Dermatology practical & conceptual最新文献

{"title":"Mortality in Patients with Acquired Perforating Dermatosis: Results from the First Multicenter Case-Control Study.","authors":"Sebastián Reyes-García, Francisco Vázquez-López, Cristina Galache-Osuna, Blanca Vivanco-Allende, Carmen González-Vela, Jorge Santos-Juanes, Marcos A González-López","doi":"10.5826/dpc.1603a6672","DOIUrl":"10.5826/dpc.1603a6672","url":null,"abstract":"<p><strong>Introduction: </strong>Mortality data in patients with acquired perforating dermatosis (APD) are limited.</p><p><strong>Objectives: </strong>To assess, for the first time, the risk of all-cause mortality in adult patients with APD and to explore associated systemic comorbidities.</p><p><strong>Methods: </strong>This retrospective multicenter case-control study included adult patients diagnosed with APD and age-, sex-, and year-matched controls. We evaluated overall survival and the prevalence of seven major comorbidities: systemic malignancy, chronic obstructive pulmonary disease (COPD), severe liver disease, diabetes mellitus, arterial disease, hypertension, and dyslipidemia. Statistical analyses included univariate comparisons (Fisher's exact test and logistic regression), Kaplan-Meier survival estimates with log-rank tests, and multivariate Cox proportional hazards models.</p><p><strong>Results: </strong>Fifty-one patients with APD and 102 controls (1:2 ratio) were finally included in this investigation. Patients with APD had a significantly increased risk of mortality compared to controls ( log-rank test, P<0.001). In the multivariate Cox regression analysis, arterial disease emerged as the sole independent predictor of mortality (adjusted hazard ratio [HR]:7.716; 95% confidence interval [CI]: 2.774-21.464; P<0.001).</p><p><strong>Conclusions: </strong>This is the first study to identify a potential association between APD and increased allcause mortality, primarily driven by coexisting arterial disease. These findings highlight the importance of comprehensive management in APD patients and emphasize the dermatologist's role in multidisciplinary care aimed at improving long-term outcomes.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Side Effects of Low-Dose Oral Minoxidil in Patients with Alopecia: An Underrecognized Association.","authors":"João Soares, Manuel Martínez-Sellés, Rui Oliveira Soares","doi":"10.5826/dpc.1603a7007","DOIUrl":"10.5826/dpc.1603a7007","url":null,"abstract":"<p><strong>Introduction: </strong>Low-dose oral minoxidil (LDOM) has become an increasingly used therapy for alopecia. While dose-dependent hypertrichosis is the most common side effect, gastrointestinal (GI) adverse effects are plausible due to smooth muscle relaxation, but they have not been systematically reported in clinical studies.</p><p><strong>Objectives: </strong>To investigate the frequency and characteristics of GI adverse effects in patients treated with LDOM for alopecia.</p><p><strong>Methods: </strong>We conducted a prospective observational study at a trichology unit including patients attending their second consultation after initiating oral minoxidil between May and August 2025. A structured questionnaire assessed new GI symptoms, temporal relationship with treatment, and concomitant medication use.</p><p><strong>Results: </strong>Among 302 patients (218 females, 84 males; mean age 46 years), 22 (7.3%) reported new GI symptoms. The most frequent symptoms were flatulence (N=18), heartburn (N=13), abdominal distension (N=12), abdominal pain (N=10), and aerophagia (N=7). Symptoms resolved after discontinuation in 15 of 16 cases and recurred after reintroduction in 14 of 15. A dose-response association was observed (mean dose in patients with GI symptoms 2.7 ± 1.6 mg vs. 1.3 ± 1.2 mg in those without, P=0.01). GI side effects were more common in males (15.5%) than in females (4.1%, P<0.001) and in patients treated with concomitant vasodilators (25.6% vs. 4.6%, P<0.001).</p><p><strong>Conclusions: </strong>GI complaints, particularly aerophagia, abdominal pain or distension, and flatulence, appear to be underrecognized adverse effects of LDOM. Although generally mild, these symptoms may affect adherence and quality of life. Clinicians should inquire about GI complaints, especially in male patients receiving higher doses or concomitant vasodilators.