Dermatology practical & conceptual最新文献

{"title":"Subungual Glomus Tumor Managed with Nd: YAG Laser: A Case Report with Clinical and Ultrasonographic Follow-Up.","authors":"Valeria Duque-Clavijo, Maria Alejandra Sánchez, Claudia González, Hernán Duque-Romero","doi":"10.5826/dpc.1603a7237","DOIUrl":"10.5826/dpc.1603a7237","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Review of Suspected Melanoma Diagnoses Made by a Single-Centre Teledermoscopy Service in New Zealand.","authors":"Savani Kannangara, Amanda Oakley","doi":"10.5826/dpc.1603a6979","DOIUrl":"10.5826/dpc.1603a6979","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stapokibart (CM310) in Atopic Dermatitis: A Narrative Review of a Next-Generation IL-4Rα Antagonist.","authors":"Esmeraldito Ferreira, Tong Wu, Yongfeng Chen","doi":"10.5826/dpc.1603a7230","DOIUrl":"10.5826/dpc.1603a7230","url":null,"abstract":"<p><strong>Introduction: </strong>The interleukin (IL)-4/IL-13 signaling pathway is central to the pathogenesis of atopic dermatitis (AD). Stapokibart (CM310) is a novel humanized monoclonal antibody targeting the IL-4 receptor alpha (IL-4Rα) subunit.</p><p><strong>Objective: </strong>To summarize current evidence on the mechanism of action, clinical efficacy, safety, and therapeutic potential of stapokibart for moderate-to-severe AD.</p><p><strong>Methods: </strong>A narrative review was conducted based on a targeted search of PubMed/MEDLINE and ClinicalTrials.gov covering literature published from January 2015 to January 2026.</p><p><strong>Results: </strong>Stapokibart binds IL-4Rα with high affinity (KD = 0.25 nM), inhibiting downstream IL-4 and IL-13 signaling. In a phase 3 trial (N=500), stapokibart 300 mg every two weeks demonstrated significant improvements at Week 16, with 66.9% achieving EASI-75 (vs. 25.8% placebo) and 44.2% achieving IGA 0/1 (vs. 16.1% placebo; P<0.0001). Among responders, 92.5% maintained EASI-75 through Week 52. The treatment was generally well tolerated, with upper respiratory tract infections and injection-site reactions being the most common adverse events. Conjunctivitis occurred at low rates (5.0-5.9%).</p><p><strong>Conclusions: </strong>Stapokibart shows robust efficacy and a favorable safety profile in adults with moderate-to-severe AD, including sustained long-term responses and low conjunctivitis rates. While early data are encouraging, all comparisons with existing IL-4/IL-13 inhibitors are indirect, and further global phase 3 studies and real-world evidence are needed to define its role within treatment algorithms.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical-Epidemiological, Trichoscopic, and Light Microscopic Evaluation of Pediatric Hair and Scalp Disorders: A Cross-Sectional Study from a Tertiary Care Hospital.","authors":"Taiba Trumboo, Yasmeen Jabeen Bhat, Obeid Shafi, Shafat Ahmad Tak, Saika Reyaz, Iffat Hassan Shah","doi":"10.5826/dpc.1603a6679","DOIUrl":"10.5826/dpc.1603a6679","url":null,"abstract":"<p><strong>Background: </strong>Pediatric hair and scalp disorders encompass a diverse array of conditions, requiring a systematic approach for accurate diagnosis. Incorporating trichoscopic and light microscopic examinations can enhance diagnostic accuracy.</p><p><strong>Objective: </strong>To evaluate the clinical-epidemiological, trichoscopic, and light microscopic features of hair and scalp disorders in the pediatric population.</p><p><strong>Methods: </strong>A hospital-based cross-sectional study was conducted involving pediatric patients aged 0-12 years seeking medical attention for hair and scalp conditions. Trichoscopic and light microscopic examinations were used for diagnosis, and the agreement between these modalities was assessed with Cohen's kappa coefficient.</p><p><strong>Results: </strong>A total of 220 children were examined, with a median age of 7 years and male-to-female ratio of 0.9:1. The median duration of illness was four months, and median age at disease onset was 5.75 years. The most prevalent conditions observed were scalp infections, followed by non-infectious scaly scalp dermatosis and alopecia areata. Rare trichoscopic findings included \"matchstick hair\" in Netherton syndrome, trichoclasis in alopecia areata, trichoscopic features of transient neonatal hair loss, and new rare variants of tinea capitis, including alopecia areata-like, seborrheic dermatitis-like, and follicular pustular presentations. High agreement was found between trichoscopy and clinical diagnosis (Cohen's kappa=0.917) as well as between trichoscopy and light microscopy (Cohen's kappa=0.769).