Cataldo Patruno, Claudio Pelucchi, Carlotta Galeone, Martino Emmi, Paolo Amerio
{"title":"Epidemiology and Severity of Prurigo Nodularis in Europe: A Literature Review with an Application to Italian Data.","authors":"Cataldo Patruno, Claudio Pelucchi, Carlotta Galeone, Martino Emmi, Paolo Amerio","doi":"10.5826/dpc.1502a4716","DOIUrl":"10.5826/dpc.1502a4716","url":null,"abstract":"<p><strong>Introduction: </strong>Prurigo nodularis is a chronic inflammatory skin disease with recent definition and relatively low prevalence. Information on prurigo nodularis, including its epidemiology, severity, and burden of disease, is still scanty.</p><p><strong>Objectives: </strong>We sought to review and summarize recent quantitative data on prurigo nodularis in Europe and to estimate the burden of disease in Italy, with a focus on moderate-to-severe prurigo nodularis.</p><p><strong>Methods: </strong>We conducted a systematic literature review of recent studies on the epidemiology of prurigo nodularis in Europe, using PubMed/MEDLINE and EMBASE. The study selection process was conducted independently by two reviewers. Articles focusing on the severity of prurigo nodularis were also searched (non-systematically), and relevant information was extracted. Synthetic results were combined to population data to derive the best estimate of the burden of prurigo nodularis in Italian adults.</p><p><strong>Results: </strong>Five articles reporting data on incidence and/or prevalence of prurigo nodularis in European populations were identified. The prevalence of prurigo nodularis ranged from 6.5 to 111.0 cases per 100,000, with a median estimate of 32.7 cases per 100,000, the incidence ranging between 2.88 and 20 per 100,000 person-years. Five other studies reported data on the severity of prurigo nodularis, measured through pruritus scores, quality-of-life indexes and/or percentage of non-response to treatment. We estimated a total of 16,280 prevalent prurigo nodularis cases in Italy, of whom 6,073 had moderate-to-severe to very severe disease. Among the latter, 1,798 estimated cases were not controlled by standard treatments.</p><p><strong>Conclusions: </strong>We retrieved and summarized recent epidemiological data on prurigo nodularis, evidencing a high burden of disease in Italy and other European countries.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermoscopy of a Rare Case of Porokeratotic Eccrine Ostial and Dermal Duct Nevus.","authors":"Ranjana Beniwal, Akriti Agrawal","doi":"10.5826/dpc.1502a4997","DOIUrl":"10.5826/dpc.1502a4997","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aarthi Parvathaneni, Madison M Taylor, T Austin Black, Kelly C Nelson
{"title":"International Survey on Dermoscopic Image Management: ISIC Data on Capture, Storage, and AI Integration in Dermatology.","authors":"Aarthi Parvathaneni, Madison M Taylor, T Austin Black, Kelly C Nelson","doi":"10.5826/dpc.1502a4896","DOIUrl":"10.5826/dpc.1502a4896","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Maria Abréu-Vélez, Willy Ramos, Michael S Howard
{"title":"Is Tunisian Endemic Pemphigus Foliaceus A Real Entity, Or Should These Cases Be Reclassified With Other Autoimmune Blistering Disease?","authors":"Ana Maria Abréu-Vélez, Willy Ramos, Michael S Howard","doi":"10.5826/dpc.1502a5008","DOIUrl":"10.5826/dpc.1502a5008","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aimilios Lallas, Konstantinos Liopyris, Zoe Apalla, Elvira Moscarella, Gabriella Brancaccio, Alexander Stratigos, Giuseppe Argenziano
{"title":"Artificial Intelligence-Based Image Analysis is Insufficient as a Stand-Alone Assessment of Skin Tumors in Real Clinical Practice.","authors":"Aimilios Lallas, Konstantinos Liopyris, Zoe Apalla, Elvira Moscarella, Gabriella Brancaccio, Alexander Stratigos, Giuseppe Argenziano","doi":"10.5826/dpc.1502a5353","DOIUrl":"10.5826/dpc.1502a5353","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systemic Inflammatory Biomarkers in Alopecia Areata: The Role of SII, SIRI, and CRP/Albumin Ratio.","authors":"Işıl Deniz Oğuz, Sevgi Kulaklı, Burak Akşan","doi":"10.5826/dpc.1502a4962","DOIUrl":"10.5826/dpc.1502a4962","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is an autoimmune disorder, with potential roles of both genetic and environmental factors. Although AA is a specific autoimmune disease targeting hair follicles, its frequent association with other autoimmune diseases supports the notion that the autoinflammation is not confined to the hair follicles but is systemic. Systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and CRP (C-reactive protein) albumin ratio (CAR) are elevated in various diseases and correlate with disease severity.</p><p><strong>Objectives: </strong>The aim of this study was to determine SII, SIRI, and CAR levels in alopecia areata patients and investigate their correlation with disease severity.</p><p><strong>Methods: </strong>The data of 118 AA patients and 122 healthy controls were analyzed. Complete blood count (CBC), CRP, and albumin values were noted during clinic visits. CAR, SII, and SIRI were calculated in both groups.