Dermatology practical & conceptual最新文献_第3页

Does a Tattoo Protect Against Chronic Spontaneous Urticaria? An Unusual Finding. 纹身能预防慢性自发性荨麻疹吗？一个不寻常的发现

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a172

Kinga Bojahr, Agata Sztramska, Weronika Zysk, Agata Rolewicz, Jan Romantowski, Marta Chełmińska

引用次数: 0

Efficacy of Fractional Versus Fully Ablative CO₂ Laser for Distolateral Onychomycosis: Experience With 20 Patients. 点阵式与完全烧蚀式 CO2 激光治疗远侧甲癣的疗效：20例患者的经验。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a121

Laura Gnesotto, Bianca Maria Piraccini, Michela Starace, Luigi Naldi, Guido Mioso, Andrea Sechi

{"title":"Efficacy of Fractional Versus Fully Ablative CO2 Laser for Distolateral Onychomycosis: Experience With 20 Patients.","authors":"Laura Gnesotto, Bianca Maria Piraccini, Michela Starace, Luigi Naldi, Guido Mioso, Andrea Sechi","doi":"10.5826/dpc.1403a121","DOIUrl":"10.5826/dpc.1403a121","url":null,"abstract":"Introduction: Oral antifungals are the treatment choice for onychomycosis, and topical therapies are favored in cases of limited nail involvement. Recently, carbon dioxide (CO2) laser treatment has emerged as an option to enhance the effectiveness of topical therapies.Objectives: Our objective was to compare the efficacy of fractional ablative and fully ablative CO2 laser treatments for distolateral subungual onychomycosis affecting a single toenail and caused by dermatophytes.Methods: The records of 10 patients treated with a single fully ablative CO2 session were matched with those of 10 patients who underwent a single CO2 fractional treatment. All had previously failed topical antifungal lacquers and were discharged with the prescription of topical ciclopirox nail lacquer (8%) for 3 months.Results: The clinical response rates were 80% for the fully ablative group and 60% for the fractional group. Additionally, the mean reduction in Onychomycosis Severity Index from baseline to 8.6±1.6 weeks after treatment completion was 6.9±5.4 in the fully ablative group and 3.6±6.6 in the fractional group. The relapse rate among responders was 12.5% in the fully ablative and 33.3% in the fractional group after a mean follow-up time of 29.4±2.3 weeks.Conclusions: Fractional and fully ablative CO2 laser in combination with ciclopirox lacquer could increase the response rate in onychomycosis resistant to topical antifungals when systemic therapy is contraindicated or not yet pursued. Fully ablative mode therapy is significantly more effective than fractional (P < 0.05). Further studies are needed to identify prognostic response factors and assess the long-term effectiveness of CO2 laser treatment.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients. 评估脱发症患者血清炎症标志物及其与治疗反应的关系

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a193

Icim Komurcugil, Nermin Karaosmanoglu

{"title":"Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients.","authors":"Icim Komurcugil, Nermin Karaosmanoglu","doi":"10.5826/dpc.1403a193","DOIUrl":"10.5826/dpc.1403a193","url":null,"abstract":"Introduction: Alopecia areata is a type of non-scarring alopecia which is thought to be associated with T-cell mediated immune response.Objective: This study aimed to compare the levels of serum inflammatory markers before and after treatment in patients with alopecia areata. The study explored the utility of the systemic immune-inflammation index (SII) in assessing the severity and treatment response in alopecia areata patients.Methods: The study included 60 alopecia areata patients and 40 control patients diagnosed with tinea unguium, aged between 18 and 65 years. Sociodemographic characteristics such as age, sex, and medical history were recorded for both groups. For alopecia areata patients, serum inflammatory markers were recorded before and at the third month of treatment. Serum inflammatory markers for the control group were also recorded. Furthermore, the Severity of Alopecia Tool (SALT) score was calculated for alopecia areata patients before and at the third month of treatment.Results: The alopecia areata group had a significantly higher neutrophil-lymphocyte ratio, mean platelet volume, and SII values compared to the control group, while high-density lipoprotein (HDL) values were significantly lower. Serum inflammatory markers, assessed at the third month of treatment in the alopecia areata group, were lower, and HDL values were significantly higher compared to pre-treatment levels. A statistically significant correlation was observed between disease severity and the SII.Conclusion: The SII is a cost-effective marker that can be utilized in assessing the severity of alopecia areata and treatment response.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Difference Between SARS-CoV-2 Associated Telogen Effluvium and Telogen Effluvium Due to Other Causes. 与 SARS-CoV-2 相关的脱发与其他原因引起的脱发之间的区别。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a170