</p><p><strong>Conclusion: </strong>The findings underscore the significance of incorporating trichoscopy and light microscopy for diagnosing pediatric hair and scalp disorders, including rare genetic hair disorders. High agreement observed between trichoscopy, clinical diagnosis, and light microscopy emphasizes their utility as reliable noninvasive diagnostic tools in pediatric dermatology.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Therapeutic Outcomes of Livedoid Vasculopathy: A Retrospective Study of 358 Chinese Patients.","authors":"Fazhan Ban, Mengyu Zhang, Daopei Zou, Yuan Yuan, Gang Wang, Wenjun Liao, Lei Wang","doi":"10.5826/dpc.1603a6930","DOIUrl":"10.5826/dpc.1603a6930","url":null,"abstract":"<p><strong>Introduction: </strong>Livedoid vasculopathy is a relatively uncommon chronic, recurrent occlusive vascular disorder. Previous reports on this condition have largely been based on small retrospective studies.</p><p><strong>Objectives: </strong>To analyze epidemiological patterns, clinical manifestations, histopathological features, laboratory parameters, therapeutic interventions, and prognostic outcomes of Chinese patients with livedoid vasculopathy.</p><p><strong>Methods: </strong>Patients with livedoid vasculopathy diagnosed in a single dermatology center between January 2010 and October 2022 were included for retrospective analysis.</p><p><strong>Results: </strong>A total of 358 patients were included in the study. A female predominance was observed (male-to-female ratio 1:2.4). The mean age at onset was 28.0 ± 15.4 years (median: 23 years), with the highest proportion of patients (149/358, 41.6%) developing symptom onset before age 20 years. The common alternate clinical diagnoses were allergic vasculitis and Henoch-Schönlein purpura. Disease exacerbation during summer occurred in 82.4% (150/183) of patients. Beyond classic symptoms, atypical presentations included pigmented purpuric dermatosis-like lesions (64/358, 17.9%) and stasis dermatitis-like lesions (12/358, 3.4%). Of a total of 409 treatment episodes, 70.7% involved anticoagulation therapy, both as a monotherapy and in combination regimens. During follow-up, 62.3% (147/236) of patients experienced recurrences within two years.</p><p><strong>Conclusions: </strong>At our center, livedoid vasculopathy is not uncommon, and affected patients exhibit a substantially younger age at onset. Certain livedoid vasculopathy cases demonstrate atypical clinical presentations, such as pigmented purpuric dermatosis-like lesions or stasis dermatitis-like lesions. In our cohort, the primary therapeutic approaches consist of anticoagulation therapy alone or in combination with other medications. However, these strategies are associated with a high recurrence rate.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Recalcitrant Pyoderma Gangrenosum with Baricitinib in Two Patients with Rheumatoid Arthritis.","authors":"Christian Ciolfi, Bernd Raffeiner, Margherita Zen, Anna Giorgia Osele, Jacopo Tartaglia, Stefano Piaserico","doi":"10.5826/dpc.1603a7240","DOIUrl":"10.5826/dpc.1603a7240","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Pathways between Psoriasis and Atopic Dermatitis.","authors":"Federica Trovato, Camilla Chello, Simone Amato, Antonio Di Guardo, Emanuele Amore, Luigi Bennardo, Antonio Giovanni Richetta, Teresa Grieco, Steven Paul Nisticò, Giovanni Pellacani, Annunziata Dattola","doi":"10.5826/dpc.1603a6662","DOIUrl":"10.5826/dpc.1603a6662","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis and atopic dermatitis are leading examples of chronic inflammatory dermatoses with distinct clinical manifestations, pathogenesis, and demographic patterns. However, recent research has revealed overlapping immunological pathways that could serve as promising therapeutic targets.</p><p><strong>Objectives: </strong>To synthesize the principal immunological, epidermal barrier, and microbiome pathways shared by psoriasis and atopic dermatitis and to discuss their potential translational and therapeutic implications.