Dermatology practical & conceptual最新文献

{"title":"Negative Emotions Induce Urticaria by Regulating Metabolites: A Two-Step Mendelian Randomization Study.","authors":"Keyi Zhang, Yibo Hu, Li Lei, Chuhan Fu, Shu Zhou, Yaqing Wen, Jiangfeng Huang, Jinhua Huang, Jing Chen, Qinghai Zeng","doi":"10.5826/dpc.1603a6592","DOIUrl":"10.5826/dpc.1603a6592","url":null,"abstract":"<p><strong>Introduction: </strong>Several studies have indicated a potential link between emotions and urticaria. However, the causal relationship between different emotions and urticaria and its subtypes, as well as whether circulating metabolites act as mediators, remains unclear.</p><p><strong>Objectives: </strong>To investigate the causal relationships between negative emotions, circulating metabolites, and urticaria and its subtypes, and to assess the mediating effects of circulating metabolites.</p><p><strong>Methods: </strong>Instrumental variables for eight negative emotions, 1400 circulating metabolic factors, and urticaria were sourced from publicly available GWAS summary data. We used Mendelian randomization (MR) to explore the causal links between emotions, circulating metabolites, and urticaria, utilizing inverse variance weighting (IVW) as the main statistical approach.</p><p><strong>Result: </strong>The MR analysis results showed that nervous feelings (P=0.046; 95% CI:1.02-7.65) and worrier/anxious feelings (P=0.016; 95% CI:1.17-4.60) may be risk factors of urticaria. In addition, we found that 17 metabolites and three metabolite ratios increased the risk of urticaria, while 18 metabolites and two metabolite ratios were protective factors.</p><p><strong>Conclusion: </strong>The mediating MR analysis revealed that worrier/anxious feelings increase urticaria risk by decreasing mannose, mannonate, and glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)) levels and by increasing the phosphate-to-mannose ratio and glucose-to-mannose ratio. However, the relationship between nervous feelings and urticaria is not mediated by metabolites. These findings provide new perspectives and potential strategies for the comprehensive prevention and treatment of urticaria through emotional and metabolic interventions.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate, Seasons, and Skin Cancer: A 16-Year Retrospective Study of Trends in New Zealand.","authors":"Sharad P Paul, Suresh Lama, Mahsa Mohaghegh, Allanah Knight","doi":"10.5826/dpc.1603a7139","DOIUrl":"10.5826/dpc.1603a7139","url":null,"abstract":"<p><strong>Introduction: </strong>Skin cancer remains a major public health concern in New Zealand, where high ultra-violet (UV) radiation and a predominantly fair-skinned population contribute to some of the world's highest incidence rates. While national prevalence has recently been documented, less is known about how skin cancer incidence fluctuates across months, seasons, and years, or how these temporal patterns relate to short-term environmental factors such as UV index, temperature, and rainfall.</p><p><strong>Objectives: </strong>This study aimed to quantify seasonal and long-term trends in basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM) diagnosed between 2009 and 2024 and to examine their associations with environmental conditions.</p><p><strong>Methods: </strong>A retrospective analysis of 24,653 biopsy-confirmed cases was conducted using clinical records from a New Zealand skin cancer clinic over a 16-year period. Monthly incidence rates were modelled with negative-binomial regression incorporating Fourier terms to test for seasonality and long-term temporal trends were evaluated. Lagged Pearson correlations (0-6 months) were calculated to assess associations between cancer incidence and environmental variables (UV, temperature, rainfall).</p><p><strong>Results: </strong>BCC and SCC showed significant seasonal peaks in late summer and early autumn, demonstrating a delayed but consistent rise following peak UV exposure over summer months, while MM displayed minimal or inconsistent seasonality. These results may help public health advice and prevention measures..