Dermatology practical & conceptual最新文献

{"title":"The Interconnection Between Dermatology and Mental Health: Exploring ADHD and Acne Treatment Adherence.","authors":"Jiayang Liu, Haihang Zhang","doi":"10.5826/dpc.1503a5785","DOIUrl":"10.5826/dpc.1503a5785","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Magnified Dermoscopy and Reflectance Confocal Microscopy in Assessing Melanocytic Lesions.","authors":"Stefania Guida, Silvana Ciardo, Shaniko Kaleci, Francesca Farnetani, Marco Spadafora, Giulia Radi, Renato Rossi, Elisa Molinelli, Sabrina Longhitano, Claudio Conforti, Carmen Cantisani, Camilla Chello, Oriana Simonetti, Anna Maria Offidani, Pietro Rubegni, Franco Rongioletti, Caterina Longo, Elisa Cinotti, Giovanni Pellacani","doi":"10.5826/dpc.1503a5253","DOIUrl":"10.5826/dpc.1503a5253","url":null,"abstract":"<p><strong>Introduction: </strong>Magnified dermoscopy (MD), or optical super-high magnification dermoscopy, is an emerging technique in dermatology.</p><p><strong>Objectives: </strong>The study aimed to evaluate the distribution of conventional dermoscopy, MD, and reflectance confocal microscopy (RCM) features in dermoscopically equivocal pigmented lesions and to estimate their diagnostic accuracy.</p><p><strong>Methods: </strong>A retrospective analysis of conventional dermoscopic (20x), MD (400x), and RCM images of dermoscopically equivocal pigmented lesions, diagnosed as either nevi or melanoma, was performed. Distribution of features, sensitivity, and specificity for dermoscopy, MD, RCM, and a combination of these last two with conventional dermoscopy was estimated.</p><p><strong>Results: </strong>A total of 74 nevi and 20 melanomas were included in the analysis. A positive correlation was observed between seven-point checklist in conventional dermoscopy and the diagnosis of melanoma. With MD, a significant correlation between dots, non-edged papillae, and melanoma was observed, but the technique did not have a significant impact on diagnostic accuracy as compared to traditional dermoscopy. On the other hand, RCM, alone or in combination with traditional dermoscopy, proved to increase diagnostic accuracy, in particular, specificity for melanoma diagnosis.</p><p><strong>Conclusions: </strong>RCM has a defined role in increasing diagnostic accuracy of doubtful dermoscopic lesions, while the role of MD in clinical practice has yet to be defined, and methodologic standardization as well as a revision of terminology is encouraged to improve the recognition of features.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatotoxicity Associated with Adalimumab in Hidradenitis Suppurativa: A Report of Two Cases of Drug-Induced Liver Injury.","authors":"Cristian Fernando Caballero-Linares, Bianca Cei, Fernando Alfageme","doi":"10.5826/dpc.1503a5320","DOIUrl":"10.5826/dpc.1503a5320","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia.","authors":"Thanh Le Thai Van, Thong Nguyen Tri, Hung Ta Quoc, Tuan Ngo Anh, Yen Thai Thanh, Thao Nguyen Phuong, Anh Le Vi, Nam Tran Ngoc Khanh, Vy Tran Hanh","doi":"10.5826/dpc.1503a5382","DOIUrl":"10.5826/dpc.1503a5382","url":null,"abstract":"<p><strong>Introduction: </strong>Infiltrative anesthesia with lidocaine plays a vital role in pain management during dermatological procedures, ensuring patient comfort throughout the process.</p><p><strong>Objective: </strong>We aimed to investigate the correlation between three different concentrations of lidocaine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, and 1:6) used in infiltrative anesthesia and their analgesic efficacy and adverse effects in dermatological procedures.</p><p><strong>Methods: </strong>This study employed a randomized design, with 240 patients assigned to receive varying concentrations of lidocaine with epinephrine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, or 1:6) during seven common dermatological procedures: punch biopsy, excisional biopsy, CO2 laser biopsy, surgical excision, CO2 laser excision, fractional CO2 laser treatment, and filler injection. Total lidocaine dosage and patient comfort assessments were recorded for each participant.</p><p><strong>Results: </strong>All three lidocaine concentrations demonstrated comparable analgesic efficacy during the procedures, as measured by visual analog scale scores. The 1:6 dilution group required a significantly lower lidocaine dose, with a 39.3% reduction compared to the 1:4 dilution group and a 75.3% reduction compared to the 1:2 dilution group (P<0.001). The 1:6 dilution group experienced significantly less pain during injection than that of the 1:4 dilution group and the 1:2 dilution group (P<0.001).</p><p><strong>Conclusion: </strong>Lidocaine 2% with 1:100,000 epinephrine at dilutions ranging from 1:2 to 1:6 for infiltrative anesthesia in dermatological procedures provided similar analgesic efficacy. Importantly, the 1:6 dilution significantly reduced both injection pain and total lidocaine dosage. More studies are required to confirm our results.