</p><p><strong>Methods: </strong>We conducted a narrative review of the literature on PubMed from January 2000 to June 2024, using keywords such as \"psoriasis,\" \"atopic dermatitis,\" \"cytokine pathways,\" \"T cells,\" and \"environmental triggers.\" Studies were selected based on their relevance to shared mechanisms between these diseases, focusing on cytokine profiles, immune cell activity, and skin barrier dysfunction.</p><p><strong>Results: </strong>Our review identified significant overlaps in cytokine-mediated pathways, particularly the IL-17/IL-22 axis, which mediates keratinocyte hyperproliferation and inflammation in both diseases. T cell dysregulation, including Th17 and Th22 activity, plays a pivotal role in maintaining chronic inflammation. Both conditions also exhibit impaired skin barrier function, linked to filaggrin loss-of-function mutations in atopic dermatitis and abnormal keratinocyte differentiation in psoriasis.</p><p><strong>Conclusion: </strong>These findings suggest that targeting shared mechanisms, such as the Th17 and Th22 pathways, along with barrier repair strategies may enable dual therapeutic benefits. This review underscores the potential for integrative treatment approaches and personalized medicine in managing chronic inflammatory skin disorders.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spitz Nevus with HRAS Q61R Arising in a Giant Nevus Spilus of the Leg.","authors":"Tugba Kevser Uzuncakmak, Narmin Zahedi, Ayse Mine Onenerk, Ovgu Aydın","doi":"10.5826/dpc.1603a6716","DOIUrl":"10.5826/dpc.1603a6716","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ribociclib-Induced Vitiligo: A Case Report with Histological, Dermatoscopic, Confocal Microscopy, and LC-OCT Findings Along with a Narrative Literature Review.","authors":"Silvia Mezi, Flavia Persechino, Andrea Ascione, Antonella Chiavassa, Adele Artemi, Camilla Capasso, Simone Amato, Alessia Paganelli, Giovanni Pellacani","doi":"10.5826/dpc.1603a6849","DOIUrl":"10.5826/dpc.1603a6849","url":null,"abstract":"<p><strong>Introduction: </strong>CDK4/6 inhibitors have revolutionized the therapeutic management of metastatic estrogen receptor-positive (ER+), HER2-negative breast cancer (BC) by increasing treatment efficacy while maintaining a favorable safety profile. An exceedingly rare adverse event associated with these agents is the development of vitiligo-like skin depigmentation.</p><p><strong>Objectives: </strong>This study aimed to characterize a case of ribociclib-induced vitiligo and investigate its underlying pathogenic mechanisms, with particular focus on vitiligo onset. We report the case of a 60-year-old postmenopausal female with metastatic, hormone-sensitive BC who experienced a durable partial remission during treatment with ribociclib in combination with aromatase inhibitors. During therapy, the patient developed hypopigmented lesions on her upper limbs 34 months after initiation of ribociclib, preceded by pruritus and erythema.</p><p><strong>Methods: </strong>Reflectance confocal microscopy (RCM) optical coherence tomography (OCT), and histopathological examination were used.</p><p><strong>Result: </strong>RCM and OCT proved valuable for real-time assessment and monitoring of skin changes, thereby informing clinical decisions regarding the management of skin toxicity. The presence of an inflammatory infiltrate, comprising lymphocytes and hyper-reflective inflammatory cells, suggests that inhibition of the CDK4/6 pathway may enhance antitumor activity beyond cell cycle arrest by modulating the immune response and promoting immune-mediated tumor control.</p><p><strong>Conclusions: </strong>The observed alterations in melanocyte regression could represent evidence of systemic immune activation and autoimmunity influencing melanocyte viability. These mechanisms may have significant implications for improving patient prognosis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Morphological Evaluation of Facial Pigmented Lesions with Line-Field Confocal Optical Coherence Tomography: Correlation with Reflectance Confocal Microscopy: A Pilot Study.","authors":"Manas Bajpai","doi":"10.5826/dpc.1603a6509","DOIUrl":"10.5826/dpc.1603a6509","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}