Dermatology practical & conceptual最新文献_第4页

Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of The Literature. 杜匹单抗和斑秃：可能的联合治疗还是干扰治疗？文献综述。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a270

Michela Starace, Stephano Cedirian, Federico Quadrelli, Francesca Pampaloni, Tullio Brunetti, Marco Adriano Chessa, Carlotta Gurioli, Bianca Maria Piraccini, Iria Neri

{"title":"Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of The Literature.","authors":"Michela Starace, Stephano Cedirian, Federico Quadrelli, Francesca Pampaloni, Tullio Brunetti, Marco Adriano Chessa, Carlotta Gurioli, Bianca Maria Piraccini, Iria Neri","doi":"10.5826/dpc.1404a270","DOIUrl":"10.5826/dpc.1404a270","url":null,"abstract":"Introduction: Dupilumab, a monoclonal antibody targeting IL-4 receptor subunit alpha, treats atopic dermatitis (AD) and may impact alopecia areata (AA). AA involves Th1-driven immune activity, and recent studies suggest a role for Th2 pathways. Dupilumab's effects on AA are mixed, with reports of both improvement and worsening.Objectives: This study aims to review the effects of dupilumab on AA in patients with AD, analyzing literature to understand cases of improvement or worsening and identifying contributing factors.Methods: A literature review was conducted using articles in platforms such as PubMed, Scopus, and Web of Science written up to April 2024, focusing on studies involving AA, AD, and dupilumab. Articles were analyzed for patient demographics, disease characteristics, and responses to treatment.Results: Out of 35 articles reviewed, 13 AA cases worsened after dupilumab (mean age 32.8; mostly males with patchy alopecia), and 38 cases showed improvement (mean age 27.6; majority females, varying AA types). Full hair regrowth occurred in 11 improved cases, while 9 had partial regrowth.Conclusions: Dupilumab shows dual effects on AA, influenced by Th1/Th2 immune profiles. Worsening was more common in males with Th1-driven AA, while females with Th2-skewed AA saw improvement. Factors like age, disease severity, and IgE levels may affect outcomes, suggesting a need for personalized treatment approaches for AA patients with AD.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Accessory Tragus with Cervical Chondro-Cutaneous Branchial Remnant of the Neck. 多发副耳屏伴颈软骨-皮鳃残余。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a257

Cristina Bertoli, Caterina Longo, Vito Di Lernia

引用次数: 0

Elaioconiosis: An Uncommon Dermatoses of a Common Occupation. 尘肺病：一种常见职业的罕见皮肤病。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a255

Arjun Prakashey, Gitesh U Sawatkar, Prerna Nagi

引用次数: 0

Filling the Gaps: Vitamin D Status in Diffuse Hair Fall Among Pakistanis. 填补空白：巴基斯坦人散发性脱发中的维生素D状况。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a232

Palwasha Jalil, Sadia Masood, Muhammad Sadique, Maimoona Abdul Jalil, Malghalura Jalil, Laila Khan

{"title":"Filling the Gaps: Vitamin D Status in Diffuse Hair Fall Among Pakistanis.","authors":"Palwasha Jalil, Sadia Masood, Muhammad Sadique, Maimoona Abdul Jalil, Malghalura Jalil, Laila Khan","doi":"10.5826/dpc.1404a232","DOIUrl":"10.5826/dpc.1404a232","url":null,"abstract":"Introduction: Hair loss can happen for various reasons, including emotional stress, physical strain, certain medical issues, and nutritional gaps. When it comes to nutrition, a lack of vitamin D3 could be linked to diffuse hair loss.Objectives: The aim was to look for the frequency of vitamin D3 deficiency with diffuse hair fall, especially in the Pakistani population.Methods: A total of 120 patients of both sexes and all ages presenting to the Dermatology Clinic with complaints of non-scarring alopecia and loss of over 100 strands of hair within a 24-hour period (counted by patient) of any duration and positive hair pull test were advised to take serum vitamin D3. Tests and results were then analyzed by SPSS statistical software package (version 19.0 for Windows).Results: The mean age of participants enrolled in the study was 28.56 ± 11.62 years. The majority of the patients, i.e., 77 (63.64%), were ≤30 years of age. Among the 120 patients, 17 were males and 103 were females. Mean serum vitamin D3 levels were 17.33 ± 5.43 ng/ml. 95 (79.17%) patients were found to be vitamin D3 deficient, with 37 patients having female pattern hair loss, seven patients with male pattern hair loss, seven patients with diffuse alopecia areata, and 44 patients with telogen effluvium.Conclusions: This study concluded that there is considerable frequency of vitamin D3 deficiency in individuals with diffuse hair fall. Therefore, we recommend that there should be early recognition and treatment of this condition in these particular patients in order to reduce hair fall.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mTORC1 and mTORC2 Levels in Patients with Psoriasis. 银屑病患者的 mTORC1 和 mTORC2 水平。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a266