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Line-Field Confocal OCT and Clinical Correlation in Plaque Psoriasis Treated with Calcipotriol/Betamethasone Dipropionate and Polyaphron Dispersion Technology.","authors":"Martina Dragotto, Eugenio Capalbo, Pietro Rubegni, Emanuele Trovato","doi":"10.5826/dpc.1503a5450","DOIUrl":"10.5826/dpc.1503a5450","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.","authors":"Mohamed J Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Suhas Ballal, Shilpa Sharma, J Guntaj, G V Siva Prasad, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad","doi":"10.5826/dpc.1503a5333","DOIUrl":"10.5826/dpc.1503a5333","url":null,"abstract":"<p><strong>Introduction: </strong>The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.</p><p><strong>Objectives: </strong>A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p><p><strong>Methods: </strong>In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.</p><p><strong>Results: </strong>Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.</p><p><strong>Conclusions: </strong>Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Rosacea on Keratinocyte Skin Cancers: A Prospective Case-Control Study of Basal and Squamous Cell Carcinoma Risk.","authors":"Aslı Aksu, Ayşenur Demir, Hatice Günay, Pinar Ozdemir Cetinkaya, Birgul Ozkesici Kurt, Hazel Ezgi Kaya, İlknur Kıvanç Altunay, Deniz Altınel","doi":"10.5826/dpc.1503a5264","DOIUrl":"10.5826/dpc.1503a5264","url":null,"abstract":"<p><strong>Introduction: </strong>The full range of cutaneous comorbidities associated with keratinocyte skin cancers remains to be elucidated.</p><p><strong>Objectives: </strong>We aimed to examine other skin diseases in patients with keratinocyte cancer (KC) and to reveal potential associations between them.</p><p><strong>Methods: </strong>Included in the study were 200 patients with KC and 200 disease-free controls. To identify any additional concomitant dermatological conditions, all study groups underwent examination by two dermatologists.</p><p><strong>Results: </strong>In patients with KC, 87.5% were diagnosed with basal cell carcinoma and 13.5% were diagnosed with squamous cell carcinoma. There was no statistically significant difference between the two groups regarding sunscreen use habits (P =0.284). Patients with KC exhibited a significantly elevated odds ratio (OR) for the presence of rosacea (OR 5.13, 95% CI: 3.2-8.3, P=0.000) and especially erythematotelangiectatic rosacea (ETR) subtype (OR 5.03, 95% CI: 3.1-8.2, P=0.000). An Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the efficacy of rosacea in differentiating between the control group and patients with KC. The sensitivity, specificity, negative predictive value, and positive predictive value for rosacea were 45.5%, 86%, 61.2%, and 76.5%, respectively (AUC 0.658, 95% CI: 0.604-0.711, P=0.000), while for ETR it was 44%, 86.5%, 60.7%, and 76.5%, respectively (AUC 0.653, 95% CI: 0.599-0.706, P=0.000). The presence of rosacea demonstrated a significant efficacy in differentiating patients with KC from the control group in all localizations (P< 0.05).</p><p><strong>Conclusion: </strong>The risk of rosacea in patients with KC, particularly those with the ETR subtype, was found to be significantly elevated, irrespective of age, sex, or localization.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Vascular Patterns in Skin Lesions with LC-OCT and Dermoscopy with a Tridimensional Perspective: A Pilot Study.","authors":"Clément Lenoir, Mariano Suppa, Susana Puig, Véronique Del Marmol, Raquel Albero, Llucia Also, Carmen Orte Cano, Gwendoline Diet, Margot Fontaine, Linda Tognetti, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, Josep Malvehy, Javiera Perez-Anker","doi":"10.5826/dpc.1503a5297","DOIUrl":"10.5826/dpc.1503a5297","url":null,"abstract":"<p><strong>Introduction: </strong>Vascular patterns play a crucial role in the diagnosis and differentiation of skin lesions by providing insight into underlying pathology and aid in distinguishing between benign and malignant lesions. While dermoscopy has proven valuable for visualizing these vascular structures, line-field confocal optical coherence tomography (LC-OCT) offers high-resolution, 3-dimensional (3D) imaging of the skin, potentially providing detailed visualization of vascular architecture and new insights into their projection in dermoscopy.</p><p><strong>Objectives: </strong>This pilot study aimed to investigate the correlation between vascular patterns in skin lesions with LC-OCT and dermoscopy and explored tridimensional imaging in assessing microvascular architecture.</p><p><strong>Methods: </strong>A cohort of patients with 14 diverse skin lesions showing typical dermoscopic vascular patterns were examined using dermoscopy and LC-OCT. LC-OCT images were analyzed, and manual segmentation with tridimensional reconstruction of the vascular structures was performed. The correlation between these vascular structures and their dermoscopic projection was then assessed qualitatively.</p><p><strong>Results: </strong>LC-OCT demonstrated a strong visual correlation with dermoscopy in identifying vascular patterns, offering additional depth and 3D details of the intricate relationship between skin micro-architecture and the development of specific vascular patterns in skin lesions.