Dermatology practical & conceptual最新文献

{"title":"Real-Life Analysis of Therapeutic Management and Its Correlation with the Dermatology Life Quality Index Score in 108 Patients with Pustular Psoriasis: An Italian Monocenter Study.","authors":"Dario Buononato, Emanuele Scala, Pierfrancesco Benvenuto, Stefano Caccavale, Eugenia Veronica Di Brizzi, Roberta Di Caprio, Giuseppe Argenziano, Anna Balato","doi":"10.5826/dpc.1501a4871","DOIUrl":"10.5826/dpc.1501a4871","url":null,"abstract":"<p><strong>Introduction: </strong>Pustular psoriasis (PP) is a rare life-threatening skin disease with negatively impact on quality of life (QoL). Clinically, it may be systemic (generalized pustular psoriasis [GPP]) or localized on palms and soles (palmoplantar pustulosis [PPP]). It is not rare to observe plaque psoriasis associated with GPP.</p><p><strong>Objectives: </strong>We explored the therapies used for PP and their correlation with patient QoL scores, through a cross-sectional study using retrospective data from a monocentric database in the period 2017-2021.</p><p><strong>Methods: </strong>Patient characteristics were summarized using descriptive statistics and treatment predictors of QoL were identified by multiple regression analysis. Among 108 patients with PP, 57.4% had GPP + PSO whereas 42.6% had PPP. The therapeutic management is based on systemic conventional treatments and biological therapies in both GPP and PPP.</p><p><strong>Results: </strong>GPP + PSO patients with an impaired QoL (DLQI≥10) were associated with biological therapy including certolizumab (odds ratio [OR]=2.38), etanercept (OR=2.25), secukinumab (OR=2.03) or ustekinumab (OR=2.79) whereas, PPP patients were positively associated with secukinumab (OR=2.85) or apremilast (OR 4.28, 95%-CI 0.56-9.62).</p><p><strong>Conclusions: </strong>Currently, systemic conventional therapy remains the therapeutic fulcrum of PP management. A great effect on QoL, especially for GPP+PSO, was assessed regardless the ongoing treatment and only newer biologic options were able to somehow positively impact.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Onychoscopy Patterns In Fingernail Onychomycosis - A Study By The International Dermoscopy Society \"Trichoscopy and Onychoscopy\" Task Force.","authors":"Matilde Iorizzo, Bianca Maria Piraccini, Aurora Alessandrini, Francesca Bruni, Laura Vollono, Francesca Pampaloni, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio, Juan Jimenez-Cauhe, Chander Grover, Zoe Apalla, Asmahne Souissi, Awatef Kelati, Eirini Kyrmanidou, Elizabeth Lazaridou, Michela Starace","doi":"10.5826/dpc.1501a4887","DOIUrl":"10.5826/dpc.1501a4887","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis is one of the most common nail diseases. Fingernail onychomycosis is significantly less frequent than toenail onychomycosis and it is often misdiagnosed due to its subtle clinical presentations.</p><p><strong>Objectives: </strong>We sought to analyze the clinical and onychoscopic features of culture-proven cases of fingernail onychomycosis in adult and pediatric patients.</p><p><strong>Methods: </strong>Medical records of 120 patients with onychomycosis limited to the fingernails were collected and analyzed across several dermatological centers (Italy, Switzerland, Spain, Greece, Brazil, India, Morocco, Tunisia). Data collected included age, sex, affected hand, affected fingernails, isolated fungal microorganism, clinical, and onychoscopic signs.</p><p><strong>Results: </strong>A total of 341 fingernails were analyzed. The most commonly affected hand was the right one, and the most frequently affected digits were the second and third. The mean number of affected digits per patient was 2.84. Cultures identified Trichophyton rubrum in 54 cases, T. mentagrophytes var. interdigitalis in 20 cases, Aspergillus spp. in 8 cases, Candida spp. in 31 cases, and various other fungi in the remaining cases. Major clinical and onychoscopic features observed included onycholysis, subungual hyperkeratosis, leukonychia, chromonychia and absence of the cuticles. On the basis of all findings, 4 main types of fingernail onychomycosis were identified.</p><p><strong>Conclusions: </strong>Fingernail onychomycosis presents with distinct clinical and onychoscopy characteristics that can overlap with other nail conditions. Dermoscopy enhances diagnostic accuracy, but mycological confirmation is mandatory for a definitive diagnosis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzyl Benzoate 25% Versus Permethrin 5% for Scabies. Are Topical Drugs Still Required in the Oral Ivermectin Era?","authors":"Vittorio Tancredi, Gaetano Licata, Luca Damiani, Pierfrancesco Benvenuto, Giuseppe Argenziano, Caterina Mariarosaria Giorgio","doi":"10.5826/dpc.1501a4529","DOIUrl":"10.5826/dpc.1501a4529","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Superficial Actinic Porokeratosis Treated with Topical Simvastatin: Evaluation of