</p><p><strong>Conclusions: </strong>This 16-year analysis highlights distinct seasonal and long-term temporal dimensions in skin cancer incidence within New Zealand's high-UV environment, with clear increases in non-melanoma skin cancer incidence (but not melanoma incidence) following summer months.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Disease Activity, Depression Severity, and Quality of Life in Chronic Spontaneous Urticaria.","authors":"Tuba Vural, Hacer Vural Karatoprak","doi":"10.5826/dpc.1603a7067","DOIUrl":"10.5826/dpc.1603a7067","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic spontaneous urticaria (CSU) is often a psychophysiological comorbidity. Depression is believed to both cause and sustain CSU.</p><p><strong>Objectives: </strong>We aimed to investigate the severity of depression in patients with CSU and the impact of CSU on quality of life.</p><p><strong>Methods: </strong>We enrolled 150 CSU and 75 healthy controls. We calculated the disease activity with Urticaria Activity Score 7 (UAS7) and divided the chronic urticaria patients into two groups as mild-moderate CSU (N=75) and severe CSU (N=75). We used the Patient Health Questionnaire-9 (PHQ-9) to measure the severity of depression in all patients and the Dermatology Life Quality Index (DLQI) to measure the quality of life in 150 CSU patients.</p><p><strong>Results: </strong>Significant main effects were observed for disease severity (P<0.001) and sex (P<0.001) on rank-transformed DLQI scores and PHQ-9 scores. Patients with severe CSU had substantially higher adjusted rank-transformed DLQI and PHQ-9 scores than those with mild-moderate CSU (P<0.001). Similarly, females exhibited higher rank-transformed DLQI and PHQ-9 scores compared to males (P<0.001). Among covariates, disease duration exerted a strong positive effect on rank-transformed DLQI and PHQ-9 scores (P<0.001). Additionally, the presence of angioedema was associated with increased depressive symptoms (P=0.042), whereas allergic comorbidities had a minor protective effect (P=0.001).</p><p><strong>Conclusion: </strong>This multicenter study demonstrated that disease severity and duration are the primary determinants of elevated rank-transformed DLQI and PHQ-9 scores in patients with chronic spontaneous urticaria, while female sex contributes a modest but significant effect.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing the Treatment Response of Tetracyclines for Papulopustular Rash Induced by Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors: A Retrospective Study.","authors":"Tae Min Kim, Namkyu Kim, Jimin Woo, Bhumsuk Keam, Ji Su Lee, Seong Jin Jo","doi":"10.5826/dpc.1603a7022","DOIUrl":"10.5826/dpc.1603a7022","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthralgia in Patients with Chronic Plaque Psoriasis: Practical Insights for Dermatologists.","authors":"Paolo Gisondi, Francesco Bellinato, Enzo Errichetti, Luca Idolazzi, Alen Zabotti","doi":"10.5826/dpc.1603a7416","DOIUrl":"10.5826/dpc.1603a7416","url":null,"abstract":"<p><strong>Introduction: </strong>Arthralgia is a frequent but often overlooked symptom in patients with psoriasis (PsO) and may represent an early manifestation of psoriatic arthritis (PsA).</p><p><strong>Objective: </strong>To provide a practical overview aiming to support dermatologists in the identification and management of arthralgia in PsO.</p><p><strong>Methods: </strong>An expert panel comprising three dermatologists and two rheumatologists convened to discuss data from a literature search of PubMed/MEDLINE and EMBASE conducted using the terms \"arthralgia\" and \"psoriasis.\" Relevant studies were qualitatively analyzed based on clinical relevance and available data on epidemiology, pathophysiology, diagnosis, and management.</p><p><strong>Results: </strong>Predictors of PsA development and distinctions between inflammatory and noninflammatory joint pain are presented, and the main differential diagnoses such as osteoarthritis and fibromyalgia are discussed. The importance of validated screening tools, early imaging, and timely rheumatology referral is emphasized, along with recommendations for patient education and risk factor management.