İlayda Esna Gülsunay, İlknur Altunay, Tuğba Kum, Aslı Aksu Çerman

{"title":"mTORC1 and mTORC2 Levels in Patients with Psoriasis.","authors":"İlayda Esna Gülsunay, İlknur Altunay, Tuğba Kum, Aslı Aksu Çerman","doi":"10.5826/dpc.1404a266","DOIUrl":"10.5826/dpc.1404a266","url":null,"abstract":"Introduction: In recent years, there has been a growing emphasis on the role of the mammalian target of rapamycin (mTOR) pathway in the pathogenesis of psoriasis. This intracellular signaling pathway is known as the main control pathway of metabolism and is of particular interest in this context.Objectives: To investigate the importance of the mTOR pathway in the pathogenesis of plaque psoriasis.Methods: A total of forty patients with plaque psoriasis and 40 non-psoriatic volunteers were included in this case-control study. The fasting serum levels of mTORC1 and mTORC2 in the study groups were examined by enzyme-linked immunosorbent assay.Results: Serum levels of both mTORC1 and mTORC2 were found to be significantly lower in patients with plaque psoriasis than in controls (P = 0.001). A positive correlation was identified between serum mTORC1 and serum mTORC2 levels in patients with plaque psoriasis (p=0.001, r=0.826).Conclusion: The lower serum levels of mTORC1 and mTORC2 complexes, which are active signaling molecules in the cell, were observed in patients with plaque psoriasis. This suggests that these levels may serve as an indicator of increased intracellular activation of these molecules. It is our opinion that agents that can effectively inhibit both mTOR complexes may be more effective in the treatment of psoriasis.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Xerosis in Patients with Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional Prospective Pilot Study. 干旱对接受表皮生长因子受体或丝裂原活化蛋白激酶抑制剂的癌症患者的影响：ATIXI，一项非介入性前瞻性先导研究

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a259

Pietro Quaglino, Giuseppe Argenziano, Emi Dika, Michela Starace, Simone Amabile, Paolo Fava, Elvira Moscarella, Bianca Maria Piraccini, Alain Delarue, Olivia Dialla, Fabienne Zumaglini, Giampiero Girolomoni

引用次数: 0

Increased Serum Vitamin D and Decreased Serum Cholesterol Are Associated with Development of Squamous Cell Carcinoma in Actinic Keratosis Patients: A Retrospective Machine-Learning Analysis of the All of Us Database. 光化性角化病患者血清维生素D升高和血清胆固醇降低与鳞状细胞癌的发展相关：All of Us数据库的回顾性机器学习分析

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a228

Nilesh Kodali, Rohan Singh, Shari R Lipner

引用次数: 0

Psoriasis Is Associated With Increased Risk of Psychiatric Disorders and Sexual Dysfunction in a Case-Control Study of 29,912 Patients. 在一项针对 29,912 名患者的病例对照研究中，银屑病与精神障碍和性功能障碍的风险增加有关。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a256