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Rosacea: Clinical, Diagnostic, and Therapeutic Insights into an Underestimated Pediatric Condition.","authors":"Vincenzo Piccolo, Julia Nowowiejska-Purpurowicz, Andrea Bassi, Dirk Van Gysel, Alex Alexopoulos, Talia Kakourou, Caterina Mariarosaria Giorgio, Giuseppe Argenziano","doi":"10.5826/dpc.1603a7924","DOIUrl":"10.5826/dpc.1603a7924","url":null,"abstract":"<p><strong>Introduction: </strong>Rosacea is a very frequent skin disease; however, its prevalence in children is underestimated, and there are not enough data on this dermatosis in the pediatric population.</p><p><strong>Objective: </strong>This study aimed to give comprehensive insight into childhood rosacea (CR), pointing out predisposing factors, clinical presentation, diagnostic clues, and therapy of this subgroup of the disease spectrum.</p><p><strong>Methods: </strong>This is a narrative review of the existing data on rosacea in children.</p><p><strong>Results: </strong>Children affected by rosacea often present with recurrent erythema of the convex areas of the face as an early sign of the disease, mostly occurring after cold/heat/sun exposure or triggered by crying/playing/exercise. Phymatous lesions do not occur in children, and Morbihan disease has been very rarely reported. On the other hand, special rosacea subtypes, such as periorificial dermatitis, granulomatous rosacea, or idiopathic facial aseptic granuloma, are observed more often in children. The diagnosis is usually made based on the clinical picture; however, dermoscopy, and in some cases other imaging techniques, may aid the diagnosis. It is still a matter of debate whether a child affected by rosacea will become an adult with rosacea over time. The holistic approach to therapy of rosacea in children should include in particular the avoidance of triggering factors, proper skin care, and finally, adequate pharmacological treatment. Although procedural therapeutic options are frequently used in adults, their use in children should be tailored to the patient's age and discussed with the parents or caregivers.</p><p><strong>Conclusion: </strong>Rosacea may also occur in children. Therapeutic options do not significantly differ from those in adults; however, they must be adjusted to the child's age.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab in Epidermolysis Bullosa Pruriginosa: \"All That Glisters Is Not Gold for Every Age\".","authors":"Michela Magnano, Riccardo Balestri, Giulia Rech, Andrea Bassi, Carlo Mazzatenta","doi":"10.5826/dpc.1603a7049","DOIUrl":"10.5826/dpc.1603a7049","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Tuberculosis: A Dermatologic Masquerader Not to Be Overlooked.","authors":"Sibel Altunisik Toplu, Nihal Altunisik","doi":"10.5826/dpc.1603a6580","DOIUrl":"10.5826/dpc.1603a6580","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal Dermal Hypoplasia in Males: A Systematic Review.","authors":"Vincent Gao, Christopher Castelow, Kara Braudis, Benjamin Warren Casterline, Jonathan Dyer","doi":"10.5826/dpc.1603a6858","DOIUrl":"10.5826/dpc.1603a6858","url":null,"abstract":"<p><strong>Background: </strong>Focal dermal hypoplasia (FDH) is an X-linked dominant disorder characterized by dermal atrophy, fat herniations, telangiectasias, and pigmentary changes along Blaschko's lines, with multisystem involvement affecting the teeth, nails, eyes, and the skeletal, cardiovascular, and other systems. Initially thought embryonically lethal in males, later reports identified somatic mosaicism as a survival mechanism. The male phenotype remains incompletely defined.</p><p><strong>Objectives: </strong>To systematically review reported male FDH cases to consolidate phenotypic patterns, identify key features, and explore genotype-phenotype correlations.</p><p><strong>Methods: </strong>A systematic review of PubMed was conducted with no restrictions on publication date. This review was conducted in accordance with the PRISMA guidelines. Inclusion criteria were case reports and systematic reviews solely investigating FDH or Goltz syndrome.</p><p><strong>Results: </strong>Forty-five patient cases were identified across 38 case reports and studies. Dermal and skeletal involvement primarily involved extremities. Ophthalmological and dental anomalies, including microphthalmia, colobomas, and enamel defects, were variably present. PORCN variants were confirmed in all but one genetically tested patient, though phenotypes varied. The retrospective nature likely biased toward more severe or unusual presentations.