Didem Kazan, Defne Özkoca, Nazlı Dizen Namdar

{"title":"The Difference Between SARS-CoV-2 Associated Telogen Effluvium and Telogen Effluvium Due to Other Causes.","authors":"Didem Kazan, Defne Özkoca, Nazlı Dizen Namdar","doi":"10.5826/dpc.1403a170","DOIUrl":"10.5826/dpc.1403a170","url":null,"abstract":"Introduction: Telogen effluvium (TE) is a common type of non-cicatricial alopecia, and it is reported frequently in patients with SARS-CoV-2 infection.Objectives: Herein, we aimed to examine the demographic, dermoscopic, and laboratory features of the patients with SARS-CoV-2 associated TE (CATE) and compare them with TE due to other causes (TEDOC) according to these features.Methods: In this retrospective case-control study we evaluated the patients who were diagnosed with TE and were above 18 years of age between April and June 2022. The patients were divided into two groups based on their medical history and SARS-CoV-2 PCR positivity. The first group included patients with CATE and positive SARS-CoV-2 PCR test results in the last 3 months. The second group consisted of patients with TEDOC. Patients gender, age, disease duration, additional systemic disease, dermoscopic findings, and laboratory results were recorded.Results: A total of 92 patients, 86 (93.5%) females, and 6 (6.5%) males, were included in the study. CATE was detected in 52 (56.5%) patients whereas 40 (44.5%) patients had TEDOC. The mean time between the onset of SARS-CoV-2 infection and hair loss complaint was calculated as 64.8 + 25.6 days, and this time was significantly shorter than patients with TEDOC (P = 0.003). The dermoscopic evaluation showed that empty follicular openings and yellow dots were statistically higher in patients with CATE, whereas short regrowing hair were markedly higher in patients with TEDOC (P = 0.001, P = 0.001,and P = 0.001, respectively) CONCLUSIONS: CATE is characterized by excessive hair-shedding that begins sooner after infection than classic TE. Dermoscopic findings can assist clinicians in diagnosis.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Immune Checkpoint Inhibitors-Induced Skin Toxicity on Patients Quality of Life and the Role of Dermatologic Intervention. 免疫检查点抑制剂引起的皮肤毒性对患者生活质量的影响以及皮肤病干预的作用。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a118

Christina Kemanetzi, Konstantinos Lallas, Elizavet Lazaridou, Chrysoula Papageorgiou, Aimilios Lallas, Alexandros Stratigos, Eleni Timotheadou, George Lazaridis, Dimitrios Dionysopoulos, Kalliopi Kalaitzi, Antonios Tsimpidakis, Myrto Trakatelli, Aikaterini Patsatsi, Vasiliki Nikolao, Zoe Apalla

