Dermatology practical & conceptual最新文献_第6页

Keep an Eye on At-Home Devices: Energy-Based Acne and Anti-Aging Devices are Associated with Ocular Adverse Events in a Retrospective Analysis Using the MAUDE Database. 密切关注家用设备：使用 MAUDE 数据库进行的一项回顾性分析显示，基于能量的痤疮和抗衰老设备与眼部不良事件有关。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a174

Rachel C Hill, Shari R Lipner

引用次数: 0

Stage IIA Cutaneous Melanoma: Do Regional Ultrasound and CT scan Improve Detection of Relapses? A Multicenter Retrospective Observational Study. IIA 期皮肤黑色素瘤：区域超声波和 CT 扫描能提高复发的检测率吗？一项多中心回顾性观察研究。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a155

Giulia Briatico, Gabriella Brancaccio, Elvira Moscarella, Caterina Longo, Stefania Borsari, Roberta Ruggeri, Giovanni Docimo, Giuseppe Argenziano

{"title":"Stage IIA Cutaneous Melanoma: Do Regional Ultrasound and CT scan Improve Detection of Relapses? A Multicenter Retrospective Observational Study.","authors":"Giulia Briatico, Gabriella Brancaccio, Elvira Moscarella, Caterina Longo, Stefania Borsari, Roberta Ruggeri, Giovanni Docimo, Giuseppe Argenziano","doi":"10.5826/dpc.1403a155","DOIUrl":"10.5826/dpc.1403a155","url":null,"abstract":"Introduction: Stage IIA cutaneous melanoma is typified by a Breslow thickness between 1.1 and 2.0 mm with ulceration or between 2.1 and 4.0 mm without ulceration. The role of radiological investigations in staging and follow-up of this intermediate-risk subgroup of patients is still debated.Objectives: The aim of this study is to investigate the role of imaging procedures in the follow-up of stage IIA melanoma asymptomatic patients.Methods: Data were retrieved from two tertiary referral centers in Italy. Among patients with stage IIA melanoma, those who relapsed were investigated concerning type of detection (by patient or by doctor), and modality of detection (clinical examination, ultrasound, CT scan). In addition, false positive data were collected.Results: In total, 213 patients were retrieved, with 26 patients showing relapse (recurrence rate, 12.2%). The mean follow-up time was 3 years and the mean time to recurrence was 17.8 months. 21/26 (80.7%) recurrences were identified by the doctor and 5/26 (19.2%) by the patient (P < 0.05). Among those identified by the doctor, 16/21 (76,1%) were identified by radiological examinations. Nine out of 15 (60%) lymph node recurrences were detected by ultrasound and 6/7 (85.7%) distant metastases were detected by CT. The false positive rate was 7% (P < 0.05).Conclusions: In our study the great majority of metastases were detected using imaging procedures. Given the new therapeutic options offered by targeted therapy and immunotherapy in relapsing patients, the role of radiological investigations in the follow-up of stage IIA patients should be reconsidered.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sun Exposure of Preschoolers, Parental Sun Protection Behavior, and Sun Protection Measures at Preschool in Bavaria-Comparison of Two Cross-Sectional Studies of 2010/11 and 2018/19. 巴伐利亚学龄前儿童的日晒、家长的防晒行为和学龄前儿童的防晒措施--2010/11 年和 2018/19 年两项横断面研究的比较。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a127

Christine Korbely, Jonas Huß, Caroline Quartucci, Uta Nennstiel, Rike Severin, Burkhard Summer, Eva Oppel, Dennis Nowak, Caroline Herr, Stefanie Heinze, Susanne Kutzora

{"title":"Sun Exposure of Preschoolers, Parental Sun Protection Behavior, and Sun Protection Measures at Preschool in Bavaria-Comparison of Two Cross-Sectional Studies of 2010/11 and 2018/19.","authors":"Christine Korbely, Jonas Huß, Caroline Quartucci, Uta Nennstiel, Rike Severin, Burkhard Summer, Eva Oppel, Dennis Nowak, Caroline Herr, Stefanie Heinze, Susanne Kutzora","doi":"10.5826/dpc.1403a127","DOIUrl":"10.5826/dpc.1403a127","url":null,"abstract":"Introduction: Children's skin is particularly susceptible to the carcinogenic effects of ultraviolet radiation. Young children are dependent on sun protection measures taken by parents and other caregivers.Objectives: The aim of the study is to evaluate parental sun protection behavior and sun protection measures at preschool at two points in time (2010/11 and 2018/19) in Bavaria and to test for a secular trend.Methods: Two cross-sectional surveys were carried out. For each survey, more than 4,000 parents of preschoolers completed a self-administered questionnaire about parental sun protection behavior and sun protection measures at preschool. To identify possible associations between parental sun protection behavior and sociodemographic characteristics, logistic regression analysis was carried out.Results: In the survey of 2018/19, six out of eight sun protection measures are adequately applied by over two-thirds of the parents. Two out of eight sun protection measures are adequately applied by less than one-third of the parents. Those two measures are aligning sun protection to actual UV index and preschoolers wearing sunglasses. The comparison of the study population of the survey of 2010/11 and of 2018/19 shows an improvement in parental sun protection behavior for seven out of eight sun protection measures. In both surveys more than 80% of parents state that preschool staff ensures preschoolers wear sun hats and sunscreen outside on sunny days.Conclusions: Future campaigns should focus on the use of sunglasses and promote the UV index, as these sun protection measures are used very little.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Dermoscopic Diagnosis of Actinic Keratosis. 放电性角化病的临床和皮肤镜诊断。

