Association Between Periostin Expression and Disease Progression in Lichen Planopilaris: Insights Into Pathophysiology.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Şenay Ağırgöl, Ceyda Çaytemel, Burak Ünlü, Elif Çetinkaya, Baran Cayhan, Begüm Çalım, Zafer Türkoğlu
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Abstract

Introduction: Lichen planopilaris (LPP) is the most prevalent form of scarring alopecia and lymphocytic infiltration that affects the infundibulum and isthmus, perifollicular melanophages, and perifollicular constrictive fibrosis OBJECTIVE: We aimed to assess the contribution of periostin tissue levels to the pathogenesis of LPP and its association with disease severity.

Methods: A total of 30 cases diagnosed with LPP between July 15 and October 15, 2022 were studied. Patient age, disease duration, disease severity, and periostin levels were recorded, and periostin immunohistochemistry was performed to obtain histoscores for the perifollicular area, dermoepidermal junction, fibroblasts, and inflammatory cells, and these were compared with the control group.

Results: The female sex predominated, with the majority (67%); 25 patients were classified with mild disease and five with severe LPP. Statistically significant differences were found in keratinocyte staining intensities between the mild and severe groups (P=0.023; P<0.01), with the LPP group exhibiting a higher rate of moderate staining intensity compared to the control group. In terms of perifollicular staining intensities, the rate of non-staining was higher in the control group compared to the LPP group. Statistically significant differences were also observed in fibroblast (P=0.001) and inflammatory cell (P=0.001) staining intensities between the groups. No statistically significant difference was found between the patients with mild or severe disease in the LPP group.

Conclusion: The relationship between periostin and disease severity could not be conclusively established. The presence of periostin staining in all histopathologically-affected areas of patients with LPP suggests that periostin may serve as a promising marker in LPP.

扁平苔藓骨膜蛋白表达与疾病进展之间的关系:病理生理学的见解。
扁平苔藓(LPP)是一种最常见的瘢痕性脱发和淋巴细胞浸润,可影响垂体和峡部、滤泡周围黑色素细胞和滤泡周围收缩性纤维化。目的:我们旨在评估骨膜蛋白组织水平在LPP发病机制中的作用及其与疾病严重程度的关系。方法:对2022年7月15日至10月15日诊断为LPP的30例患者进行分析。记录患者年龄、病程、疾病严重程度和骨膜蛋白水平,并进行骨膜蛋白免疫组化以获得滤泡周围区域、皮表皮交界、成纤维细胞和炎症细胞的组织评分,并与对照组进行比较。结果:以女性为主,占多数(67%);轻度LPP 25例,重度LPP 5例。轻度组与重度组角化细胞染色强度差异有统计学意义(P=0.023;结论:骨膜素与疾病严重程度的关系尚不能确定。在LPP患者的所有组织病理学影响区域都存在骨膜蛋白染色,这表明骨膜蛋白可能作为LPP的一个有希望的标志物。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
217
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