Dermatology practical & conceptual最新文献

{"title":"Sexual Functions are Impaired in Males and Females with Chronic Spontaneous and Inducible Urticaria; A Controlled Study.","authors":"Pelin Kuteyla Can, Utku Can","doi":"10.5826/dpc.1501a4470","DOIUrl":"10.5826/dpc.1501a4470","url":null,"abstract":"<p><strong>Introduction: </strong>Sexual dysfunction (SD) related to chronic dermatological diseases in females and males have been reported in the literature, but there are few reports on the effects of chronic urticaria (CU) on male and female sexual function.</p><p><strong>Objectives: </strong>The aim was to investigate the prevalence of SD in females and erectile dysfunction (ED) caused by two different CU subtypes.</p><p><strong>Methods: </strong>Our study included 100 patients with CU (60 chronic spontaneous urticaria ([CSU]) and 40 chronic inducible urticaria [CIndU]) and 60 healthy controls. The Urticaria Activity Score 7, Urticaria Control Test, Dermatology Life Quality Index, Beck Depression Inventory, International Index of Erectile Function (IIEF), and Female Sexual Function Index (FSFI) were assessed in patients and controls.</p><p><strong>Results: </strong>Patients with CSU and CIndU had a higher prevalence of female SD (83% and 70%, respectively, vs 20%; P <0.001) and ED (43% and 50%, respectively vs 10%; P <0.05, for all) than controls. CSU and CIndU patients both had lower FSFI scores than controls (median 23.35 and 23.9, respectively, vs controls 30.75; P <0.001). Overall score of IIEF was lower in the CSU group than in the control group (median 60 vs 67; P = 0.005). Depressive symptoms both in males and females with CU was associated with more impairment in sexual functions (r=-0.44, r=-0.47; P <0.001).</p><p><strong>Conclusions: </strong>Sexual function is affected in both female and male patients with CSU and CIndU. Given that sexual health is a crucial aspect of QoL, it should be considered when assessing treatment outcomes and disease control.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Advances in Vitiligo: An Updated Review.","authors":"Ishrat Binti Ismail, Yasmeen Jabeen Bhat, Mohd Shurjeel Ul Islam","doi":"10.5826/dpc.1501a4600","DOIUrl":"10.5826/dpc.1501a4600","url":null,"abstract":"<p><strong>Introduction: </strong>Vitiligo is a common disorder of depigmentation caused by the progressive destruction of melanocytes that affects the skin, hair, and mucous membranes, clinically presenting as depigmented macules and leukotrichia. This condition, affecting millions of people worldwide, has a significant psychosocial burden on patients' quality of life, particularly in relation to skin colour. The etiopathogenesis of this disorder is obscure, but multiple factors contribute to the loss of melanocytes in the skin, like oxidative stress, inflammation, genetics, and autoimmunity. The treatment of vitiligo has been challenging over the past years, but recent developments in understanding the etiopathogenesis of the disease have paved the way for the development of more effective and promising therapeutic treatment options.</p><p><strong>Objective: </strong>The aim of this review was to provide an overview of the underlying mechanisms and highlight the latest advances in the treatment of vitiligo.</p><p><strong>Methodology: </strong>This review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Metanalyses) guidelines. A comprehensive search of the literature was carried out through the PubMed electronic database from inception to 31 December 2023 using the following search terms \"vitiligo\" AND \"JAK inhibitors\", \"vitiligo\" AND \"prostaglandin\", \" vitiligo\" AND \" afamelanotide\", \"vitiligo\" AND \"antioxidants\", \"vitiligo\" AND \"vitamin D3\", \"vitiligo\" AND \"statins\", \"vitiligo\" AND \"TNF-alpha\", \"vitiligo\" AND \"interleukin\", \"vitiligo\" AND \"light therapy\". Two independent reviewers screened titles, abstracts, and full texts to select papers dealing with vitiligo and its treatment.</p><p><strong>Conclusion: </strong>The advent of treatment modalities like Janus kinase inhibitors, prostaglandin analogues, antioxidants, TNF-α inhibitors, targeted phototherapy, and excimer lasers has revolutionized the therapeutic possibilities, offering a ray of hope to the individuals suffering from this devastating condition.