Epidemiology and Severity of Prurigo Nodularis in Europe: A Literature Review with an Application to Italian Data.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Cataldo Patruno, Claudio Pelucchi, Carlotta Galeone, Martino Emmi, Paolo Amerio
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Abstract

Introduction: Prurigo nodularis is a chronic inflammatory skin disease with recent definition and relatively low prevalence. Information on prurigo nodularis, including its epidemiology, severity, and burden of disease, is still scanty.

Objectives: We sought to review and summarize recent quantitative data on prurigo nodularis in Europe and to estimate the burden of disease in Italy, with a focus on moderate-to-severe prurigo nodularis.

Methods: We conducted a systematic literature review of recent studies on the epidemiology of prurigo nodularis in Europe, using PubMed/MEDLINE and EMBASE. The study selection process was conducted independently by two reviewers. Articles focusing on the severity of prurigo nodularis were also searched (non-systematically), and relevant information was extracted. Synthetic results were combined to population data to derive the best estimate of the burden of prurigo nodularis in Italian adults.

Results: Five articles reporting data on incidence and/or prevalence of prurigo nodularis in European populations were identified. The prevalence of prurigo nodularis ranged from 6.5 to 111.0 cases per 100,000, with a median estimate of 32.7 cases per 100,000, the incidence ranging between 2.88 and 20 per 100,000 person-years. Five other studies reported data on the severity of prurigo nodularis, measured through pruritus scores, quality-of-life indexes and/or percentage of non-response to treatment. We estimated a total of 16,280 prevalent prurigo nodularis cases in Italy, of whom 6,073 had moderate-to-severe to very severe disease. Among the latter, 1,798 estimated cases were not controlled by standard treatments.

Conclusions: We retrieved and summarized recent epidemiological data on prurigo nodularis, evidencing a high burden of disease in Italy and other European countries.

Abstract Image

Abstract Image

欧洲结节性痒疹的流行病学和严重程度:文献综述与意大利数据的应用。
摘要结节性痒疹是一种慢性炎症性皮肤病,近年来才出现,发病率相对较低。关于结节性痒疹的信息,包括其流行病学、严重程度和疾病负担,仍然很少。目的:我们试图回顾和总结欧洲最近关于结节性痒疹的定量数据,并估计意大利的疾病负担,重点是中度至重度结节性痒疹。方法:利用PubMed/MEDLINE和EMBASE对欧洲近年来有关结节性痒疹流行病学的研究进行系统的文献综述。研究选择过程由两位审稿人独立进行。同时,我们也对有关结节性痒疹严重性的文章进行了检索(非系统地),并提取了相关信息。将综合结果与人口数据相结合,得出意大利成人结节性痒疹负担的最佳估计。结果:五篇报道欧洲人群结节性痒疹发病率和/或患病率的文章被确认。结节性痒疹的患病率范围为每10万人中6.5至111.0例,中位数估计为每10万人中32.7例,发病率范围为每10万人年2.88至20例。其他五项研究报告了结节性痒疹严重程度的数据,通过瘙痒评分、生活质量指数和/或治疗无反应的百分比来衡量。我们估计意大利共有16,280例普遍的结节性痒疹病例,其中6,073例患有中度至重度至极重度疾病。在后者中,1798例估计病例没有得到标准治疗的控制。结论:我们检索并总结了最近关于结节性痒疹的流行病学资料,证明该疾病在意大利和其他欧洲国家具有很高的负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.40
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