</p><p><strong>Conclusions: </strong>Dermatologists play a central role in the early detection of arthralgia in patients with PsO. Timely rheumatology referral is essential to facilitating early intervention, preventing irreversible joint damage, and improving long-term outcomes.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatoscopic Assessment of Nail Fold Capillary Patterns in Patients of Color with Different Autoimmune Connective Tissue Diseases.","authors":"Eman Ayesha, Sumera Hanif, Madeline Tchack, Emma Didzbalis, Maria Elisabetta Greco, Talat Akbar, Aliza Hashim, Rabia Shaukat, Hooryia Shafiq Butt, Noah Musolff, Babar Rao, Haroon Nabi","doi":"10.5826/dpc.1603a6840","DOIUrl":"10.5826/dpc.1603a6840","url":null,"abstract":"<p><strong>Introduction: </strong>Nail fold capillaroscopy is a noninvasive tool for assessing early capillary changes in proximal nail fold capillaries in autoimmune connective tissue diseases. Handheld dermatoscopes have expanded its clinical application.</p><p><strong>Objectives: </strong>To characterize nail fold capillary patterns using dermatoscopy and evaluate their association with autoimmune connective tissue disease severity in patients with skin of color (Fitzpatrick skin types IV, V and VI).</p><p><strong>Methods: </strong>A six-month cross-sectional study was conducted at Ghurki Trust Teaching Hospital in Lahore, Pakistan. Ninety-six patients with Fitzpatrick skin types IV-VI and autoimmune connective tissue diseases underwent dermatoscopic evaluation (HEINE DELTA 30 Dermatoscope) and clinical assessment of disease activity.</p><p><strong>Results: </strong>Most participants were female (84.4%). The diagnoses included rheumatoid arthritis (RA) (51%), systemic lupus erythematosus (SLE) (27%), systemic scleroderma (SSc) (17%), and dermatomyositis (DM) (5%). Capillary patterns varied significantly with disease duration (p = 0.001) and diagnosis. Normal patterns were observed in 27 patients (28.1%), nonspecific patterns in 28 patients (29.2%), and scleroderma patterns in 41 patients (42.7%). Scleroderma patterns were most frequent in those with SSC and SLE. Focal microhemorrhages (52.1%) and areas of discrete devascularization (50%) were the most prevalent microvascular findings. Capillary patterns were significantly associated with disease severity (p < 0.001).</p><p><strong>Conclusions: </strong>Dermatoscopic assessment of nail fold capillaries may provide a valuable, noninvasive biomarker of disease activity in autoimmune connective tissue diseases. This study provides valuable data on skin of color, which remains underrepresented in dermatological research.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Nodular Melanomas May Represent Epidermotropic Melanoma Metastases Diagnosed at a Later Stage.","authors":"Félix Khoa Pham, Marie Danset, Olivier Harou, Damien Vasseur, Jonathan Lopez, Luc Thomas","doi":"10.5826/dpc.1603a7087","DOIUrl":"10.5826/dpc.1603a7087","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and Immunohistochemical Study of Hypopigmented Patches in Trichrome Non-Segmental Vitiligo.","authors":"Mona Ibrahim Abdel Hafiz, Ghada Abdel Badea Omar, Nafissa Mohamed El-Badawy, Radwa Osama Mohamed Kamel","doi":"10.5826/dpc.1603a7077","DOIUrl":"10.5826/dpc.1603a7077","url":null,"abstract":"<p><strong>Introduction: </strong>Vitiligo is a multifactorial autoimmune disease. A comprehensive understanding of the pathogenesis within the trichrome area, particularly of the role of CD8+ and CD4+ T lymphocytes, is crucial to developing effective therapeutic strategies.</p><p><strong>Objectives: </strong>We aimed to characterize the distinct histopathological and immunohistochemical features of trichrome non-segmental vitiligo, with a specific focus on CD4+ and CD8+ T lymphocyte populations within different pigmentary zones of a single lesion to elucidate the pathogenesis of this vitiligo subtype.</p><p><strong>Methods: </strong>Thirty patients with trichrome non-segmental vitiligo were enrolled. Four mm skin punch biopsies were obtained from vitiligo, trichrome, and adjacent apparently normal skin areas of each patient. Biopsies were immunohistochemically stained to assess the expression of CD4+ and CD8+ T cells.