Dermatology practical & conceptual最新文献

{"title":"Identifying SCC Lesions Capable of Spontaneous Regression by Using Immunohistochemistry: A Systematic Review and Meta-Analysis.","authors":"Maryam Hedayati, Behzad Garousi, Zahrasadat Rezaei, Yasaman Nazerian, Younes Yassaghi, Arian Tavasol, Dorsa Bahrami Zanjanbar, Sanaz Sharifpour, Amir Golestani, Mansoor Bolideei, Farajolah Maleki","doi":"10.5826/dpc.1402a47","DOIUrl":"10.5826/dpc.1402a47","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoacanthoma (KA) and squamous cell carcinoma (SCC) are two cutaneous conditions with morphological resemblance, which can complicate the diagnosis in some cases. Using immunohistochemistry staining of biomarkers could be beneficial in resolving this obstacle.</p><p><strong>Objectives: </strong>We investigated a variety of biomarkers assessed in different studies in order to find the most important and helpful biomarkers for differentiation between SCC and lesions capable of spontaneous regression.</p><p><strong>Methods: </strong>MEDLINE via PubMed and Google Scholar database were used to identify relevant literature up to 15 June 2022. The aim of our analyses was to determine the capability of biomarkers to distinguish between SCC and lesions capable of spontaneous regression using calculated individual and pooled odds ratios (OR) and 95% confidence intervals (CI) and I² tests.</p><p><strong>Results: </strong>Six potential biomarkers were CD10 with pooled OR= 0.006 (95% CI: 0.001-0.057) and I²=0%; COX-2 with pooled OR=0.089 (95% CI: 0.029-0.269) and I²=17.1%; elastic fibers with pooled OR= 6.69 (95% CI: 2.928-15.281) and I²=0%; IMP-3 with pooled OR=0.145 (95% CI: 0.021-1.001) and I²=44.5%; P53 with pooled OR=0.371 (95% CI: 0.188-0.733) and I²=55.9%; AT1R with OR=0.026 (95% CI: 0.006-0.107).</p><p><strong>Conclusions: </strong>We suggest the utilization of the following IHC biomarkers for discrimination between lesions with spontaneous regression such as KA and SCC: CD10, COX-2, and elastic fibers.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Preferences Regarding the Novel Systemic Treatment for Atopic Dermatitis in Children.","authors":"Alicja Mesjasz, Monika Suszyńska, Marta Jaskulak, Magdalena Trzeciak","doi":"10.5826/dpc.1402a108","DOIUrl":"10.5826/dpc.1402a108","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilomatricoma: Clinical, Dermoscopic Findings and Management in 55 Pediatric Patients and Concise Review of the Literature with Special Emphasis on Dermoscopy.","authors":"Marco Adriano Chessa, Maria Francesca Baracca, Alice Nadia Rossi, Bianca Maria Piraccini, Vittorio De Pietro, Valentino Marino Picciola, Alessandra Gelmetti, Iria Neri","doi":"10.5826/dpc.1402a140","DOIUrl":"10.5826/dpc.1402a140","url":null,"abstract":"<p><strong>Introduction: </strong>Pilomatricoma is a benign adnexal dermal or subcutaneous tumor derived from immature hair matrix cells.</p><p><strong>Objectives: </strong>The aim of our study is to evaluate clinical and dermoscopic features of pilomatricomas, with a specific focus on pediatric lesions, and to provide a concise review of the existing literature.</p><p><strong>Methods: </strong>A single-center retrospective study was undertaken on 55 patients with a histopathological diagnosis of pilomatricoma referred to the Dermatology Unit, University of Bologna, Bologna, Italy, between 2005 and 2023. Pilomatricomas were retrospectively evaluated relying on clinical and dermoscopic images. A PubMed search was conducted. All the relevant research up to July 31, 2023, was reviewed. We classified the cases as \"typical\" or \"atypical\" based on whether they were suspected of being pilomatricomas or not.</p><p><strong>Results: </strong>A total of 55 children with pilomatricomas were observed and studied. Two patients presented with 2 pilomatricomas, leading to the identification of 58 pilomatricomas. 'Typical' pilomatricomas were observed in 79% of cases as nodular and pigmented lesions with one or more colors, ranging from blue-gray to red to yellow/white, evident on clinical examination and even better on dermoscopy. In 21% of cases, pilomatricomas presented in an 'atypical' form, which did not allow for a well-founded suspicion, placing them in differential diagnosis with other lesions and therefore requiring histological examination.</p><p><strong>Conclusions: </strong>According to our case series and systematic review of the literature, clinical appearance and dermoscopy may be sufficient to diagnose or suspect pilomatricoma in around 80% of cases, while histological examination is necessary to confirm the diagnosis in the remaining 20% of cases.