Dermatology practical & conceptual最新文献

{"title":"Efficacy of Bimekizumab in the Management of Refractory Erythrodermic Pityriasis Rubra Pilaris: Clinical Insights.","authors":"Sofia Theotokoglou, Dimitrios Sgouros, Konstantinos Theodoropoulos, Anna Syrmali, Georgia Pappa, Alexandros Katoulis","doi":"10.5826/dpc.1503a5316","DOIUrl":"10.5826/dpc.1503a5316","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of a Smartphone-Based Neural Network Application for the Risk Assessment of Skin Lesions under Real-World Conditions.","authors":"Teresa Kränke, Philipp Efferl, Katharina Tripolt-Droschl, Rainer Hofmann-Wellenhof","doi":"10.5826/dpc.1503a5110","DOIUrl":"10.5826/dpc.1503a5110","url":null,"abstract":"<p><strong>Introduction: </strong>The diagnostic performance of convolutional neural networks (CNNs) in diagnosing different types of skin cancer has been quite promising. Mobile phone applications with integrated artificial intelligence (AI) are an understudied area.</p><p><strong>Objective: </strong>We evaluated the risk assessment of the SkinScreener (Medaia GmbH, Graz, Austria) AI-based algorithm in comparison with an expert panel of three dermatologists.</p><p><strong>Methods: </strong>In this retrospective single-center study at the Department of Dermatology and Venereology in Graz, Austria. Photographs of lesions were taken by the users' mobile phone cameras. The algorithm allocated them to three risk classes. Blinded to AI's results, the images were evaluated by three dermatologists-our reference standard. A consensus was defined as at least a two-thirds majority.</p><p><strong>Results: </strong>A total of 1,428 skin lesions were included. In 902 lesions (63.16%), there was full agreement, and in 441 lesions (30.88%) a two-thirds majority was reached. Eighty-five lesions (5.69%) had to be discussed in a joint review process. The tested algorithm reached a sensitivity of 76.9% (95% CI: 71.7%-81.5%) and a specificity of 80.9% (95% CI: 78.5%-83.2%). Overall accuracy results were 77.2%.</p><p><strong>Conclusions: </strong>Our results indicate that the tested mobile phone algorithm is a valuable tool for the correct risk classification of various skin lesions. As expected, its performance is worse than in a professional setting. Nonetheless, the use of these applications on mobile phones should raise awareness of skin cancer and encourage users to deal more intensively with preventive measures. In light of our results, these applications are also reliable for use by non-professionals.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis and Autoimmune Connective Tissue Diseases: Systematic Review and Meta-Analysis.","authors":"Somaia Naassan, Misbah Noshela Ghazanfar, Simon Francis Thomsen, Zarqa Ali","doi":"10.5826/dpc.1503a5064","DOIUrl":"10.5826/dpc.1503a5064","url":null,"abstract":"<p><strong>Introduction: </strong>The association between atopic dermatitis (AD) and autoimmune connective tissue diseases (ACTD) is not well investigated.</p><p><strong>Objective: </strong>We aimed to conduct a systematic review and meta-analysis to assess the association between AD and ACTD.</p><p><strong>Methods: </strong>A comprehensive literature search was performed on PubMed, Embase, Cochrane Library, and Web of Science to identify relevant studies, which included those providing original data on the prevalence, incidence, or risk of ACTD in people with AD. Pooled point prevalence and odds ratio (OR) with 95% confidence intervals (CI) were estimated using a random effect inverse variance method.</p><p><strong>Results: </strong>Twenty-one studies were included in the systematic review, of which 18 were included in the meta-analysis. The pooled ORs were statistically significant overall for ACTD, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren syndrome (SS), and polymyositis (PM)/dermatomyositis (DM), but not for ankylosing spondylitis (AS) or systemic scleroderma (SSc): any ACTD 1.76 (95% CI: 1.57-1.97, I² =94%, P<0.01), RA 1.40 (95% CI: 1.23-1.58, I² = 97%, P<0.01), SLE 1.92 (95% CI: 1.66-2.23, I² = 86%, P<0.01), SS 2.08 (95% CI: 1.48-2.94, I² = 92%, P<0.01), AS 1.75 (95% CI: 1.32-2.33, I² = 47%, P=0.13), PM/DM 2.37 (95% CI: 1.54-3.67, I² = 73%, P<0.01), and SSc 2.75 (95% CI: 1.44-5.27, I² = 60%, P=0.06).</p><p><strong>Conclusion: </strong>AD is associated with a significantly increased risk of ACTD, particularly RA, SLE, SS, and PM/DM, while no significant association was observed with AS or SSc.