Dermatology practical & conceptual最新文献

{"title":"Unilateral Laterothoracic Exanthem in an Adult Following Recombinant Zoster Vaccination.","authors":"Xinjin Liu, Deyu Song, Xian Jiang","doi":"10.5826/dpc.1503a5370","DOIUrl":"10.5826/dpc.1503a5370","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Trichoscopy Features in Trichorhinophalangeal Syndrome: A Multicenter Retrospective Study.","authors":"Daniel Fernandes Melo, Rita Fernanda Cortez de Almeida, Carla Jorge Machado, Marcela Benez, Pedro da Rocha Andrade Neto, André Luiz Vairo Donda, Isabela Peron Melhado, Rogerio Nabor Kondo, Sidney Frattini, Giselle Pinto, Aline Donati","doi":"10.5826/dpc.1503a5285","DOIUrl":"10.5826/dpc.1503a5285","url":null,"abstract":"<p><strong>Introduction: </strong>Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant genetic disorder characterized by trichological, craniofacial, and skeletal abnormalities. To date, limited data are available on hair involvement in TRPS, especially those focusing on trichoscopy.</p><p><strong>Objective: </strong>We aimed to describe the epidemiology and the clinical and trichoscopy features of TRPS.</p><p><strong>Methods: </strong>We performed a retrospective multicenter study using chart review and images from six patients with a confirmed diagnosis of TRPS. Hair density (hair/field; field 13×1.4 mm) was classified as high (>30), medium (21-30), low (11-20), very low (5-10), or hairless (<4). The distance between follicular units, ranging from 1.0 mm to 1.4 mm, was considered normal.</p><p><strong>Results: </strong>Most patients were females, with a median age of 12 at diagnosis. Hair density ranged from very low to medium. All female patients presented a high occipital hairline. Our patients had exclusively non-terminal hairs and no case with high hair density, following the literature, which describes thin and sparse hairs. Hair density was related to a higher proportion of single hair units, while the distance between follicles was within normal limits.</p><p><strong>Conclusion: </strong>TRPS is notably uncommon, with hair alterations being important for diagnosis, where trichoscopy serves as a valuable tool. Our study found a normal hair diameter relationship (frontal ≥ occipital) in females, while the male patient exhibited frontal-occipital inversion. Low hair density may result from an increased number of single hair units rather than from follicular distance. The high occipital hairline is proposed as a diagnostic pearl, warranting further studies to validate our findings.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Risk of Hypotension in Women Treated with Spironolactone for Hair Loss.","authors":"Rachel C Hill, Yu Wang, Bilal Shaikh, Michael M Ong, Paul J Christos, Shari R Lipner","doi":"10.5826/dpc.1503a5337","DOIUrl":"10.5826/dpc.1503a5337","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Serum Oxidative Stress Biomarkers in Pemphigus Vulgaris: Clinical Insights and Implications for Pathogenesis.","authors":"Naglaa M El Sayed, Dalia I Halwag, Nesrine A Helaly, Iman M Abdelmeniem","doi":"10.5826/dpc.1503a5346","DOIUrl":"10.5826/dpc.1503a5346","url":null,"abstract":"<p><strong>Introduction: </strong>Pemphigus vulgaris is an autoimmune disorder characterized by blistering of the skin and mucous membranes due to the loss of cohesion between keratinocytes. Oxidative stress, a condition caused by an excess of reactive oxygen species that overwhelms the body's antioxidant defenses, has been implicated in various autoimmune diseases, including pemphigus vulgaris.</p><p><strong>Objectives: </strong>This study aimed to evaluate serum levels of advanced glycation end products and advanced oxidation protein products as novel biomarkers of oxidative stress in pemphigus vulgaris patients and to correlate these levels with disease activity.</p><p><strong>Methods: </strong>Sixty participants were included, divided into three equal groups: 20 patients with active mucocutaneous pemphigus vulgaris not on systemic treatment, 20 patients in remission on minimal therapy, and 20 healthy controls. Serum levels of advanced glycation end products and advanced oxidation protein products were measured using the enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Serum levels of advanced glycation end products and advanced oxidation protein products were significantly higher in the active pemphigus vulgaris patient group compared to both the remission group and healthy controls (P<0.001). No significant correlation was found between the oxidative stress markers, desmoglein 3, and the Pemphigus Disease Activity Index.