Therapeutic Response with Dermoscopy.","authors":"Horacio Cabo, Emilia Cohen Sabban, Rosario Peralta, Gabriel Salerni","doi":"10.5826/dpc.1404a247","DOIUrl":"10.5826/dpc.1404a247","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized Calcium Hydroxylapatite Formulation and Its Injection Technique for Hand Rejuvenation: A Retrospective Study.","authors":"Emanuele Bartoletti, Alison Favaroni, Loredana Cavalieri","doi":"10.5826/dpc.1404a283","DOIUrl":"10.5826/dpc.1404a283","url":null,"abstract":"<p><strong>Introduction: </strong>Hand rejuvenation treatment is in high demand in cosmetic medicine. Radiesse®, a commercially available formulation of calcium hydroxylapatite (CaHA), is safe, biocompatible, and provides long-lasting results.</p><p><strong>Objective: </strong>The study aimed to retrospectively evaluate the efficacy and safety of the presented formulation of Radiesse® and its injection procedure.</p><p><strong>Methods: </strong>The hands of 58 women were treated employing Radiesse® diluted with lidocaine. The treatment was performed using a blunt cannula following the proximal-to-distal fanning technique at two entry points on the dorsum of the hands. The patients received 1-4 treatments over a follow-up period of up to five years.</p><p><strong>Results: </strong>The hands of 58 females were evaluated using the Merz Hand Grading Scale (MHGS) and treated with the presented CaHA formulation. After the first treatment, 55 patients (94.8%) achieved a 1-point improvement, and 19 patients (32.8%) did not receive further treatment, being satisfied with the results. The remaining 39 women (67.2%) received 2-4 follow-up treatments. At the end of the treatment(s), 46 women (79%) achieved a final improvement of one point, and 12 women (21%) a final improvement of two points. Three minor adverse events were registered.</p><p><strong>Conclusions: </strong>Radiesse® diluted with lidocaine is an excellent choice for hand rejuvenation. The formulation and technique proved to be safe and efficient. In our experience, a blunt cannula should be employed for optimal vein correction. The treatment was highly satisfying, although planning a second treatment during the 1-month follow-up visit is recommended to best achieve long-lasting results.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecthyma Gangrenosum Secondary to Panton-Valentine Leukocidin-Secreting Staphylococcus aureus in an Immunocompetent Patient.","authors":"François-Xavier Blanchet, Marion Delannoy, Christine Forasassi, Juliette Fontaine, Fabienne Carre, Dorothée Chopin, Hester Colboc","doi":"10.5826/dpc.1404a233","DOIUrl":"10.5826/dpc.1404a233","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous Pigmentation by Foreign Body Under Reflectance Confocal Microscopy Mimicking Recurrence of Lentigo Maligna.","authors":"Piscazzi Francesco, Di Giulio Sara, Ardigò Marco","doi":"10.5826/dpc.1404a234","DOIUrl":"10.5826/dpc.1404a234","url":null,"abstract":"","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onychoscopy in Palmoplantar Psoriasis: A Comparative Study of Nonpustular Palmoplantar Psoriasis and Palmoplantar Pustulosis.","authors":"Ahu Yorulmaz","doi":"10.5826/dpc.1404a227","DOIUrl":"10.5826/dpc.1404a227","url":null,"abstract":"<p><strong>Introduction: </strong>Palmoplantar psoriasis is classified as nonpustular palmoplantar psoriasis (NPPP) or palmoplantar pustulosis (PPP).</p><p><strong>Objective: </strong>We sought to shed light on the phenotypic diversity of nail psoriasis and conducted a thorough study of the dermoscopic features of nail lesions from patients with NPPP and PPP.</p><p><strong>Methods: </strong>A prospective study included 35 patients with NPPP and 20 patients with PPP who had findings of nail psoriasis in at least three of their nails. Demographic and clinical data, such as general characteristics, history, a thorough dermatological examination, and musculoskeletal assessment, were recorded. Each patient had their nails evaluated with videodermoscopy. The statistical analysis was carried out using SPSS software, including descriptive and analytical statistics.</p><p><strong>Results: </strong>Dermoscopic patterns of nail lesions in both groups differed from those seen in psoriasis vulgaris. Trachyonychia was the most common dermoscopic pattern among NPPP patients. Nail bed pustules were found in 75% of the PPP patients, and they were the most common dermoscopic finding identifying PPP nail lesions. In comparison to the NPPP group, patients with PPP had a higher frequency of psoriatic arthritis (PsA) and higher palmoplantar psoriasis and nail psoriasis severity scores. In the PPP group, all patients with PsA had pustules.</p><p><strong>Conclusions: </strong>Nail psoriasis has a heterogeneous presentation and various clinical manifestations in NPPP, PPP, and psoriasis vulgaris. The differences in dermoscopic patterns of nail lesions among NPPP, PPP, and psoriasis vulgaris reflect the diseases' distinct characteristics. A thorough dermoscopic examination of the nails may reveal information about both the underlying pathophysiological pathways and the overall course of psoriasis.