE. Dermoscopic findings can assist clinicians in diagnosis.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Immune Checkpoint Inhibitors-Induced Skin Toxicity on Patients Quality of Life and the Role of Dermatologic Intervention. 免疫检查点抑制剂引起的皮肤毒性对患者生活质量的影响以及皮肤病干预的作用。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a118

Christina Kemanetzi, Konstantinos Lallas, Elizavet Lazaridou, Chrysoula Papageorgiou, Aimilios Lallas, Alexandros Stratigos, Eleni Timotheadou, George Lazaridis, Dimitrios Dionysopoulos, Kalliopi Kalaitzi, Antonios Tsimpidakis, Myrto Trakatelli, Aikaterini Patsatsi, Vasiliki Nikolao, Zoe Apalla

{"title":"The Impact of Immune Checkpoint Inhibitors-Induced Skin Toxicity on Patients Quality of Life and the Role of Dermatologic Intervention.","authors":"Christina Kemanetzi, Konstantinos Lallas, Elizavet Lazaridou, Chrysoula Papageorgiou, Aimilios Lallas, Alexandros Stratigos, Eleni Timotheadou, George Lazaridis, Dimitrios Dionysopoulos, Kalliopi Kalaitzi, Antonios Tsimpidakis, Myrto Trakatelli, Aikaterini Patsatsi, Vasiliki Nikolao, Zoe Apalla","doi":"10.5826/dpc.1403a118","DOIUrl":"10.5826/dpc.1403a118","url":null,"abstract":"Introduction: Data regarding quality of life (QoL) of oncologic patients experiencing dermatologic immune-related adverse events (dirAEs) and their course after dermatologic intervention are scarce.Objectives: To assess the impact of dirAEs on patients QoL and to investigate the correlation between dermatologic and oncologic indexes used for estimating QoL.Methods: We enrolled oncologic patients with dirAEs managed in two supportive onco-dermatology outpatient clinics in Greece. Patient-reported outcomes included DLQI, EORTC-QLQ-C30 and Numerical Rating Scale for pruritus (pNRS).Results: Overall, 110 patients were enrolled in the study. Mean (standard deviation) DLQI and pNRS scores were 15.54 (5.44) and 7.25 (2.95), correspondingly, while functional, symptom and summary scores of EORTC-C30 were 79.17 (2.11), 17.66 (3.60) and 80.67 (3.08), respectively. After therapeutic interventions, there was a statistically significant decrease in DLQI scores after first intervention compared to baseline, and second intervention compared to first (mean decrease 4.38 (2.91), P < 0.001 and 5.16 (3.99), P < 0.001, respectively). DLQI showed no correlation with global health status/QoLs (rho 0.01, P = 0.90) of EORTC-C30.Conclusions: DirAEs negatively affect QoL. Dermatologic intervention improves patients QoL, facilitating an unimpaired oncologic treatment. Poor correlation between DLQI and EORTC-QLQ-30 highlights the need for adapted QoL measurement tools in the context of immune checkpoint inhibitors treatment.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0