甲型银屑病的临床及超声评价:一项综合研究。

IF 2.3 4区 医学 Q2 DERMATOLOGY
Maria Esposito, Lina Maria Magnanimi, Paolo Antonetti, Andrea De Berardinis, Cristina Pellegrini, Emanuele Vagnozzi, Manfredo Bruni, Camilla Gianneramo, Paola Cipriani, Maria Concetta Fargnoli, Antonio Barile, Piero Ruscitti
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引用次数: 0

摘要

在斑块型银屑病(PsO)患者中,进展为银屑病关节炎(PsA)加剧了疾病的影响并增加了残疾风险。指甲牛皮癣(NP)影响高达90%的PsO患者,具有广泛的临床特征,并且是炎症的重要预测因子,通常与早期PsA阶段相关。目的:本研究旨在对PsO患者的甲单位进行临床和超声评价,重点探讨伴有/不伴有PsA的患者与伴有/不伴有甲病的患者的差异。方法:纳入60例患者(23/60 PsO和37/60 PsO + PsA)。在本横断面单中心研究中,评估和比较了PsO和PsA患者,以及诊断为指甲银屑病/未诊断为指甲银屑病的患者。采用高频探头(27 MHz)进行高频超声(HFUS)检查。描述性评估后,指甲银屑病严重程度指数(NAPSI)和布朗大学指甲内陷量表(BUNES)用于临床和超声评估指甲。结果:HFUS评估确定了指甲和血流变化的频谱。指甲疾病的特征是NAPSI中位数16(范围28),BUNES形态测量中位数1.5(范围0.9),BUNES功率多普勒(PD)中位数2.2(范围4.03)。在研究样本中,43/60(71.7%)的患者表现为甲牛皮癣,其中69.7%的患者存在PsA,而PsO患者(30.3%)存在PsA (P=0.04)。结论:我们的研究结果强调了皮肤科医生和风湿病学家在评估PsO患者时密切合作的重要性,利用临床和超声评估指甲损伤的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and Ultrasonographic Assessment of Nail Psoriasis: A Comprehensive Study.

Introduction: In patients with plaque type psoriasis (PsO), the progression to psoriatic arthritis (PsA) exacerbates the disease's impact and increases disability risk. Nail psoriasis (NP) affects up to 90% of PsO patients, with a wide spectrum of clinical features, and is a significant predictor of enthesitis, often associated with early PsA stages.

Objective: This study aimed to clinically and ultrasonographically evaluate nail units in PsO patients, focusing on differences between those with/without PsA and those with/without onychopathy.

Methods: Sixty patients were enrolled (23/60 PsO and 37/60 PsO and PsA). PsO and PsA patients were evaluated and compared, as were patients with/without diagnosis of nail psoriasis in this cross-sectional single-center study. Nail abnormalities were evaluated by high frequency ultrasound (HFUS) using high frequency probes (27 MHz). After a descriptive assessment, the Nail Psoriasis Severity Index (NAPSI) and the Brown University Nail Enthesis Scale (BUNES) were used to clinically and ultrasonographically assess nails.

Results: HFUS evaluation identified a spectrum of nail and blood flow alterations. Nail disease was characterized by median NAPSI 16 (range 28), median BUNES morphometry 1.5 (range 0.9), and median BUNES power doppler (PD) 2.2 (range 4.03). Among the studied sample, 43/60 (71.7%) presented nail psoriasis, with 69.7% presenting coexisting PsA as compared to PsO patients (30.3%) (P=0.04).

Conclusion: Our findings highlight the importance of close collaboration between dermatologists and rheumatologists in the evaluation of PsO patients, taking advantage of both clinical and ultrasonographic assessment of nail damage.

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CiteScore
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