Dermatology practical & conceptual最新文献

{"title":"New-Onset Blepharitis in Patient Treated with Secukinumab for Severe Psoriasis.","authors":"Maria Francesca Baracca, Filippo Viviani, Alessandro Pileri, Giacomo Clarizio, Federico Bardazzi","doi":"10.5826/dpc.1403a185","DOIUrl":"10.5826/dpc.1403a185","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis with Leg Involvement as the New Difficult-To-Treat Area: A Cohort Study of Patients Treated With Risankizumab.","authors":"Federico Bardazzi, Federica Filippi, Martina Mussi, Claudia Lasagni, Laura Bigi, Giulia Odorici, Francesca Peccerillo, Miriam Rovesti, Francesca Satolli, Michela Tabanelli, Sandra Schianchi, Vito Di Lernia, Marco Manfredini","doi":"10.5826/dpc.1403a171","DOIUrl":"10.5826/dpc.1403a171","url":null,"abstract":"<p><strong>Introduction: </strong>Historically, difficult-to-treat areas in psoriasis included face, scalp, folds, genitalia, nails, and palmoplantar region. Recent studies have found that lower limbs behave like a \"new\" difficult-to-treat area as they can be the only site of residual disease even in patients undergoing biologic therapies.</p><p><strong>Objectives: </strong>We aimed to evaluate whether legs had different response rates and response times to treatment with a new biologic drug, risankizumab, compared to other body sites.</p><p><strong>Methods: </strong>We conducted a real-life, observational, retrospective, multicenter study including patients affected by moderate-to-severe psoriasis with leg involvement and undergoing biological therapy with risankizumab for more than 16 weeks. The Psoriasis Area Severity Index (PASI) and Leg-PASI were collected at T0 and at weeks 16, 28, 40, 52, 64, and 76. Statistical analysis using Student's t test and linear regression analysis were performed.</p><p><strong>Results: </strong>A total of 124 patients were included. The difference between the improvement percentage compared to baseline was statistically significant at weeks 16 and 28, demonstrating that Leg-PASI improved less than PASI. From the linear regression it was deduced that the slope is statistically less steep for Leg-PASI than for overall PASI, confirming that this site responds more slowly to the therapy.</p><p><strong>Conclusions: </strong>Leg response to risankizumab appears to differ significantly from other body sites in the first weeks of treatment, even if after 28 weeks, statistical significance is lost. Our preliminary finding suggests that risankizumab can be considered an effective treatment for leg psoriasis but with longer response times than other areas, demonstrating the relative nature of resistance to treatment of this district.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acne Keloidalis Nuchae: A Multicenter Retrospective Study of 142 Hispanic Patients.","authors":"Luis E Sánchez-Dueñas, Mariana G Ungson-García, Joel Alejandro Ramírez-Sánchez, Antonio Michell Ayala Barrera, Miguel Marti Machado, Sonia Sofía Ocampo-Garza, Lizet K Rojano-Fritz, Aldo Gálvez-Canseco, Lidia Elena Bernal López, Daniela Gutierrez Mendoza, Roxana Castañeda Yepiz, Araceli Alvarado Delgadillo, Yakelin Morales Miranda","doi":"10.5826/dpc.1403a198","DOIUrl":"10.5826/dpc.1403a198","url":null,"abstract":"<p><strong>Introduction: </strong>Acne keloidalis nuchae (AKN) is a primary cicatricial alopecia with mixed infiltrate. It is more common in Africans or persons of African descent.</p><p><strong>Objectives: </strong>Our objective was to describe the epidemiology and clinical and trichoscopic presentations of AKN in a large series of Hispanic patients.</p><p><strong>Methods: </strong>This was a retrospective study from 10 different dermatological centers in Argentina, Colombia, Mexico, and Peru. Patients with a clinical diagnosis of AKN treated by 12 dermatologists experienced in trichology from 2018 to 2022 were included. The Umar classification system was used to determine severity.</p><p><strong>Results: </strong>We identified 142 patients with AKN: 98% were male (n=140) with a mean age of 32 years; 108 patients had a previous history of trauma to the nuchal area (76%, P < 0.001); and 48 were positive for a history of acne (33.8%, P = 0.021). Patients with >50 months of evolution were mainly classified in classes III and IV compared to patients with an evolution of <50 months (30%, n=9 vs. 14%, n=15; P = 0.019; respectively).</p><p><strong>Conclusion: </strong>AKN should be considered in the differential diagnosis in the Hispanic population. Advanced stages of the disease are correlated with chronic evolution.