Dermatology practical & conceptual最新文献

{"title":"Intra-Individual Comparative Study of Methotrexate versus Triamcinolone Acetonide Delivered via Microneedling for Recalcitrant Alopecia Areata.","authors":"Mofreh Mansour, Refaat R Mohamed, Athar Fathy Abodief Mohamed, Mahmoud A Rageh","doi":"10.5826/dpc.1603a6805","DOIUrl":"10.5826/dpc.1603a6805","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is a chronic, immune-mediated, non-scarring hair loss disorder. While intralesional corticosteroids remain first-line treatment, some patients with recalcitrant AA respond poorly. Microneedling enhances transdermal drug delivery via microchannel formation. Methotrexate, an established systemic immunomodulator, is effective in resistant AA but has been less extensively studied for topical administration.</p><p><strong>Objectives: </strong>To compare the efficacy and safety of methotrexate and triamcinolone acetonide, both delivered via microneedling, in recalcitrant AA.</p><p><strong>Methods: </strong>In this prospective, intra-individual comparative study, 34 patients with at least two patches of recalcitrant AA received microneedling followed by topical methotrexate (25 mg/mL) on one site and triamcinolone acetonide (5 mg/mL) on a matched site, administered fortnightly for 12 weeks. The primary outcome was the change in Severity of Alopecia Tool (SALT) score. Secondary outcomes included trichoscopic assessment, blinded photographic evaluation, patient satisfaction, and relapse rates at three-month follow-up. Safety was assessed at each visit.</p><p><strong>Results: </strong>Both treatment modalities were associated with overall clinical improvement. Methotrexate-treated areas showed significantly greater reductions in SALT scores (P<0.05), higher levels of patient satisfaction, and lower relapse rates at follow-up compared to triamcinolone-treated areas. Both modalities were well tolerated, with only mild, transient adverse effects reported.</p><p><strong>Conclusions: </strong>In this pilot intra-individual study, microneedling-assisted methotrexate appeared to provide superior short-term clinical outcomes to triamcinolone acetonide with an acceptable safety profile in recalcitrant AA. These findings warrant confirmation in larger, adequately powered controlled trials with 6-12-month follow-up to evaluate durability, relapse, and long-term safety.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyelid Cutaneous Metastasis of Parotid Gland Ductal Carcinoma.","authors":"Zdeněk Drlík, Martin Tichý, Barbora Šopíková, Veronika Slonková","doi":"10.5826/dpc.1603a7165","DOIUrl":"10.5826/dpc.1603a7165","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Nail Psoriasis with Topical Ruxolitinib in a Patient with Vitiligo.","authors":"Francesca Ambrogio, Caterina Foti, Benedetta Tirone, Alexandre Raphael Meduri","doi":"10.5826/dpc.1603a6523","DOIUrl":"10.5826/dpc.1603a6523","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Size and Early Response to Sonidegib in Locally Advanced Basal Cell Carcinoma: A Real-Life Case Series.","authors":"Vincenzo De Giorgi, Gabriella Perillo, Giovanni Cecchi, Federica Fazzari, Biancamaria Zuccaro","doi":"10.5826/dpc.1603a7083","DOIUrl":"10.5826/dpc.1603a7083","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striking Limb Asymmetry in Linear Morphea.","authors":"Clara Ureña-Paniego, Francisco Vilchez-Márquez","doi":"10.5826/dpc.1603a6675","DOIUrl":"10.5826/dpc.1603a6675","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking Facial Melanosis: A Prospective Clinico-Dermoscopic Study.","authors":"Sheethal K Jose, Priya Sara Kuryan, Diya Katrina Koikkara, Gauri Dinesh Mahabal, Leni George, C V Dincy Peter, Susanne A Pulimood, Meera Thomas","doi":"10.5826/dpc.1603a7032","DOIUrl":"10.5826/dpc.1603a7032","url":null,"abstract":"<p><strong>Introduction: </strong>Various entities of acquired facial melanosis present with considerable clinical overlap, posing diagnostic challenges. Dermoscopy is being increasingly used in its diagnosis.</p><p><strong>Objectives: </strong>To assess dermoscopic and clinicopathological features of facial melanosis in Fitzpatrick skin types IV-VI.</p><p><strong>Methods: </strong>A prospective cross-sectional study of clinical and dermoscopic features of facial melanosis-lichen planus pigmentosus (LPP), pigmented contact dermatitis (PCD), and facial acanthosis nigricans (FAN)-was conducted. Melasma, periorbital hyperpigmentation, and nevus of Ota were excluded.