{"title":"The Impact of Immune Checkpoint Inhibitors-Induced Skin Toxicity on Patients Quality of Life and the Role of Dermatologic Intervention.","authors":"Christina Kemanetzi, Konstantinos Lallas, Elizavet Lazaridou, Chrysoula Papageorgiou, Aimilios Lallas, Alexandros Stratigos, Eleni Timotheadou, George Lazaridis, Dimitrios Dionysopoulos, Kalliopi Kalaitzi, Antonios Tsimpidakis, Myrto Trakatelli, Aikaterini Patsatsi, Vasiliki Nikolao, Zoe Apalla","doi":"10.5826/dpc.1403a118","DOIUrl":"10.5826/dpc.1403a118","url":null,"abstract":"Introduction: Data regarding quality of life (QoL) of oncologic patients experiencing dermatologic immune-related adverse events (dirAEs) and their course after dermatologic intervention are scarce.Objectives: To assess the impact of dirAEs on patients QoL and to investigate the correlation between dermatologic and oncologic indexes used for estimating QoL.Methods: We enrolled oncologic patients with dirAEs managed in two supportive onco-dermatology outpatient clinics in Greece. Patient-reported outcomes included DLQI, EORTC-QLQ-C30 and Numerical Rating Scale for pruritus (pNRS).Results: Overall, 110 patients were enrolled in the study. Mean (standard deviation) DLQI and pNRS scores were 15.54 (5.44) and 7.25 (2.95), correspondingly, while functional, symptom and summary scores of EORTC-C30 were 79.17 (2.11), 17.66 (3.60) and 80.67 (3.08), respectively. After therapeutic interventions, there was a statistically significant decrease in DLQI scores after first intervention compared to baseline, and second intervention compared to first (mean decrease 4.38 (2.91), P < 0.001 and 5.16 (3.99), P < 0.001, respectively). DLQI showed no correlation with global health status/QoLs (rho 0.01, P = 0.90) of EORTC-C30.Conclusions: DirAEs negatively affect QoL. Dermatologic intervention improves patients QoL, facilitating an unimpaired oncologic treatment. Poor correlation between DLQI and EORTC-QLQ-30 highlights the need for adapted QoL measurement tools in the context of immune checkpoint inhibitors treatment.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Signs of Breast Cancer: When a Dermatologic Evaluation is Useful After a Negative Mammography. 乳腺癌的皮肤征兆：乳房 X 射线照相术阴性后，皮肤学评估何时有用？

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a180

Nello Tommasino, Federica Feo, Mariateresa Cantelli, Davide Fattore

引用次数: 0

Indications for and Contraindications to Digital Monitoring of Patients with Melanocytic Lesions. 对黑色素细胞病变患者进行数字监控的适应症和禁忌症。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a200

Giulia Briatico, Gabriella Brancaccio, Camila Scharf, Elvira Moscarella, Eugenia Veronica Di Brizzi, Anna Balato, Giuseppe Argenziano

引用次数: 0

Relationship Between PD-L1, PD-1, CD8 and Clinicopathological Factors in Primary SCCs. 原发性 SCC 中 PD-L1、PD-1、CD8 与临床病理因素之间的关系

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a176

Preslav Vasilev, Savelina Popovska, Elitsa Petrova Kraevska, Martin Karamanliev, Dobromir Dimitrov, Ivelina Yordanova

{"title":"Relationship Between PD-L1, PD-1, CD8 and Clinicopathological Factors in Primary SCCs.","authors":"Preslav Vasilev, Savelina Popovska, Elitsa Petrova Kraevska, Martin Karamanliev, Dobromir Dimitrov, Ivelina Yordanova","doi":"10.5826/dpc.1403a176","DOIUrl":"10.5826/dpc.1403a176","url":null,"abstract":"Introduction: Squamous cell carcinoma of the skin (SCCs) is the second most common skin cancer, with continuously increasing incidence. Programmed cell death ligand 1 (PD-L1), programmed cell death 1 receptor (PD-1), and CD8 expression in primary SCCs have not been described in many studies.Objective: We investigated the association between PD-L1, PD-1, CD8, and clinicopathological prognostic factors for recurrence, metastasis, and mortality of SCCs.Patients and methods: Immunohistochemically stained sections of 100 primary SCCs divided into two groups according to diameter of the tumors (<20 mm and >20 mm) were assessed. Recombinant rabbit anti-PD-L1 antibody [SP142] - C-terminal, rabbit monoclonal anti-PD1 antibody [NAT105], and FLEX Mono Mo A-Hu CD8, cl C8/144B, RTU were used.Results: We did not establish statistically significant differences between PD-L1, PD-1, CD8 expression, and high-risk clinicopathological features - tumor size >20 mm, depth >6 mm, poor tumor cell differentiation, perineural/lymphovascular invasion, low/absent lymphocyte stromal reaction.Conclusions: In primary SCCs, the expression of PD-L1, PD-1, and CD8 are not associated with high-risk clinicopathological factors. We suggest that these immunohistochemical markers are more significant in advanced cases and metastatic tissues.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gasdermin A (GSDMA) Tissue Expression, Serum and Urinary Concentrations with Clinicopathologic Outcome in Psoriasis. Gasdermin A (GSDMA) 组织表达、血清和尿液浓度与银屑病临床病理结果的关系。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a177