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-step-7-Pink Rule: A Practical Tool for the Dermoscopic Evaluation of Fully Amelanotic Skin Lesions.","authors":"Riccardo Pampena, Stefano Migliorati, Giovanni Paolino, Michela Lai, Nicola Lippolis, Stefania Guida, Stefania Borsari, Sebastiano Pellerone, Sofia Maria Di Ciaccio, Elvira Moscarella, Giovanni Pellacani, Giuseppe Argenziano, Caterina Longo","doi":"10.5826/dpc.1501a4768","DOIUrl":"10.5826/dpc.1501a4768","url":null,"abstract":"<p><strong>Introduction: </strong>The diagnosis of fully amelanotic skin tumors is difficult on clinical and dermoscopic examination.</p><p><strong>Objectives: </strong>We sought to identify an accurate and user-friendly dermoscopic algorithm to differentiate between benign and malignant pink lesions.</p><p><strong>Methods: </strong>The database of 1 referral center was retrospectively reviewed for images of non-inflammatory fully amelanotic skin lesions. Two dermatologists jointly assessed a validation set of images for dermoscopic criteria and constructed a diagnostic algorithm, the 2-step-7-pink rule (2S-7PR). Two external clinicians, with different skills in dermoscopy and blinded to the final diagnosis, separately evaluated images from the validation test sets using the prevalent criterion method and the new 2S-7PR algorithm.</p><p><strong>Results: </strong>A total of 763 lesions from 652 patients were included in the validation set database, of which 68.3% were malignant and 31.7% were benign. Three suspicious dermoscopic criteria were included in the first step of the 2S-7PR: polymorphous or sharply focused vessels, scales or crusts, and erosions or ulcerations; and 4 non-suspicious criteria were included in the second: white collarette, white scar-like area, vascular lacunae, and necklace pinpoint vessels. High levels of specificity and sensitivity were calculated in the validation and test phases for both the expert and non-expert evaluators, the former achieving higher levels of both sensitivity and specificity by employing the 2S-7PR compared to the prevalent method, and the latter only improved specificity.</p><p><strong>Conclusions: </strong>The present study showed that an algorithm focused on a few reproducible and easily recognizable criteria could improve diagnostic accuracy in the management of amelanotic lesions.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Psoriasis and Bullous Pemphigoid: A Mendelian Randomization Analysis.","authors":"Xiaoxue Wang, Zexin Zhu","doi":"10.5826/dpc.1501a4458","DOIUrl":"10.5826/dpc.1501a4458","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis and bullous pemphigoid (BP) are the two major types of immune-mediated inflammatory skin diseases. Studies have reported the association between psoriasis and BP; however, no studies have reported whether a causal relationship exists between these two skin diseases.</p><p><strong>Objectives: </strong>In order to explore the causal relationship between psoriasis and BP, we performed a bidirectional two-sample Mendelian randomization (MR) study.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) data related to psoriasis and BP were collected. The inverse-variance weighted (IVW) method was primarily applied for our MR analysis; MR-Egger, weighted median, simple mode, and weighted mode methods were also used. Heterogeneity, horizontal pleiotropy, and potential outliers were assessed for the MR analysis results.</p><p><strong>Results: </strong>GWAS data for psoriasis (three cohorts) and BP (one cohort) from publicly available trials were selected. Our MR results showed that psoriasis was causally associated with BP, that psoriasis could increase the risk of BP, and that reversed MR showed BP has no causal effect on psoriasis. No heterogeneity or pleiotropy was detected.</p><p><strong>Conclusion: </strong>These findings provided new evidence of the causal relationship between psoriasis and BP. Our MR suggested that psoriasis is potentially causal to BP, which helps us to improve the treatment strategy for patients with psoriasis. The mechanism remains open for further investigation.