Dermatology practical & conceptual最新文献

{"title":"A Lesion Surrounded by the Rainbow: Merkel Cell Carcinoma.","authors":"Melek Aslan Kayıran, Ahmet Sait Şahin, Bengu Cobanoglu Simsek","doi":"10.5826/dpc.1402a64","DOIUrl":"10.5826/dpc.1402a64","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatology Quality of Life and Depression, Anxiety, and Stress Scale-42 in Scabies Patients.","authors":"Serap Köran Karadoğan, Berna Ulgen Altay","doi":"10.5826/dpc.1402a112","DOIUrl":"10.5826/dpc.1402a112","url":null,"abstract":"<p><strong>Introduction: </strong>Scabies is a pruritic skin infestation with a globally increasing prevalence. Sleep problems and impaired social and personal interactions, mainly due to itching, have been reported.</p><p><strong>Objectives: </strong>We aimed to determine the influence of scabies on quality of life and psychosocial health using Dermatology Life Quality Index (DLQI) and Depression Anxiety and Stress Scale-42 (DASS-42) and analyze whether there is a correlation between the two scales and any sociodemographic and clinical characteristic.</p><p><strong>Methods: </strong>Scabies patients (>16 years) who presented to our outpatient clinics were enrolled. Age, sex, occupation, marital status, and education level and clinical features were recorded. DLQI and DASS-42 were used. Possible influence of demographic and clinical characteristics on total scores were analyzed. The Spearman coefficient analysis was performed to determine whether there is a correlation between these scores.</p><p><strong>Results: </strong>Of 92 patients (mean age:37.76±15.355, Female/Male: 1.09/1), 63% were married and 35.9% were high-school graduates; 27.2% and 23.9% were housewives and officers, respectively. Disease was generalized in 57.6% and duration of disease was mostly <4 weeks. Mean DLQI and DASS-42 scores were 13.16±7.638 and 42.10±30.644, respectively. Symptoms/feelings were affected predominantly. DLQI was affected 'severely' in 41.3% of patients.</p><p><strong>Conclusions: </strong>Impairment of DLQI is a significant predictive parameter for higher DASS levels. Scabies is not only associated with impairment in DLQI but may also lead to psychosocial problems. All scabies patients should be evaluated and consulted-if needed-for possible problems of psychosocial status, including depression, anxiety, and stress, as well as clinical symptoms and secondary complications.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circumscribed Acral Hypokeratosis: Clinical and Dermoscopic Signs of an Evolving Condition.","authors":"Alessandra Petruzzellis, Eleonora Di Matteo, Luca Bianchi, Francesca Lupi, Ornella De Pita, Giuseppe Cianchini","doi":"10.5826/dpc.1402a139","DOIUrl":"10.5826/dpc.1402a139","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining Reflectance Confocal Microscopy, Optical Coherence Tomography and Ex-Vivo Fluorescence Confocal Microscopy for Margin Assessment in Basal Cell Carcinoma Excision.","authors":"Simone Michelini, Victor Desmond Mandel, Marco Ardigò, Silvana Ciardo, Carlo Cota, Anna Maria Cesinaro, Elena Rossi, Barbara Ferrari, Shaniko Kaleci, Marco Di Fraia, Camilla Chello, Carmen Cantisani, Federica Trovato, Caterina Longo, Giovanni Pellacani","doi":"10.5826/dpc.1402a90","DOIUrl":"10.5826/dpc.1402a90","url":null,"abstract":"<p><strong>Introduction: </strong>Recent developments of noninvasive, high-resolution imaging techniques, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), have enhanced skin cancer detection and precise tumor excision particularly in highly aggressive and poorly defined basal cell carcinomas (BCCs).</p><p><strong>Objectives: </strong>The aim of this pilot study is to assess the feasibility and reproducibility of a systematic clinical workflow combining noninvasive (RCM-OCT) and invasive fluorescence confocal microscopy (FCM) imaging modalities in pre- and intra-surgical evaluations of the lateral and deep margins of BCC.