Dermatology practical & conceptual最新文献_第3页

Management of Lichen Sclerosus and Related Comorbidities at a Tertiary Referral Center: Beyond Topical Steroids. 一家三级转诊中心对硬皮病及相关合并症的管理：超越局部类固醇

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a262

Alessia Paganelli, Luca Contu, Elena Ficarelli, Federico Garbarino, Alberico Motolese

{"title":"Management of Lichen Sclerosus and Related Comorbidities at a Tertiary Referral Center: Beyond Topical Steroids.","authors":"Alessia Paganelli, Luca Contu, Elena Ficarelli, Federico Garbarino, Alberico Motolese","doi":"10.5826/dpc.1404a262","DOIUrl":"10.5826/dpc.1404a262","url":null,"abstract":"Introduction: Lichen sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the anogenital area, with potential systemic implications.Objective: Our aim was to elucidate its clinical characteristics and management strategies.Methods: We conducted a retrospective observational study on adult patients with LS referred to our center between January 2022 and December 2023.Results: Forty-six adult subjects affected with LS were enrolled in the present study. The majority of patients presented with genital involvement, but a significant subset also exhibited extragenital LS and concomitant immune-mediated disorders. Common symptoms included itching, soreness, and dyspareunia, with characteristic skin findings of erythema and atrophy. Topical corticosteroids were the mainstay of therapy, complemented by alternative treatments in refractory cases. Alternative therapeutic approaches, such as PRP (platelet rich plasma) or ADSC (adipose-tissue derived stromal/stem cell)-based strategies, were effectively employed in refractory cases, in the absence of major adverse events.Conclusions: Our findings underscore the importance of alternative approaches in the management of LS and highlight the need for further research to elucidate its pathogenesis and optimize therapeutic interventions.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omalizumab In The Treatment Of Refractory Urticarial Vasculitis Triggered By SARS-Cov-2 Infection: A Pediatric Case Report.

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a252

Yusuf Can Edek, Ecem Ertürk, Esra Adışen

引用次数: 0

Cutaneous Drug Reaction Due to Bortezomib Characterized by Erythematous Ramified Plaques in a Patient with Multiple Myeloma.

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a243

Emre Güven, Yusuf Can Edek, Funda Tamer, Özlem Erdem

引用次数: 0

Dermoscopy of Acquired Brachial Cutaneous Dyschromatosis (ABCD).

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a275

Noemi Plozner, Fulvio Antoniazzi, Giuseppe Stinco, Enzo Errichetti

引用次数: 0

Three Cases of Squamous Cell Carcinoma and One Case of Basal Cell Carcinoma Arising Within Hidradenitis Suppurativa Lesions. 三例鳞状细胞癌和一例基底细胞癌发生在化脓性扁桃体隐窝炎病变中。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a269

Jose M Villa-Gonzalez, Marta Mendieta Eckert, Maria Nerea Agesta Sánchez, Patricia Martín Playa, Ane Gartzia Rivero, Verónica Velasco Benito

引用次数: 0

Trichoscopic Evaluation of Focal Non-Cicatricial Alopecia in Egyptian Children.

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a238

Gehad Mohammed Abdelaziz Ahmed, Sawsan Khalifa El-Sayed, Sara Ahmed Galal

{"title":"Trichoscopic Evaluation of Focal Non-Cicatricial Alopecia in Egyptian Children.","authors":"Gehad Mohammed Abdelaziz Ahmed, Sawsan Khalifa El-Sayed, Sara Ahmed Galal","doi":"10.5826/dpc.1404a238","DOIUrl":"10.5826/dpc.1404a238","url":null,"abstract":"Introduction: Dermoscopy is a noninvasive diagnostic tool that allows the recognition of morphologic structures not visible to the naked eye. Trichoscopy is useful for the diagnosis and follow-up of hair and scalp disorders.Objective: The aim of the present study was to evaluate the causes of focal non-cicatricial alopecia in Egyptian children and to assess the importance of the trichoscope in the diagnosis of each disease.Methods: This study was done with 200 Egyptian pediatric patients aged from 2 to 18 years who suffered from focal non-cicatricial alopecia. Clinical and dermoscopic evaluations were performed on all patients, and informed consent was obtained from their parents.Results: The most prevalent diagnoses were alopecia areata (42%) and tinea capitis (40.5%), followed by trichotillomania (8%) and tractional alopecia (7%). Congenital triangular alopecia (1.5%) and patchy androgenetic alopecia (1%) were less common. Trichoscopy revealed distinct features in alopecia areata cases, such as short vellus hair, exclamation mark hair, black dots, broken hair, pigtail hair, and upright regrowing hair. The most common trichoscopic features of tinea capitis were comma hair, corkscrew hair, broken hair, bent hair, zigzag hair, morse code hair, perifollicular scaling, and diffuse scaling. These findings contribute to understanding the etiology and clinical presentation of childhood alopecia, facilitating accurate diagnosis and appropriate management.Conclusion: The routine use of trichoscopy in the clinical evaluation of scalp and hair disorders enhances diagnostic capabilities beyond simple clinical inspection. Trichoscopy reveals disease features that contribute to accurate diagnosis and improved management.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Use of Photodynamic Therapy for Treatment of Palbociclib-Induced Periorificial Dermatitis. 成功使用光动力疗法治疗帕博西尼诱发的口周皮炎

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a225

Davide Fattore, Giuseppe Lauletta, Matteo Megna, Nello Tommasino

引用次数: 0

Sulfasalazine-Induced Nail Changes: A Unique Clinical Observation.

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a253

Shrinivas Patil, Anuj Bhatnagar, Debdeep Mitra

引用次数: 0

mTORC1 and mTORC2 Levels in Patients with Psoriasis. 银屑病患者的 mTORC1 和 mTORC2 水平。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a266

İlayda Esna Gülsunay, İlknur Altunay, Tuğba Kum, Aslı Aksu Çerman

{"title":"mTORC1 and mTORC2 Levels in Patients with Psoriasis.","authors":"İlayda Esna Gülsunay, İlknur Altunay, Tuğba Kum, Aslı Aksu Çerman","doi":"10.5826/dpc.1404a266","DOIUrl":"10.5826/dpc.1404a266","url":null,"abstract":"Introduction: In recent years, there has been a growing emphasis on the role of the mammalian target of rapamycin (mTOR) pathway in the pathogenesis of psoriasis. This intracellular signaling pathway is known as the main control pathway of metabolism and is of particular interest in this context.Objectives: To investigate the importance of the mTOR pathway in the pathogenesis of plaque psoriasis.Methods: A total of forty patients with plaque psoriasis and 40 non-psoriatic volunteers were included in this case-control study. The fasting serum levels of mTORC1 and mTORC2 in the study groups were examined by enzyme-linked immunosorbent assay.Results: Serum levels of both mTORC1 and mTORC2 were found to be significantly lower in patients with plaque psoriasis than in controls (P = 0.001). A positive correlation was identified between serum mTORC1 and serum mTORC2 levels in patients with plaque psoriasis (p=0.001, r=0.826).Conclusion: The lower serum levels of mTORC1 and mTORC2 complexes, which are active signaling molecules in the cell, were observed in patients with plaque psoriasis. This suggests that these levels may serve as an indicator of increased intracellular activation of these molecules. It is our opinion that agents that can effectively inhibit both mTOR complexes may be more effective in the treatment of psoriasis.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Accessory Tragus with Cervical Chondro-Cutaneous Branchial Remnant of the Neck.

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a257

Cristina Bertoli, Caterina Longo, Vito Di Lernia

引用次数: 0