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Resolution Imaging of Bullous and Hemorrhagic Lichen Sclerosus Using LC-OCT.","authors":"Simone Cappilli, Maria Teresa Perri, Vittoria Carbone, Alessandro Di Stefani","doi":"10.5826/dpc.1503a5397","DOIUrl":"10.5826/dpc.1503a5397","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Dermoscopic, and Histopathological Features of Spitzoid Lesions in Adult Patients: Insights from a Retrospective Study.","authors":"Riccardo Castelli, Ilaria Salvi, Ilaria Trave, Gianmaria Viglizzo, Antonio Guadagno, Francesco Cabiddu, Silvia Riva, Aurora Parodi, Emanuele Cozzani","doi":"10.5826/dpc.1503a5401","DOIUrl":"10.5826/dpc.1503a5401","url":null,"abstract":"<p><strong>Introduction: </strong>Spitzoid lesions are a group of melanocytic tumors, including Spitz nevi, atypical Spitz tumors, and Spitz melanomas, that pose a considerable diagnostic challenge.</p><p><strong>Objectives: </strong>Our aim was to describe the clinical, dermoscopic, and histopathological characteristics of spitzoid melanocytic lesions in adult patients in our center and to find possible associations between certain clinical-dermoscopic characteristics and the diagnosis of melanoma.</p><p><strong>Methods: </strong>We conducted a single-center retrospective study and included all cases of histopathologically-confirmed spitzoid melanocytic lesions diagnosed in adult patients between January 2012 and December 2022. We collected patient demographic characteristics and clinical, dermoscopic, and histopathological characteristics of the studied lesions.</p><p><strong>Results: </strong>Histopathological examinations of the 103 lesions included in the study revealed four Spitz melanomas (3.9%) and 99 non-melanomas, of which 92 were Spitz nevi (89.3%) and seven atypical Spitz tumors (6.8%). The association between lower limb localization and diagnosis of melanoma was statistically significant (4/4 vs 45/99 patients, P=0.048). A statistically significant association between raised and pigmented morphology and malignant histology was found (4/4 vs 37/99 lesions, P=0.0229). Dermoscopy revealed that a multicomponent pattern was significantly associated with a diagnosis of melanoma (100% vs 21.6%, P<0.01) and that a vascular pattern was significantly associated with atypical Spitz tumors (80% vs 28.8%, P=0.0343).</p><p><strong>Conclusions: </strong>In our cohort, some clinical characteristics (lower limb location, greater size, pigmentation, and palpability) and dermoscopic patterns (multicomponent) were associated with a diagnosis of melanoma. Dermatologists should be careful whenever they encounter any spitzoid-looking lesions in adults, especially in cases of older patients.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Perineal Groove in Males: A Comprehensive Review of a Rare Anomaly.","authors":"Julia Nowowiejska, Vincenzo Piccolo, Dirk Van Gysel, Ramon Grimalt, Andrea Bassi, Mario Cutrone","doi":"10.5826/dpc.1503a5303","DOIUrl":"10.5826/dpc.1503a5303","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post translational Modifications and Protein-Protein Interactome of Endemic Pemphigus in El Bagre, Colombia: A New Variant Analysis.","authors":"Ana Maria Abreu Velez, Mariana Ramírez-Posada, Michael S Howard","doi":"10.5826/dpc.1503a5097","DOIUrl":"10.5826/dpc.1503a5097","url":null,"abstract":"<p><strong>Introduction: </strong>A new variant of endemic pemphigus foliaceus, El Bagre-EPF, is an orphan autoimmune disease occurring in El Bagre and neighboring municipalities in Colombia, South America.</p><p><strong>Objectives: </strong>We aimed to evaluate current state-of-the-art databases and protein-protein interactomes, focusing on post-translational modifications as potential tools to study interactions among El Bagre-EPF antigen proteins.</p><p><strong>Methods: </strong>We consulted multiple databases for the known target antigens and their protein-protein interactions. We searched for their network nodes (they represent proteins; each node corresponded to all the proteins produced by a single, protein-coding gene locus). We also searched for any post-translational modifications.</p><p><strong>Results: </strong>We identified similarities in proteins bound by several autoantigens but also found differences in protein linkages. We found that desmoglein, periplakin, desmoplakins, and proteins from subfamilies of the Armadillo repeat proteins and some spectrin domains linked to other cell junctions; these played important roles in membrane-plaque and intermediate filament junctions. A typical drawback in current databases is the lack of information on lipid-protein interactions.