Diagnostic Accuracy of Magnified Dermoscopy and Reflectance Confocal Microscopy in Assessing Melanocytic Lesions.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Stefania Guida, Silvana Ciardo, Shaniko Kaleci, Francesca Farnetani, Marco Spadafora, Giulia Radi, Renato Rossi, Elisa Molinelli, Sabrina Longhitano, Claudio Conforti, Carmen Cantisani, Camilla Chello, Oriana Simonetti, Anna Maria Offidani, Pietro Rubegni, Franco Rongioletti, Caterina Longo, Elisa Cinotti, Giovanni Pellacani
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Abstract

Introduction: Magnified dermoscopy (MD), or optical super-high magnification dermoscopy, is an emerging technique in dermatology.

Objectives: The study aimed to evaluate the distribution of conventional dermoscopy, MD, and reflectance confocal microscopy (RCM) features in dermoscopically equivocal pigmented lesions and to estimate their diagnostic accuracy.

Methods: A retrospective analysis of conventional dermoscopic (20x), MD (400x), and RCM images of dermoscopically equivocal pigmented lesions, diagnosed as either nevi or melanoma, was performed. Distribution of features, sensitivity, and specificity for dermoscopy, MD, RCM, and a combination of these last two with conventional dermoscopy was estimated.

Results: A total of 74 nevi and 20 melanomas were included in the analysis. A positive correlation was observed between seven-point checklist in conventional dermoscopy and the diagnosis of melanoma. With MD, a significant correlation between dots, non-edged papillae, and melanoma was observed, but the technique did not have a significant impact on diagnostic accuracy as compared to traditional dermoscopy. On the other hand, RCM, alone or in combination with traditional dermoscopy, proved to increase diagnostic accuracy, in particular, specificity for melanoma diagnosis.

Conclusions: RCM has a defined role in increasing diagnostic accuracy of doubtful dermoscopic lesions, while the role of MD in clinical practice has yet to be defined, and methodologic standardization as well as a revision of terminology is encouraged to improve the recognition of features.

放大皮肤镜和反射共聚焦显微镜诊断黑素细胞病变的准确性。
简介:放大皮肤镜(MD),或光学超高放大皮肤镜,是一种新兴的皮肤病学技术。目的:本研究旨在评估常规皮肤镜、MD和反射共聚焦显微镜(RCM)特征在皮肤镜下模糊性色素病变中的分布,并评估其诊断准确性。方法:回顾性分析常规皮肤镜(20倍),MD(400倍)和RCM图像的皮肤镜模棱两可的色素病变,诊断为痣或黑色素瘤,进行。估计皮肤镜检查、MD、RCM以及后两者与常规皮肤镜检查的结合的特征分布、敏感性和特异性。结果:共纳入74例痣和20例黑色素瘤。常规皮肤镜检查的七点检查表与黑色素瘤的诊断呈正相关。对于MD,观察到斑点、无边缘乳头和黑色素瘤之间存在显著相关性,但与传统皮肤镜检查相比,该技术对诊断准确性没有显著影响。另一方面,RCM单独使用或与传统皮肤镜检查相结合,可提高诊断准确性,特别是黑色素瘤诊断的特异性。结论:RCM在提高可疑皮镜病变的诊断准确性方面具有明确的作用,而MD在临床实践中的作用尚未明确,鼓励方法学标准化和术语修订以提高对特征的识别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.40
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217
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