</p><p><strong>Conclusions: </strong>FDH in males exhibits marked clinical variability. The observed heterogeneity in histopathological findings reinforces the need for flexible diagnostic criteria, with genetic testing for PORCN variants recommended when clinical suspicion remains high. A multidisciplinary approach is recommended, with surveillance of ocular, dental, and skeletal manifestations even in patients with minimal cutaneous findings. Further research into PORCN function and Wnt signaling is needed to refine genotype-phenotype relationships and explore alternative disease mechanisms.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented Orocutaneous Fistula: A Diagnostic Dilemma Unmasked by Dermoscopy.","authors":"Umberto Santaniello, Paolo Fava, Silvia Giordano, Francesco Cavallo, Simone Ribero, Pietro Quaglino","doi":"10.5826/dpc.1603a6619","DOIUrl":"10.5826/dpc.1603a6619","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopy of Transient Lingual Papillitis: The 'Jellyfish in a Sea of Red' Sign.","authors":"Srishti Dabas, Sree Parvathy, Vishal Gaurav, Krishan Deb Barman","doi":"10.5826/dpc.1603a6751","DOIUrl":"10.5826/dpc.1603a6751","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langerhans Cell Histiocytosis of the Vulva: A Pediatric Case.","authors":"Marina Romero Navarrete, María Elisa Vega Memije, Sabrina Escandón Pérez, Carla Itzel Figueroa Basurto, Roberto Arenas, Aureliano Delfino Castillo Solana","doi":"10.5826/dpc.1603a7045","DOIUrl":"10.5826/dpc.1603a7045","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generational Divides and Guidance Needs in the Use of Social Media: Results from an Italian Dermatology Survey.","authors":"Fortunato Cassalia, Andrea Danese, Carmine D'Acunto, Antonio Russo, Corrado Zengarini, Michelangelo La Placa, Christian Ciolfi, Filippo Scolaro, Ignazio Stanganelli, Francesco Cusano, Fabrizio Fantini, Salvatore Amato, Davide Melandri, Cesare Massone, Laura Ventura, Andrea Serracchia, Anna Belloni Fortina","doi":"10.5826/dpc.1603a6556","DOIUrl":"10.5826/dpc.1603a6556","url":null,"abstract":"<p><strong>Background: </strong>The growing influence of social media in healthcare raises ethical, regulatory, and professional concerns. Dermatology, positioned at the intersection of clinical, surgical, and aesthetic medicine, faces unique challenges in navigating this digital landscape.</p><p><strong>Objectives: </strong>To assess how dermatology professionals in Italy use social media; identify behavioural patterns and sociodemographic correlates; and explore perceived challenges, educational needs, and the potential role of institutional guidance.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted among Italian dermatologists, residents, students, and nurses (n = 201). The 25-item questionnaire explored demographics, platform use, content shared, and perceptions. Descriptive statistics, hierarchical clustering (Ward's method), and Multiple Correspondence Analysis (MCA) were used to assess usage patterns and their association with age, experience, and role.</p><p><strong>Results: </strong>Among respondents, 49.8% reported professional use of social media. Two clusters emerged: Cluster 1 (n = 52), mainly older, experienced professionals with low activity and limited platform use; and Cluster 2 (n = 48), younger, less experienced users more active on platforms like TikTok and Instagram. Significant associations were found with age (p < 0.001), experience (p < 0.001), and professional role (p = 0.0039). While most acknowledged social media's value for education and prevention, concerns emerged about misinformation, legal risks, and inadequate training. Only 11.4% had received formal instruction. Over 75% supported official recommendations.</p><p><strong>Conclusions: </strong>A generational divide and lack of structured training result in fragmented digital engagement among Italian dermatologists. Institutional guidance could help promote ethical communication, reinforce professional credibility, and support public health through trustworthy digital content.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}