Mohamed J Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Suhas Ballal, Shilpa Sharma, J Guntaj, G V Siva Prasad, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad
{"title":"干细胞治疗:银屑病的新途径和有效治疗。","authors":"Mohamed J Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Suhas Ballal, Shilpa Sharma, J Guntaj, G V Siva Prasad, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad","doi":"10.5826/dpc.1503a5333","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.</p><p><strong>Objectives: </strong>A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p><p><strong>Methods: </strong>In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.</p><p><strong>Results: </strong>Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.</p><p><strong>Conclusions: </strong>Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p>","PeriodicalId":11168,"journal":{"name":"Dermatology practical & conceptual","volume":"15 3","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339094/pdf/","citationCount":"0","resultStr":"{\"title\":\"Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.\",\"authors\":\"Mohamed J Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Suhas Ballal, Shilpa Sharma, J Guntaj, G V Siva Prasad, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad\",\"doi\":\"10.5826/dpc.1503a5333\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.</p><p><strong>Objectives: </strong>A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p><p><strong>Methods: </strong>In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.</p><p><strong>Results: </strong>Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.</p><p><strong>Conclusions: </strong>Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.</p>\",\"PeriodicalId\":11168,\"journal\":{\"name\":\"Dermatology practical & conceptual\",\"volume\":\"15 3\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339094/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology practical & conceptual\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5826/dpc.1503a5333\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology practical & conceptual","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5826/dpc.1503a5333","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.
Introduction: The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.
Objectives: A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.
Methods: In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.
Results: Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.
Conclusions: Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.