</p><p><strong>Methods: </strong>Superficial incisions were made 2 mm beyond the clinical-dermoscopic BCC margins. Lateral margins were then explored with OCT and RCM. In positive margins, a further cut was made 2 mm distal from the previous. A final RCM/OCT-based double-negative margin was drawn around the entire perimeter of the lesion before referring to surgery. The freshly excised specimen was then examined with FCM (ex-vivo) for the evaluation of the deep margin. Histopathologic examination eventually confirmed margin involvement.</p><p><strong>Results: </strong>The study included 22 lesions from 13 patients. At the end of the study, 146 margins-106 negative (73%) and 40 positive (27%) at RCM/OCT-were collected. The RCM/OCT margin evaluation showed an overall sensitivity of 100% and a specificity of 96.3%. The overall positive margins diagnostic accuracy was 98.2%. Reproducibility was evaluated on recorded images and the raters showed a substantial inter-observer agreement on both RCM (κ = 0.752) and OCT images (κ = 0.724).</p><p><strong>Conclusions: </strong>The combined RCM/OCT/FCM ex-vivo approach noninvasively facilitates the presurgical and intrasurgical lateral and deep margin assessment of poorly defined BCCs.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Among Serum Calcidiol, Sun Index, and Vitamin D Intake in Individuals With Seborrheic Keratoses Living in Coastal Area.","authors":"Izzah Aulia, Larisa Paramitha Wibawa, Lis Surachmiati Suseno, Nurul Ratna Mutu Manikam","doi":"10.5826/dpc.1402a37","DOIUrl":"10.5826/dpc.1402a37","url":null,"abstract":"<p><strong>Introduction: </strong>Seborrheic keratoses (SK) are benign epidermal tumors with high sun exposure as a major risk factor. Vitamin D deficiency is also thought to play a role in its pathogenesis. There has been no data regarding SK, calcidiol level, vitamin D intake, and sun index (SI) among people living in coastal areas in Indonesia.</p><p><strong>Objectives: </strong>To assess the correlation between 1) serum calcidiol levels with SI and vitamin D intake and 2) lesion size with SI and serum calcidiol level among SK patients living in a coastal area.</p><p><strong>Methods: </strong>This is a cross-sectional study. We performed interviews using the sun index questionnaire and semiquantitative food frequency questionnaire for vitamin D; physical examination; dermoscopy to determine the largest SK lesion size; and measurement of serum calcidiol levels in participants with SK living in Cilincing District, North Jakarta. Spearman correlation test was used to assess the relationship between variables.</p><p><strong>Results: </strong>Thirty-nine participants with SK aged 19-59 years were analyzed. The median of the SK largest diameter, SI, serum calcidiol, and vitamin D intake was 2 (1-10) mm, 3.95 (1.1-23.52), 14.3 (5.25-35.30) ng/ml, and 4.3 (0.1-30.1) mcg/day, respectively. SI and vitamin D intake were not significantly correlated with calcidiol levels. Similarly, SI and calcidiol levels were not significantly correlated with the largest SK lesion size.</p><p><strong>Conclusions: </strong>We found low calcidiol levels and vitamin D intake in this coastal population. The SI and vitamin D intake had no correlations with calcidiol levels. Furthermore, calcidiol levels and SI had no correlations with the lesion largest diameter.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Evaluation of Combined Treatment with Fractional Co2 and Nanosecond Q-1064 nm Laser for Traumatic Facial Tattoo.","authors":"Claudio Conforti, Piergiorgio Turco, Sebastian Laspina, Domenico Piccolo, Vito Cazzato","doi":"10.5826/dpc.1402a87","DOIUrl":"10.5826/dpc.1402a87","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acral Arteriovenous Hemangioma: A Case Report and the Utility of Ultra-High Frequency Ultrasound (UHFUS) in Diagnosis.","authors":"Stefania Guida, Antonio Podo Brunetti, Gianmarco Diego Bigotto, Giorgio Stabile, Franco Rongioletti","doi":"10.5826/dpc.1402a89","DOIUrl":"10.5826/dpc.1402a89","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologic Gray Zone of Melanocytic Tumors in Reality: Defining 'Non-Conventional' Melanocytic Tumors.","authors":"Gerardo Ferrara, Alberto Gualandi, Nathalie Rizzo","doi":"10.5826/dpc.1402a149","DOIUrl":"10.5826/dpc.1402a149","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study.","authors":"Asude Kara Polat, Mehmet Kamil Mülayim, Tuğba Falay Gür, Ayda Acar, Burçin Cansu Bozca, Can Ceylan, Fadime Kılınç, Rukiye Yasak Güner, Hülya Albayrak, Murat Durdu, Ayşe Esra Koku Aksu, Fatma Nalbant, Ekin Şavk, Dilek Bayramgürler, Munise Daye, Ralfi Singer, Emine Tuğba Alataş, Vefa Aslı Erdemir, Mehmet Salih Gürel, Soner Uzun, Savaş Yaylı","doi":"10.5826/dpc.1402a99","DOIUrl":"10.5826/dpc.1402a99","url":null,"abstract":"<p><strong>Introduction: </strong>Pemphigus vulgaris (PV) is an autoimmune disease primarily affecting the oral mucosa.