IF 4.6 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403S1a147S

Claudio Conforti, Luca Ambrosio, Chiara Retrosi, Carmen Cantisani, Giovanni Di Lella, Luca Fania, Roberta Rotunno, Iris Zalaudek, Giovanni Pellacani

引用次数: 0

Might Necrotic Keratinocytes Contribute to the Diagnosis and Pathogenesis of Psoriasis? 坏死的角质形成细胞可能有助于牛皮癣的诊断和发病机制吗？

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a213

Bengü Çevirgen Cemil, Aysun Gökçe, Gamze Taş Aygar, Selda Pelin Kartal

{"title":"Might Necrotic Keratinocytes Contribute to the Diagnosis and Pathogenesis of Psoriasis?","authors":"Bengü Çevirgen Cemil, Aysun Gökçe, Gamze Taş Aygar, Selda Pelin Kartal","doi":"10.5826/dpc.1403a213","DOIUrl":"10.5826/dpc.1403a213","url":null,"abstract":"Introduction: Psoriasis is a chronic inflammatory skin disease that can pose challenges for histopathological diagnosis. Recent research has emphasized the importance of necrotic keratinocytes, meaning keratinocytes undergoing programmed cell death, for diagnosing psoriasis. It has also become increasingly evident that programmed cell death pathways play a significant role in psoriasis's pathogenesis, development, and progression, including via a recently identified programmed cell death mechanism called \"PANoptosis.\"Objectives: In our study, we aimed to investigate the significance of necrotic keratinocytes in both the diagnosis and pathogenesis of psoriasis.Methods: We analyzed the number of necrotic keratinocytes in 135 samples of psoriasis, 57 samples of psoriasiform spongiotic dermatitis, and 71 samples of normal skin. We additionally assessed the distribution of necrotic keratinocytes in the upper, middle, and lower thirds of the epidermis.Results: Our findings revealed a significant difference in the total number of necrotic keratinocytes and their distribution within epidermal regions between patients with psoriasis and both the psoriasiform spongiotic dermatitis and control groups (p < .001). In particular, necrotic keratinocytes were predominantly found in the upper epidermis (77.5%) in patients with psoriasis. We also observed a strong correlation between Psoriasis Area and Severity Index scores and the total count of necrotic keratinocytes in patients with psoriasis (r = .72).Conclusions: Our results highlight the role of necrotic keratinocytes, resulting from programmed cell death, as important marker cells in both the diagnosis and pathogenesis of psoriasis.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatoscopy and Histology of Primary Cutaneous Aggressive Epidermotropic CD8+ T-Cell Lymphoma. 原发性皮肤侵袭性表皮向性 CD8+ T 细胞淋巴瘤的皮肤镜检查和组织学研究。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a141

Katerina Grafanaki, Helen Kourea, Maria Liga, E Vryzaki, Sophia Georgiou, Zoe Apalla

引用次数: 0

Efficacy of Leflunomide Compared to Methotrexate in the Treatment of Moderate to Severe Plaques Psoriasis: A Randomized Controlled Clinical Trial. 来氟米特治疗中重度斑块型银屑病的疗效与甲氨蝶呤相比：随机对照临床试验》。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a165

Hany Othman Aboelwafa, Hassan Abou Khodair Mohamed, Doaa Mamdouh Ibrahim, Nermeen Ibrahim Bedair

{"title":"Efficacy of Leflunomide Compared to Methotrexate in the Treatment of Moderate to Severe Plaques Psoriasis: A Randomized Controlled Clinical Trial.","authors":"Hany Othman Aboelwafa, Hassan Abou Khodair Mohamed, Doaa Mamdouh Ibrahim, Nermeen Ibrahim Bedair","doi":"10.5826/dpc.1403a165","DOIUrl":"10.5826/dpc.1403a165","url":null,"abstract":"Introduction: Psoriasis is a chronic inflammatory autoimmune skin disease. Several treatment options are available including topical and systemic options. Methotrexate was the main systemic medication in treating severe psoriasis, yet adverse events can limit its use. Leflunomide is an isoxazole derivative that inhibits the synthesis of pyrimidines, and subsequently inhibits RNA and DNA synthesis.Objectives: As available data directly comparing MTX to leflunomide in psoriasis are lacking, this double blinded study was designed to compare the efficacy of methotrexate versus leflunomide in the treatment of moderate to severe psoriasis.Methods: The study included 40 patients (25 males and 15 females) with chronic plaque psoriasis. s. Patients were randomly assigned to one of two equal groups, group A for subcutaneous methotrexate injections and group B for leflunomide (loading dose 100mg daily for the first 3 days, then 20 mg daily for 3 months. Disease severity was determined by psoriasis area and severity index (PASI) score before and at the end of treatment The treatment response was evaluated at the baseline and weeks 4, 8 and 12 PASI score.Results: Both groups were matching at the baseline in aspects of gender, age, disease duration and PASI scores Both medications yielded comparable results with no significant difference between both groups in PASI score neither in side effects.Conclusions: Leflunomide can be as effective as methotrexate in treatment of moderate to severe psoriasis.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Demographic and Clinical Characteristics of Turkish Patients With Primary Cutaneous Melanoma: A 5-Year Experience of a Tertiary Referral Center. 评估土耳其原发性皮肤黑色素瘤患者的人口统计学和临床特征：一家三级转诊中心的五年经验。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a135