Priya Marella, Shari R Lipner

引用次数: 0

Impact of Psoriasis on Pregnancy Desire and Possible Consequences on Fertility. 牛皮癣对怀孕愿望的影响以及对生育能力可能造成的后果。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a221

Martina Burlando, Ilaria Salvi, Gabriele Poddine, Emanuele Cozzani, Aurora Parodi

{"title":"Impact of Psoriasis on Pregnancy Desire and Possible Consequences on Fertility.","authors":"Martina Burlando, Ilaria Salvi, Gabriele Poddine, Emanuele Cozzani, Aurora Parodi","doi":"10.5826/dpc.1404a221","DOIUrl":"10.5826/dpc.1404a221","url":null,"abstract":"Introduction: Approximately half of patients affected by psoriasis are women, and the management of female patients of childbearing age is an under-investigated topic. Some studies have shown a significant decrease in births in psoriatic patients due to intimacy and pregnancy avoidance and to potential birth complications.Objectives: We sought to evaluate data on reproductive health in a cohort of female patients, to compare them with similar data in the general population and to assess the impact of psoriasis, especially genital psoriasis, on pregnancy desire and the prevalence of psoriasis in the children of patients with psoriasis.Methods: This retrospective observational study involved adult female patients with a diagnosis of psoriasis made during or before childbearing age. The enrolled patients were asked questions concerning fertility and previous pregnancies in relation to their dermatologic disease.Results: Of 100 women enrolled, 73 reported a history of pregnancy, for a total of 170 pregnancies. The average number of pregnancies to term and the average number of children per woman (1.2 ± 1) were lower than the national average. The percentage of miscarriages was 18.2%, higher than the national average; in particular, women with psoriatic arthritis had a greater percentage of miscarriages (27.4%). During the pregnancies, psoriasis was mainly stable (36.1%) or improved (29.2%), even though most patients (91.5%) did not follow any treatment.Conclusions: Psoriasis impacts pregnancy desire and course. The management of psoriasis in women of childbearing age is crucial to minimize its burden on this vulnerable population.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence and Clinical Significance of Skin Manifestations in Parkinson's Disease Patients. 帕金森病患者皮肤表现的患病率和临床意义。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-10-30 DOI: 10.5826/dpc.1404a241

Ayşegül Yalçınkaya Iyidal, Funda Erduran, Yıldız Hayran, Yeşim Sücüllü Karadağ

{"title":"The Prevalence and Clinical Significance of Skin Manifestations in Parkinson's Disease Patients.","authors":"Ayşegül Yalçınkaya Iyidal, Funda Erduran, Yıldız Hayran, Yeşim Sücüllü Karadağ","doi":"10.5826/dpc.1404a241","DOIUrl":"10.5826/dpc.1404a241","url":null,"abstract":"Background: Parkinson's disease (PD) is primarily characterized by motor symptoms, but non-motor symptoms, including skin manifestations, are increasingly recognized. These remain underexplored despite their potential impact on quality of life.Objectives: This study aimed to evaluate the prevalence and clinical features of skin findings in PD patients, with a focus on identifying potential pathogenetic links between dermatological conditions and PD.Methods: A total of 215 PD patients were included. Comprehensive dermatological examinations were performed, and demographic and clinical data were collected. Statistical analysis was conducted using SPSS 23.0, with significance set at P < 0.05.Results: Skin conditions were found in 92.1% of PD patients. Xerosis, seborrheic dermatitis, and hyperhidrosis were the most common findings. Pre-PD xerosis was associated with an earlier stage of PD (P = 0.001). Use of PD medications, such as levodopa/carbidopa/entacapone, was linked to a lower incidence of seborrheic dermatitis (P = 0.040). A significant correlation was also noted between rosacea and cherry angioma (P = 0.01).Conclusion: Dermatological conditions are prevalent in PD and may precede its motor symptoms. Skin assessments could aid early diagnosis and management of PD, highlighting the need for further research on their pathogenetic mechanisms.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0