</p><p><strong>Objectives: </strong>This study aimed to determine the demographic, clinical and treatment characteristics of PV patients with oral mucosal involvement and to assess the impact on their quality of life.</p><p><strong>Methods: </strong>We conducted a prospective observational study among 106 patients diagnosed with PV and presenting oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded.</p><p><strong>Results: </strong>The study included 106 patients, 55 (51.89%) were male and there was a predominance of the mucocutaneous subtype in 83 individuals (78.38%). Oral mucosa was the initial site of manifestation in 44 patients (41.51%). Bilateral buccal mucosa was the most frequently affected site. The predominant symptom reported was a burning sensation, noted in 91 patients (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. Systemic steroids were the most commonly administered treatment, and rituximab was used in 18 patients (16.98%). A positive and significant correlation was found between pemphigus severity and Oral Health Impact Profile-14, Dermatology Life Quality Index and Dermatological Quality of Life Scale scores (P < 0.05). The presence of superficial ulcers, flaccid bullae, lesion diameter ≥1 cm, and >10 lesions were factors that markedly diminished quality of life. Complete response to treatment was noted in all patients administered rituximab.</p><p><strong>Conclusions: </strong>The most common area of involvement was bilateral buccal mucosa, and the severity of PV closely correlated with a decline in quality of life measures. These results highlight the need for careful clinical oversight of PV, taking into account its effects on patients quality of life.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying SCC Lesions Capable of Spontaneous Regression by Using Immunohistochemistry: A Systematic Review and Meta-Analysis.","authors":"Maryam Hedayati, Behzad Garousi, Zahrasadat Rezaei, Yasaman Nazerian, Younes Yassaghi, Arian Tavasol, Dorsa Bahrami Zanjanbar, Sanaz Sharifpour, Amir Golestani, Mansoor Bolideei, Farajolah Maleki","doi":"10.5826/dpc.1402a47","DOIUrl":"10.5826/dpc.1402a47","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoacanthoma (KA) and squamous cell carcinoma (SCC) are two cutaneous conditions with morphological resemblance, which can complicate the diagnosis in some cases. Using immunohistochemistry staining of biomarkers could be beneficial in resolving this obstacle.</p><p><strong>Objectives: </strong>We investigated a variety of biomarkers assessed in different studies in order to find the most important and helpful biomarkers for differentiation between SCC and lesions capable of spontaneous regression.</p><p><strong>Methods: </strong>MEDLINE via PubMed and Google Scholar database were used to identify relevant literature up to 15 June 2022. The aim of our analyses was to determine the capability of biomarkers to distinguish between SCC and lesions capable of spontaneous regression using calculated individual and pooled odds ratios (OR) and 95% confidence intervals (CI) and I² tests.</p><p><strong>Results: </strong>Six potential biomarkers were CD10 with pooled OR= 0.006 (95% CI: 0.001-0.057) and I²=0%; COX-2 with pooled OR=0.089 (95% CI: 0.029-0.269) and I²=17.1%; elastic fibers with pooled OR= 6.69 (95% CI: 2.928-15.281) and I²=0%; IMP-3 with pooled OR=0.145 (95% CI: 0.021-1.001) and I²=44.5%; P53 with pooled OR=0.371 (95% CI: 0.188-0.733) and I²=55.9%; AT1R with OR=0.026 (95% CI: 0.006-0.107).</p><p><strong>Conclusions: </strong>We suggest the utilization of the following IHC biomarkers for discrimination between lesions with spontaneous regression such as KA and SCC: CD10, COX-2, and elastic fibers.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}