</p><p><strong>Results: </strong>The study revealed a statistically significant difference in CD4+ T cell count across vitiliginous, trichrome, and apparently normal skin areas (P<0.001), with significantly higher values in the vitiliginous area than the apparently normal skin, and both elicited significantly higher values than the trichrome area. CD8+ T cell count was significantly different across the three skin areas (P<0.001), being significantly lower in the vitiliginous area than the trichrome and significantly higher in both than in the apparently normal skin area. Furthermore, a significant positive correlation was found between VIDA scores and CD8+ T cell numbers in trichrome areas (r=0.688, P<0.001).</p><p><strong>Conclusion: </strong>The trichrome area represents a critical area to consider in the development of effective treatment strategies for vitiligo.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Presentation of Epidermolysis Bullosa Simplex with Predominant Plantar Keratoderma Due to a Novel KRT14 Variant.","authors":"Bassi Andrea, Brena Michela, Colavito Davide, Tadini Gianluca, Mazzatenta Carlo","doi":"10.5826/dpc.1603a6547","DOIUrl":"10.5826/dpc.1603a6547","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Adverse Reactions to IL-17 and IL-23 Inhibitors: A Clinical Review of Reaction Patterns.","authors":"Ingyun Park, Ali Bayrouti, Duncan MacIntyre, Vivian Le, Khoa B Nguyen","doi":"10.5826/dpc.1603a6731","DOIUrl":"10.5826/dpc.1603a6731","url":null,"abstract":"<p><strong>Introduction: </strong>IL-17 and IL-23 inhibitors have transformed the management of moderate-to-severe psoriasis and other inflammatory diseases through targeted immune modulation. Although generally well tolerated, an expanding spectrum of cutaneous adverse reactions has been reported, ranging from common paradoxical eruptions to rare immune-mediated dermatoses that may mimic primary inflammatory or autoimmune conditions.</p><p><strong>Objectives: </strong>We present a narrative review of cutaneous adverse reactions associated with IL-17 and IL-23 inhibitors. This review aims to summarize reported reaction patterns, proposed mechanisms, clinical and histopathologic features, and current diagnostic and therapeutic considerations to support clinical decision-making.</p><p><strong>Methods: </strong>We performed a narrative review of English-language literature describing cutaneous adverse reactions associated with IL-17, IL-23, and IL-12/23 inhibitors indexed in PubMed, Google Scholar, and Web of Science from database inception through August 2025. Clinical trials, observational studies, case series, case reports, and reviews were evaluated, and findings were synthesized according to reaction phenotype.</p><p><strong>Results: </strong>Psoriasiform and eczematous eruptions represent the most frequently reported cutaneous adverse reactions and may be clinically and histologically indistinguishable from idiopathic dermatoses. Less commonly reported reactions include lupus-like syndromes, bullous pemphigoid, lichenoid drug reactions, granulomatous eruptions, and vasculitic presentations, including IgA vasculitis. Proposed mechanisms involve paradoxical alterations in immune signaling following cytokine blockade rather than direct drug toxicity, although definitive pathways remain incompletely understood. Management strategies vary according to severity and phenotype, ranging from topical therapies and continued biologic use to discontinuation of the offending agent and systemic immunosuppression.</p><p><strong>Conclusions: </strong>IL-17 and IL-23 inhibitors are associated with a diverse spectrum of cutaneous adverse reactions that require recognition due to their potential overlap with primary dermatologic diseases. A structured approach to diagnosis and management may facilitate timely intervention. Further studies are needed to clarify incidence, risk factors, mechanisms, and evidence-based treatment strategies.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"16 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}