Age-related Survival Declines in Turkish Patients with Cutaneous Melanoma: A Retrospective Analysis.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Faruk Tas, Kayhan Erturk
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Abstract

Introduction: In cancer patients, the age of a patient at the time of diagnosis is considered among the important clinical indicators.

Objectives: We aimed to investigate this significance in melanoma patients by creating patient age groups.

Methods: A total of 1,496 adult skin melanoma patients were evaluated retrospectively. Patients were divided into six age groups: under 30 (<30), 31-39 (30s), 40-49 (40s), 50-59 (50s), 60-69 (60s), and 70 and older (70+).

Results: The median age was 52 years (range 16-104), and the most common age group was the 50s (n=340, 22.7%). As age increased, so did the Clark level (P=0.0001), the rate of ulceration (P=0.0001), and the rate of BRAF wild-type (P=0.002). The recurrence rates of early-stage patients were similar for all age groups. A significant overall survival (OS) advantage was found only between the following age groups: <30 and 60s (P=0.04) and <30 and 70+ (P=0.01). Five-year OS were, from young to old: 70.5%, 66%, 63.1%, 66.3%, 57.2%, and 46.8%. A significant OS advantage was found only between the following age groups: <30 and 60s (P=0.04) and <30 and 70+ (P=0.01). The 70+ group had significantly worse OS rates in all age groups (<30: P=0.0001; 30s P=0.0001; 40s: P= 0.001; 50s: P=0.0001; and 60s: P=0.04).

Conclusion: While some unfavorable histopathological prognostic factors are associated more frequently with increasing age, clinical stage and recurrence do not differ significantly between age groups. A possible explanation for this might be that the elderly have more comorbidities and die of different causes.

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土耳其皮肤黑色素瘤患者年龄相关性生存率下降:回顾性分析
在癌症患者中,患者诊断时的年龄被认为是重要的临床指标之一。目的:我们旨在通过创建患者年龄组来研究黑色素瘤患者的这种意义。方法:对1496例成人皮肤黑色素瘤患者进行回顾性分析。患者分为6个年龄组:30岁以下(结果:中位年龄52岁(16 ~ 104岁),50岁最常见(n=340, 22.7%)。随着年龄的增长,克拉克水平(P=0.0001)、溃疡发生率(P=0.0001)和BRAF野生型发生率(P=0.002)也随之增加。所有年龄组早期患者的复发率相似。结论:虽然一些不利的组织病理学预后因素与年龄的增长有关,但临床分期和复发在年龄组之间没有显着差异。一种可能的解释是,老年人有更多的合并症,死于不同的原因。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
217
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