</p><p><strong>Results: </strong>Fifty-six patients were included: 31 (55.4%) with LPP, 18 (32.1%) FAN, and seven (12.5%) PCD. Clinically, LPP showed significantly more involvement of face (55.2 ± 22.2%) (P=0.029), especially the chin (29, 93.5%) (P=0.006). Dermoscopy revealed more than one pattern of pigment structures in 54 (96.4%) patients. Predominant patterns in LPP were reticular (21, 67.7%), peppered (15, 48.4%), and annular (13, 41.9%). There was an overlap of patterns like annular, annular-granular, and reticular in both LPP and PCD. Peppered (15, 48.4%) was significantly more in LPP (P=0.023), while linear dots were seen exclusively in LPP (4, 12.9%); smudged was significantly more in PCD (6, 85.7%) and FAN (15, 83.3%) (P=0.003). Concentric circles (16, 88.9%) and parallel lines (14, 77.8%) were significantly more in FAN (P<0.001 each), while crypts-gyri (10, 55.6%) and papillary projections (8, 44.4%) were seen exclusively in FAN. Combination of dots and clods was also significantly more in LPP (26, 83.9%; P=0.007), whereas blue-gray pigmentation (19, 61.3%) was observed exclusively in LPP.</p><p><strong>Conclusion: </strong>Distinct dermoscopic features aid in differentiating acquired facial melanosis. Blue-gray dots and clods in peppered, reticular, and linear dots patterns favor LPP, while concentric circles, parallel lines, crypts-gyri, and papillary projections suggest FAN. Recognition of these patterns may obviate biopsy in cosmetically sensitive areas.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evaluation of Clinical and Dermatoscopic Features of Scalp Nevi in Adults.","authors":"Hatice Gamze Demirdağ, Elif Demirci Saadet","doi":"10.5826/dpc.1603a6726","DOIUrl":"10.5826/dpc.1603a6726","url":null,"abstract":"<p><strong>Introduction: </strong>The dermatoscopic appearance of scalp tumors, especially melanocytic scalp lesions, differs from that on other body areas. Few studies have revealed the dermatoscopic characteristics of scalp nevi.</p><p><strong>Objectives: </strong>This study aimed to establish the clinical and dermatoscopic features of scalp nevi in adults and to compare dermatoscopic patterns according to the demographic and clinical features.</p><p><strong>Methods: </strong>This prospective study included 129 adult patients with 253 nevi. Demographic data of patients, clinical characteristics, and dermatoscopic features were recorded and compared.</p><p><strong>Results: </strong>The study enrolled 86 females (67%) and 43 males (33%) with a median age of 33.6 ± 11.3 years. The eclipse/reverse eclipse patterns were observed more frequently, while the papillomatous pattern was notably less common among younger patients than in older patients (P<0.001). The mean diameter of nevi was smaller in reticular pattern and larger in eclipse/reverse eclipse patterns (P<0.001). Vascular structures were present in 35.2% (N=89) of the nevi. While vessels were not observed in reticular pattern, vessels were present in 70% of the papillomatous pattern (P<0.001). Perifollicular hypopigmentation was observed in 53.8% (N=136) of the scalp nevi, and it was seen in almost all eclipse/reverse eclipse and reticular patterns (P<0.001).</p><p><strong>Conclusions: </strong>Dermatoscopic evaluation of scalp nevi provides more detailed information, helps to make a correct diagnosis, and facilitates patient management compared to clinical examination alone. Increasing awareness of the clinical characteristics and dermatoscopic features of scalp nevi can potentially decrease unnecessary surgical excisions.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin Equivocal Melanocytic Lesions and Melanoma in Situ: The Monitoring Versus Excision Dilemma in Daily Clinical Practice.","authors":"Saturnino Gasparini","doi":"10.5826/dpc.1603a7547","DOIUrl":"10.5826/dpc.1603a7547","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Dermoscopic Presentation of Rhabdomyomatous Mesenchymal Hamartoma: Differential Diagnosis and Review of the Literature.","authors":"Julia Nowowiejska-Purpurowicz, Mario Cutrone, Giuseppe Argenziano, Francesca Pagliuca, Andrea Bassi, Vincenzo Piccolo","doi":"10.5826/dpc.1603a7135","DOIUrl":"10.5826/dpc.1603a7135","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ablative Fractional CO₂ Laser Therapy for a Post-Mpox Facial Scar.","authors":"Justyna Czarny-Kamm, Damian Kadylak, Monika Sikorska, Roman J Nowicki","doi":"10.5826/dpc.1603a7149","DOIUrl":"10.5826/dpc.1603a7149","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}