Kevin Jacobsen, Emily Wenande, Martin Glud, Merete Haedersdal, Vinzent Kevin Ortner
{"title":"Line-field Confocal Optical Coherence Tomography Image Markers of Basal Cell Carcinoma in Excised Mohs Micrographic Surgery Tissue: A Case Series.","authors":"Kevin Jacobsen, Emily Wenande, Martin Glud, Merete Haedersdal, Vinzent Kevin Ortner","doi":"10.5826/dpc.1501a5031","DOIUrl":"10.5826/dpc.1501a5031","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermoscopy of Early-Stage Mycosis Fungoides: Comparative Study with Inflammatory Dermatoses.","authors":"Amel Chabbouh, Noureddine Litaiem, Houda Hammami, Mourad Mokni, Faten Zeglaoui","doi":"10.5826/dpc.1501a4693","DOIUrl":"10.5826/dpc.1501a4693","url":null,"abstract":"<p><strong>Introduction: </strong>The diagnosis of early-stage mycosis fungoides (MF) is challenging and may be confused with plaque psoriasis (PP) and chronic dermatitis (CD).</p><p><strong>Objectives: </strong>Our study aimed to describe the dermoscopic features of early-stage MF and compare them with PP and CD.</p><p><strong>Methods: </strong>This was a multicenter cross-sectional study conducted in three tertiary referral dermatology departments in Tunisia between January 2021 and December 2021, including 89 patients with phototype III-V. For all patients, up to three representative cutaneous lesions were selected and examined using dermoscopy. Both clinical and dermoscopic photos were recorded for each selected lesion. Dermoscopic photos were interpreted by two independent evaluators.</p><p><strong>Results: </strong>Vascular structures significantly associated with the diagnosis of early-stage MF included polymorphic, coiled, serpentine, and linear vessels, in an unspecific distribution. Perpendicular white lines, white circles, and spermatozoa-like vessels were only noted in MF. Branched vessels were only observed in granulomatous MF. Conversely, monomorphous vessels in uniform distribution were associated with PP, whereas CD was associated with monomorphous vessels with unspecific distribution. Non-vascular structures associated with the diagnosis of MF included reticular lines, orange background color, and structureless areas. Pink background was more prevalent in PP and CD. Additionally, yellow clods were more frequently observed in patients with CD.</p><p><strong>Conclusions: </strong>This study highlights the characteristic dermoscopic features of early-stage MF compared with PP and CD. Perpendicular white lines, white circles, and spermatozoa-like vessels were only seen in MF. Follicular plugs and clods were features of folliculotropic MF and can help guide skin biopsy sites in difficult cases.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simge Ünal, Selda Pelin Kartal, Ahmet Özsoy, Fevzi Nuri Aydin
{"title":"Evaluation of Serum Zonulin Level and Intestinal Permeability in Patients with Chronic Spontaneous Urticaria and the Relationship Between Serum Zonulin Level and Disease Severity.","authors":"Simge Ünal, Selda Pelin Kartal, Ahmet Özsoy, Fevzi Nuri Aydin","doi":"10.5826/dpc.1501a4237","DOIUrl":"10.5826/dpc.1501a4237","url":null,"abstract":"<p><strong>Introduction: </strong>An emerging hypothesis suggests a potential link between enhanced intestinal permeability and the advancement of chronic spontaneous urticaria (CSU).</p><p><strong>Objective: </strong>This study aimed to investigate the role of intestinal permeability in the etiopathogenesis of CSU by measuring serum zonulin levels, a marker of intestinal permeability, in both CSU patients and control subjects. Additionally, the study sought to explore the correlation between the severity of the illness and zonulin levels.</p><p><strong>Methods: </strong>The study involved 61 patients with CSU and 59 healthy control individuals. For the CSU patients, comprehensive data were collected encompassing various aspects: age at onset of the condition, duration of the most recent attack, presence of any comorbid conditions, dosage of antihistamines being used, and urticaria activity score as well as detailed personal and family medical histories. Additionally, demographic information for these patients was also meticulously documented.</p><p><strong>Result: </strong>The study revealed a statistically significant difference in zonulin levels between the CSU patient group and the control group, with a p-value of 0.000, indicating a highly significant disparity. Furthermore, among the CSU patients, those who presented with angioedema exhibited considerably higher zonulin levels compared to those without angioedema. This variation in zonulin levels based on the presence of angioedema was also statistically significant, with a p-value of 0.023.</p><p><strong>Conclusion: </strong>The observed results suggest that increased intestinal permeability, as indicated by elevated zonulin levels, may play a crucial role in the pathophysiology of both CSU and angioedema. This association highlights the potential significance of intestinal permeability in the development and manifestation of these conditions.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eline Vandersteen, Katrien Smets, Sophie Bravo, Valerie Reynaert, Sherief R Janmohammed, Dirk Van Gysel
{"title":"Petechiae and Limb Weakness in a 12-Year-Old Boy.","authors":"Eline Vandersteen, Katrien Smets, Sophie Bravo, Valerie Reynaert, Sherief R Janmohammed, Dirk Van Gysel","doi":"10.5826/dpc.1501a4738","DOIUrl":"10.5826/dpc.1501a4738","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marek Pásek, Eva Sticová, Emanuel Marques, Vojtěch Tretera, Petr Arenberger, Monika Arenbergerová
{"title":"Lichen Planus-Like Exanthema Induced by Anti-PD-1 and Anti-LAG-3 Combination Immunotherapy Could Potentially Predict the Treatment Response in Metastatic Melanoma.","authors":"Marek Pásek, Eva Sticová, Emanuel Marques, Vojtěch Tretera, Petr Arenberger, Monika Arenbergerová","doi":"10.5826/dpc.1501a4967","DOIUrl":"10.5826/dpc.1501a4967","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patients with Isolated Nail Psoriasis Are at Increased Risk for Asthma Compared to Controls in a Retrospective Cohort Study at a Single Academic Institution.","authors":"Rachel C Hill, Rhiannon C Miller, Shari R Lipner","doi":"10.5826/dpc.1501a4797","DOIUrl":"10.5826/dpc.1501a4797","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}