</p><p><strong>Conclusions: </strong>The findings of the present study demonstrate that oxidative stress may not play a primary role in the pathogenesis or severity of pemphigus vulgaris but could instead be a secondary effect associated with tissue damage. Factors such as diet and ethnicity could have influenced the results, indicating the need for larger scale, population-specific studies.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoid Basal Cell Carcinoma as a Late Complication of Acute Lymphoblastic Leukemia: A Case Study in Adult Survivors.","authors":"Luísa Homem de Mello Maciel Campilongo, Lívia Ugikawa Fujiwara, Júlia Berenguer Farias, Francisco Macedo Paschoal","doi":"10.5826/dpc.1503a5262","DOIUrl":"10.5826/dpc.1503a5262","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Assisted Mnemonics in Dermatology.","authors":"Mohammed I AlJasser","doi":"10.5826/dpc.1503a5469","DOIUrl":"10.5826/dpc.1503a5469","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black Superficial Onychomycosis Caused by Neoscytalidium Dimidiatum: A Clinical Overview.","authors":"Hugo Monteiro Faver, Aline Barbosa de Almeida, João Paulo Monteiro Yamagata, Dávson Aguilar Guimarães, Paula Sá, Danilo Luis Boechat Marins","doi":"10.5826/dpc.1503a5302","DOIUrl":"10.5826/dpc.1503a5302","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Penile Median Raphe Cysts: A Comprehensive Review.","authors":"Julia Nowowiejska, Vincenzo Piccolo, Dirk Van Gysel, Ramon Grimalt, Mario Cutrone","doi":"10.5826/dpc.1503a5288","DOIUrl":"10.5826/dpc.1503a5288","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distant Metastasis of Merkel Cell Carcinoma: A Descriptive Study.","authors":"Clara Muntaner-Virgili, Júlia Boronat-Cucarull, Josep Ramon Ferreres, Marta Gamissans, Joaquim Marcoval, Davinia Fernández-Calvo, Rosa María Penín, Josep Bermejo, Lia Huesa-Barceló, Sergio Manzano-Mora, Eric Ruzafa-Martínez, María Teresa Bajen-Lázaro, Ana Benítez-Segura, Paula Cecilia Notta, Laura Jiménez-Colomo, Juan Martín-Liberal, Pablo Araguas-Mora, Marc Juárez-Lozano, Isabel Linares-Galiana","doi":"10.5826/dpc.1503a5134","DOIUrl":"10.5826/dpc.1503a5134","url":null,"abstract":"<p><strong>Introduction: </strong>There are few studies on the pattern of distant spread of Merkel cell carcinoma (MCC).</p><p><strong>Objectives: </strong>To analyse the most frequent locations of distant metastases from MCC and their possible relationship with the location of the primary tumour.</p><p><strong>Methods: </strong>Patients diagnosed with cutaneous MCC between 1988 and 2022 were included in the study. The locations of the first metastases detected were recorded, both at tumour diagnosis and during follow-up after initial treatment.</p><p><strong>Results: </strong>One hundred patients were diagnosed with MCC. Distant metastases were detected in 31 patients (seven at diagnosis and 24 during follow-up), with a total of 52 locations: 17 non-regional lymph node metastases, 10 bone, seven liver, six lung, four non-regional cutaneous/subcutaneous, three pancreatic, two adrenal, two pharyngeal, and one mammary. No patient developed metastasis to the central nervous system. Recurrences occurred in 84% of patients before two years of follow-up. Although differences were not significant, MCCs located in the extremities tended to metastasize to extra-regional lymph nodes and those in the head and neck to bone, liver, and lung.</p><p><strong>Conclusions: </strong>MCC produces metastases mainly in non-regional lymph nodes, bone, liver, and lung. Given its high frequency (1/3 of patients), we consider performing scheduled imaging tests during the first two years of follow-up advisable. Specific imaging tests for central nervous system could be reserved for patients with neurological symptoms.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Halo Split-Skin Grafts for Treating Non-Melanoma Skin Cancers in the Foot and Ankle: A Clinical Case Series.","authors":"Clara Jimenez Balcells","doi":"10.5826/dpc.1503a5512","DOIUrl":"10.5826/dpc.1503a5512","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}