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PASS Syndrome: Clinical Observation.","authors":"Olga Valentinovna Grabovskaya, Natalia Pavlovna Teplyuk, Anna Evgenievna Bobkova, Vera Nikolaevna Busol","doi":"10.5826/dpc.1501a4975","DOIUrl":"10.5826/dpc.1501a4975","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention Deficit Hyperactivity Disorder and Treatment Adherence in Adolescent Acne Patients: Investigating the Relationship for Better Care Strategies.","authors":"Huriye Aybüke Koç, Cansu Altınöz Güney, Bedia Sultan Önal","doi":"10.5826/dpc.1501a4854","DOIUrl":"10.5826/dpc.1501a4854","url":null,"abstract":"<p><strong>Introduction: </strong>Accompanying comorbidities in acne vulgaris (AV) patients affect treatment adherence.</p><p><strong>Objectives: </strong>The purpose of this study was to investigate the relationship between treatment compliance and attention deficit hyperactivity disorder (ADHD) in adolescents with AV.</p><p><strong>Methods: </strong>This study included 140 patients with AV. At the beginning of the treatment, each patient acne severity was assessed, and the Conners-Wells Adolescent Self-Report Scale-Long Form (CASS-L) was administered. The Morisky Medication Adherence Scale (MMAS-8) was used to assess treatment adherence. The treatment response was assessed using a six-point scale.</p><p><strong>Results: </strong>Significant differences were found in the scores on the 10 subscales of the CASS-L among the 3 groups. The Global Acne Grading System (GAGS) scores showed a positive correlation with the scores of the subscales of the CASS-L, with 3 of them at a moderate level and 7 at a weak level. Five MMAS subscales had a weak correlation and 5 had a moderate correlation with the CASS-L subscale scores. The 9 subscales and the treatment response showed a slight negative correlation.</p><p><strong>Conclusions: </strong>ADHD is one of the many psychiatric comorbidities that frequently coexist with acne vulgaris. Its treatment is long-term and achieving a good treatment response relies heavily on patient adherence. Our study, which showed a decrease in acne treatment adherence and response as ADHD symptoms increased, will raise awareness among dermatologists to be more vigilant in their approach to this patient group.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevens-Johnson Syndrome and Erythema Multiforme Induced by Imiquimod 5% Cream.","authors":"Ilaria Salvi, Ilaria Trave, Riccardo Castelli, Aurora Parodi, Emanuele Cozzani","doi":"10.5826/dpc.1501a4629","DOIUrl":"10.5826/dpc.1501a4629","url":null,"abstract":"<p><strong>Introduction: </strong>Topical imiquimod is a safe and effective treatment for actinic keratoses, superficial basal cell carcinomas, and anogenital warts. The treatment is commonly associated with local inflammatory reactions, while systemic side effects are rare and generally mild. Only few cases of erythema multiforme and Stevens-Johnson syndrome have been described in association with topical imiquimod application.</p><p><strong>Objective: </strong>We present a narrative review of the existing cases of erythema multiforme and Stevens- Johnson syndrome reported in the literature, analyzing the clinical appearance, the histology, and the treatment of the lesions.</p><p><strong>Method: </strong>Twenty-one articles were retrieved. All the sourced articles were full-text reviewed to ensure that the contents were relevant to the study, which resulted in the exclusion of 10 articles.</p><p><strong>Results: </strong>Nine case of erythema multiforme were reported, characterized by cutaneous rash, bullae, crusting, and erosive and targetoid lesions, mainly located at the extremities. Mucosal involvement and systemic symptoms were present in five and in three cases, respectively. Three cases of Stevens-Johnson syndrome were associated with topical imiquimod. In all cases, the authors reported targetoid lesions and areas of erosion affecting trunk and limbs, associated with systemic symptoms, and, in two cases, with mucosal erosions.</p><p><strong>Conclusions: </strong>We hypothesize a possible role of interferon-γ, a cytokine involved in the pathogenesis of both herpes-associated erythema multiforme and Stevens-Johnson syndrome, which is released in response to the administration of imiquimod.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopy of Periungual Papules in Multicentric Reticulohistiocytosis.","authors":"José María Llamas-Molina, María Narváez-Simón, Ricardo Ruiz-Villaverde","doi":"10.5826/dpc.1501a4850","DOIUrl":"10.5826/dpc.1501a4850","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Psychosocial Burden in Psoriasis Patients Using the PRISM-RII Tool: A Comprehensive Evaluation.","authors":"Elif Afacan Yıldırım, Muhterem Polat, Yusuf Ezel Yıldırım","doi":"10.5826/dpc.1501a4831","DOIUrl":"10.5826/dpc.1501a4831","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic, immune-mediated inflammatory disease that significantly impacts patients' quality of life due to its visible lesions and associated stigma. Psychological comorbidities are prevalent among psoriasis patients.