Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.

Abstract

Introduction: The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.

Objectives: A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.

Methods: In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.

Results: Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.

Conclusions: Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.