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulvar Acantholytic Warty Dyskeratoma.","authors":"Sabina Vaccari, Luca Rapparini, Cosimo Misciali, Emi Dika","doi":"10.5826/dpc.1402a124","DOIUrl":"10.5826/dpc.1402a124","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gray Zone of Melanocytic Tumors - A Clinical Point of View.","authors":"Camila Scharf, Giulia Briatico, Gabriella Brancaccio, Elvira Moscarella, Andrea Ronchi, Giuseppe Argenziano","doi":"10.5826/dpc.1402a153","DOIUrl":"10.5826/dpc.1402a153","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center.","authors":"Yusuf Can Edek, Yağmur Aypek, Betül Öğüt, Özlem Erdem, Esra Adışen","doi":"10.5826/dpc.1402a100","DOIUrl":"10.5826/dpc.1402a100","url":null,"abstract":"<p><strong>Introduction: </strong>Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions.</p><p><strong>Objectives: </strong>In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options.</p><p><strong>Methods: </strong>This study was designed as a single-center retrospective, observational, cross-sectional study. We evaluated all accessible APD cases between January 2004 and June 2022 in a tertiary care hospital.</p><p><strong>Results: </strong>A total of 95 patients with confirmed APD were included in the study. Sixty percent of the patients were women and 40% were men. The median age at diagnosis was 63.1 years (35-85 years). The most common site of lesions was the lower extremities which were detected in 86.31% of the patients. The concomitant systemic disease was identified in 84.21% of the patients. The most common systemic disease was type 2 diabetes mellitus (65.26%). Antihistamines and topical corticosteroids were the most commonly prescribed treatment agents.</p><p><strong>Conclusions: </strong>Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug. The diagnosis of APD requires a clinical examination and histological investigation. APD is usually accompanied by systemic comorbidities. There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous Kaposi Sarcoma: An Uncommon Blistering Variant in an HIV-Negative Patient.","authors":"Eleonora Gherardi, Luca Tinunin, Tommaso Grassi, Vincenza Maio, Vieri Grandi","doi":"10.5826/dpc.1402a113","DOIUrl":"10.5826/dpc.1402a113","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nilotinib Induced Keratosis Pilaris in a Female with Chronic Myeloid Leukemia.","authors":"Ranjana Beniwal, Akriti Agrawal","doi":"10.5826/dpc.1402a82","DOIUrl":"10.5826/dpc.1402a82","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Experience of Tofacitinib and Baricitinib Use in Alopecia Areata in Greek Population: A Retrospective Analysis With Focus on Safety.","authors":"Zoe Apalla, Efterpi Zafiriou, Effimia Zagkliverinou, Angeliki-Viktoria Roussaki-Schulze, Polyxeni Gidarokosta, Niki Ntavari, Stella Sakellaropoulou, Maria Boziou, Anastasia Emvalomati, Eirini Kyrmanidou, Elizabeth Lazaridou","doi":"10.5826/dpc.1402a73","DOIUrl":"10.5826/dpc.1402a73","url":null,"abstract":"<p><strong>Introduction: </strong>The introduction of Janus Kinase inhibitors (JAKi) seems to revolutionize the field of alopecia areata (AA) therapeutics. However, real-world data are still missing.</p><p><strong>Objectives: </strong>To provide evidence about effectiveness and safety of tofacitinib and baricitinib in AA in real-world settings and describe baseline disease characteristics and patients profiles that are considered good candidates for JAKi in the daily practice. Furthermore, we intended to investigate potential correlations between baseline characteristics and treatment outcomes.</p><p><strong>Methods: </strong>We retrospectively reviewed the databases of two tertiary Hospitals in Greece, to identify individuals of any age currently being treated with systemic JAKi for severe AA.</p><p><strong>Results: </strong>We identified 42 individuals, including 3 adolescents. In our cohort, 52.3% (22/42) were under tofacitinib and 47.6% (20/42) under baricitinib treatment. Efficacy analysis was performed on the subgroup of 30 patients that had completed at least a 3-month follow-up on treatment. In the latter group, mean time on treatment was 10 months. Mean Severity of Alopecia Tool and mean Dermatology Life Quality Index scores decreased from 84.46% and 12.86 at baseline, to 43.26% and 6.63, respectively. Complete response (CR) was recorded in 4 (13.33%), partial in 12 (40%) and no response in 14 patients (46.66%), correspondingly. Seventeen out of 42 (40.5%) individuals in total, reported at least 1 adverse event. No patient required hospitalization. Among 15 patients (35.7%) who got COVID-19, one suffered from serious infection. The 3 adolescents achieved CR with no significant adverse events.</p><p><strong>Conclusions: </strong>Real-world data suggest efficacy and safety of JAKi in severe forms of AA. Tolerability is optimal in younger individuals.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There Exist Educational Deficiencies in Specialized Dermatologic Care: Implications for Patients of Different Sexes, Genders, and Sexual Orientations.","authors":"Isabella Mark, Michael J Diaz, Jasmine T Tran, Shari R Lipner","doi":"10.5826/dpc.1402a128","DOIUrl":"10.5826/dpc.1402a128","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 2","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}