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chik Sign With Dermoscopic Findings in 10 Patients With Dengue: Case Series.","authors":"Bhavya Sangal, Shruti Barnwal, Devi Priya, Astha Pant, Aditi Vashisht","doi":"10.5826/dpc.1403a187","DOIUrl":"10.5826/dpc.1403a187","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Emerging Lentigo Maligna and the Role of Confocal Microscopy in Guiding PRAME-Directed Immunohistochemical Staining.","authors":"Sebastián González-Valdés, Alvaro Abarzúa-Araya","doi":"10.5826/dpc.1403a194","DOIUrl":"10.5826/dpc.1403a194","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Line-Field Optical Coherence Tomography: Usefulness in the Non-Invasive Differential Diagnosis of Congenital Alopecia of Infancy.","authors":"Linda Tognetti, Giulia Galluccio, Teresa Oranges, Elisa Pianigiani, Francesca Ierardi, Elisa Cinotti, Pietro Rubegni","doi":"10.5826/dpc.1403a142","DOIUrl":"10.5826/dpc.1403a142","url":null,"abstract":"<p><strong>Introduction: </strong>Soon after birth, the clinical differential diagnosis between sebaceous of Jadassohn (NSJ), congenital triangular alopecia (CTA) and aplasia cutis congenita (ACC) may be challenging. A certain overlap of standard dermoscopic features can occur, especially in atypical cases, depending on scalp skin morphology and maturation age. The recently developed line-field confocal optical coherence tomography (LC-OCT) can provide morphological skin details with cellular resolution trough a rapid non-invasive examination.</p><p><strong>Objectives: </strong>To assess the LC-OCT features of 6 cases of congenital alopecia of different aetiologies, with both typical and atypical clinical appearance.</p><p><strong>Methods: </strong>A non-invasive imaging examination combining standard dermoscopy, high-resolution videodermoscopy (HRVD) and LC-OCT was realized in 7 babies presenting for congenital alopecia with overlapping features, aged between 5 months and 5 years.</p><p><strong>Results: </strong>Based on the specific LC-OCT features, and supported by HRVD features, a diagnosis of NSJ, congenital triangular alopecia (CTA) and AC) were made in 4, 2 and 1 case, respectively.</p><p><strong>Conclusions: </strong>The combined LC-OCT plus HRVD non-invasive imaging bring the advantage to have a real time diagnosis, to set the proper management and allows to avoid a skin biopsy in the perinatal age/first years of life at delicate skin site.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the Treatment of Tinea Capitis With Trichoscopy - Are There Signs of Trichoscopic Cure?","authors":"Theodosia Gkentsidi, Konstantinos Kampouridis, Katerina Bakirtzi, Angeliki Panagopoulou, Aimilios Lallas, Eleni Sotiriou","doi":"10.5826/dpc.1403a158","DOIUrl":"10.5826/dpc.1403a158","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented Demodicosis: Non-Invasive Skin Imaging of a Rare Entity.","authors":"Stefania Guida, Claudia Lasagni, Silvana Ciardo, Francesca Farnetani, Caterina Longo, Giovanni Pellacani","doi":"10.5826/dpc.1403a164","DOIUrl":"10.5826/dpc.1403a164","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grinspan Syndrome: Does it Really Exist? - An Opinion Article.","authors":"Federico Bardazzi, Alessio Natale, Giacomo Clarizio, Alice Massi, Lidia Sacchelli, Michela Valeria Rita Starace","doi":"10.5826/dpc.1403a178","DOIUrl":"10.5826/dpc.1403a178","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hailey-Hailey Disease: Case Series and Review of Systemic Medications.","authors":"Kamran Balighi, Zahra Razavi, Maryam Daneshpazhooh, Vahide Lajevardi, Kambiz Kamyab-Hesari, Kimia Ghafouri","doi":"10.5826/dpc.1403a160","DOIUrl":"10.5826/dpc.1403a160","url":null,"abstract":"<p><strong>Introduction: </strong>Hailey-Hailey disease (HHD) is a rare inherited blistering skin disorder characterized by a chronic relapsing course. While it does not pose a serious threat to the patient's health, the quality of life can change. Unfortunately, there is currently no standard treatment for this condition.</p><p><strong>Objectives: </strong>In this observational retrospective cohort study, our aim was to discover the demographic characteristics and treatment strategies for managing HHD.</p><p><strong>Methods: </strong>In this retrospective cohort study, we documented the demographic, clinical, and histopathological characteristics beside various treatment employed options of patients diagnosed with HHD at Razi Hospital over the past 14 years.</p><p><strong>Results: </strong>A total of 32 patients with HHD were enrolled in the study (15 male and 17 female). The mean age of patients was 50.41 ± 13.15 (22-77) years. The average age of disease onset was 37.31 ± 11.88 (15-60) years. Among the participants, 16 individuals (50%) affirm a positive family history of some kind of pemphigoid blisters. The most common site of disease activity was the inguinal area, observed in 14 patients (33.33%). Histopathological examination discovered the existence of suprabasal acantholysis in all of the specimens. Worthily, direct immunofluorescence analysis showed negative results in all skin biopsies. All patients received topical steroids and either topical or systemic antimicrobial agents. In cases of flares, systemic steroids were the most popular and favorable treatment choice during flares.</p><p><strong>Conclusion: </strong>Indeed, Hailey-Hailey disease, characterized by its chronic inflammatory and rare nature with a relapsing and remitting course, poses a significant challenge for dermatologists. The treatment of HHD has been less than satisfactory and it often presents a challenge and could be misdiagnosed. Among the available treatment options, topical steroids and antimicrobial agents are the most administered therapies.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}