Irfan Gahramanov, Gulsen Akoglu, Eda Karaismailoglu, Nuri Karadurmus

{"title":"Evaluation of Demographic and Clinical Characteristics of Turkish Patients With Primary Cutaneous Melanoma: A 5-Year Experience of a Tertiary Referral Center.","authors":"Irfan Gahramanov, Gulsen Akoglu, Eda Karaismailoglu, Nuri Karadurmus","doi":"10.5826/dpc.1403a135","DOIUrl":"10.5826/dpc.1403a135","url":null,"abstract":"Introduction: Data about the demographic and clinical characteristics of melanoma patients in Turkey is limited.Objectives: Data about the demographic and clinical characteristics of melanoma patients in Turkey is limited. We aimed to review the features of patients with primary cutaneous melanoma (PCM) diagnosed and treated in a tertiary referral center.Methods: The medical records of melanoma patients followed up by the Departments of Dermatology and Medical Oncology were retrospectively reviewed.Results: Within a 5-year period, 180 patients had been diagnosed with melanoma. Of all, 158 (87.8%) had PCM, 9 (5%) had mucosal melanoma, 9 (5%) had unknown primary melanoma, and 4 (2.2%) had ocular melanoma. Of 146 patients with PCM, 32.9% had stage I, 28.8% had stage II, 17.8% had stage III, and 20.5% had stage IV disease. The most common subtype was superficial spreading melanoma (38.8%). A statistically significant correlation was found between the patients Breslow thickness and lymph node involvement, histopathological subtype, and tumor ulceration (P < 0.001). Among all PCM patients, those in stage IV had the lowest 5-year survival rate when compared to the other disease stages (P < 0.001).Conclusions: Relatively younger age at melanoma diagnosis, frequent presence of thick (> 4 mm) tumor, and frequent acral lentiginous subtype are the most remarkable features that suggest the low awareness and knowledge of melanoma in our population.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11314554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study. 使用局部胰岛素微针注射与使用非交联透明质酸微针注射治疗萎缩性痤疮后瘢痕：分脸研究

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a183

Shaimaa Hassan Mohamed, Ghada Abd-Elbadea Omar, Aliaa El-Sayed Hamdy

{"title":"Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study.","authors":"Shaimaa Hassan Mohamed, Ghada Abd-Elbadea Omar, Aliaa El-Sayed Hamdy","doi":"10.5826/dpc.1403a183","DOIUrl":"10.5826/dpc.1403a183","url":null,"abstract":"Introduction: Post-acne scars are a prevalent cosmetic complaint that usually require multi-modality treatment to achieve accepted results.Objectives: The target of this research was to evaluate and compare the efficacy and safety of microneedling with topical insulin versus microneedling with non-cross-linked hyaluronic acid in atrophic post-acne scar treatment.Methods: The current comparative split-face research included 30 patients with atrophic facial acne scars. Each patient received six sessions of microneedling with topical insulin on one side of the face and microneedling with non-cross-linked hyaluronic acid on the other side. Sessions were done three weeks apart, and digital photographs were taken before and three months after the last treatment session. Goodman and Baron qualitative and quantitative grading system was used to evaluate the improvement across both sides of the face, along with patient satisfaction.Results: Three months after the last session, a statistically significant improvement in qualitative acne scar grading on both sides of the face (P < 0.001) was reported, with non-significant difference between the two sides (P = 0.864). Moreover, the mean percentage of improvement in quantitative acne scar grading was 49.18 ± 13.22 on the insulin side and 47.72 ± 15.08 on the hyaluronic acid side, with non-significant difference between the two sides after treatment (P = 0.235).Conclusion: Both microneedling with topical insulin and with non-cross-linked hyaluronic acid achieved comparable significant improvement of atrophic post-acne scars.","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11313770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Invasive Imaging of Basal Cell Carcinoma with Neuroendocrine Differentiation with Line-Field Confocal Optical Coherence Tomography. 用线场共聚焦光学相干断层扫描对神经内分泌分化的基底细胞癌进行非侵入性成像。

IF 2.5 4区医学

Dermatology practical & conceptual Pub Date : 2024-07-01 DOI: 10.5826/dpc.1403a173

Lorenzo Barbarossa, Arianna Lamberti, Costantino Ricci, Mariano Suppa, Elisa Cinotti, Pietro Rubegni, Linda Tognetti

引用次数: 0