酒渣鼻对角质细胞皮肤癌的影响:基底细胞癌和鳞状细胞癌风险的前瞻性病例对照研究。

IF 2.3 4区 医学 Q2 DERMATOLOGY
Aslı Aksu, Ayşenur Demir, Hatice Günay, Pinar Ozdemir Cetinkaya, Birgul Ozkesici Kurt, Hazel Ezgi Kaya, İlknur Kıvanç Altunay, Deniz Altınel
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引用次数: 0

摘要

与角质细胞皮肤癌相关的皮肤合并症的全部范围仍有待阐明。目的:我们旨在研究角质细胞癌(KC)患者的其他皮肤病,并揭示它们之间的潜在关联。方法:纳入200例KC患者和200例无病对照。为了确定任何附加的皮肤病,所有研究组都接受了两位皮肤科医生的检查。结果:在KC患者中,87.5%诊断为基底细胞癌,13.5%诊断为鳞状细胞癌。两组的防晒霜使用习惯差异无统计学意义(P =0.284)。KC患者出现酒渣鼻的优势比(OR)显著升高(OR 5.13, 95% CI: 3.2-8.3, P=0.000),尤其是红斑毛细血管扩张型酒渣鼻(ETR)型(OR 5.03, 95% CI: 3.1-8.2, P=0.000)。采用受试者工作特征(ROC)曲线分析评价酒sacea对对照组与KC患者的鉴别效果,酒sacea的敏感性、特异性、阴性预测值、阳性预测值分别为45.5%、86%、61.2%、76.5% (AUC 0.658, 95% CI: 0.604 ~ 0.711, P=0.000), ETR的敏感性、特异性、阴性预测值、阳性预测值分别为44%、86.5%、60.7%、76.5% (AUC 0.653, 95% CI: 0.599 ~ 0.706, P=0.000)。酒渣鼻的存在对KC患者和对照组在所有部位的鉴别都有显著的疗效(P< 0.05)。结论:KC患者发生酒渣鼻的风险显著升高,尤其是ETR亚型患者,与年龄、性别或部位无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Rosacea on Keratinocyte Skin Cancers: A Prospective Case-Control Study of Basal and Squamous Cell Carcinoma Risk.

Introduction: The full range of cutaneous comorbidities associated with keratinocyte skin cancers remains to be elucidated.

Objectives: We aimed to examine other skin diseases in patients with keratinocyte cancer (KC) and to reveal potential associations between them.

Methods: Included in the study were 200 patients with KC and 200 disease-free controls. To identify any additional concomitant dermatological conditions, all study groups underwent examination by two dermatologists.

Results: In patients with KC, 87.5% were diagnosed with basal cell carcinoma and 13.5% were diagnosed with squamous cell carcinoma. There was no statistically significant difference between the two groups regarding sunscreen use habits (P =0.284). Patients with KC exhibited a significantly elevated odds ratio (OR) for the presence of rosacea (OR 5.13, 95% CI: 3.2-8.3, P=0.000) and especially erythematotelangiectatic rosacea (ETR) subtype (OR 5.03, 95% CI: 3.1-8.2, P=0.000). An Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the efficacy of rosacea in differentiating between the control group and patients with KC. The sensitivity, specificity, negative predictive value, and positive predictive value for rosacea were 45.5%, 86%, 61.2%, and 76.5%, respectively (AUC 0.658, 95% CI: 0.604-0.711, P=0.000), while for ETR it was 44%, 86.5%, 60.7%, and 76.5%, respectively (AUC 0.653, 95% CI: 0.599-0.706, P=0.000). The presence of rosacea demonstrated a significant efficacy in differentiating patients with KC from the control group in all localizations (P< 0.05).

Conclusion: The risk of rosacea in patients with KC, particularly those with the ETR subtype, was found to be significantly elevated, irrespective of age, sex, or localization.

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