{"title":"A Window into the Vascular Endothelium in Covid-19: Nails.","authors":"Ozge Sevil Karstarli Bakay, Niyazi Cetin, Umut Bakay, Gokhan Cinar, Sule Goksin","doi":"10.5826/dpc.1501a4927","DOIUrl":"10.5826/dpc.1501a4927","url":null,"abstract":"<p><strong>Introduction: </strong>Endothelial damage is associated with acute and long-term coronavirus disease 2019 (COVID-19) complications. Proximal nailfold capillaries and nail beds give important clues to microvascular changes associated with endothelial dysfunction.</p><p><strong>Objective: </strong>We aimed to use dermoscopy to examine the proximal nailfold capillaries and nail bed of COVID-19 patients and identify microvascular changes.</p><p><strong>Methods: </strong>A prospective study was designed to evaluate the dermoscopic features of proximal nail fold capillaries and nail bed in mild-to-moderate COVID-19 patients and healthy controls between June 2022 and December 2023. The patients underwent their initial dermoscopic examination two weeks after the onset of symptoms, followed by a follow-up evaluation 10-14 months later.</p><p><strong>Results: </strong>The study included 46 patients with mild-to-moderate COVID-19 and 62 healthy controls. The presence of avascular areas (P <0.001), meandering capillaries (P = 0.016), microhemorrhages (P = 0.007), and enlarged capillaries (P = 0.009) in the proximal nail fold was significantly higher in COVID-19 patients than in healthy controls. The capillary architecture was disorganized (P = 0.002) and density reduced (P <0.001) in COVID-19 patients compared to healthy controls. In the follow-up examination, microvascular changes were observed to have regressed.</p><p><strong>Conclusions: </strong>Proximal nailfold dermoscopy is an effective, low-cost, easily accessible method that enables observation of microvascular changes in COVID-19 patients.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eugenia Veronica Di Brizzi, Anna Balato, Stefano Caccavale, Amalia Lupoli, Carlo Panetti, Giuseppe Argenziano
{"title":"A Comparative Study to Evaluate the Effectiveness between Synergic Activities of 0.1% Polyhexanide and Rigenase® (Fitostimoline® Plus spray) versus a Hydrating Formulation for the Topical Management of Rubbing Injuries Secondary to Atopic Dermatitis.","authors":"Eugenia Veronica Di Brizzi, Anna Balato, Stefano Caccavale, Amalia Lupoli, Carlo Panetti, Giuseppe Argenziano","doi":"10.5826/dpc.1501a4906","DOIUrl":"10.5826/dpc.1501a4906","url":null,"abstract":"<p><strong>Introduction: </strong>Managing rubbing injuries in atopic dermatitis is challenging and has a significant impact on patients' quality of life. Polyhexamethylene biguanide (PHMB) and Rigenase® (a patented Triticum vulgare extract) show promise in tissue repair and antimicrobial activity.</p><p><strong>Objective: </strong>The aim of this study was to compare the effectiveness of two topical treatments, Fitostimoline® Plus spray and a hydrating formulation with hyaluronic acid, in rubbing injuries secondary to atopic dermatitis.</p><p><strong>Materials and methods: </strong>This comparative study enrolled 68 patients with atopic dermatitis and rubbing injuries, randomly assigned to Group A (N=38) receiving Fitostimoline® Plus spray (0.1% PHMB and Rigenase®) or Group B (N=30) receiving a hyaluronic acid spray. The primary endpoint was the clinical lesion response at 10 days post-treatment. Secondary endpoints included pain reduction (Visual Analogue Scale, VAS) and patient satisfaction (Dermatology Life Quality Index, DLQI).</p><p><strong>Results: </strong>Group A had a significantly higher complete response rate (81.3% vs. 64.3%, P <0.001). Partial response rates were also higher in Group A (P = 0.045). Pain reduction was greater in Group A (VAS: 6.8 ± 1.2 to 2.4 ± 0.8) compared to Group B (7.1 ± 1.3 to 3.9 ± 1.0) (P <0.001). DLQI scores improved more in Group A (12.5 ± 3.5 to 3.2 ± 1.1) than in Group B (13.0 ± 3.2 to 6.5 ± 1.4) (P <0.001). Dermoscopic examinations showed significant skin barrier improvement in Group A (P <0.001).</p><p><strong>Conclusion: </strong>Fitostimoline® Plus spray, with 0.1% PHMB and Rigenase®, offers superior treatment for chronic lesions in atopic dermatitis, enhancing wound healing and patient quality of life.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caterina Mariarosaria Giorgio, Eugenia Veronica Di Brizzi, Anna Balato, Paolino Franzese, Nicola Maria Giorgio, Gaetano Licata
{"title":"Dermoscopy in the Diagnosis of Keratosis Lichenoides Striata (Nekam Disease): A Rare Clinical Entity.","authors":"Caterina Mariarosaria Giorgio, Eugenia Veronica Di Brizzi, Anna Balato, Paolino Franzese, Nicola Maria Giorgio, Gaetano Licata","doi":"10.5826/dpc.1501a5108","DOIUrl":"10.5826/dpc.1501a5108","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nada J Alghamdi, Abdullah A Aljalfan, Abdulmajeed S Alharbi, Omar I Alrubaish, Serene R Almuhaidib
{"title":"Refractory Chronic Hand Eczema Responds to Oral Upadacitinib.","authors":"Nada J Alghamdi, Abdullah A Aljalfan, Abdulmajeed S Alharbi, Omar I Alrubaish, Serene R Almuhaidib","doi":"10.5826/dpc.1501a4685","DOIUrl":"10.5826/dpc.1501a4685","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Painful Ulcers Affecting The Genitalia.","authors":"Yihang Xie, Mei Yang, Fan Li","doi":"10.5826/dpc.1501a4772","DOIUrl":"10.5826/dpc.1501a4772","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo De Giorgi, Gabriella Perillo, Pietro Antonini, Giovanni Cecchi, Biancamaria Zuccaro, Elisabetta Magnaterra, Eleonora Castellacci, Daniela Massi
{"title":"Lichen Sclerosus or Vulvar Angiokeratoma: A Diagnosis That is not always so easy.","authors":"Vincenzo De Giorgi, Gabriella Perillo, Pietro Antonini, Giovanni Cecchi, Biancamaria Zuccaro, Elisabetta Magnaterra, Eleonora Castellacci, Daniela Massi","doi":"10.5826/dpc.1501a4691","DOIUrl":"10.5826/dpc.1501a4691","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}