</p><p><strong>Results: </strong>Although median SIRI and CAR levels were higher in the AA group, the difference was not statistically significant (P>0.05). However, median SII was significantly higher in the AA group (P<0.001). AA patients were divided into two groups according to disease severity: mild disease group (MD) and moderate and severe disease (MSD) group. SII, SIRI, and CAR did not differ between the two groups.</p><p><strong>Conclusions: </strong>In AA patients, SIRI and CAR did not show significant differences compared to the normal population, while SII was significantly higher. SII was not found to be associated with disease severity, suggesting that systemic inflammation may occur even in the mildest cases of the disease.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dalia Ibrahim Halwag, Samar Mohamed Samy Gad, Eman M ElEryan, Hend Mostafa Ali Ali, Eman M Osman, Iman Mohamed Abdelmeniem
{"title":"Thyroid Dysfunction in Mycosis Fungoides: Sonographic and Laboratory Insights.","authors":"Dalia Ibrahim Halwag, Samar Mohamed Samy Gad, Eman M ElEryan, Hend Mostafa Ali Ali, Eman M Osman, Iman Mohamed Abdelmeniem","doi":"10.5826/dpc.1502a4961","DOIUrl":"10.5826/dpc.1502a4961","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid gland affection in mycosis fungoides has rarely been reported. It occurs as extracutaneous involvement, incidentally, as a second malignancy, or as a side effect of systemic retinoids.</p><p><strong>Objective: </strong>This study aimed to specifically screen for biochemical or structural thyroid gland affection in a larger number of mycoses fungoides patients.</p><p><strong>Methods: </strong>Twenty-eight mycosis fungoides patients received a formal thyroid ultrasound examination, and their thyroid hormones and anti-thyroid peroxidase antibody levels were evaluated.</p><p><strong>Results: </strong>Hypoechogenic thyroid gland (suggesting thyroiditis) was detected in 39.3% of patients, and 39.3% had thyroid nodules. Thyroid hormones and anti-thyroid peroxidase antibodies were normal in 92.9% of patients. There was a statistically significant relationship between the mycosis fungoides variant and glandular echogenicity. Eighty percent of patients with the hypopigmented variant had hypoechoic gland, compared to 43.8 % of patients with the patch stage and none of the patients with the poikilodermatous variant (P=0.017*). There was a statistically significant relationship between the mycosis fungoides variant and DTD-TIRADS score (P=0.014*). The mean duration of mycosis fungoides was longer in patients with DTD-TIRADS III and IV and with thyroid nodules, however, without statistical significance. Patients treated with systemic psoralen ultraviolet A phototherapy, compared to narrow-band ultraviolet B phototherapy, were more likely to have thyroiditis, however, without statistical significance (P=0.265).</p><p><strong>Conclusions: </strong>We recommend regular screening for thyroid gland affection in mycosis fungoides patients because of the possible association with thyroiditis and thyroid nodules, especially in patients with the hypopigmented variant.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric Scabies: Association with Sleep Disorders, Anxiety, Depression, and Impaired Quality of Life.","authors":"Nihal Sarı, Gülsüm Yitik Tonkaz, Şeyda Arslan","doi":"10.5826/dpc.1502a4979","DOIUrl":"10.5826/dpc.1502a4979","url":null,"abstract":"<p><strong>Introduction: </strong>Scabies is a contagious, infectious skin disease that is observed worldwide. Scabies affects individuals of all ages, although it exhibits significant differences between childhood and adulthood. While the number of publications documenting the co-occurrence of anxiety, depression, and impaired quality of life (QoL) in adult patients with scabies is increasing, the presence of these issues in pediatric patients remains a topic of curiosity.</p><p><strong>Objectives: </strong>In this study, we aimed to investigate the presence of sleep disorders, QoL, anxiety, and depression in children with scabies.</p><p><strong>Methods: </strong>In this analytical case-control study, 68 scabies patients and 69 healthy controls aged 6-17 years were included.</p><p><strong>Results: </strong>In patients with scabies, sleep quality was significantly poorer compared to the control group (P<0.001). There was no difference between the two groups in terms of RCADS (Revised Children's Anxiety and Depression Scale) and total anxiety and depression scores. In the control group, the number of individuals with upper and upper-middle socioeconomic levels was higher (P=0.036). A moderate correlation was found between impairment in dermatology-related QoL and deterioration in sleep quality in patients with scabies (r=0.606, P<0.001).</p><p><strong>Conclusion: </strong>This study found that sleep disorders are common among children diagnosed with scabies, negatively impacting their QoL compared to healthy controls. We believe that obtaining information about both night and day sleep patterns during dermatological follow-ups of children diagnosed with scabies and providing recommendations on sleep hygiene as part of the treatment process may have positive effects on a child's QoL.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}