Julia Nowowiejska, Anna Baran, Anna Pryczynicz, Justyna Magdalena Hermanowicz, Beata Sieklucka, Dariusz Pawlak, Iwona Flisiak

{"title":"Gasdermin A (GSDMA) Tissue Expression, Serum and Urinary Concentrations with Clinicopathologic Outcome in Psoriasis.","authors":"Julia Nowowiejska, Anna Baran, Anna Pryczynicz, Justyna Magdalena Hermanowicz, Beata Sieklucka, Dariusz Pawlak, Iwona Flisiak","doi":"10.5826/dpc.1403a177","DOIUrl":"10.5826/dpc.1403a177","url":null,"abstract":"Introduction: Psoriasis is a frequent and incurable skin disease that is an important issue in contemporary dermatology, although its pathogenesis is still uncertain. Gasdermin A (GSDMA) is a member of the gasdermin protein family which are able to cause pore formation in cellular membranes leading to cell death called pyroptosis.Objective: Our aim was to investigate the role of GSDMA in psoriatic patients.Method: The study enrolled 60 patients with active plaque-type psoriasis and 30 sex- and age-matched volunteers without dermatoses. GSDMA concentration was assessed in serum and urine samples of all participants using ELISA. GSDMA tissue expression was assessed by immunohistochemistry.Results: GSDMA serum concentration was significantly higher in patients compared to controls, whereas urinary GSDMA/creatinine ratio was insignificantly lower. GSDMA tissue expression was more prominent in psoriatic plaque compared to non-lesional patients' skin and healthy skin of subjects without dermatoses. There was a strong negative correlation between GSDMA serum concentration and ALT activity. GSDMA did not correlate with PASI or psoriasis duration.Conclusions: Obtained results point to the probable involvement of GSDMA in psoriasis. GSDMA overexpression may probably lead to keratinocytes hyperproliferation and be responsible for triggering inflammation in psoriatic skin. Serum GSDMA could become psoriasis biomarker, whereas urinary GSDMA, not at this point.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive Assessment and Management of Folliculitis Decalvans by Trichoscopy and Reflectance Confocal Microscopy. 通过三镜检查和反射共聚焦显微镜对德科毛囊炎进行无创评估和管理

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a167

Francesco Piscazzi, Chiara Franceschini, Alessandra Narcisi, Mario Valenti, Alfredo Rossi, Marco Ardigò

{"title":"Non-invasive Assessment and Management of Folliculitis Decalvans by Trichoscopy and Reflectance Confocal Microscopy.","authors":"Francesco Piscazzi, Chiara Franceschini, Alessandra Narcisi, Mario Valenti, Alfredo Rossi, Marco Ardigò","doi":"10.5826/dpc.1403a167","DOIUrl":"10.5826/dpc.1403a167","url":null,"abstract":"Introduction: Folliculitis decalvans (FD) is a rare scarring alopecia mainly affecting middle-aged men, characterized by recurring episodes of follicular pustules, crusts, erythema, tufted hairs, and scars.Objectives: This study investigates the effectiveness of reflectance confocal microscopy (RCM) compared to trichoscopy for diagnosing and monitoring FD.Methods: The study involved 24 Caucasian patients diagnosed with FD. Patients were examined using trichoscopy and RCM, with a focus on specific features like erythema and inflammatory cell distribution. A subgroup of 16 patients was followed up after 3 months of therapy. The reproducibility of RCM and trichoscopy was assessed using Cohen Kappa Test.Results: RCM and trichoscopy consistently detected features such as tufted hairs, pustules, and perifollicular fibrosis. However, RCM provided more detailed insights into inflammatory activity and types of fibrosis, often overlooked by trichoscopy. It showed a reduction in vessels and inflammatory cells, which trichoscopy failed to detect. The concordance between RCM evaluations was excellent, indicating high reproducibility.Conclusions: RCM is effective in diagnosing and monitoring FD, offering detailed insights into inflammation and fibrosis. It complements trichoscopy, especially in aspects where trichoscopy is limited, such as precise measurement of inflammation. The study suggests that combining RCM with trichoscopy could enhance the accuracy of diagnosis and monitoring of FD, leading to tailored therapeutic approaches. Further studies with larger sample sizes and longitudinal designs are recommended to confirm these findings.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0