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance Among In Vivo Reflectance Confocal Microscopy, Trichoscopy, and Histopathology in the Evaluation of Alopecia Areata Incognita.","authors":"Michela Starace, Nathalie De Carvalho, Daniel Fernandes Melo, Stephano Cedirian, Victor Desmond Mandel, Carla Jorge Machado, Cosimo Misciali, Giovanni Pellacani, Bianca Maria Piraccini, Marco Ardigò","doi":"10.5826/dpc.1404a229","DOIUrl":"10.5826/dpc.1404a229","url":null,"abstract":"<p><strong>Objectives: </strong>Alopecia areata incognita is a non-scarring autoimmune hair loss condition primarily affecting women aged 20 to 40. It is often misdiagnosed due to its resemblance to other conditions. Diagnosis relies on clinical suspicion, trichoscopic findings, and histological features. Reflectance confocal microscopy (RCM) shows promise as a non-invasive diagnostic tool for alopecia areata incognita. In this study, we aimed to explore RCM's diagnostic potential by investigating its association with trichoscopic and histopathological findings.</p><p><strong>Methods: </strong>We conducted a prospective study with 12 female patients affected by alopecia areata incognita. Patient data, trichoscopy, and RCM were used for diagnosis. Biopsies were taken based on trichoscopic and RCM criteria. Agreement between RCM, trichoscopy, and histopathology was assessed.</p><p><strong>Results: </strong>RCM showed substantial agreement with histopathology for fibrous tracts (92.9%). Other criteria, like infundibular ostia and inflammation, exhibited reasonable agreement (71.4% to 78.6%), with varying Kappa values. Miniaturized follicles had the lowest agreement (64.3%).</p><p><strong>Conclusion: </strong>This study suggests that RCM holds promise as a diagnostic tool for alopecia areata incognita, offering advantages in non-invasiveness and real-time monitoring. It demonstrated substantial agreement with histopathology in identifying key features. While some discrepancies were noted, especially in detecting inflammatory infiltrates, further research may enhance RCM's sensitivity. The non-invasive nature of RCM could improve patient experiences and offer dynamic disease tracking for better treatment decisions. This technology's potential extends beyond alopecia areata incognita, presenting opportunities for more patient-friendly diagnostic procedures in trichology.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Thiol Disulfide, Ischemia Modified Albumin, and Prolidase Parameters in Patients with Localized Scleroderma.","authors":"Ayşe Akbaş, Orhan Şen, Fadime Kılınç, Salim Neşelioğlu, Gülhan Aksoy Saraç, Akın Aktaş","doi":"10.5826/dpc.1404a249","DOIUrl":"10.5826/dpc.1404a249","url":null,"abstract":"<p><strong>Introduction: </strong>Localized scleroderma is a rare inflammatory skin disease that causes sclerosis in the dermis and subcutaneous tissue. Oxidative stress may play a role in the etiology or be responsible for the chronicity or progression of the disease.</p><p><strong>Objectives: </strong>We aimed to investigate the presence of oxidative stress in patients with localized scleroderma by examining thiol-disulfide balance, ischemia-modified albumin (IMA), and prolidase parameters.</p><p><strong>Methods: </strong>Twenty patients over the age of 18 who were diagnosed with localized scleroderma both clinically and histopathologically and 20 control subjects were included in the study. Age, sex, age at disease onset, duration of the disease, and presence of accompanying systemic diseases were questioned and recorded. Lesion type and modified Rodnan and LoSSI scores were calculated through dermatological examination. CRP, sedimentation rate, total thiol, native thiol, and disulfide levels indicated by the Erel profile, IMA level, and prolidase levels were measured and compared in both the patient and control groups.</p><p><strong>Results: </strong>Levels of native thiol (P=0.958), total thiol (P=0.979), disulfide (P=0.449), (disulfide/native thiol%) (P=0.368), (disulfide/total thiol%) (P=0.361), (native thiol/total thiol%) (P=0.368), and prolidase (P=0.121) were similar in both patient and control groups. Only IMA was significantly different. No significant relationship was found between the levels of native thiol, total thiol, disulfide, (disulfide/native thiol), (disulfide/total thiol), IMA, prolidase, and Rodnan and LoSSI scores.</p><p><strong>Conclusion: </strong>According to the data obtained from this study, we can say that the thiol-disulfide balance is not disrupted and that prolidase levels are not affected in localized scleroderma; however, IMA is negatively affected.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"14 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}