</p><p><strong>Conclusions: </strong>Our results show that state-of-the-art protein databases as tools for studies of interactomes fall short in areas including tertiary and quaternary protein interactions and in vivo protein functioning. Enhanced three-dimensional or multi-dimensional functions are required for more accurate interactome analyses.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study.","authors":"Melodi Çekiç, Ayşın Köktürk, Lülüfer Tamer, Rojda Tanrıverdi","doi":"10.5826/dpc.1503a5015","DOIUrl":"10.5826/dpc.1503a5015","url":null,"abstract":"<p><strong>Introduction: </strong>Rosacea, a chronic skin disease characterized by facial redness, is believed to involve inflammation and angiogenesis in its pathogenesis. Endocan and endoglin, biomarkers associated with vascular and inflammatory processes, might play roles in rosacea and cardiovascular comorbidities.</p><p><strong>Objectives: </strong>This study aimed to assess serum levels of endocan and endoglin in individuals with rosacea and the function of these biomarkers in indicating comorbidities associated with rosacea.</p><p><strong>Methods: </strong>A total of forty-four patients diagnosed with rosacea and thirty-three healthy controls were included in this case-control study. The endocan and endoglin levels in serum samples from both groups were measured.</p><p><strong>Results: </strong>No significant difference in endocan and endoglin levels was observed between the patient and control groups. However, their levels were associated with various clinical features, including symptom and disease severity. A notable association was identified between waist circumference, body mass index, and endoglin levels. However, this association was not evident for endocan.</p><p><strong>Conclusions: </strong>This study suggests endocan and endoglin may play roles in rosacea pathogenesis, with endoglin potentially associated with increased cardiovascular risk.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sparse Brittle Hair and Bilateral Temporal Alopecia in a Child.","authors":"Eduardo Rozas-Muñoz, Jaime Piquero-Casals, Juan Andres Madariaga, Juan-Francisco Mir-Bonafé","doi":"10.5826/dpc.1503a5544","DOIUrl":"10.5826/dpc.1503a5544","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Melanoma Screening in Primary Care: The Experience of the Association of French General Practitioners Practicing Dermoscopy.","authors":"Julien Anriot, Nadia Ikhlef, Gérard Duru, Sophie Darnis, Pauline Scouarnec, Younes Tamarat, Mona Amini-Adle, Luc Thomas","doi":"10.5826/dpc.1503a6122","DOIUrl":"10.5826/dpc.1503a6122","url":null,"abstract":"<p><strong>Background: </strong>Melanoma constitutes an increasing global health burden. In the light of a growing shortage of dermatologists in several countries, primary care has emerged as an optimal setting for skin cancer screening. Historically, skin cancer detection in France was typically managed by dermatologists, while general practitioners (GPs) were barely involved. In 2021, the Association of French GPs Practicing Dermoscopy was created to address this gap by promoting and legitimizing dermoscopy practice among primary care physicians.</p><p><strong>Objectives: </strong>To assess the number of melanomas detected by dermoscopy-trained GPs three years after the association's foundation and to compare the melanomas' histopathological characteristics to those documented in the existing literature.</p><p><strong>Methods: </strong>A survey was shared via Google^® Forms with all the members of the association's Facebook ^® account between 26 November 2024 and 26 December 2024.</p><p><strong>Results: </strong>A total of 85 general practitioners responded to the survey. They reported the detection of 266 melanomas, corresponding to a median of approximately 1.6 per year of dermoscopy practice (mean: 2.9). Of the detected melanomas, 39.5% (105/266) were in situ, while only 22.4% (36/161) had a Breslow thickness above 1 mm, which constitutes a substantial improvement compared to previously reported data on GP-detected melanomas.</p><p><strong>Conclusions: </strong>Empowerment of primary care medicine through dermoscopy learning appears to be a promising way to overcome the relative shortage of diagnostic offer observed in several countries. Integrating skin cancer screening into a GP's practice may contribute to early melanoma detection and support ongoing efforts to lower melanoma mortality.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}