</p><p><strong>Objectives: </strong>This study aimed to evaluate the utility of the Pictorial Representation of Illness and Self Measure Revised II (PRISM-RII) tool in assessing the psychosocial burden, including internalized stigma, in psoriasis patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 190 psoriasis patients recruited from a university hospital dermatology treatment center. Participants completed the PRISM-RII Psoriasis Internalized Stigma Scale (PISS), Hospital Anxiety and Depression Scale (HADS), and Dermatology Life Quality Index (DLQI). Clinical severity was measured using the Psoriasis Area and Severity Index (PASI).</p><p><strong>Results: </strong>Significant correlations were observed between PRISM-RII parameters and measures of quality of life, internalized stigma, anxiety, and depression. Our study revealed significant differences in PASI scores among different Illness Perception Measures (IPM). A negative correlation was found between PASI and Self-Illness Separation (SIS), suggesting that increased disease severity is associated with a higher perceived burden of illness. Additionally, significant negative correlations were observed between SIS and DLQI, HADS, and PISS. Patients with larger IPM reported higher levels of anxiety, depression, and internalized stigma, as well as lower treatment satisfaction.</p><p><strong>Conclusions: </strong>The PRISM-RII tool effectively captures the psychosocial burden of psoriasis including internalized stigmatization, highlighting the need to address both physical and psychological aspects in clinical practice. Incorporating PRISM-RII into routine assessments can enhance patient-centered care by identifying and addressing the psychosocial dimensions of psoriasis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients with Pemphigus.","authors":"Mehmet Enes Güner, Perihan Öztürk, Mine Müjde Kuş","doi":"10.5826/dpc.1501a4969","DOIUrl":"10.5826/dpc.1501a4969","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, various inflammatory markers that can change in inflammatory states have been investigated. On the basis of these, we thought that inflammatory markers could also be used in the follow-up of pemphigus disease and monitoring its activity.</p><p><strong>Objectives: </strong>In this study, our objective was to investigate changes in the inflammatory markers neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), lymphocyte to monocyte ratio (LMR), C-reactive protein (CRP) erythrocyte sedimentation rate (ESR), which are inflammatory markers, before treatment and during follow-up, and the correlation of disease severity with these markers in patients with pemphigus receiving intravenous immunoglobulin (IVIG) and/or systemic immunosuppressant agents.</p><p><strong>Methods: </strong>Seventy-six pemphigus patients (69 had pemphigus vulgaris, 5 had pemphigus foliaceus, 2 had paraneoplastic pemphigus) who received IVIG and/or systemic immunosuppressant agents such as corticosteroids and azathioprine and used these treatments for at least 6 months were included. Changes in NLR, PLR, LMR, MPV, CRP and sedimentation values were examined in patients who received systemic treatment for at least 6 months, before the start of treatment and 3 and 6 months after the start of treatment.</p><p><strong>Results: </strong>Significant changes in inflammatory markers and correlation values were found in all patients.</p><p><strong>Conclusions: </strong>We think that neutrophil, platelet, NLR and PLR values can be used to monitor the response to treatment in pemphigus, since they show a significant decrease with treatment and are significantly positively correlated with Pemphigus Disease Area Index, which indicates the severity of the disease. LMR values were indicators of a poor prognosis. We found that the duration of remission was longer in the group receiving IVIG. Although there was no difference between the treatments in terms of disease recovery, only IVIG prolonged the duration of remission.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}