</p><p><strong>Conclusions: </strong>LC-OCT correlates with dermoscopy in vascular pattern analysis in skin lesions. The added advantage of 3D imaging helped us understand the way vascular structures are formed in skin lesions depending on their micro-architecture. LC-OCT could potentially play a significant role in precisely assessing the vascular environment of skin lesions. Further studies are necessary to assess how this could provide clinical value for diagnosing or monitoring skin lesions.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Psychological Factors on Early vs. Late-Onset Psoriasis: A Comparative Analysis.","authors":"E Elif Afacan Yıldırım, Muhterem Polat","doi":"10.5826/dpc.1503a5249","DOIUrl":"10.5826/dpc.1503a5249","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic inflammatory disease that significantly impacts psychosocial well-being. This study compared the clinical and psychosocial characteristics of early-onset (<40 years) and late-onset (≥40 years) psoriasis.</p><p><strong>Methods: </strong>This cross-sectional study included 190 patients with psoriasis categorized as early-onset (n=135) and late-onset (n=55). Data on demographics, clinical features, comorbidities, and psychosocial factors were collected. The Hospital Anxiety and Depression Scale (HADS) and the Dermatology Life Quality Index (DLQI) assessed psychological impact and quality of life. Statistical analyses included chi-squared tests, t-tests, and correlation analyses.</p><p><strong>Results: </strong>Early-onset patients were more likely to have a family history of psoriasis (43.7% vs. 16.4%, P<0.001), while pustular psoriasis was more common in the late-onset group (27.3% vs. 11.1%, P=0.006). A significant positive correlation was observed between DLQI scores and HADS-Total, HADS-Anxiety, and HADS-Depression scores (P<0.001). Psychological stress was reported as a disease trigger by 63.1% of patients, with a higher proportion in the early-onset group (P=0.025). Although initial comparisons revealed no significant difference in DLQI or HAD scores between groups, an additional analysis limited to chronic plaque psoriasis revealed significantly higher anxiety and total HADS scores in the early-onset group (P=0.002 and P=0.035, respectively), suggesting a stronger psychological burden when clinical subtype is controlled.</p><p><strong>Conclusions: </strong>Early-onset psoriasis patients are more likely to report stress as a trigger and have a family history, while late-onset patients exhibit higher rates of pustular psoriasis and increased body mass index. Early-onset patients with chronic plaque psoriasis experience greater psychological burden, particularly anxiety. These findings highlight the importance of age of onset in tailoring psychosocial support and treatment strategies in psoriasis care.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study.","authors":"Pablo De La Cueva Dobao, Laia Curto Barredo, Juan Francisco Silvestre Salvador, Esther Serra-Baldrich, Pedro Herranz Pinto, Natalia Hernández Cano, Francisco Javier Ortiz De Frutos, Gastón Roustan Gullón, Rosa María Lzu Belloso, Irene Arévalo Ortega, Alicia González Quesada, Manuel Galán Gutiérrez, Yolanda Gilaberte Calzada, Daniel Arumi Torredemer, Noelia Llevat Felius, Irene Hernández Martín, Francisco José Rebollo Laserna","doi":"10.5826/dpc.1503a5538","DOIUrl":"10.5826/dpc.1503a5538","url":null,"abstract":"<p><strong>Introduction: </strong>Atopic dermatitis (AD) is a chronic inflammatory condition associated with a significant physical, psychological, and economic burden. This study aimed to determine the multidimensional impact of AD on patients and the Spanish healthcare system.</p><p><strong>Methods: </strong>The present multicenter descriptive cross-sectional study was conducted at 12 Spanish sites to detect clinical practice assessments and validated patient-reported measures.</p><p><strong>Results: </strong>A total of 62 patients were included (54.8% males; mean age: 33.1 years). According to the validated Investigator Global Assessment scale for AD, 61.3% and 38.7% of patients had moderate and severe AD, respectively. AD involved a mean of 43.3% body surface area, with patients reporting a median of 4.0 flares in the past year. The mean Patient-Oriented Eczema Measure (POEM) questionnaire score was 19.8, indicating severe eczema. In addition, 57.1% of patients reported daily pain from scratching or skin inflammation. The mean Dermatology Life Quality Index (DLQI) was 14.3, showing a strong AD impact on patients' quality of life, positively correlated with severity, pruritus, and pain. AD also affected work productivity and sleep, with over 50% of patients reporting impairments in daily activities. Treatment patterns showed predominant use of topical corticosteroids (81.5%). Although no patient required hospitalization in the previous year, 25% resorted to alternative therapies/unlicensed products.</p><p><strong>Conclusions: </strong>AD profoundly impacts patients' quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}