Cataldo Patruno, Claudio Pelucchi, Carlotta Galeone, Martino Emmi, Paolo Amerio
{"title":"欧洲结节性痒疹的流行病学和严重程度:文献综述与意大利数据的应用。","authors":"Cataldo Patruno, Claudio Pelucchi, Carlotta Galeone, Martino Emmi, Paolo Amerio","doi":"10.5826/dpc.1502a4716","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Prurigo nodularis is a chronic inflammatory skin disease with recent definition and relatively low prevalence. Information on prurigo nodularis, including its epidemiology, severity, and burden of disease, is still scanty.</p><p><strong>Objectives: </strong>We sought to review and summarize recent quantitative data on prurigo nodularis in Europe and to estimate the burden of disease in Italy, with a focus on moderate-to-severe prurigo nodularis.</p><p><strong>Methods: </strong>We conducted a systematic literature review of recent studies on the epidemiology of prurigo nodularis in Europe, using PubMed/MEDLINE and EMBASE. The study selection process was conducted independently by two reviewers. Articles focusing on the severity of prurigo nodularis were also searched (non-systematically), and relevant information was extracted. Synthetic results were combined to population data to derive the best estimate of the burden of prurigo nodularis in Italian adults.</p><p><strong>Results: </strong>Five articles reporting data on incidence and/or prevalence of prurigo nodularis in European populations were identified. The prevalence of prurigo nodularis ranged from 6.5 to 111.0 cases per 100,000, with a median estimate of 32.7 cases per 100,000, the incidence ranging between 2.88 and 20 per 100,000 person-years. Five other studies reported data on the severity of prurigo nodularis, measured through pruritus scores, quality-of-life indexes and/or percentage of non-response to treatment. We estimated a total of 16,280 prevalent prurigo nodularis cases in Italy, of whom 6,073 had moderate-to-severe to very severe disease. Among the latter, 1,798 estimated cases were not controlled by standard treatments.</p><p><strong>Conclusions: </strong>We retrieved and summarized recent epidemiological data on prurigo nodularis, evidencing a high burden of disease in Italy and other European countries.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090948/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epidemiology and Severity of Prurigo Nodularis in Europe: A Literature Review with an Application to Italian Data.\",\"authors\":\"Cataldo Patruno, Claudio Pelucchi, Carlotta Galeone, Martino Emmi, Paolo Amerio\",\"doi\":\"10.5826/dpc.1502a4716\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Prurigo nodularis is a chronic inflammatory skin disease with recent definition and relatively low prevalence. Information on prurigo nodularis, including its epidemiology, severity, and burden of disease, is still scanty.</p><p><strong>Objectives: </strong>We sought to review and summarize recent quantitative data on prurigo nodularis in Europe and to estimate the burden of disease in Italy, with a focus on moderate-to-severe prurigo nodularis.</p><p><strong>Methods: </strong>We conducted a systematic literature review of recent studies on the epidemiology of prurigo nodularis in Europe, using PubMed/MEDLINE and EMBASE. The study selection process was conducted independently by two reviewers. Articles focusing on the severity of prurigo nodularis were also searched (non-systematically), and relevant information was extracted. Synthetic results were combined to population data to derive the best estimate of the burden of prurigo nodularis in Italian adults.</p><p><strong>Results: </strong>Five articles reporting data on incidence and/or prevalence of prurigo nodularis in European populations were identified. The prevalence of prurigo nodularis ranged from 6.5 to 111.0 cases per 100,000, with a median estimate of 32.7 cases per 100,000, the incidence ranging between 2.88 and 20 per 100,000 person-years. Five other studies reported data on the severity of prurigo nodularis, measured through pruritus scores, quality-of-life indexes and/or percentage of non-response to treatment. We estimated a total of 16,280 prevalent prurigo nodularis cases in Italy, of whom 6,073 had moderate-to-severe to very severe disease. Among the latter, 1,798 estimated cases were not controlled by standard treatments.</p><p><strong>Conclusions: </strong>We retrieved and summarized recent epidemiological data on prurigo nodularis, evidencing a high burden of disease in Italy and other European countries.</p>\",\"PeriodicalId\":11168,\"journal\":{\"name\":\"Dermatology practical & conceptual\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090948/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology practical & conceptual\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5826/dpc.1502a4716\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology practical & conceptual","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5826/dpc.1502a4716","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Epidemiology and Severity of Prurigo Nodularis in Europe: A Literature Review with an Application to Italian Data.
Introduction: Prurigo nodularis is a chronic inflammatory skin disease with recent definition and relatively low prevalence. Information on prurigo nodularis, including its epidemiology, severity, and burden of disease, is still scanty.
Objectives: We sought to review and summarize recent quantitative data on prurigo nodularis in Europe and to estimate the burden of disease in Italy, with a focus on moderate-to-severe prurigo nodularis.
Methods: We conducted a systematic literature review of recent studies on the epidemiology of prurigo nodularis in Europe, using PubMed/MEDLINE and EMBASE. The study selection process was conducted independently by two reviewers. Articles focusing on the severity of prurigo nodularis were also searched (non-systematically), and relevant information was extracted. Synthetic results were combined to population data to derive the best estimate of the burden of prurigo nodularis in Italian adults.
Results: Five articles reporting data on incidence and/or prevalence of prurigo nodularis in European populations were identified. The prevalence of prurigo nodularis ranged from 6.5 to 111.0 cases per 100,000, with a median estimate of 32.7 cases per 100,000, the incidence ranging between 2.88 and 20 per 100,000 person-years. Five other studies reported data on the severity of prurigo nodularis, measured through pruritus scores, quality-of-life indexes and/or percentage of non-response to treatment. We estimated a total of 16,280 prevalent prurigo nodularis cases in Italy, of whom 6,073 had moderate-to-severe to very severe disease. Among the latter, 1,798 estimated cases were not controlled by standard treatments.
Conclusions: We retrieved and summarized recent epidemiological data on prurigo nodularis, evidencing a high burden of disease in Italy and other European countries.